DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and myh9a

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_001091647.2 Gene:myh9a / 333938 ZFINID:ZDB-GENE-030131-5870 Length:1961 Species:Danio rerio


Alignment Length:2006 Identity:515/2006 - (25%)
Similarity:825/2006 - (41%) Gaps:417/2006 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   120 KRLSTLCSDVIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLI 184
            |::.....|:...:|..|                 |.||||..|..|:|||:|.|||.||..|||
Zfish    61 KKIKVNKDDIQKMNPPKF-----------------SKVEDMAELTCLNEASVLHNLRERYYSGLI 108

  Fly   185 YTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISG 246
            ||::|...:.:||||..| .|..|:.:.|.|:....:|||::||...|:.::   ...|.::.:|
Zfish   109 YTYSGLFCVVINPYKYLP-IYTEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTG 172

  Fly   247 ESGSGKTESTKLVMQYLAAVVPG-----GGSASAV----ITEQILEAAPLLEAFGNARTARNDNS 302
            |||:||||:||.|:||||.|...     ..|:.|:    :.:|:|:|.|:|||||||:|.:||||
Zfish   173 ESGAGKTENTKKVIQYLAYVASSFKTKKDQSSIALSHGELEKQLLQANPILEAFGNAKTVKNDNS 237

  Fly   303 SRFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEA 366
            |||||::.:.|. :|.||||.|..|||||||.:.||..||.:|:||.||.|..:..||:..|.:.
Zfish   238 SRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKDERAFHIFYYLLTGAGDKLRSELCLEDY 302

  Fly   367 DKYFYLNQGATDCASGRVDWESLQ---GAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRH 428
            :||.:|:.|.. ...|:.|.|...   .|.:::|:.|.|:.|:::|::|||.|||:.|.:.:   
Zfish   303 NKYRFLSNGNV-TIPGQQDRELFAETIDAFRIMGIPEDEQTGLLKVVSAVLQLGNMSFKKER--- 363

  Fly   429 GQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYA 493
            ..:...:..|...:..:|||.::.....||:.|...:...:.:......:||..|.:|.|||.|.
Zfish   364 NSDQASMPDDTAAQKVSHLLGMNVTDFTRAILSPRIKVGRDFVQKAQTQEQAEFAVEALAKATYE 428

  Fly   494 GLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLE 558
            .||.|||.|||..:.|.....|..|.||||.|||....||||||||||.||.||..||..:|.||
Zfish   429 RLFRWLVMRINKALDKTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILE 493

  Fly   559 QAEYARERLEWTPLAWD-DNLPVIHLLAKK--PVGICHLLDDESNFPRATDLSFLEKCHYNHALS 620
            |.||.||.:||:.:.:. |..|.|.|:.|.  |.||..|||:|..||:|||.||:||     .:.
Zfish   494 QEEYQREGIEWSFIDFGLDLQPCIELIEKPNGPPGILALLDEECWFPKATDKSFVEK-----VVQ 553

  Fly   621 ELYARPRI-------GAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTK 678
            ||...|:.       ...:|.:.||||:|.|..:.:|.||.|.|..:|..||..|....|.||.|
Zfish   554 ELGNNPKFQKPKKLKDDADFCIIHYAGKVDYKANEWLMKNMDPLNDNVATLLNQSVDKFVSELWK 618

  Fly   679 QLRAQRDAGKTLPKGS--NGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKH 741
            .:.......|....|.  :|...|.|....||...:.:.|..|:.::...:|.|||||.||.||.
Zfish   619 DVDRIVGLDKVAGMGESLHGAVKTRKGMFRTVGQLYKEQLMNLMTTLRNTNPNFVRCIIPNHEKK 683

  Fly   742 ALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARG-TPYRELCRALL 805
            |.::....||.|||..|:|:.|:|.::|:|.|:.||.|.:||..|.|:.:.:| ...::.|..::
Zfish   684 AGKLAHHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQACVLMV 748

  Fly   806 EAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAA 870
            :|:.   ::...|::|.::||.|..:...||..|..::....::.|...||.:.||..|:||...
Zfish   749 KALE---LDSNLYRIGQSKVFFRAGVLAHLEEERDMKITDVIINFQAWCRGYVARRAFAKRQQQL 810

  Fly   871 TRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQE---AREAAQRAREA 932
            |.::..   ||....|.:||.        |:..:...:|:.|....|:.:|   ..|...:.:|.
Zfish   811 TAMRVI---QRNCAAYLKLRN--------WQWWRLFTKVKPLLQVTRQEEEMVAKEEELVKMKER 864

  Fly   933 REAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQF 997
            ::..:..|:.|:.....:.||...:..:||.                    .:...|..|::.. 
Zfish   865 QQQAEDQLKESEAKQKQLNAEKLALQEQLQA--------------------ETELCQEAEEMRS- 908

  Fly   998 SFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKAL--------- 1053
                         ||..|.:.: ..:|....||.::.::.:|.|:     |..|.:         
Zfish   909 -------------RLTARMQEM-EEVLHELESRLEEEEERVAQFQ-----SEKKKMQQNIGDLEQ 954

  Fly  1054 -----EGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQP 1113
                 |.|::||..:.:...|...:...|.::::..|     ...|.|..::.:.:.:.......
Zfish   955 QLDEEEAARQKLQLEKVTMDAKLKKIEEDLMVIEDQN-----AKLSKEKKQMEERISEFTTNLAE 1014

  Fly  1114 SAAFSKYLMRF----------VDD--EAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAW 1166
            ....||.|.:.          ::|  ...|.:|..|.:...:.:|..|......|          
Zfish  1015 EEEKSKSLQKLKTKHETMITDLEDRLRKEEKMRQELEKNRRKLEGDSTELHDQIA---------- 1069

