DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and Mhc

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster


Alignment Length:2606 Identity:549/2606 - (21%)
Similarity:960/2606 - (36%) Gaps:809/2606 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 ASLEDFEDLPNLSAKHPALPSSRLRRLK-------CRYPQ-----VVKRLSTLCSDVIARHPQTF 137
            |:.||.:..|.|..   :|...|:.:.|       |..|.     ::..:.....|::     :.
  Fly     6 ANQEDEDPTPYLFV---SLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIV-----SV 62

  Fly   138 ALQPGEGSLRARQDLGSSGV-----------EDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSI 191
            .||.||     .:|:.|..|           |||..:..|:...:|.|||.||...||||::|..
  Fly    63 GLQGGE-----VRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLF 122

  Fly   192 LIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPSPQV---VVISGESGSGKT 253
            .:|:||||.:| .|....||.|.|:....:|||:|||...|:..:.:..|   ::|:||||:|||
  Fly   123 CVAINPYKRYP-VYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKT 186

  Fly   254 ESTKLVMQYLAAVVPGGGS--------ASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLE 310
            |:||.|:.|.|.|   |.|        :...:.:|:::..|:|||||||:|.||||||||||::.
  Fly   187 ENTKKVIAYFATV---GASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIR 248

  Fly   311 VYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFY--L 372
            ::| .:|.:.||.|..|||||:|:::|...||:||:||:::.| |........||..:.|.|  :
  Fly   249 IHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSG-SVPGVKDICLLTDNIYDYHIV 312

  Fly   373 NQGATDCAS--GRVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHR--RQLRHGQEGV 433
            :||....||  ...::.....|..:||.::.|:|.:.|:.|||:|:|.:.|.:  |:.:..|:|.
  Fly   313 SQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGE 377

  Fly   434 EVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNW 498
            |.|..     .:.|.......|::.|.....:...|.:.....:.|..::..|..|.::..||.|
  Fly   378 EEGGR-----VSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKW 437

  Fly   499 LVSRINSIV---QKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQA 560
            ||.:.|..:   ||    ..|.|.:|||.|||....|.|||||||:.||.||.:||.|:|.|||.
  Fly   438 LVKKCNETLDTQQK----RQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQE 498

  Fly   561 EYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYA 624
            ||.||.::|..:.:..:|.....|.:||:||..:|::||.||:|||.:|.||....| ..|..:.
  Fly   499 EYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQ 563

  Fly   625 RPR-----IGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQR 684
            :|:     ..|..|.:.||||.|.|.:.|:|:||:|.|...|::....|:..|:.|:......|.
  Fly   564 KPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQS 628

  Fly   685 DAGKTLPKGSNGR----FVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRM 745
            ..|:. .||..|:    |.       ||::.:.:.|..|:.::....|.|||||.||:.|....:
  Fly   629 GGGEQ-AKGGRGKKGGGFA-------TVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVV 685

  Fly   746 DMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPR 810
            |...|:.||...|:|:.|:|.::|:|.|:.:..|..||:.:.|..|......::....:::.   
  Fly   686 DAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKATEIIIKF--- 747

  Fly   811 TGVEGPD--YQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRL 873
              ::.|:  |:||.|:||.|..:...:|..|.|||.:....:|...||.|.|:...:.|.....|
  Fly   748 --IDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVAL 810

  Fly   874 QARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQA 938
            :.   .||..::|.:|        |.|...:..::|:.|.:..|...|.....::|::|.|...|
  Fly   811 KV---VQRNLRKYLQL--------RTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAA 864

  Fly   939 VLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFS 1003
            .::        :..||..:.:||..        ....:|.::.|...:.....|...:.:..|  
  Fly   865 EVK--------VRKELEALNAKLLA--------EKTALLDSLSGEKGALQDYQERNAKLTAQK-- 911

  Fly  1004 SVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHK 1068
                |.|..|.|  .|...|.....:|:|.||.         :...|:.:.|.|           
  Fly   912 ----NDLENQLR--DIQERLTQEEDARNQLFQQ---------KKKADQEISGLK----------- 950

