DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and smyhc1

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_001018343.1 Gene:smyhc1 / 321552 ZFINID:ZDB-GENE-030131-271 Length:1938 Species:Danio rerio


Alignment Length:2053 Identity:507/2053 - (24%)
Similarity:823/2053 - (40%) Gaps:499/2053 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.:...|||.::|:||:.||...:|||::|...:.|||||..| .|...|.|.|.|:.....
Zfish    87 IEDMAMFTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYDSSVVKAYRGKKRTEA 150

  Fly   222 PPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASA------VI 277
            |||:|:|...|:..:.|.   |.|:|:||||:|||.:||.|:||.|::....|...|      .:
Zfish   151 PPHIFSISDNAYQYMLSDRENQSVLITGESGAGKTVNTKRVIQYFASIAAVSGKKDAASEKKGTL 215

  Fly   278 TEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGER 341
            .:||::|.|.|||||||:|.||||||||||::.::| .||.:..|.|..|||||||:..|...||
Zfish   216 EDQIIQANPALEAFGNAKTIRNDNSSRFGKFIRIHFGVSGKLASADIETYLLEKSRVTYQLKAER 280

  Fly   342 NYHVFYELLGGLSETERSKYGLLE-------ADKYFYLNQGATDCASGRVDWESL---QGAMQVL 396
            :||:||::|      .:.|..|||       ...|.|::||.|..|| ..|.|.|   ..|..||
Zfish   281 DYHIFYQIL------SQKKPELLEMLLITNNPYDYSYISQGETQVAS-IDDAEELIATDDAFDVL 338

  Fly   397 GVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTS 461
            |.::.|:.||.::..|::|.||:.|.::|   .:|..|.....:....|:|:.:::..|.:.|..
Zfish   339 GFTQDEKSGIYKLTGAIMHFGNMKFKQKQ---REEQAEADGTEDADKVAYLMGLNSADLIKGLCH 400

  Fly   462 RTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR--ISILDIF 524
            ...:...|.:.....:.|...:..|.||::|..:|.|:|.|||   |...|....:  |.:|||.
Zfish   401 PRVKVGNEWVTKGQNVQQVYYSIGALAKSVYEKMFLWMVVRIN---QSLDTKQPRQYFIGVLDIA 462

  Fly   525 GFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPV 589
            |||....|:|||||||:.||.||.:||.|:|.|||.||.:|.::|..:.:..:|.....|.:||:
Zfish   463 GFEIFDFNTFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGMDLQACIELIEKPM 527

  Fly   590 GICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARPRI--GAQE--FGVTHYAGQVWYCVDGF 649
            ||..:|::|..||:|:|.:|..|.:.|| ..:..:.:|||  |..|  |.:.||||.|.|.:..:
Zfish   528 GIMSILEEECMFPKASDQTFKAKLYDNHLGKNPTFQKPRIVKGRPEAHFALVHYAGTVDYNISNW 592

  Fly   650 LDKNRDALRGDVLELLASSRLPLVGEL---------TKQLRAQRDAGKTLPKGSNGRFVTMKPRT 705
            |.||:|.|...|:.|...|.:.|:..|         .:..:..:..||  .|||:.:        
Zfish   593 LVKNKDPLNETVVGLFQKSTVKLLSFLFAGYSGADSAQDSKGGKGGGK--KKGSSFQ-------- 647

  Fly   706 PTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGY 770
             ||:|...::|.:|:.::...||.||||:.||:.|....|:.|.|:.|||..|:|:.|:|.::|:
Zfish   648 -TVSALHRENLNKLMTNLRSTHPHFVRCLIPNETKTPGAMENPLVMHQLRCNGVLEGIRICRKGF 711

  Fly   771 PVRLRFQHFVERYRHLLPS--PLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHR 833
            |.|:.:..|.:|||.|.||  |..:....::....||.::   .::...|:||.|:||.:..|..
Zfish   712 PNRILYGDFKQRYRILNPSANPEGQFIDNKKAAEKLLGSL---DIDHNQYKLGHTKVFFKAGLLG 773

