DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and Myh7b

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_001101264.2 Gene:Myh7b / 311570 RGDID:1307994 Length:1941 Species:Rattus norvegicus


Alignment Length:2141 Identity:545/2141 - (25%)
Similarity:862/2141 - (40%) Gaps:453/2141 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   149 RQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQY 213
            |.||    :|||.::..|:||::|.|||.||.:.:|||::|...:.:||||..| .|...|...|
  Rat    82 RFDL----LEDMAMMTHLNEAAVLHNLRQRYARWMIYTYSGLFCVTINPYKWLP-VYTATVVAAY 141

  Fly   214 AGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVV-----PG- 269
            .|:.....|||::|:...|:..:   ...|.::|:||||:|||.:||.|:||.|.|.     || 
  Rat   142 KGKRRSEAPPHIYAVADNAYNDMLRNRENQSMLITGESGAGKTVNTKRVIQYFAIVAALGDGPGK 206

  Fly   270 ---------GGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKIT 324
                     ||:    :.:||:||.|.:||||||:|.||||||||||::.::| .:|.:..|.|.
  Rat   207 KAQFLATKTGGT----LEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPTGKLASADID 267

  Fly   325 QYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFY--LNQGATDCASGRVDWE 387
            .|||||||::.|.||||.|||:|::|.| .:.|.....||..:.|.|  .:||.| ......|.|
  Rat   268 SYLLEKSRVIFQLPGERGYHVYYQILSG-KKPELQDMLLLSMNPYDYHFCSQGVT-TVDNMNDGE 330

  Fly   388 SL---QGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLH 449
            .|   ..||.:||.|..|:....:::.|:||.||:.|.::|   .:|..|.........||:|:.
  Rat   331 ELIATDHAMDILGFSVDEKCACYKIVGALLHFGNMKFKQKQ---REEQAEADGTESADKAAYLMG 392

  Fly   450 ISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHD 514
            :|:..|.:.|.........|.:.....::|.:.|..|.|||.|..||.|||||||.      |.|
  Rat   393 VSSGDLLKGLLHPRVRVGNEYVTKGQSVEQVVFAVGALAKATYDRLFRWLVSRINQ------TLD 451

  Fly   515 AHR-----ISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAW 574
            ...     |.:|||.|||....|||||||||:.||.||.:||:|:|.|||.||.||.::|..:.:
  Rat   452 TKLPRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNQHMFVLEQEEYKREGIDWVFIDF 516

  Fly   575 D-DNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHA-LSELYARPRIGAQ-----E 632
            . |..|.|.|: :||:||..:|::|..||:|:|.||..|.:.||: .|..:.:||...:     .
  Rat   517 GLDLQPCIDLI-EKPLGILSILEEECMFPKASDASFRAKLYDNHSGKSPNFQQPRPDKKRKYQAH 580

  Fly   633 FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAG--KTLPKGSN 695
            |.|.||||.|.|.:.|:|:||:|.|...|:.:...|:..|:..|.:..     ||  .|.|..|.
  Rat   581 FEVVHYAGVVPYSIVGWLEKNKDPLNETVVPIFQKSQNRLLATLYENY-----AGSCSTEPPKSG 640

  Fly   696 GRFVTMKPRT-PTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGM 759
            .:....|..: .||:....::|.:|:.::....|.|||||.||:.|....||...||.|||..|:
  Rat   641 VKEKRKKAASFQTVSQLHKENLNKLMTNLRATQPHFVRCIVPNENKTPGVMDSFLVLHQLRCNGV 705

  Fly   760 LDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGT--PYRELCRALLEAMPRTGVEGPDYQLGA 822
            |:.|:|.::|:|.||.:..|.:|||.|.||.:...|  ..|:....||.::   .::...||.|.
  Rat   706 LEGIRICRQGFPNRLLYADFRQRYRILNPSAIPDDTFVDSRKATEKLLGSL---DIDHTQYQFGH 767

