Protein Alignment Myo10A and ck

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Alignment Length: 3130
• Identity: 715/3130 - (22%)
• Similarity: 1112/3130 - (35%)
• Gaps: 1144/3130 - (36%)

  Fly   143 EGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGL 207
            |..::|.......|||||..|.|||||.:|.||.:||.:.||||:.||||:|||||::.|...|.
  Fly    51 ERRIKAMHASSVQGVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGD 115

  Fly   208 EVAKQYAGRPLGSLPPHLFAIGAAAHAALP---SPQVVVISGESGSGKTESTKLVMQYLAAVVPG 269
            :: |.|..|.:|.||||:||||..|:|.:.   ..|.:|||||||:||||||||::|||||:
  Fly   116 QI-KLYKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAI--- 176

  Fly   270 GGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRI 333
             ....:.|.:|||||.|:|||||||:|.|||||||||||::::|. :|.|.||||.|||||||||
  Fly   177 -SGKHSWIEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRI 240

  Fly   334 VTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVD---WESLQGAMQV 395
            |:|...||||||||.:|.|||..|:|:..|..|..|.||..|.:....||.|   :..::.||:|
  Fly   241 VSQNHSERNYHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKV 305

  Fly   396 LGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALT 460
            |..|:.|...|:::|||:||.||:.: :..:....:..|:.....::..|.||.:....|..|||
  Fly   306 LLFSDQEIWEIIKLLAALLHCGNIKY-KATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALT 369

  Fly   461 SRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFG 525
            .||..|..|.:.:.|..||::|.||||.|.:|..:|..:|.:||:.:.|......:.|.:|||||
  Fly   370 RRTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFG 434

  Fly   526 FEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVG 590
            ||:..:|||||.||||||||||.:|.:|:|||||.||..|.:.|..:.:.||...:.|:|.|.:.
  Fly   435 FENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLN 499

  Fly   591 ICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQ-EFGVTHYAGQVWYCVDGFLDKNR 654
            |..|:|:|:.||:.||.:.|.|.|..|...:.|.:|:.... .||:.|:||.|:|...|||||||
  Fly   500 IMALIDEEARFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNR 564

  Fly   655 DALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQL 719
            |....|:|.|::.|    ..:..:|:.||     .:..|:..|     .||||::.:|..||..|
  Fly   565 DTFSPDLLHLVSQS----TNKFLRQIFAQ-----DIEMGAETR-----KRTPTLSTQFRKSLDAL 615

  Fly   720 LQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYR 784
            ::::..|.|:|:||||||:.|..:..|.....:||||.||::||:||:.|||:|..|:.||||||
  Fly   616 MKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYR 680

  Fly   785 HLLPSPLARGTP--YRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAA 847
            .|:|     |.|  :|..|:|....:....:...|||||.|:|||::|....||..|...|.|..
  Fly   681 FLIP-----GVPPAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKI 740

  Fly   848 VSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQL 912
            :.:||.:||.:.||:..|.:|||..:|..|:|...::||..:|.|.:..|.|.|.|....|.:.|
  Fly   741 LILQRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHL 805

  Fly   913 RSD------HRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDR 971
            |..      |.|....|      ||......||:                   |:|.
  Fly   806 RGHIVGLQAHARGYLVR------REYGHKMWAVI-------------------KIQS-------- 837

  Fly   972 HLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQD 1036
            |:.:::                    :..::..     |||:.::                 |.:
  Fly   838 HVRRMI--------------------AMRRYRK-----LRLEHKQ-----------------FAE 860

  Fly  1037 ALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLW 1101
            .|.:.||            .:::||          .||
  Fly   861 VLQLRKL------------EEQELL----------HRG--------------------------- 876

  Fly  1102 QLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAW 1166
                            :|:.....:....:.|..|..|::..|
  Fly   877 ----------------NKHAREIAEQHYRDRLHELERREIQEQ---------------------- 903

  Fly  1167 LEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDS 1231
            ||.|...             |.:..:..|:....||.                  :|||:
  Fly   904 LENRRRV-------------EVNMNIINDAARKQEEP------------------VDDGK----- 932

  Fly  1232 CGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRER 1296
                                     |:.:...|    |||:      ...||....|:|
  Fly   933 -------------------------LVEAMFDF----LPDS------SSDAPTPHGGRE------ 956

  Fly  1297 RSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHT 1361
                     :|..|:                  ...:::.:.||::|              |:|
  Fly   957 ---------TSVFND------------------LPHAQNVNQDDIIA--------------PIH- 979

  Fly  1362 LGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASH--GSHSSKYADKAEYATRSSA 1424
              :||..        |.|:..      ::||        .||::  |:.:.:||.||
  Fly   980 --ISEDE--------EDLSEF------KFQK--------FAATYFQGNVNHQYAKKA-------- 1012

  Fly  1425 MSDTSEAPSLASHVRRVRVPSQA--SDVDQFLDDLFSP---VLDGSLDELSDARSLAASIRGGSY 1484
                .:.|.|..|.:..::.:||  ..:.:|..|:..|   .:| .:|..|....:.|::.....
  Fly  1013 ----LKHPLLPLHTQGDQLAAQALWITILRFTGDMPEPKYHTMD-RMDTTSVMSKVTATLGRNFI 1072

