DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and Myh14

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	XP_038967907.1	Gene:	Myh14 / 308572	RGDID:	1306821	Length:	2041	Species:	Rattus norvegicus

Alignment Length:	2254	Identity:	555/2254 - (24%)
Similarity:	881/2254 - (39%)	Gaps:	621/2254 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 PQV---VKRLSTLCSDVIARHPQTFALQPGEGSLRARQDLGSSG--------------------V 157
            |||   .:|:..:.|::   |....|....||...|..:|..||                    .
  Rat    42 PQVEWTARRMVWVPSEL---HGFEAAALRDEGEEEAEVELAESGRRLRLPRDQIQRMNPPKFSKA 103

  Fly   158 EDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLP 222
            |||..|..|:|||:|.|||.||..|||||::|...:.:||||..| .|...:.:.|.|:....:|
  Rat   104 EDMAELTCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLP-IYTEAIVEMYRGKKRHEVP 167

  Fly   223 PHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVV--PGG----GSASAVIT 278
            ||::|:...|:.::   ...|.::.:||||:||||:||.|:||||.|.  |.|    |..::|.|
  Rat   168 PHIYAVTEGAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSPKGRKEPGVPASVST 232

  Fly   279 -------EQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVT 335
                   .|:|:|.|:|||||||:|.:|||||||||::.:.|. :|.||||.|..|||||||.:.
  Rat   233 MSYGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDIAGYIVGANIETYLLEKSRAIR 297

  Fly   336 QAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVD--WESLQGAMQVLGV 398
            ||..|.::|:||:||||..|..::...|.....|.:|..|.:.......:  .|:|: :::|||:
  Rat   298 QAKDECSFHIFYQLLGGAGEQLKADLLLEPYSHYRFLTNGPSSSPGQERELFQETLE-SLRVLGL 361

  Fly   399 SEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRT 463
            ...|...::|.::|||..||:...:.  |:..:.....:.|..| ...||.:......|||.:..
  Rat   362 LPEEITAMLRTVSAVLQFGNIVLKKE--RNTDQATMPDNTAAQK-LCRLLGLGVTDFSRALLTPR 423

  Fly   464 TEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFED 528
            .:...:.:......:||..|.:|.|||.|..||.|||.|:|..:.:.....|..:.||||.|||.
  Rat   424 IKVGRDYVQKAQTKEQADFALEALAKATYERLFRWLVLRLNRALDRSPRQGASFLGILDIAGFEI 488

  Fly   529 LAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWD-DNLPVIHLLAK--KPVG 590
            ...||||||||||.||.||..||..:|.|||.||.||.:.||.|.:. |..|.|.|:.:  .|.|
  Rat   489 FQLNSFEQLCINYTNEKLQQLFNHTMFVLEQEEYQREGIPWTFLDFGLDLQPCIDLIERPANPPG 553

  Fly   591 ICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPR--IGAQEFGVTHYAGQVWYCVDGFLDKN 653
            :..|||:|..||:|||.||:||..........:.|||  ....:|.|.||||:|.|..:.:|.||
  Rat   554 LLALLDEECWFPKATDKSFVEKVAQEQGSHPKFQRPRNLRDQADFSVLHYAGKVDYKANEWLMKN 618

  Fly   654 RDALRGDVLELLASSRLPLVGELTKQ--------------------------------------- 679
            .|.|..:|..||..|...|..|:.|.
  Rat   619 MDPLNDNVAALLHQSTDRLTAEIWKDEQGGLQQFTFLGSFPSPSPGPAGGLSSGASPPGLGSLCA 683

  Fly   680 --------LRAQRDAGKTLPKGSNGRFVTMKPRT---PTVAARFADSLQQLLQSMGRCHPWFVRC 733
                    |......|...|.|        :||.   .||...:.:||.:|:.::...:|.||||
  Rat   684 PTVEGIVGLEQVSSLGDGPPGG--------RPRRGMFRTVGQLYKESLSRLMATLSNTNPSFVRC 740