  Fly   823 TRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVR----RQLARRQAAATRLQARWRGQRAQ 883
            |:||.:..|...||..|.:||.:....:|...||.|:|    |.|..|.|..| :|...|...|.
  Rat   768 TKVFFKAGLLGILEELRDQRLAKVLTLLQARSRGRLMRLEYQRMLGGRDALFT-IQWNIRAFNAV 831

  Fly   884 QRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYL 948
            :.:..: |.....:.|.|..||...:..||::.|..:.|...|       |||:..||.:|:|..
  Rat   832 KNWSWM-KLFFKMKPLLRSAQAEEELAALRAELRGLRGALATA-------EAKRQELEETQVSVT 888

  Fly   949 DIPAELAFIYSKLQGWSPPHGDRH-----LVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCN 1008
            ....:||.   :||.......|..     |:|          |.|||...:.:.:          
  Rat   889 QEKNDLAL---QLQAEQDNLADAEERCHLLIK----------SKVQLEAKVKELN---------- 930

  Fly  1009 GLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKAL---EGAKEKLLADYIVHKAL 1070
             .||:...| :.|.|    |:|.:..:|.....|..:   :|..|   :..|||...:..|....
  Rat   931 -ERLEDEEE-VNADL----AARRRKLEDECTELKKDI---DDLELTLAKAEKEKQATENKVKNLT 986

  Fly  1071 SSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRF---VDD----- 1127
            ......||.:|:|..:...|.    ||.:  |.||.........:|.:|..:|.   |:|     
  Rat   987 EEMAALDESVVRLTKEKKALQ----EAHQ--QALGDLQAEEDRVSALAKAKIRLEQQVEDLECSL 1045

  Fly  1128 EAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTV 1192
            |..:.||....|...:.:|.                                |.||   :.:.|.
  Rat  1046 EQEKKLRMDTERAKRKLEGD--------------------------------LKLT---QETVTD 1075

  Fly  1193 AVDSWTSCEEAAALAVSSLGVASRGWTLVLDD----GQQLTDSCGLDYVMDLIA-----EKELCP 1248
            ........||......|.|...|    |.::|    |.||...     :.:|.|     |:|| .
  Rat  1076 TTQDKQQLEEKLKKKDSELSQLS----LRVEDEQLLGAQLQKK-----IKELQARAEELEEEL-E 1130

  Fly  1249 AFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERY 1313
            |..|.|:.:.:..|:.|| .|.:..:|   ...|...|:|:.:..|:|.:....|.|.  |.|..
  Rat  1131 AERAARARVEKQRAEAAR-ELEELSER---LEEAGGASAGQREGCRKREAELGRLRRE--LEETV 1189

  Fly  1314 FEREPSPGPGQGSSTGQAKSRSKSLDDL------LAGDIVPVPTDCDSQEPLHTLGLSESRLNDR 1372
            ...|.:....:......|...|:.:|.|      |..:...:..:.|.      ||.|...|...
  Rat  1190 LRHEATVAALRRKQADSAAELSEQVDSLQRIRQKLEKEKSELRMEVDD------LGASVETLARG 1248

  Fly  1373 YHSAERLAPVGKD---------TGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDT 1428
            ..|||:|....:|         ...:.|.:..:.:|....:......:..::.|......:...|
  Rat  1249 KASAEKLCRTYEDQLSEAKIKVEELQRQLTDASTQRGRLQTENGELGRLLEEKESMISQLSRGKT 1313

  Fly  1429 SEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESE 1493
            |.|.||....|::...|:|.               |:|.....|......:....:|:|:||::|
  Rat  1314 SAAQSLEELRRQLEEESKAK---------------GALAHAVQALRHDCDLLREQHEEESEAQAE 1363

  Fly  1494 IDDLDDYIN-DIFQ-----PIPLVQNLEKL-TSKDQLAAII----KGGGVASKPEERDEESEIE- 1546
            :..|....| ::.|     ....:|..|:| .:|.:||..:    :|...|:......|::::. 
  Rat  1364 LQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRL 1428

