Protein Alignment Myo10A and Myo1f

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_001101546.1
• Gene: Myo1f / 314654
• RGDID: 1309750
• Length: 1098
• Species: Rattus norvegicus
• Alignment Length: 1275
• Identity: 367/1275 - (28%)
• Similarity: 553/1275 - (43%)
• Gaps: 317/1275 - (24%)

  Fly   155 SGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFP-------DAYGLEVAKQ 212
            |||:||.||..:.|.:::.|||.|:....|:|:.||:||:|||:|..|       |.|  :.|.|
  Rat    17 SGVDDMVLLPQITEDAIVSNLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLY--QGAAQ 79

  Fly   213 YAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSAS 274
            |..      |||::|:....:..:   ...|.|:||||||:|||.:.|.:|.|::. |.|||...
  Rat    80 YEN------PPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISK-VSGGGDKV 137

  Fly   275 AVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAP 338
            ..:.:.||::.|||||||||:|.||:||||||||.|:.| :.|...|.||:.:||||||:|.|..
  Rat   138 QHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVMQNE 202

  Fly   339 GERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASG---RVDWESLQGAMQVLGVSE 400
            .|||:|::|:||.|.|:.::...||:..|.|:||||..|....|   |.|:.....||||:|:..
  Rat   203 NERNFHIYYQLLEGASQEQQQNLGLMTPDYYYYLNQSDTYKVEGTDDRSDFNETLNAMQVIGIPT 267

  Fly   401 GEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIK------WAAHLLHISADGLHRAL 459
            ..::.:::::|.:|||||:.|           .|.|:.|.::      :.|:||.|.:..|...|
  Rat   268 SVQQLVLQLVAGILHLGNISF-----------CEEGNYARVESVDLLAFPAYLLGIDSGRLQEKL 321

  Fly   460 TSRTTEA----RAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISI 520
            |||..::    |:|.:...|.::||...|||.||.|||.||::||..||..:||  ..:.:.|.:
  Rat   322 TSRKMDSKWGGRSESIDVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAMQK--PQEEYSIGV 384

  Fly   521 LDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLA 585
            |||:|||...:|.|||.|||:.||.||..|.:...|.||.||.:|.:.|||:.:.:|..|..|:.
  Rat   385 LDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIE 449

  Fly   586 KK--PVGICHLLDDESNFPRAT----DLSFLEKCHYNHALSELYARPRIGAQE--------FGVT 636
            .|  |.||..:|||......||    |.:.|:|           .:..:|..|        |.:.
  Rat   450 NKLNPPGIMSVLDDVCATMHATGGGADQTLLQK-----------LQAAVGTHEHFNSWSAGFVIH 503

  Fly   637 HYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTM 701
            ||||:|.|.|.||.::|||.|..|::||:.||....:..|..:   :.|..|
  Rat   504 HYAGKVSYDVSGFCERNRDVLFSDLIELMQSSDQAFLRMLFPE---KLDVDK------------- 552

  Fly   702 KPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIR 766
            |.|..|..::.......|:.::.:|.|.::||||||:.|.....:...|..|:.|||:.:.|::|
  Rat   553 KGRPSTAGSKIKKQANDLVSTLKKCTPHYIRCIKPNETKRPRDWEESRVKHQVEYLGLRENIRVR 617

  Fly   767 QRGYPVRLRFQHFVERYRHLLPS--PLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLR- 828
            :.|:..|.:|..|::||..|.|.  |..||.. |:..:.||.|:   .:|...||:|:|:||::
  Rat   618 RAGFAYRRQFSKFLQRYAILTPETWPRWRGDE-RQGVQHLLRAV---NMEPDQYQMGSTKVFVKN 678

  Fly   829 -EALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKG 892
             |:|. .||..|           :|...|.            |..:|..||...|.::||.:|:
  Rat   679 PESLF-LLEEMR-----------ERKFDGF------------ARTIQKAWRRHIAVRKYEEMRE- 718

  Fly   893 ALTAQRLWRGRQARRRVQQLRS---DHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAEL 954
              .|..:...::.|||....|:   |:...:          |..|.:|.:.:|.::.:.|
  Rat   719 --EASNILLNKKERRRNSINRNFVGDYLGLE----------ERPELRQFLAKRERVDFAD----- 766

  Fly   955 AFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQP-RREP 1018
                                                       |..|:..      |.:| :|:.
  Rat   767 -------------------------------------------SVTKYDR------RFKPIKRDL 782

  Fly  1019 ITAPLLTRAASRDQDFQDALAVFKLILRWSNDKAL--EGAKEKLLADYIVHKALSSRGLRDEILV 1081
            |..|.......|::            ::...:|.|  |..|:||....:...:||:|  :|:..:
  Rat   783 ILTPKCVYVIGREK------------VKKGPEKGLVREVLKKKLEIQALRGVSLSTR--QDDFFI 833

  Fly  1082 QLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQG 1146
                                         .|..||          |...||:.......||
  Rat   834 -----------------------------LQEEAA----------DSFLESIFKTEFVSLL---- 855

  Fly  1147 GGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSW--------TSCEEA 1203
                        |:.|..|          ....||||..|.....|..:.|        |.....
  Rat   856 ------------CKRFEEA----------ARRPLPLTFSDMLQFRVKKEGWGGGSTRNVTFSRGT 898

  Fly  1204 AALAVSSLGVASRGWTLVLDDGQQLTDSC-----GLDYVMDLIAEKELCPAFPAPRSDLLRSGAK 1263
            ..|||...|  ||..|:.:.||  |..|.     ||.......:.:....|.|.|...|.|:|..
  Rat   899 GDLAVLKAG--SRALTISIGDG--LPKSTKPTRKGLAQGRPRRSAQAPTRAAPGPPRGLNRNGVP 959

  Fly  1264 FAR--TTLPDAV---KRPAVPPPAPPTSS-GKEDVPRERRSSR---ELLS----------RSSAL 1309
            .:.  .:||..:   :....||..||:|: |....||.|..|.   |.|:          |..::
  Rat   960 PSSQVRSLPMEITSGRSSQRPPRGPPSSTLGASRRPRARPPSEHNTEFLNVPDQGVAGMQRKRSI 1024

  Fly  1310 NERYFEREPSPGPGQGSSTGQAKS---RSKSLDDLLAGDI 1346
            .:|       |.||.|....|.::   |.::|...:..|:
  Rat  1025 GQR-------PVPGVGRPKPQPRTHGPRCRALYQYIGQDV 1057

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	253/698 (36%)
		PTZ00121	<828..>943	CDD:173412	24/119 (20%)
		MyTH4	1014..1171	CDD:470587	26/159 (16%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	21/79 (27%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myo1f	NP_001101546.1	MYSc_Myo1	31..677	CDD:276829	253/698 (36%)
		Myosin_TH1	717..915	CDD:461801	56/345 (16%)
		PHA03378	<924..>1044	CDD:223065	29/126 (23%)
		SH3_MyoIe_If_like	1045..1097	CDD:212761	3/13 (23%)