  Fly   734 IKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARG-TPY 797
            |.||.||.|.:::...||.|||..|:|:.|:|.::|:|.|:.||.|.:||..|.|:.:.:| ...
  Rat   741 IVPNHEKRAGKLEPRLVLDQLRCNGVLEGIRICRQGFPNRILFQEFRQRYEILTPNAIPKGFMDG 805

  Fly   798 RELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQ 862
            ::.|..:::|:.   ::...|::|.:::|.|..:...||..|..::....||.|...||.|.||.
  Rat   806 KQACEKMIQALE---LDPNLYRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARGYLARRA 867

  Fly   863 LARR--QAAATRLQAR-------------WR--------------GQRAQQRYERLRK-GALTAQ 897
            ..||  |.:|.|:..|             ||              .:..|.|.:.|:| ..|..|
  Rat   868 FQRRQQQQSALRVMQRNCAAYLKLRNWQWWRLFIKVKPLLQVTRQDEVLQARAQELQKVQELQQQ 932

  Fly   898 RLWRGRQARRRVQQLRSDHRR-RQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKL 961
            ......:.:.||.||..:..| .::.|..|:...||.|.:..:..|.|        ||..:.::|
  Rat   933 SAREVGELQGRVAQLEEERARLAEQLRAEAELCSEAEETRARLAARKQ--------ELELVVTEL 989

  Fly   962 QGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTR 1026
            :                       :.|...|:..:              :||..::        |
  Rat   990 E-----------------------ARVGEEEECSR--------------QLQSEKK--------R 1009

  Fly  1027 AASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLP 1091
            .....|:.:..|            :|.|||::||..:.:..:|...:...|.:|         |.
  Rat  1010 LQQHIQELETHL------------EAEEGARQKLQLEKVTTEAKMKKFEEDLLL---------LE 1053

  Fly  1092 PNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLR----------QLLRQQG 1146
            ..:.:.::..:||.:.|..|...||        .::|..:||..|.::          :|.:::.
  Rat  1054 DQNSKLSKERRLLEERLAEFSSQAA--------EEEEKVKSLNKLRVKYEATIADMEDRLKKEEK 1110

  Fly  1147 G------------GTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTS 1199
            |            |.||         ......:|.:  .|..::.:.|...:|..|:..|    .
  Rat  1111 GRQELEKLKRRLDGESS---------ELQEQMMEQK--QRAEELLIQLGRKEEELQSALV----R 1160

  Fly  1200 CEE---AAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAE-----------KELCPAF 1250
            .||   |.|..:.||..|..|    |.:.|:           ||.||           ::|....
  Rat  1161 AEEEGGARAQLLKSLREAQAG----LAEAQE-----------DLEAERVARAKAEKQRRDLGEEL 1210

  Fly  1251 PAPRSDL------------LRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELL 1303
            .|.|.:|            |||..:...|.|...:               :|:......:.:||.
  Rat  1211 EALRGELEDTLDSTNAQQELRSKREQEVTELKKTL---------------EEEARTHEVAMQELR 1260

  Fly  1304 SR-SSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDD----LLAGDIVPVPTDCDS-----QEP 1358
            .| |.||.|...:.|            ||: |.||:.:    .|..::..:.|:..|     ||.
  Rat  1261 QRHSQALVELTEQLE------------QAR-RGKSVWEKTRLSLEAEVSELKTELSSLQTSRQEG 1312

  Fly  1359 LHTLGLSESRLND---RYHSAERLAPVGKDTGPRYQKSQ-----HAGRRSHAASHGSHSSKYADK 1415
            .......||:|.:   |...:||   ...:...:.|::|     .:...|.|.|.....||....
  Rat  1313 EQKRRRLESQLQEVQGRSSDSER---ARAEAAEKLQRAQVELESVSTALSEAESKAIRLSKELSS 1374

