Protein Alignment Myo10A and smyhc1

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_001018343.1
• Gene: smyhc1 / 321552
• ZFINID: ZDB-GENE-030131-271
• Length: 1938
• Species: Danio rerio
• Alignment Length: 2053
• Identity: 507/2053 - (24%)
• Similarity: 823/2053 - (40%)
• Gaps: 499/2053 - (24%)

  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.:...|||.::|:||:.||...:|||::|...:.|||||..| .|...|.|.|.|:.....
Zfish    87 IEDMAMFTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYDSSVVKAYRGKKRTEA 150

  Fly   222 PPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASA------VI 277
            |||:|:|...|:..:.|.   |.|:|:||||:|||.:||.|:||.|::....|...|      .:
Zfish   151 PPHIFSISDNAYQYMLSDRENQSVLITGESGAGKTVNTKRVIQYFASIAAVSGKKDAASEKKGTL 215

  Fly   278 TEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGER 341
            .:||::|.|.|||||||:|.||||||||||::.::| .||.:..|.|..|||||||:..|...||
Zfish   216 EDQIIQANPALEAFGNAKTIRNDNSSRFGKFIRIHFGVSGKLASADIETYLLEKSRVTYQLKAER 280

  Fly   342 NYHVFYELLGGLSETERSKYGLLE-------ADKYFYLNQGATDCASGRVDWESL---QGAMQVL 396
            :||:||::|      .:.|..|||       ...|.|::||.|..|| ..|.|.|   ..|..||
Zfish   281 DYHIFYQIL------SQKKPELLEMLLITNNPYDYSYISQGETQVAS-IDDAEELIATDDAFDVL 338

  Fly   397 GVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTS 461
            |.::.|:.||.::..|::|.||:.|.::|   .:|..|.....:....|:|:.:::..|.:.|..
Zfish   339 GFTQDEKSGIYKLTGAIMHFGNMKFKQKQ---REEQAEADGTEDADKVAYLMGLNSADLIKGLCH 400

  Fly   462 RTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR--ISILDIF 524
            ...:...|.:.....:.|...:..|.||::|..:|.|:|.|||   |...|....:  |.:|||.
Zfish   401 PRVKVGNEWVTKGQNVQQVYYSIGALAKSVYEKMFLWMVVRIN---QSLDTKQPRQYFIGVLDIA 462

  Fly   525 GFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPV 589
            |||....|:|||||||:.||.||.:||.|:|.|||.||.:|.::|..:.:..:|.....|.:||:
Zfish   463 GFEIFDFNTFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGMDLQACIELIEKPM 527

  Fly   590 GICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARPRI--GAQE--FGVTHYAGQVWYCVDGF 649
            ||..:|::|..||:|:|.:|..|.:.|| ..:..:.:|||  |..|  |.:.||||.|.|.:..:
Zfish   528 GIMSILEEECMFPKASDQTFKAKLYDNHLGKNPTFQKPRIVKGRPEAHFALVHYAGTVDYNISNW 592

  Fly   650 LDKNRDALRGDVLELLASSRLPLVGEL---------TKQLRAQRDAGKTLPKGSNGRFVTMKPRT 705
            |.||:|.|...|:.|...|.:.|:..|         .:..:..:..||  .|||:.:
Zfish   593 LVKNKDPLNETVVGLFQKSTVKLLSFLFAGYSGADSAQDSKGGKGGGK--KKGSSFQ-------- 647

  Fly   706 PTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGY 770
             ||:|...::|.:|:.::...||.||||:.||:.|....|:.|.|:.|||..|:|:.|:|.::|:
Zfish   648 -TVSALHRENLNKLMTNLRSTHPHFVRCLIPNETKTPGAMENPLVMHQLRCNGVLEGIRICRKGF 711

  Fly   771 PVRLRFQHFVERYRHLLPS--PLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHR 833
            |.|:.:..|.:|||.|.||  |..:....::....||.::   .::...|:||.|:||.:..|..
Zfish   712 PNRILYGDFKQRYRILNPSANPEGQFIDNKKAAEKLLGSL---DIDHNQYKLGHTKVFFKAGLLG 773