  Fly  1069 ALSSRGLRD-EILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPES 1132
                :.:.| |:.||...|        .:||:..|:                   |.::||... 
  Fly   951 ----KDIEDLELNVQKAEQ--------DKATKDHQI-------------------RNLNDEIAH- 983

  Fly  1133 LRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSW 1197
             :..|:.:|.:::                                     .:..|.:|....:. 
  Fly   984 -QDELINKLNKEK-------------------------------------KMQGETNQKTGEEL- 1009

  Fly  1198 TSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGA 1262
                :||...::.|..........||   :|.||        |..||::       |.|:.:|..
  Fly  1010 ----QAAEDKINHLNKVKAKLEQTLD---ELEDS--------LEREKKV-------RGDVEKSKR 1052

  Fly  1263 KFA----------------RTTLPDAVKRPAVPPPAPPTSSGKED----VPRERRSSRELLSRSS 1307
            |..                :..|...::|.  .......::..||    |.:.:|..:||.:|..
  Fly  1053 KVEGDLKLTQEAVADLERNKKELEQTIQRK--DKELSSITAKLEDEQVVVLKHQRQIKELQARIE 1115

  Fly  1308 ALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDR 1372
            .|.|..          :.....:||:..:..|  ||.:             |..||         
  Fly  1116 ELEEEV----------EAERQARAKAEKQRAD--LARE-------------LEELG--------- 1146

  Fly  1373 YHSAERLAPVGKDTGPRYQ--KSQHAG----RRSHAASHGSHSSKYADKAEYATRSSAMSDTSEA 1431
                |||...|..|..:.:  |.:.|.    ||....::..|.|..|:..:  ..:.|:::.:|.
  Fly  1147 ----ERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLANLRK--KHNDAVAEMAEQ 1205

  Fly  1432 PSLASHVRRVRVPSQASDVDQF--LDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEI 1494
               ...:.:::..::....:.:  |:||.:.|     |.:::.::....|........||.:|::
  Fly  1206 ---VDQLNKLKAKAEKEKNEYYGQLNDLRAGV-----DHITNEKAAQEKIAKQLQHTLNEVQSKL 1262

  Fly  1495 DDLDDYINDI--------FQPIPLVQNLEKLTSK-DQLAAIIKGGGVASKPEERDEESEIEDLDD 1550
            |:.:..:||.        .:...|::.||:..|: .||:.|           :....:::||...
  Fly  1263 DETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKI-----------KISLTTQLEDTKR 1316

  Fly  1551 YINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQ 1615
            ..:|  |....|..|.|..:.||...::|.....::.|...|..||.:...|.         ||.
  Fly  1317 LADE--ESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEA---------QVW 1370

  Fly  1616 RAFLQS-AMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSP 1679
            |:..:| .:|::.::::    ..:.||..|::               |...:.||:      |..
  Fly  1371 RSKYESDGVARSEELEE----AKRKLQARLAE---------------AEETIESLN------QKC 1410

  Fly  1680 MRMKATRSSL-VVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQD 1743
            :.::.|:..| ..:|.||             ||....:...:..:...:|....||:|:      
  Fly  1411 IGLEKTKQRLSTEVEDLQ-------------LEVDRANAIANAAEKKQKAFDKIIGEWK------ 1456

  Fly  1744 EPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPP 1808
                 .:.|..|.::...|::                      .|..|.     |.|.::.... 
  Fly  1457 -----LKVDDLAAELDASQKE----------------------CRNYST-----ELFRLKGAYE- 1488

  Fly  1809 PMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQD----VGQPMQSVVTTKLAKKSFEIGADRPP 1869
              .||....::|.|           |::...|.:|    :|:..:::...:.|:|..|...|   
  Fly  1489 --EGQEQLEAVRRE-----------NKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKD--- 1537