  Fly   834 ALESGRTERLRRAAVSVQRHVRGMLVR---RQLARRQAAATRLQ---------ARWRGQRAQQRY 886
            .||..|.:||......:|...||:|.|   :::..|:.:...:|         ..|...:...:.
Zfish   774 TLEEMRDDRLALIITGIQARARGILSRLEFQKIVERRDSLLVIQWNVRAFMGVKNWPWMKLYFKI 838

  Fly   887 ERLRKGALTAQRLWRGRQARRRVQQ--LRSDHRRRQ----------------------------- 920
            :.|.|.|.|.:.:...::...::::  .:|:.|:::                             
Zfish   839 KPLLKTAETEKEMANMKEEFTKLKEAYAKSEARKKELEEKMVSLLQEKNDLQLAVQSEQDNLVDA 903

  Fly   921 ----------------EAREAAQRAREARE------AKQAVLERSQLSYL--DIPAELAFIYSKL 961
                            :|:|..:|..:..|      ||:..|| .:.|.|  ||. :|....:|:
Zfish   904 EERCEGLIKSKIQLEAKAKELTERLEDEEEMNAELVAKKRKLE-DECSELKKDID-DLELTLAKV 966

  Fly   962 QGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGK--FSSVYCNGL-RLQPRREPITAPL 1023
            :  ...|...:.||.|      ......|.|.:.:.:..|  ....:...| .||...:.:..  
Zfish   967 E--KEKHATENKVKNL------TEEMAALDEIIAKLTKEKKALQEAHQQTLDDLQSEEDKVNT-- 1021

  Fly  1024 LTRA-ASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCN-- 1085
            ||:| |..:|...|.....:...:...|  ||.||.||..|.         .|..|.::.|.|  
Zfish  1022 LTKAKAKLEQQVDDLEGSLEQEKKLRMD--LERAKRKLEGDL---------KLTQESIMDLENDK 1075

  Fly  1086 --QVHGLPPNSGEATRL------WQLLGQCLCCFQPSAAFSKYLMRF------VDDEAP------ 1130
              ....|.....|.::|      .|.||         |...|.|...      :::|..      
Zfish  1076 QQMEEKLKKKDFEISQLNSKIEDEQALG---------AQLQKKLKELQARIEELEEELEAERAAR 1131

  Fly  1131 ---ESLRPLLLRQLLR-----QQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDE 1187
               |..|..|.|:|..     ::.||.::..:.....|.     .|::...|..:.|   ||..|
Zfish  1132 AKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKRE-----AEFQKLRRDLEEA---TLQHE 1188

  Fly  1188 ASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTD---------SCGLDYV---MDL 1240
            |:.       .:..:..|.:|:.||..       :|:.|::..         ...||.|   |:.
Zfish  1189 ATA-------ATLRKKHADSVADLGEQ-------IDNLQRVKQKLEKEKSELKLELDDVVSNMEQ 1239

  Fly  1241 IAE-----KELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSR 1300
            |.:     :::|.......|: .|:.|:..:.|:.|...:.|    ...|.:|:        .||
Zfish  1240 IVKSKSNLEKMCRTLEDQMSE-YRTKAEEGQRTINDFTMQKA----KLQTENGE--------LSR 1291

  Fly  1301 ELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDD------LLAGDIVPVPTDCD----- 1354
            :|..:.|.:::  ..|      |:.|.|.|.:...:.|::      .||..:.....|.|     
Zfish  1292 QLEEKDSLVSQ--LTR------GKQSYTQQIEDLKRQLEEEVKAKNALAHAVQSARHDSDLLREQ 1348

  Fly  1355 ---SQEPLHTLGLSESRLN------------DRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAAS 1404
               .||....|..|.|:.|            |.....|.|....|....|.|:::.|....:|..
Zfish  1349 FEEEQEAKAELQRSLSKTNSEVAQWRTKYETDAIQRTEELEDAKKKLAQRLQEAEEAVEAVNAKC 1413

