Protein Alignment Myo10A and Myo6

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_008764645.1
• Gene: Myo6 / 315840
• RGDID: 1560646
• Length: 1294
• Species: Rattus norvegicus
• Alignment Length: 968
• Identity: 309/968 - (31%)
• Similarity: 454/968 - (46%)
• Gaps: 194/968 - (20%)

  Fly   134 PQTFALQP----GEGSLR-------ARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTF 187
            |.:..::|    |:..|.       |.:| ....|||...|..|:||:||.|:::||.|..|||:
  Rat    26 PDSLTIEPLNQKGKTFLALINQVFPAEED-SKKDVEDNCSLMYLNEATLLHNVKVRYSKDRIYTY 89

  Fly   188 AGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAH---AALPSPQVVVISGESG 249
            ..:||||||||...|..|..:..|.|.|:.||::|||:|||...|.   ..|...|.:::|||||
  Rat    90 VANILIAVNPYFDIPKIYSSDTIKSYQGKSLGTMPPHVFAIADKAFRDMKVLKMSQSIIVSGESG 154

  Fly   250 SGKTESTKLVMQYLAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF- 313
            :||||:||.|::||......|..    |.::|:||.|||||||||:|.||:|||||||::|::|
  Rat   155 AGKTENTKFVLRYLTESYGTGQD----IDDRIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFN 215

  Fly   314 KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATD 378
            :..::||..::.||||||||..|...|||||:||.|..|.||..|.|..|...|.:.|||:|.|.
  Rat   216 EKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTR 280

  Fly   379 -CASGRVDWESLQG----------------------------AMQVLGVSEGEREGIVRVLAAVL 414
             .|:...|.:.||.                            ||:.:|:.:.|:..:.||:|.||
  Rat   281 YFANKETDKQILQNRKSPEYVKAGSLKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVL 345

  Fly   415 HLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSR---TTE--ARAERLHTP 474
            ||||:.|.......|...::..|...:::.|.||.:..|.|..:||:|   ||.  .:...:..|
  Rat   346 HLGNIDFEEAGSTSGGCNLKNKSAPSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVP 410

  Fly   475 LGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCI 539
            |.::||..||||.||.:|:.||:.:|.|:|....  ....::.|.:|||.|||....|||||.||
  Rat   411 LKVEQANSARDALAKTVYSHLFDHVVDRVNQCFP--FETSSYFIGVLDIAGFEYFEHNSFEQFCI 473

  Fly   540 NYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRA 604
            ||.||.||.:||:.:.|.||..|.:|.|....:.:.||...|.|:..|.|||..:||:|:..|:.
  Rat   474 NYCNEKLQQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEVKLVGILDILDEENRLPQP 538

  Fly   605 TDLSFLEKCHYNH---------ALSELYARPRIGAQE-FGVTHYAGQVWYCVDGFLDKNRDALRG 659
            :|..|....|..|         ..|:|.....:...| |.:.|:||.|.|....|::||.|||..
  Rat   539 SDQHFTSVVHQKHKDHFRLTIPRKSKLAVHRNLRDDEGFIIRHFAGAVCYETTQFVEKNNDALHM 603

  Fly   660 DVLELLASSRLPLVGEL----------TKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFAD 714
            .:..|:..||...:..|          |||     .|||.       .|:       :|..:|..
  Rat   604 SLESLICESRDKFIRALFESSTNNNKDTKQ-----KAGKL-------SFI-------SVGNKFKT 649

  Fly   715 SLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHF 779
            .|..||..:......|:||||||.:..:...:...:|.||:..||:..:.:.|.|:|.|..|...
  Rat   650 QLNLLLDKLRSTGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGFPSRASFHEL 714

  Fly   780 VERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLR---------------- 828
            ...|:..:|..|||..| |..|:||.:|:   |:...||:.|.|:||.|
  Rat   715 YNMYKKYMPEKLARLDP-RLFCKALFKAL---GLNEVDYKFGLTKVFFRPGKFAEFDQIMKSDPD 775

  Fly   829 ---EALHRA---LESGRTERLRRAAVSV---------------------------QRH---VRGM 857
               |.:.|.   |...|.::::..::||                           :||   :.|:
  Rat   776 HLAELVKRVNLWLVCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGL 840

  Fly   858 L-------------------------VRRQLARRQAAATRLQARWRG-----QRAQQRYERLRKG 892
            :                         |.||:...:.:...|.|:.:.     ::.|:.|:.|.|.
  Rat   841 VKVGTLKKRLDKFNEVVSALKDGKPEVNRQIKDLEISIDALMAKIKSTMMTREQIQKEYDALVKS 905

  Fly   893 A---LTAQRLWRGRQAR------RRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLE 941
            :   |:|  |.:.:|..      ||:|:.....|:|:|  |..||.|:..|.::..||
  Rat   906 SEDLLSA--LQKKKQQEEEAERLRRIQEEMEKERKRRE--EDEQRRRKEEEERRMKLE 959

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	261/716 (36%)
		PTZ00121	<828..>943	CDD:173412	36/205 (18%)
		MyTH4	1014..1171	CDD:470587
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myo6	XP_008764645.1	MYSc_Myo6	71..759	CDD:276833	261/716 (36%)
		CBD_MYO6-like	770..917	CDD:409646	21/148 (14%)
		MYO6_MIU_linker	999..1068	CDD:412090
		MyUb_Myo6	1082..1122	CDD:439319
		Myosin-VI_CBD	1177..1267	CDD:465157