DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and myhc4

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_001018321.1 Gene:myhc4 / 334274 ZFINID:ZDB-GENE-030131-6206 Length:1935 Species:Danio rerio


Alignment Length:2147 Identity:486/2147 - (22%)
Similarity:847/2147 - (39%) Gaps:498/2147 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.::..|:|.|:|:||:.||...:|||::|.....|||||..| .|..||...|.|:.....
Zfish    89 IEDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLP-VYDAEVVAAYRGKKRMEA 152

  Fly   222 PPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAV-VPGG--------GSAS 274
            |||:|::...|:..:.:.   |.|:|:||||:|||.:||.|:||.|.| |.||        |...
Zfish   153 PPHIFSVSDNAYQFMLTDRENQSVLITGESGAGKTVNTKRVIQYFATVAVQGGDKKKEQAPGKMQ 217

  Fly   275 AVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAP 338
            ..:.:||:.|.|||||:|||:|.||||||||||::.::| .:|.:..|.|..|||||||:..|.|
Zfish   218 GSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLP 282

  Fly   339 GERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRV------DWESL---QGAMQ 394
            .||.||:||:::.. .:.|..:..|:..:.|.:     ..|:.|::      |.|.|   ..|:.
Zfish   283 DERGYHIFYQMMTN-HKPELIEMTLITTNPYDF-----PMCSQGQITVASIDDKEELMATDSAID 341

  Fly   395 VLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRAL 459
            :||.:..|:.||.:...||||.||:.|.::|   .:|..|.....|....::||.:::..|.:||
Zfish   342 ILGFTGEEKMGIYKFTGAVLHHGNMKFKQKQ---REEQAEPDGTEEADKISYLLGLNSAELLKAL 403

  Fly   460 TSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIF 524
            .....:...|.:.....:.|..::..|.:|::|..:|.|:|.|||.::......:.. |.:|||.
Zfish   404 CYPRVKVGNEFVTKGQTVPQVYNSVSALSKSIYEKMFLWMVIRINQMLDTKQQRNFF-IGVLDIA 467

  Fly   525 GFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPV 589
            |||....||.||||||:.||.||.:||.|:|.|||.||.:|.:.|..:.:..:|.....|.:||:
Zfish   468 GFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMDLAACIELIEKPM 532

  Fly   590 GICHLLDDESNFPRATDLSFLEKCHYNHALSELYA----RPRIGAQE--FGVTHYAGQVWYCVDG 648
            ||..:|::|..||:|||:||..|.:..| |.:..|    ||:.|..|  |.:.||||.|.|.|:|
Zfish   533 GIFSILEEECMFPKATDVSFKNKLYDQH-LGKCNAFQKPRPQKGKAEAHFSLVHYAGTVDYNVNG 596

  Fly   649 FLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFA 713
            :||||:|.|...|::|...|.:.|:..|...:..:...||   ||...:..:|:    ||:::|.
Zfish   597 WLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEETGGGK---KGGKKKGGSMQ----TVSSQFR 654

  Fly   714 DSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQH 778
            ::|.:|:.::...||.||||:.||:.|....|:...|:.|||..|:|:.|:|.::|:|.|:.:..
Zfish   655 ENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYGD 719

  Fly   779 FVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERL 843
            |.:||:.|..|.:..| .:.:..:|..:.:....|...:|:.|.|:||.:..|...||..|.|:|
Zfish   720 FKQRYKVLNASVIPEG-QFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFKAGLLGTLEEMRDEKL 783

  Fly   844 RRAAVSVQRHVRGMLVRRQ----LARRQAAATRLQ---------ARWRGQRAQQRYERLRKGALT 895
            .......|...|..|:||:    :.||::..| :|         ..|...:...:.:.|.|.|.|
Zfish   784 ATLVTMTQALCRAYLMRREFVKMMERRESIYT-IQYNIRSFMNVKHWPWMKVYYKIKPLLKSAET 847

  Fly   896 AQRLWRGRQARRRVQQLRSDH-RRRQEAREAAQRAREAREAKQAVLERS---QLSYLDIPAELAF 956
            .:.|          ..::.|. :.:::..:|..:.:|..|...|:|:..   ||:.......|:.
Zfish   848 EKEL----------ATMKEDFVKCKEDLVKAEAKKKELEEKMVALLQEKNDLQLAVASEAENLSD 902

  Fly   957 IYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITA 1021
            ...:.:|         |:|          |.:||...|.:.:           .||:...| |.|
Zfish   903 AEERCEG---------LIK----------SKIQLEAKLKETT-----------ERLEDEEE-INA 936

  Fly  1022 PLLTRAASRDQDFQDALAVFKLILRWSNDKALEGA---KEKLLADYIVHKALSSRGLRDEILVQL 1083
            .|    .::.:..:|..:..|..:   :|..|..|   |||...:..|.........:||.:.:|
Zfish   937 EL----TAKKRKLEDECSELKKDI---DDLELTLAKVEKEKHATENKVKNLTEEMASQDESIAKL 994

  Fly  1084 CNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGG 1148
            ..:...|                                                 |...||   
Zfish   995 TKEKKAL-------------------------------------------------QEAHQQ--- 1007

  Fly  1149 TSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGV 1213
                                              ||.|..::...|::.|..:....        
Zfish  1008 ----------------------------------TLDDLQAEEDKVNTLTKSKTKLE-------- 1030

  Fly  1214 ASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDL------LRSGAKFARTTLPDA 1272
                        ||:.|..|     .|..||:|       |.||      |....|.|:.::.|.
Zfish  1031 ------------QQVDDLEG-----SLEQEKKL-------RMDLERAKRKLEGDLKLAQESIMDL 1071

