Protein Alignment Myo10A and Myo1d

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_036012676.1
• Gene: Myo1d / 338367
• MGIID: 107728
• Length: 1010
• Species: Mus musculus
• Alignment Length: 1046
• Identity: 326/1046 - (31%)
• Similarity: 493/1046 - (47%)
• Gaps: 175/1046 - (16%)

  Fly   178 RYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSP 239
            |::||.||||.|.::::|||||:. :.||.:..:||.||.|...|||||||..||:.|:   ...
Mouse    36 RFEKGRIYTFIGEVVVSVNPYKVL-NIYGRDTVEQYKGRELYERPPHLFAIADAAYKAMKRRSKD 99

  Fly   240 QVVVISGESGSGKTESTKLVMQYLAAVV-PGGGSASAVITEQILEAAPLLEAFGNARTARNDNSS 303
            ..::||||||:||||::|.:|||:||:. |...:....:...:|::..:|||||||:|.||||||
Mouse   100 TCIMISGESGAGKTEASKYIMQYIAAITNPSQRAEIERVKNMLLKSNCVLEAFGNAKTNRNDNSS 164

  Fly   304 RFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEA- 366
            |||||:::.|. .|..:|..|..|||||||::.|.||||::|.||:||.|.||.......|.::
Mouse   165 RFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGERSFHSFYQLLQGGSEQMLHSLHLQKSL 229

  Fly   367 DKYFYLNQGA------TDCASGRVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQ 425
            ..|.|:..||      .|.|..:|    :..||:|:|....|.:.:.::||.:|||||:.|
Mouse   230 SSYNYIRVGAQLKSSINDAAEFKV----VADAMKVIGFKPEEIQTVYKILAVILHLGNLKF---- 286

  Fly   426 LRHGQEG-VEVGSDAEIKWAAHLLHISADGLHRALTSRTTEAR---AERLHTPLGIDQALDARDA 486
            :..|... :|.|....:  .|.||...||.:.:||..||....   .::.||.   .:|...|||
Mouse   287 IVDGDTPLIENGKVVSV--IAELLSTKADMVEKALLYRTVATGRDIIDKQHTE---QEASYGRDA 346

  Fly   487 FAKALYAGLFNWLVSRINSIVQ-KGGTHDAHR----ISILDIFGFEDLAENSFEQLCINYANENL 546
            ||||:|..||.|:|:|||.|:: |......|.    |.:|||:|||....|||||.||||.||.|
Mouse   347 FAKAIYERLFCWIVTRINDIIEVKNYDTTIHGKNTVIGVLDIYGFEIFDNNSFEQFCINYCNEKL 411

  Fly   547 QLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDE-SNFPRATDLSFL 610
            |..|.:.|.|.||.||.||.:.|..:.:.:|..::.|:.::..||..:|||. .|..:.||..||
Mouse   412 QQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIIAILDDACMNVGKVTDGMFL 476

  Fly   611 EKC------HYNHALSELYARPRI--GAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLAS 667
            |..      |.:.:..:..|..:|  ..::|.:.||||.|.|...||:|||:|.|..|...|:.:
Mouse   477 EALNSKLGKHGHFSSRKTCASDKILEFDRDFRIRHYAGDVVYSAIGFIDKNKDTLFQDFKRLMYN 541

  Fly   668 SRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTP-TVAARFADSLQQLLQSMGRCHPWFV 731
            |..|::..:             .|:|...  :|...:.| |.|..|.:|:..|:.::....|::|
Mouse   542 SSNPVLKNM-------------WPEGKLS--ITEVTKRPLTAATLFKNSMIALVDNLASKEPYYV 591

  Fly   732 RCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYR---------HLL 787
            ||||||.:|.....|......|:.|||:|:.:::|:.|:..|..::.|:.||:         |.|
Mouse   592 RCIKPNDKKSPQIFDDERCRHQVEYLGLLENVRVRRAGFAFRQTYEKFLHRYKMISEFTWPNHDL 656

  Fly   788 PSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRT----ERLRRAAV 848
            ||.       :|..:.|:|   |.|.: .|...|.:::|:|        :.||    |.||..
Mouse   657 PSD-------KEAVKKLIE---RCGFQ-DDVAYGKSKIFIR--------TPRTLFTLEELRAQ-- 700

  Fly   849 SVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLR 913
                    ||||..|.        ||..|||..|:.||:| .|.|||..|.:|..:.:..:.::.
Mouse   701 --------MLVRVVLF--------LQKVWRGTLARMRYKR-TKAALTIIRYYRRYKVKSYIHEVA 748

  Fly   914 SDHRRRQEAREAAQRA---------REAREAKQAVLERSQLSYL--DIPA-ELAFIYSKLQGWSP 966
            ......:..|:..:..         |...||.|::..|.:.|.|  .||| :|..:.:|:.....
Mouse   749 RRFHGVKNMRDYGKHVKWPTPPKVLRRFEEALQSIFNRWRASQLIKTIPASDLPQVRAKVAAMEM 813

  Fly   967 PHGDRHLV--------KVLGTVPGPPSSA---VQLPEDLGQ--------FS-----FGKFSSVYC 1007
            ..|.|..:        ..|.:.|..|.::   |.:..:|.:        ||     ..:||.|..
Mouse   814 LKGQRADLGLQRAWEGNYLASKPDTPQTSGTFVPVANELKRKDKYMNVLFSCHVRKVNRFSKVED 878

  Fly  1008 NGL--------RLQPRRE---PITAPLLTRAASRDQDFQDALAVFK-------LILRWSNDKALE 1054
            ..:        ::.|.::   ..|.||.........:.:|.|.||.       ::..:|.....|
Mouse   879 RAIFVTDRHLYKMDPTKQYKVMKTIPLYNLTGLSVSNGKDQLVVFHTKDNKDLIVCLFSKQPTHE 943

  Fly  1055 GAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSK 1119
            ....:|:...:.|.....|.|:..:...:...:||........|||          .||...|:|
Mouse   944 SRIGELVGVLVNHFKSEKRHLQVNVTNPVQCSLHGKKCTVSVETRL----------NQPQPDFTK 998

  Fly  1120 YLMRFV 1125
            ....|:
Mouse   999 NRSGFI 1004

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	251/689 (36%)
		PTZ00121	<828..>943	CDD:173412	31/127 (24%)
		MyTH4	1014..1171	CDD:470587	24/122 (20%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myo1d	XP_036012676.1	MYSc_Myo1	36..686	CDD:276829	251/689 (36%)
		Myosin_TH1	807..1000	CDD:461801	36/202 (18%)