  Fly  1405 HGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVL------- 1462
            .....:|:..:             :|...|...|.|....:.|.|..|   ..|..||       
Zfish  1414 SSLEKTKHRLQ-------------NEIEDLMVDVERSNAAAAALDKKQ---RNFDKVLAEWKQKY 1462

  Fly  1463 DGSLDELSDA----RSLAASI--RGGSYEQ----------ENE-AESEIDDLDDYINDIFQPIPL 1510
            :.|..||..|    |||:..:  ...|||:          ||: .:.||.||.:.:.:..:.|..
Zfish  1463 EESQTELESAQKESRSLSTELFKLKNSYEEVLDQLETMKRENKNLQEEISDLTEQLGETGKSIHE 1527

  Fly  1511 VQNLEKLTSKDQL---AAIIKGGG----------------------VASKPEERDEESE------ 1544
            ::.:.|...:::.   .|:.:..|                      :..|..|:|||.|      
Zfish  1528 LEKIRKQLEQEKAEIQTALEEAEGSLEHEEGKILRAQLEFNQVKADIERKLSEKDEEMEQAKRNQ 1592

  Fly  1545 ---IEDLDDYI-------NELFEPIPVAEG-LDKL--------------------------TSKE 1572
               ::.|...:       ||........|| |:::                          .|:.
Zfish  1593 QRVVDTLQSSLESETRSRNEALRLKKKMEGDLNEMEIQLSQANRQASEAQKQLKGLHGHVKDSQM 1657

  Fly  1573 HLAVSIRGGGSTDSNGA---------DPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQ 1628
            .|..::||......|.|         ...|.:|..|..:||.|..|.:|::.      .:::.:|
Zfish  1658 QLDDALRGNDDLKENIAIVERRNNLLQAELDELRSLVEQTERGRKLAEQELM------DVSERVQ 1716

  Fly  1629 IQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVME 1693
            :   |.|||   .:||:|:......|                              |:....|.|
Zfish  1717 L---LHAQN---TSLLNQKKKLEGDN------------------------------TQLQTEVEE 1745

  Fly  1694 SLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAF-- 1756
            ::|              ||::..|         :||     |..........:.:.|:|..|.  
Zfish  1746 AVQ--------------ECRNAEE---------KAK-----KAITDAAMMAEELKKEQDTSAHLE 1782

  Fly  1757 KMRQHQRKTTPQAQH-----HQMTSNGGMMESGPGARGASATAIEWE-EFEIESPTPPPMSGQLM 1815
            :|:::..:|....||     .|:...||..:    .:...|...|.| |.|:|..........:.
Zfish  1783 RMKKNMEQTIKDLQHRLDEAEQIAMKGGKKQ----VQKLEARVRELENEVELEQRKASESVKGVR 1843

  Fly  1816 RSSIRLETTTTTTTSAVNNRDRDRET----QDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKL 1876
            :...|::..|..|       :.||:.    ||:...:|  :..|..|::.| .|:.....::||.
Zfish  1844 KYERRIKELTYQT-------EEDRKNLARLQDLVDKLQ--LKVKSYKRAAE-EAEEQANSNLGKF 1898

  Fly  1877 -KLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLED 1913
             ||..|:.:..|:.....|..:.:..||....|.|..|
Zfish  1899 RKLQHELDEAEERADIAESQVNKMRAKSRDSGPKKGHD 1936

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 257/716 (36%)
MYSc_Myo15 169..828 CDD:276838 250/696 (36%)
MyTH4 1014..1171 CDD:295320 37/187 (20%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
smyhc1NP_001018343.1 Myosin_N 35..72 CDD:280832
Myosin_head 87..768 CDD:278492 256/708 (36%)
MYSc_class_II 99..768 CDD:276951 250/696 (36%)
Myosin_tail_1 848..1925 CDD:279860 228/1251 (18%)
RILP-like 963..1096 CDD:304877 32/153 (21%)
COG6 1374..>1507 CDD:303003 31/148 (21%)
TMPIT 1457..>1562 CDD:285135 20/104 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.000

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