  Fly  1167 LEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDS 1231
             |.:|  :..::...|...:|..|.    :....||.|||.    ..|.:....:.....:|.:.
Zfish  1070 -ELQA--QIAELRAQLAKKEEELQA----ALARIEEEAALK----NAAQKSIREMEAQISELQED 1123

  Fly  1232 CGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKF--ARTTLPDAVKRPAVPPP-----APPTSSGK 1289
            ..|:......|||:        |.||   |.:.  .:|.|.|.:...|....     ....:..|
Zfish  1124 LELEKAARNKAEKQ--------RRDL---GEELEALKTELEDTLDSTAAQQELRAKRETEVTQLK 1177

  Fly  1290 EDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCD 1354
            :.:..|.|:..::||.....:.:.||.       ......|:|....|:|              .
Zfish  1178 KTLEDEARAHEQMLSEVRQKHNQAFEE-------LNEQLEQSKRSKASVD--------------K 1221

  Fly  1355 SQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYA 1419
            :::.|      ||..|:.....:.|:....|:..|.:|::...:....    .|:.....|.|..
Zfish  1222 AKQAL------ESERNELQIELKSLSQSKNDSENRRKKAESQLQELQV----KHTESERQKHELL 1276

  Fly  1420 TRSSAMSDTSEAPSLASHVRRVR------------VPSQASDVDQFLDDLFSPVL---------- 1462
            .:.|.|.  :|..||...|.:|.            |.||..|....|::.....|          
Zfish  1277 DKVSKMQ--AELESLQGTVTKVESKSIKAAKDCSAVESQLKDAQALLEEETRQKLAISTRLRQLE 1339

  Fly  1463 --DGSLDEL------------------------------SDARSLAASIRGGSYEQENEAESEID 1495
              ..:|.|:                              .:|:|| .|:..|..:.:.|.||.:.
Zfish  1340 DEQNNLKEMLEEEEESKKNVEKQLHTAQAQLAEMKKKIEQEAQSL-ESMEDGKKKLQREVESVLQ 1403

  Fly  1496 ---------------------DLDDYINDIFQPIPLVQNLEKLTSK-DQLAAIIKGGGVASK-PE 1537
                                 :|||.:.|.......||.||:...| ||:.|..|  .:::| .|
Zfish  1404 QLEERNASYDKLDKTKTRLQRELDDVLVDQGHLRQTVQELERKQKKFDQMLAEEK--SISTKYAE 1466

  Fly  1538 ERDEES---------------EIEDLDDYINELFEPIPVAEGLDK--LTSKEHLAVSIRGGGST- 1584
            |||...               |:|.:.|..|||       |.::|  .|..|.|..|....|.: 
Zfish  1467 ERDRAEAEAREKETKSLTLARELEAMTDLKNEL-------ERVNKQLKTEMEDLVSSKDDAGKSV 1524

  Fly  1585 -----DSNGADPLLHQL----------MQLPGETESGPALYQQQVQRAF---LQSAMAQNLQIQQ 1631
                 ...|.:..|.::          :||..:.:....:..|.::..|   |||...|..:.::
Zfish  1525 HELERAKRGMEQQLEEMKTQLEELEDELQLTEDAKLRLEVNMQALKAQFERDLQSRDEQGEEKRK 1589

  Fly  1632 QLLAQNQALQTLL----SQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVM 1692
            ||:.|.:.::..|    .|:|.|.:.....          .|.:|....|..:..||...:|..:
Zfish  1590 QLVKQVREMEMELEDERKQRAQAVSVRKKL----------ELDLSELAAQIDLANKARDEALKQL 1644

  Fly  1693 ESLQPPPPPPPPPMPPPLECKDPSETRHFLD-PYGRAKTVRIGKWRWPPPQDEPQ--------FQ 1748
            :.||             .:.|:  :.|.|.| ...|.:::...|      ::|.:        .|
Zfish  1645 KKLQ-------------AQMKE--QMREFEDLRLSRDESLNQAK------ENERKIKSMEAEIMQ 1688

  Fly  1749 TEEDFFAF----KMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPP 1809
            ..||..|.    :..|.:|.......:.|...|.  :.|....|..:..|...||.|.|..:...
Zfish  1689 LHEDLAAADRAKRQIQQERDELQDEINSQNAKNS--LSSDERRRLEARIAQLEEELEEEHLSVEL 1751

  Fly  1810 MSGQLMRSSIRLETTTTTTTSAVNNRDR--------DRETQDVGQPMQSVVTTKLAKKSFEIGAD 1866
            ::.:|.::|::.|..|...|:..:|..|        ||:.:|:.|.:|.:.....:|....|.|.
Zfish  1752 VNDRLKKASLQAEQVTVELTAERSNSQRLEGLRSQLDRQNKDMKQKLQELEGAVKSKYKSTITAL 1816

  Fly  1867 RPPPGSVGKL--KLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQ 1920
            ..   .:.:|  :|.|||::|.:            |||..:|...||   ::::||
Zfish  1817 ET---KIQQLEEQLDSEMKERQQ------------STKQVRRVEKKL---KEVLLQ 1854

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 273/708 (39%)
MYSc_Myo15 169..828 CDD:276838 265/687 (39%)
MyTH4 1014..1171 CDD:295320 28/182 (15%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
myh9aNP_001091647.2 Myosin_N 28..66 CDD:280832 1/4 (25%)
Myosin_head 81..768 CDD:278492 272/699 (39%)
MYSc_Myh18 93..768 CDD:276895 265/687 (39%)
Myosin_tail_1 845..1925 CDD:279860 217/1181 (18%)
crotonase-like 1067..>1101 CDD:304874 8/50 (16%)
DUF2570 1777..1878 CDD:305162 23/96 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.910

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