  Fly  1547 --DLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETES---- 1605
              :.:|...||......|..|||  .:.||           ....:....|..::..|.|:    
  Rat  1429 QTESEDVTLELERATSAAAALDK--KQRHL-----------ERALEERRRQEEEMQRELEAAQRE 1480

  Fly  1606 ----GPALYQ-----QQVQRAFLQSAMAQNLQIQ-----------------QQLLAQNQALQTLL 1644
                |..|::     ::...| |::...:|..:|                 |:|....:||:...
  Rat  1481 ARGLGTELFRLRHSHEEALEA-LETLKRENKNLQEEISDLTDQVSLSGKSIQELEKAKKALEGEK 1544

  Fly  1645 SQ-QAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRM--------KATRSSLVVMESLQPPPP 1700
            |: |||...|..:........:...|.:|....:...::        ...|:....:||||    
  Rat  1545 SELQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECTNLRRNHQRAVESLQ---- 1605

  Fly  1701 PPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQD-EPQF-----QTEEDFFAFKMR 1759
                       ....:|||      .|.:.:|:.|.......| |.|.     |..|...|.::.
  Rat  1606 -----------ASLDAETR------ARNEALRLKKKMEGDLNDLELQLGHATRQAMEAQAATRLL 1653

  Fly  1760 QHQRKTTPQAQHHQMTSNGGMMESGPG-ARGASATAIEWEE----FEIESPTPPPMSGQLMRSSI 1819
            |.|.|.....:..:......:.|.|.. .|.|:..|.|.||    .|....:......:|:.::.
  Rat  1654 QAQLKEEQAGRDEEQRLAAELREQGQALERRAALLASELEELRAALEQGERSRRLAEQELLEATE 1718

  Fly  1820 RLETTTTTTTSAVNNRDR--------DRETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKL 1876
            ||....:..|..:|.:.:        ..|.::..|..:.  ..:.|||:....|           
  Rat  1719 RLNLLHSQNTGLLNQKKKLEVDLAQLSGEVEEAAQERRE--AEEKAKKAITDAA----------- 1770

  Fly  1877 KLSSEMRQRLEQVTAGHSVRSTVSTKSEQR-APAKLEDTRKLMLQQQLGGLFASVSGGNSGPGGV 1940
            .::.|:::  ||.|:.|..|...:.:...| ..|:||:..:           |::.||       
  Rat  1771 MMAEELKK--EQDTSAHLERMKKTLEQTVRELQARLEEAEQ-----------AALRGG------- 1815

  Fly  1941 VDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPP 2005
                   :.|::::|.|:                                               
  Rat  1816 -------KKQVQKLEAKV----------------------------------------------- 1826

  Fly  2006 TARSPEPEPD----YRTSSSQVVKEH---VPAFIQRQERDTFGAVRQQQMISSHHLHLEDHSASS 2063
              |..|.|.|    ....:.:.|::|   |.....:.|.|.....|.|.::......::.:... 
  Rat  1827 --RELEAELDAEQKKHAEALKGVRKHERRVKELAYQTEEDRKNLARMQDLVDKLQSKVKSYKRQ- 1888

  Fly  2064 SPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREK-RERERERL 2123
                  :|:||::.|.:.::.|..:...:...:||::        :|.:..| |.|.|:.|
  Rat  1889 ------FEEAEQQASTNLAKYRKAQHELDDAEERADM--------AETQANKLRARSRDAL 1935

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 269/720 (37%)
MYSc_Myo15 169..828 CDD:276838 263/699 (38%)
MyTH4 1014..1171 CDD:295320 33/167 (20%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
Myh7bNP_001101264.2 Myosin_N 32..71 CDD:397036
myosin head (motor domain) 86..773 268/711 (38%)
MYSc_Myh7b 98..773 CDD:276953 263/699 (38%)
Myosin_tail_1 853..1930 CDD:396244 247/1332 (19%)
myosin tail 1075..1933 186/1033 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.000

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