DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and Myo3b

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	NP_796350.2	Gene:	Myo3b / 329421	MGIID:	2448580	Length:	1333	Species:	Mus musculus

Alignment Length:	973	Identity:	346/973 - (35%)
Similarity:	524/973 - (53%)	Gaps:	122/973 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 QSPSLALLSP--------HVLRRQRPASLEDFEDLPNLS--AKHPALPSSRLRRLKCRYPQVVKR 121
            ::|...||.|        |.:.:   ..::|||..|:::  ..||.:..:: .::.|    :.|:
Mouse   266 RNPPPTLLHPDSWCEEFNHFISQ---CLIKDFEKRPSVTHLLDHPFIKGTQ-GKVLC----LQKQ 322

  Fly   122 LSTLCSDVIARHP--QTFALQPGEGSLRARQDLGSSGVE-DMTLLDDLHEASLLWNLRLRYDKGL 183
            |:.:..|...|:|  :|...:...|.....:|.|...:| |:..|:.|.|.::::.|:.||...|
Mouse   323 LAKVLQDQKHRNPVAKTRHERMHTGRPHRVEDAGKCCLEDDLVNLEVLDEDTIIYWLQKRYADAL 387

  Fly   184 IYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVIS 245
            |||:.|.||||:||::.. ..|..:.::.|.|....|.|||:||....|:..|   ...|.:|||
Mouse   388 IYTYVGDILIALNPFQNL-SIYSPQFSRLYHGVKRSSNPPHIFASADNAYQCLVTFSKDQCIVIS 451

  Fly   246 GESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLE 310
            ||||||||||..|::|:|..:   |.:.:..:.::||:...|:|||||||||.||||||||||||
Mouse   452 GESGSGKTESAHLIVQHLTFL---GKADNQTLRQKILQVNSLVEAFGNARTAINDNSSRFGKYLE 513

  Fly   311 VYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETER-SKYGLLEADKYFYL- 372
            :.| .:||::||:|::|||||||::.||.||:|:|:||.:..||...:: :::.|.|.....|:
Mouse   514 MMFTPTGAVMGARISEYLLEKSRVIQQAAGEKNFHIFYYIYAGLYHQKKLAEFRLPEEKPPRYIA 578

  Fly   373 ------NQGATDCASGRVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQE 431
                  .|..|...|.|..:|::|...:::|.::.|...:.|:||.:|::|::.|.....:|..:
Mouse   579 GETERVMQDITSKESYRTQFEAIQHCFKIIGFADKEVHSVYRILAGILNIGSIEFAAISSQHQTD 643

  Fly   432 GVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLF 496
            ..||.:...::.||.:|.||::.|..||||.....|.|.:.....:|:|.|.|||.:||||..||
Mouse   644 KSEVPNPEALENAACVLCISSEELQEALTSHCVVTRGETIVRANTVDRAEDVRDAMSKALYGRLF 708

  Fly   497 NWLVSRINSIVQKG----GTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKL 557
            :|:|:|||:::|..    ...|...:.|||||||||...|||||||||.|||.:|.|||:|||.|
Mouse   709 SWIVNRINTLLQPDKNICSAEDRMNVGILDIFGFEDFQRNSFEQLCINIANEQIQYYFNQHVFAL 773

  Fly   558 EQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSEL 622
            ||.||..|.::...:.::||.|::.:..:||:|:..|||:||.||:.||.:.::|...| ...:.
Mouse   774 EQMEYKNEGVDAVLVQYEDNRPLLDMFLQKPLGLLALLDEESRFPQGTDQTLVDKFEDN-LRCKF 837

  Fly   623 YARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGE-----LTK---- 678
            :.||:.....||:.||||.|.|...|.|:||||.|..||:.:|.:|...|:.:     |||
Mouse   838 FWRPKGVELCFGIQHYAGPVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLTKTGNL 902

  Fly   679 -QLRAQRDA-GKTLPKG-SNGRF------------VTMKPRTPTVAARFADSLQQLLQSMGRCHP 728
             |.||:..| .::||.. |.||.            .|...:..|:|:.|..||..||..|....|
Mouse   903 AQTRAKITASSRSLPPHFSAGRAKVDTLEVIRHPEETTNMKRQTMASYFRYSLMDLLSKMVVGQP 967

  Fly   729 WFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLAR 793
            .|:||||||.::.||:.....||.|||..|:|:|:.||::||..|:.|:.||:||.:|  :..|.
Mouse   968 HFIRCIKPNDDRKALQFSQDRVLAQLRSTGILETVSIRRQGYSHRIFFEEFVKRYYYL--AFRAH 1030

  Fly   794 GTP--YRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVR- 855
            .||  .:|.|.|:||   ::.::  .:.||.|:|||:                      ..||.
Mouse  1031 QTPPANKESCVAILE---KSRLD--HWVLGKTKVFLK----------------------YYHVEQ 1068

  Fly   856 -GMLVRRQLARRQAAATRLQARWRGQRAQQRYERLR----KGALTAQRLWRGRQARRRVQQLRSD 915
             .:|:|..:.|    ...|||..:|....:||:|.:    |||:|.|..|||..|||:::| ||.
Mouse  1069 LNLLLREVMGR----VVMLQAYTKGWLGARRYKRAKEKREKGAITIQSAWRGYDARRKLKQ-RSR 1128

  Fly   916 HRRRQEA--REAAQRAREAR-------EAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHG 969
            .|...||  ....|...:.:       |:.:...|.|:    :.||| |......|..|||.|
Mouse  1129 RRSESEAHIHTVLQTTPDQKYCPDSGGESNRGHEETSR----NCPAE-ADTDGHPQAQSPPTG 1186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	283/722 (39%)
		MYSc_Myo15	169..828	CDD:276838	277/700 (40%)
		MyTH4	1014..1171	CDD:295320
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myo3b	NP_796350.2	STKc_myosinIIIB_N	20..310	CDD:270808	11/46 (24%)
		S_TKc	43..309	CDD:214567	11/45 (24%)
		MYSc	362..1069	CDD:214580	284/740 (38%)
		MYSc_Myo3	373..1062	CDD:276830	277/700 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810