  Fly  1273 VKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKS 1337
            ..         .....:|.:.::...:.:|||:        .|.|.|.|........:.::|.:.
Zfish  1072 EN---------DKQQSEEKIKKKDFETAQLLSK--------IEDEQSLGAQLQKKIKELQARIEE 1119

  Fly  1338 LDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQ--KSQHAG--- 1397
            |::.:..:.. .....:.|....:..|.|        .:|||...|..|..:.:  |.:.|.   
Zfish  1120 LEEEIEAERA-ARAKVEKQRADLSRELEE--------ISERLEEAGGATAAQIEMNKKREAEFQK 1175

  Fly  1398 -RRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRV--RVPSQASDVDQFLDDLFS 1459
             ||....|...|.:..|     |.|.......:|......:::||  ::..:.|:....:|||.|
Zfish  1176 LRRDLEESTLQHEATAA-----ALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLSS 1235

  Fly  1460 PVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQ--NLE---KLTS 1519
                 :::.::.|::....:.....:|.:|.:|:.|:....|||:......:|  |.|   :|..
Zfish  1236 -----NMEAVAKAKANLEKMCRTVEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLEE 1295

  Fly  1520 KDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGST 1584
            |:.|.:.:..|..|.       ..:||:|...|.|            ::.:|..||.:::..   
Zfish  1296 KEALVSQLTRGKQAF-------TQQIEELKRQIEE------------EVKAKNALAHAVQSA--- 1338

  Fly  1585 DSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQ--------NLQIQQQLLAQNQALQ 1641
             .:..|.|..|.    .|.:...|..|:.:.:|  .|.:||        .:|..::|....:.|.
Zfish  1339 -RHDCDLLREQF----EEEQEAKAELQRGMSKA--NSEVAQWRTKYETDAIQRTEELEESKKKLA 1396

  Fly  1642 TLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPM 1706
            ..|.:......|.||.        .:||.      ::..|::.....|::               
Zfish  1397 QRLQEAEEQIEAVNSK--------CASLE------KTKQRLQGEVEDLMI--------------- 1432

  Fly  1707 PPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQ----------TEEDFFAFKMRQH 1761
                :.:..:.....||...|.....:.:|:....:.:.:.:          ||    .|||:..
Zfish  1433 ----DVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTE----LFKMKNS 1489

  Fly  1762 QRKTTPQAQHHQMTSNGGMMESGP-----GARGAS-------ATAIEWEEFEIESP------TPP 1808
            ..:|..|.:..:..:.....|...     |..|.|       ...:|.|:.||::.      |..
Zfish  1490 YEETLDQLETLKRENKNLQQEISDLTEQIGETGKSIHELEKAKKTVETEKAEIQTALEEAEGTLE 1554

  Fly  1809 PMSGQLMRSSIRLETTTTTTTSAVNNRDRD-----RETQDVGQPMQSVVTTKLAKKSFEIGADRP 1868
            ....:::|..:.|..........:..:|.:     |.:|.|.:.|||.:.:::..::..:...:.
Zfish  1555 HEESKILRVQLELNQVKGEIDRKLAEKDEEIEQIKRNSQRVTEAMQSTLDSEVRSRNDALRIKKK 1619

  Fly  1869 PPGSVGKLKL--------SSEMRQRLEQVTAG------HSVRSTVSTKSEQRAPAKLEDTRKLML 1919
            ..|.:.::::        ::|.:::|..|.|.      | :...|..:.:.:....:.:.|..::
Zfish  1620 MEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLH-LDDAVRGQEDMKEQVAMVERRNTLM 1683

  Fly  1920 QQQLGGLFASVS----GGNSGPGGVVDSHATV------RTQIERMEGKLSPPPAPPSGGWPGVLL 1974
            |.::..|.|::.    |.......:||:...|      .|.:...:.||........|       
Zfish  1684 QSEIEELRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLESDLVQIQG------- 1741

  Fly  1975 PPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDT 2039
                                    ....:...||:.|.:.....:.:.::.|.:     ::|:||
Zfish  1742 ------------------------EVEDTVQEARNAEEKAKKAITDAAMMAEEL-----KKEQDT 1777

  Fly  2040 F------------------------------GAVRQQQMISSHHLHLED-------HSASSSPAV 2067
            .                              |..:|.|.:.|....||.       ..|.:...|
Zfish  1778 SAHLERMKKNLEITVKDLQHRLDEAENLAMKGGKKQLQKLESRVRELESEVEAEQRRGADAVKGV 1842

  Fly  2068 AAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLYEIRQVERE 2132
            ..:|:..:|.:......:...:..:.:.|:.:::..|....||   |..|:....|.::|:|:.|
Zfish  1843 RKYERRVKELTYQTEEDKKNINRLQDLVDKLQLKVKAYKRQSE---EAEEQANSHLSKLRKVQHE 1904

  Fly  2133 RE 2134
            .|
Zfish  1905 LE 1906

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 252/706 (36%)
MYSc_Myo15 169..828 CDD:276838 246/686 (36%)
MyTH4 1014..1171 CDD:295320 20/159 (13%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
myhc4NP_001018321.1 Myosin_N 36..74 CDD:280832
Myosin_head 89..768 CDD:278492 251/698 (36%)
MYSc_class_II 101..768 CDD:276951 246/686 (36%)
Myosin_tail_1 848..1925 CDD:279860 215/1367 (16%)
SPEC 881..1043 CDD:295325 44/310 (14%)
RILP-like <1002..1096 CDD:304877 27/179 (15%)
MIT_CorA-like <1297..>1409 CDD:294313 25/140 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.000

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