  Fly   834 ALESGRTERLRRAAVSVQRHVRGMLVR---RQLARRQAAATRLQ---------ARWRGQRAQQRY 886
            .||..|.:||......:|...||:|.|   :::..|:.:...:|         ..|...:...:.
Zfish   774 TLEEMRDDRLALIITGIQARARGILSRLEFQKIVERRDSLLVIQWNVRAFMGVKNWPWMKLYFKI 838

  Fly   887 ERLRKGALTAQRLWRGRQARRRVQQ--LRSDHRRRQ----------------------------- 920
            :.|.|.|.|.:.:...::...::::  .:|:.|:::
Zfish   839 KPLLKTAETEKEMANMKEEFTKLKEAYAKSEARKKELEEKMVSLLQEKNDLQLAVQSEQDNLVDA 903

  Fly   921 ----------------EAREAAQRAREARE------AKQAVLERSQLSYL--DIPAELAFIYSKL 961
                            :|:|..:|..:..|      ||:..|| .:.|.|  ||. :|....:|:
Zfish   904 EERCEGLIKSKIQLEAKAKELTERLEDEEEMNAELVAKKRKLE-DECSELKKDID-DLELTLAKV 966

  Fly   962 QGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGK--FSSVYCNGL-RLQPRREPITAPL 1023
            :  ...|...:.||.|      ......|.|.:.:.:..|  ....:...| .||...:.:..
Zfish   967 E--KEKHATENKVKNL------TEEMAALDEIIAKLTKEKKALQEAHQQTLDDLQSEEDKVNT-- 1021

  Fly  1024 LTRA-ASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCN-- 1085
            ||:| |..:|...|.....:...:...|  ||.||.||..|.         .|..|.::.|.|
Zfish  1022 LTKAKAKLEQQVDDLEGSLEQEKKLRMD--LERAKRKLEGDL---------KLTQESIMDLENDK 1075

  Fly  1086 --QVHGLPPNSGEATRL------WQLLGQCLCCFQPSAAFSKYLMRF------VDDEAP------ 1130
              ....|.....|.::|      .|.||         |...|.|...      :::|..
Zfish  1076 QQMEEKLKKKDFEISQLNSKIEDEQALG---------AQLQKKLKELQARIEELEEELEAERAAR 1131

  Fly  1131 ---ESLRPLLLRQLLR-----QQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDE 1187
               |..|..|.|:|..     ::.||.::..:.....|.     .|::...|..:.|   ||..|
Zfish  1132 AKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKRE-----AEFQKLRRDLEEA---TLQHE 1188

  Fly  1188 ASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTD---------SCGLDYV---MDL 1240
            |:.       .:..:..|.:|:.||..       :|:.|::..         ...||.|   |:.
Zfish  1189 ATA-------ATLRKKHADSVADLGEQ-------IDNLQRVKQKLEKEKSELKLELDDVVSNMEQ 1239

  Fly  1241 IAE-----KELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSR 1300
            |.:     :::|.......|: .|:.|:..:.|:.|...:.|    ...|.:|:        .||
Zfish  1240 IVKSKSNLEKMCRTLEDQMSE-YRTKAEEGQRTINDFTMQKA----KLQTENGE--------LSR 1291

  Fly  1301 ELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDD------LLAGDIVPVPTDCD----- 1354
            :|..:.|.:::  ..|      |:.|.|.|.:...:.|::      .||..:.....|.|
Zfish  1292 QLEEKDSLVSQ--LTR------GKQSYTQQIEDLKRQLEEEVKAKNALAHAVQSARHDSDLLREQ 1348

  Fly  1355 ---SQEPLHTLGLSESRLN------------DRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAAS 1404
               .||....|..|.|:.|            |.....|.|....|....|.|:::.|....:|..
Zfish  1349 FEEEQEAKAELQRSLSKTNSEVAQWRTKYETDAIQRTEELEDAKKKLAQRLQEAEEAVEAVNAKC 1413