  Fly  1485 EQENEAESEIDDLDDYINDIF---QPIPLVQNLEKLT--SKDQLAAIIKGGGVASKPEERDEESE 1544
            ..:...|:::..||.   |.|   :|..:...|..||  .|::|.              .|....
  Fly  1073 RSKEFQEAQLMGLDP---DAFLKQKPRSIRHKLVSLTLKRKNKLG--------------EDVRRR 1120

  Fly  1545 IEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPAL 1609
            ::| |:|                               :.||
  Fly  1121 LQD-DEY-------------------------------TADS----------------------- 1130

  Fly  1610 YQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPP 1674
            ||     ::|||....||: :...:..:..|:..|..:.........|:.|
  Fly  1131 YQ-----SWLQSRPTSNLE-KLHFIIGHGILRAELRDEIYCQICKQLTNNP-------------- 1175

  Fly  1675 PPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWP 1739
                   :|::.:...::.||             .:.|..|||  .|:: |.|| .:|.|
  Fly  1176 -------LKSSHARGWILLSL-------------CVGCFAPSE--KFVN-YLRA-FIREG----- 1211

  Fly  1740 PPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIES 1804
            ||...|..:                     :..:.|.|.|.....|          .|.|.:...
  Fly  1212 PPGYAPYCE---------------------ERLKRTFNNGTRNQPP----------SWLELQATK 1245

  Fly  1805 PTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLAKKSFEIGADRPP 1869
            ...|.|   |..:.:...|.|....||...|:...:..|
  Fly  1246 SKKPIM---LPITFMDGNTKTLLADSATTARELCNQLSD-------------------------- 1281

  Fly  1870 PGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLG-----GLFAS 1929
                                                          |:.|:.|.|     .||..
  Fly  1282 ----------------------------------------------KISLKDQFGFSLYIALFDK 1300

  Fly  1930 VSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAP 1994
            ||...||...|:|
  Fly  1301 VSSLGSGGDHVMD---------------------------------------------------- 1313

  Fly  1995 PAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLEDH 2059
                                                                             
  Fly  1314 ----------------------------------------------------------------- 1313

  Fly  2060 SASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLY 2124
                  |::..||                 |:                   ||:..:||
  Fly  1314 ------AISQCEQ-----------------YA-------------------KEQGAQER------ 1330

  Fly  2125 EIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEHERKRKSSASS 2189
                                                                             
  Fly  1331 ----------------------------------------------------------------- 1330

  Fly  2190 GMREELDSMHMTTPPPVIVPAPVPPPSSTSPGLGVVSGVLMGSGSGGSTACLTYNRVPWKLRVRK 2254
                                                                   ..||:|..||
  Fly  1331 -------------------------------------------------------NAPWRLFFRK 1340

  Fly  2255 EVFQP-HEPIGPPVALDLLFAQVL-GDVFGVTPCLRITPQEKSSALNML--------HGHGVSVD 2309
            |:|.| |||....||.:|::.||: |..||...|      :|...|.|:        :...:|::
  Fly  1341 EIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRC------DKEEDLAMIAAQQYFIEYSTDMSME 1399

  Fly  2310 TLSNRNGSGAGGGGNGGQVRAL-------------------------VKRHLVDMAR-DWPLYFA 2348
            .|.....:........|..:|:                         :|..:|..|: .|||.|:
  Fly  1400 RLFTLLPNFIPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFS 1464

  Fly  2349 RLFAV--QGAPLYP--DVSIMGVSHSGLYLARRDADYLIVVQAISFGEIQSAVTLPR-----PAA 2404
            |.:..  ...|..|  || |:.|:.:|:|:.   .|...|:..:||.|| :||:..:     ...
  Fly  1465 RFYEAYRNSGPNLPKNDV-IIAVNWTGVYVV---DDQEQVLLELSFPEI-TAVSSQKTNKVFTQT 1524

  Fly  2405 LQLNLRNGKHLALHAARAAAIQSMVTTFVQEFRKSQSKASTLSSGARAAAQTLNVPLERLESRQA 2469
            ..|:...|:.....:..|..|:.:|..|:...:| :||........||.:
  Fly  1525 FSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKK-RSKYVIALQDYRAPS--------------- 1573

  Fly  2470 HAQRNEHGVDGGS-----------RQNEQLQQSELHHHLQQQQQQQQQQQHHQQQQQQQQLEDAM 2523
                     ||.|           .::|...:|.|::
  Fly  1574 ---------DGTSFLSFFKGDLIILEDESCGESVLNN---------------------------- 1601

  Fly  2524 EEQHMATDHQQQQQQQLGQQQGQQQR--FLKQQSYLHSARKSNAGQQPSSLTN-GQVHHQEQMLQ 2585
                         ...:|:....|:|  |..:..|: ....|...|...:|.| .:.||..:
  Fly  1602 -------------GWCIGRCDRSQERGDFPAETVYV-LPTLSKPPQDILALFNIEEAHHGRR--- 1649

