DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and d

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	1035	Identity:	292/1035 - (28%)
Similarity:	436/1035 - (42%)	Gaps:	209/1035 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 NLSAKH----PALPSSRLRRLKCRYPQVVKRLSTLCSDVIARHPQTFALQPGEGSLRARQDLGSS 155
            :||..|    |.:|.|: ....|   |.||.|           |..|.....:..::.:|..|:|
  Fly   421 HLSHAHSQQLPFIPQSK-HTNPC---QSVKTL-----------PFGFGFSESQQKMQQQQQQGNS 470

  Fly   156 GVEDMT----LLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGR 216
            ..:||.    |...|.|.:::..|:.|:::...:|..|.||:::|||        |:|     |.
  Fly   471 SPKDMQDLIHLSGPLTEHAVMRTLQARFNERRYFTNVGPILLSINPY--------LDV-----GN 522

  Fly   217 PLG-------SLPPHLFAIGAAA---HAALPSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGG 271
            ||.       .|.|.|..|...|   .:....||.:::||.||:|||.:..|:::.|.|:..||.
  Fly   523 PLTLTSTRAMPLAPQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLRQLFAIAGGGP 587

  Fly   272 SASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKSGAIVGAKITQYLLEKSRIVTQ 336
            ...|.  :.:..|..:|.:.|:|:|..|..|||.|:::||....||:...||..|.|:::|::..
  Fly   588 ETDAF--KHLAAAFTVLRSLGSAKTTTNSESSRIGQFIEVQVTDGALYRTKIHCYFLDQTRVIRP 650

  Fly   337 APGERNYHVFYELLGGLSETERSKYGLLEADKYFYLN---------QGATDCASGRVDWESLQGA 392
            .|.|:|||:||:||.|||..||.|   |..|.|...|         |...:.|:....|::..|
  Fly   651 LPKEKNYHIFYQLLAGLSREERQK---LHLDGYSPANLRYLRGDIGQNEQEDAARFQAWKTCLG- 711

  Fly   393 MQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHR 457
              :||:...:   :||||||||.||||.|    :..|...|:|..:.|:...|.||.:....|.|
  Fly   712 --ILGIPFLD---VVRVLAAVLLLGNVQF----IDGGGLEVDVKGETELNSVASLLGVPPAALFR 767

  Fly   458 ALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGT---------- 512
            .||:||...|.:.:.:..|...|...||..|||||......:|.|.||:.:.|.|
  Fly   768 GLTTRTHNVRGQLVKSVCGDGDANMTRDCLAKALYCRTVATIVRRANSLKRLGSTLGTLSSDSNE 832

  Fly   513 -----------------------------HDAHR-------ISILDIFGFEDLAENS-FEQLCIN 540
                                         ::|.|       |.|||:||||:.:.:: .|.||||
  Fly   833 SVHNQADVASQHASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDMFGFEEPSPHAHLEHLCIN 897

  Fly   541 YANENLQLYFNKHVFKLEQAEYARER--LEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPR 603
            ...|.:|.::|.|:|| ...|..|:.  :..|.:.:.||:|.|.|::....|:..:||.|.:. |
  Fly   898 LCAETMQHFYNTHIFK-SSVESCRDEGIVCDTEVDYVDNVPCIDLISSLRTGLLSMLDAECSV-R 960

  Fly   604 ATDLSFLEKCHYNHALS-ELYARPRIGAQE---FGVTHYAGQVWYCVDGFLDKNRDALRGDVLEL 664
            .|..|::.|....|..| .|..:|.....:   |.:.|:||:|.|....|||.|||.:..|::.:
  Fly   961 GTAESYVTKLKVQHRSSTRLETKPTAEPHDPRMFLIRHFAGRVEYDTTDFLDTNRDVVPDDLVGV 1025

  Fly   665 LASS------RLPLVGELTKQLRAQRDAGKTLPKG--------SNGRFVTMKPRTPTVAARFADS 715
            ....      ...|.|...|.|.||:.|    |:|        |:...:.......|:...|...
  Fly  1026 FYKHTCNFGFATHLFGSELKALYAQQQA----PRGLSFRISPTSHSDLLNGDEPVSTLTQDFHTR 1086

  Fly   716 LQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFV 780
            |..||:::....|.|||||:.|..:.|...|...|::|:|.|.:|:|:.:...|:|.|:||:.|.
  Fly  1087 LDNLLRTLVHARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQVLETVNLMASGFPHRMRFKQFN 1151

  Fly   781 ERYRHLLPSPLARGTPYREL--CRALLE-AMPRTGVEGPDYQL----GATRVFLREALHRALESG 838
            .|||.|.|..|.|.:..:.|  |:.:|: ||.:..|......|    |...|||.|.:.:.||..
  Fly  1152 ARYRMLAPFRLLRRSEDKALEDCQLILKYAMEQPPVLDGSVTLAWAPGKRHVFLSEGIRQHLEHL 1216

  Fly   839 RTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGR 903
            |||                       .|..:||.:||.|||.     :.|.:.|        .|.
  Fly  1217 RTE-----------------------IRHKSATLMQATWRGW-----WWRKKMG--------NGG 1245

  Fly   904 QARRRVQQLRSD--HRRRQEAREAAQR--AREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGW 964
            ..|.::..|:..  ...:.....|||.  |.....|..||...:.:|...:.|:...:
  Fly  1246 AKRSKIPGLQQAPLPNNKTTPNSAAQNKAASSTMAALAAVAAAAPISVPRLSAKTTSL------- 1303

  Fly   965 SPPHGDRHLVKVLGTV--PGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAP 1022
                      .:.|||  |.|...|...|.|..:....|.....||...|...|.|...|
  Fly  1304 ----------GIGGTVARPRPQPIAGTPPPDPQEKCDQKIIQQTCNLFGLDLERPPPVPP 1353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	234/776 (30%)
		MYSc_Myo15	169..828	CDD:276838	227/751 (30%)
		MyTH4	1014..1171	CDD:295320	3/9 (33%)
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
d	NP_001188730.1	MYSc	476..1217	CDD:214580	234/774 (30%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	227/751 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466234
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940