  Fly  1405 HGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVL------- 1462
            .....:|:..:             :|...|...|.|....:.|.|..|   ..|..||
Zfish  1414 SSLEKTKHRLQ-------------NEIEDLMVDVERSNAAAAALDKKQ---RNFDKVLAEWKQKY 1462

  Fly  1463 DGSLDELSDA----RSLAASI--RGGSYEQ----------ENE-AESEIDDLDDYINDIFQPIPL 1510
            :.|..||..|    |||:..:  ...|||:          ||: .:.||.||.:.:.:..:.|..
Zfish  1463 EESQTELESAQKESRSLSTELFKLKNSYEEVLDQLETMKRENKNLQEEISDLTEQLGETGKSIHE 1527

  Fly  1511 VQNLEKLTSKDQL---AAIIKGGG----------------------VASKPEERDEESE------ 1544
            ::.:.|...:::.   .|:.:..|                      :..|..|:|||.|
Zfish  1528 LEKIRKQLEQEKAEIQTALEEAEGSLEHEEGKILRAQLEFNQVKADIERKLSEKDEEMEQAKRNQ 1592

  Fly  1545 ---IEDLDDYI-------NELFEPIPVAEG-LDKL--------------------------TSKE 1572
               ::.|...:       ||........|| |:::                          .|:.
Zfish  1593 QRVVDTLQSSLESETRSRNEALRLKKKMEGDLNEMEIQLSQANRQASEAQKQLKGLHGHVKDSQM 1657

  Fly  1573 HLAVSIRGGGSTDSNGA---------DPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQ 1628
            .|..::||......|.|         ...|.:|..|..:||.|..|.:|::.      .:::.:|
Zfish  1658 QLDDALRGNDDLKENIAIVERRNNLLQAELDELRSLVEQTERGRKLAEQELM------DVSERVQ 1716

  Fly  1629 IQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVME 1693
            :   |.|||   .:||:|:......|                              |:....|.|
Zfish  1717 L---LHAQN---TSLLNQKKKLEGDN------------------------------TQLQTEVEE 1745

  Fly  1694 SLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAF-- 1756
            ::|              ||::..|         :||     |..........:.:.|:|..|.
Zfish  1746 AVQ--------------ECRNAEE---------KAK-----KAITDAAMMAEELKKEQDTSAHLE 1782

  Fly  1757 KMRQHQRKTTPQAQH-----HQMTSNGGMMESGPGARGASATAIEWE-EFEIESPTPPPMSGQLM 1815
            :|:::..:|....||     .|:...||..:    .:...|...|.| |.|:|..........:.
Zfish  1783 RMKKNMEQTIKDLQHRLDEAEQIAMKGGKKQ----VQKLEARVRELENEVELEQRKASESVKGVR 1843

  Fly  1816 RSSIRLETTTTTTTSAVNNRDRDRET----QDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKL 1876
            :...|::..|..|       :.||:.    ||:...:|  :..|..|::.| .|:.....::||.
Zfish  1844 KYERRIKELTYQT-------EEDRKNLARLQDLVDKLQ--LKVKSYKRAAE-EAEEQANSNLGKF 1898

  Fly  1877 -KLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLED 1913
             ||..|:.:..|:.....|..:.:..||....|.|..|
Zfish  1899 RKLQHELDEAEERADIAESQVNKMRAKSRDSGPKKGHD 1936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	250/696 (36%)
		PTZ00121	<828..>943	CDD:173412	28/179 (16%)
		MyTH4	1014..1171	CDD:470587	37/187 (20%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	16/83 (19%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
smyhc1	NP_001018343.1	Myosin_N	32..76	CDD:460670
		MYSc_class_II	99..768	CDD:276951	250/696 (36%)
		Myosin_tail_1	848..1925	CDD:460256	228/1251 (18%)