  Fly  1870 PGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVSGGN 1934
                       |::..||:                  |.|.||.....:|:.||           
  Fly  1538 -----------ELQAALEE------------------AEAALEQEENKVLRAQL----------- 1562

  Fly  1935 SGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPP 1999
                    ..:.||.:|:|                                              
  Fly  1563 --------ELSQVRQEIDR---------------------------------------------- 1573

  Fly  2000 APQSPPTARSPEPEPDYRTS--SSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLE---DH 2059
                    |..|.|.::..:  :.|...:.:.|.::.:.:....|:|.::.:.:....||   ||
  Fly  1574 --------RIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDH 1630

  Fly  2060 SASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLY 2124
            :..::      .:|::...|.:.:.:|.:                  :..|:|:..|:..||:| 
  Fly  1631 ANKAN------AEAQKNIKRYQQQLKDIQ------------------TALEEEQRARDDAREQL- 1670

  Fly  2125 EIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQ-KYEHERKRKSSAS 2188
                                                    |::..|.:..| :.|..|.....|.
  Fly  1671 ----------------------------------------GISERRANALQNELEESRTLLEQAD 1695

  Fly  2189 SGMREELDSMHMTTPPPVIVPAPVPPPSSTSPGLGVVSGVLMGSGSGGSTACLTYNRVPWKLRVR 2253
            .|.|:                                                          ..
  Fly  1696 RGRRQ----------------------------------------------------------AE 1702

  Fly  2254 KEVFQPHEPIGPPVALDLLFAQVLGDVFGVTPCLRITPQEKSSALNMLHGHGVSVDTLSNRNGSG 2318
            :|:...||.              |.:|......:....::..|.|..||.   .:|.|.|.    
  Fly  1703 QELADAHEQ--------------LNEVSAQNASISAAKRKLESELQTLHS---DLDELLNE---- 1746

  Fly  2319 AGGGGNGGQVRALVKRHLVDMARDWPLYFARLFAVQGAPLYPDVSIMGVSHSGLYLA---RRDAD 2380
                ....:.:|  |:.:||.||                                ||   |.:.|
  Fly  1747 ----AKNSEEKA--KKAMVDAAR--------------------------------LADELRAEQD 1773

  Fly  2381 YLIVVQAISFGEIQSAVTLPRPAALQLNLRNGKHLALHAARAAAIQSMVTTFVQEFRKSQSKAST 2445
            :                     |..|..||.            |::..:...  :.|..:::|:.
  Fly  1774 H---------------------AQTQEKLRK------------ALEQQIKEL--QVRLDEAEANA 1803

  Fly  2446 LSSGARAAAQTLNVPLERLESRQAHAQRNEHGVDGGSRQN----EQLQQSELHHHLQQQQQQQQQ 2506
            |..|.:|        :::||.|   .:..|:.:||..|::    :.|::||........|.::.:
  Fly  1804 LKGGKKA--------IQKLEQR---VRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDR 1857

  Fly  2507 QQHHQQQ------QQ-----QQQLEDAMEEQHMATDHQQQQQQQLGQQQGQQQRFLKQQSYLHSA 2560
            :.|.:.|      ||     ::|:|:|.|...:.....::.||:|  ::.:::..|.:|:.....
  Fly  1858 KNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFRKAQQEL--EEAEERADLAEQAISKFR 1920

  Fly  2561 RKSNAG 2566
            .|..||
  Fly  1921 AKGRAG 1926

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 245/723 (34%)
MYSc_Myo15 169..828 CDD:276838 239/691 (35%)
MyTH4 1014..1171 CDD:295320 23/157 (15%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 8/46 (17%)
MYSc 81..777 CDD:214580 245/722 (34%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 239/691 (35%)
Myosin_tail_1 842..1897 CDD:279860 259/1686 (15%)
V_Alix_like 1557..1877 CDD:187408 82/620 (13%)
ATP-synt_B <1671..1771 CDD:304375 29/216 (13%)
TMPIT 1739..>1825 CDD:285135 27/173 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45466279
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.840

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