  Fly  2586 QQQQQSQSLPHHDLDANYLQDESNGG-TPPSVTKYSLLQFAMQHFRNDQLRDADRHHERHQSAAN 2649
                              |...|||| ..|....::|:::|:.|||    ....|...:..:.::
  Fly  1650 ------------------LSMASNGGAVEPRDRPHTLMEYALDHFR----LPPKRTMSKTLTLSS 1692

  Fly  2650 RSYAELVKWQGHAIRLPLLR---LPNDLAPLALECFDCILRYCGDIP-----LDPDLTEVKCVYT 2706
            :...||.::....|:.||||   ...:.|..|...|..||:|.||:|     :..::|:
  Fly  1693 KRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITD------ 1751

  Fly  2707 VLMHCH----KYLALRDEVYCQLMKQTTANRSPCPDSSQRAWRLLSILAAYFGCSDALRPYLMEH 2767
               |..    |:..||||:|||||||.|.||:..  |.:|.|.|:.:....|.||..|...|:..
  Fly  1752 ---HIFDGPLKHEILRDEIYCQLMKQLTDNRNRM--SEERGWELMWLATGLFACSQGLLKELLLF 1811

  Fly  2768 LTSAASDRRRSCHGTAAVCLTNLRKTARCGGRKNVPSVEEVTAVSAGRSARRQIYR---LPGGAE 2829
            |.:     ||  |..:...:..|:||.|.|.||..|...||.|:   :....||:.   .|...:
  Fly  1812 LRT-----RR--HPISQDSMHRLQKTIRHGQRKYPPHQVEVEAI---QHKTTQIFHKVYFPDDTD 1866

  Fly  2830 RVVNTRCSTVVADVIAELCALLGVESEAEQQEFSLYCIVQGDAFTMPLAADEYILDVT---TELL 2891
            .......||...|....:...|.:.:   .:.|||:..:.....::|  ..::..|..   |:.:
  Fly  1867 EAFEVDSSTRAKDFCNNISQRLSLRT---SEGFSLFVKIADKVISVP--EGDFFFDFVRHLTDWI 1926

  Fly  2892 KSGQP----------FYLIFCRSVWHFALKREPAPMPLYVEVLFNQVAPDYLEGLLLELPGNGVP 2946
            |..:|          :.:.|.:.:|...:..:.....|...  ::|..|..|.|
  Fly  1927 KKARPIRDGANPQFTYQVFFMKKLWTNTVPGKDRNADLIFH--YHQELPKLLRG----------- 1978

  Fly  2947 VPEMVR-DMARIAALLHRA------ADLSHVPAMKEIKFLLPKPALGIREIRPAQWVGLVQSAWP 3004
            ..:..| :.|::|||:.|.      .:|..:|.|  ::.|:|...:.|:.  .::|...:.:::.
  Fly  1979 YHKCSREEAAKLAALVFRVRFGENKQELQAIPQM--LRELIPSDIMKIQS--TSEWKRSIVASYN 2039

  Fly  3005 QVANLSPGQVKAQFLNVLATWPLFGSSFFAVKRIWAEEGPHVEDNHSPMWRDLILALNRRGVLFL 3069
            |...::....|..||.::..||.|||:||.||:.       .|.|:..|   |::|:|:.||..:
  Fly  2040 QDGGMTSEDAKVAFLKIVYRWPTFGSAFFEVKQT-------TEPNYPEM---LLIAINKHGVSLI 2094

  Fly  3070 DPNTHETLQHWSFMEVISTRKVRSEDGALFLDMKVGNLMQQRVIRVQTEQAHEISRLVRQYITMA 3134
            .|.|.:.|....|     ||......|..:..|.:|||::...:..:|...:::..|:..||::.
  Fly  2095 HPVTKDILVTHPF-----TRISNWSSGNTYFHMTIGNLVRGSKLLCETSLGYKMDDLLTSYISLM 2154

  Fly  3135 QISQRDKREL 3144
            ..:....|.:
  Fly  2155 LTNMNKNRTI 2164

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	296/668 (44%)
		PTZ00121	<828..>943	CDD:173412	37/120 (31%)
		MyTH4	1014..1171	CDD:470587	15/156 (10%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	7/66 (11%)
		MyTH4	2704..2810	CDD:459939	39/109 (36%)
		FERM_B-lobe	2920..3025	CDD:271216	21/111 (19%)
		FERM_C_MyoXV	3029..3138	CDD:270022	29/108 (27%)
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	296/668 (44%)
		MyTH4	<1138..1245	CDD:214535	28/181 (15%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	37/457 (8%)
		B41	1251..1467	CDD:214604	63/581 (11%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	26/103 (25%)
		SH3	1560..1624	CDD:473055	14/128 (11%)
		MyTH4	1701..1849	CDD:214535	55/168 (33%)
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613	16/101 (16%)
		B41	1856..2068	CDD:214604	42/233 (18%)
		FERM_C2_MyoVII	2064..2159	CDD:270020	29/109 (27%)