  Fly  1416 AE---YATRSSAMSDTSEAPSLASHVRRVRVPSQASDV-DQFLDDLFS-----PVLDGSLDELSD 1471
            ||   :.|:.....:|....:|.|.||.:.  ::|:.: :|..:::.:     ..|..:..:||:
  Rat  1375 AESQLHDTQELLQEETRAKLALGSRVRALE--AEAAGLREQMEEEVVARERAGRELQTTQAQLSE 1437

  Fly  1472 AR----SLAASIRGGS----------------YEQENEAESEID--------DLDDYINDIFQPI 1508
            .|    ..||.:..|.                ..::.||...::        :|||...|:.|..
  Rat  1438 WRRRQEEEAAVLEAGEEARRRAAREAETLAQRLAEKTEAVERLERARRRLQQELDDATVDLGQQK 1502

  Fly  1509 PLVQNLEKLTSK-DQL-----AAIIKG----------------------GGVASKPEERDE---- 1541
            .|:..|||...| |||     ||:::.                      ..:..:.|.|:|
  Rat  1503 QLLSTLEKKQRKFDQLLAEEKAAVLRAVEDRERVEAEGREREARALSLTRALEEEQEAREELERQ 1567

  Fly  1542 ----ESEIEDL----DDY---INELFEPIPVAEGL------------DKLTSKE----HLAVSI- 1578
                .:|:|.|    ||.   ::||.....|||..            |:||:.|    .|.|::
  Rat  1568 NRALRAELEALLSSKDDVGKNVHELERARRVAEQAASDLRTQVTELEDELTAAEDAKLRLEVTVQ 1632

  Fly  1579 --RGGGSTDSNGAD--------PLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQL 1633
              :.....|..|.|        .|..||.....|.:      :::.|||.   |||...:::.:
  Rat  1633 ALKAQHERDLQGRDDAGEERRRQLAKQLRDAEVERD------EERKQRAL---AMAARKKLELE- 1687

  Fly  1634 LAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMR-----MKATRSSLVVME 1693
                  |:.|.:|.:||......     |...|..:       |:.|:     ::.||||...|.
  Rat  1688 ------LEELKAQTSAAGQGKEE-----AVKQLKKM-------QAQMKELWREVEETRSSREEMF 1734

  Fly  1694 SLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKM 1758
            :|.                ::..:....|:    |:.:|:.:......:...|.|.:.|..|.::
  Rat  1735 TLS----------------RESEKRLKGLE----AEVLRLQEELAASDRARRQAQQDRDEMAEEV 1779

  Fly  1759 RQ-HQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLE 1822
            .. :..|.....:..|:....|.:|               ||.|.|......:.....:..:::|
  Rat  1780 ASGNLSKAATLEEKRQLEGRLGQLE---------------EELEEEQNNSELLKDHYRKLVLQVE 1829

  Fly  1823 TTTTT-------TTSAVNNRDR-DRETQ---------DVG-----QPMQSVVTTKLAKKSFEIGA 1865
            |.||.       :..|.:.|.: :|:.|         |.|     :.:.:.:.:|||:...::..
  Rat  1830 TLTTELSAERSFSAKAESGRQQLERQIQELRARLGEEDAGARARQKMLIAALESKLAQAEEQLEQ 1894

  Fly  1866 DRPPPGSVGKL-------------------KLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKL 1911
            :.......|||                   :::.::|.:||        :|.:..|..:|...:.
  Rat  1895 ESRERILSGKLVRRAEKRLKEVVLQVDEERRVADQLRDQLE--------KSNLRLKQLKRQLEEA 1951

  Fly  1912 ED------TRKLMLQQQLGGLFASVSGGN-----------SGPGGVVDSHATVRTQIERMEGKLS 1959
            |:      ..:..||::|..:..|....|           .||  :..:..||| |:.|:|..::
  Rat  1952 EEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGP--LTFTTRTVR-QVFRLEEGVA 2013

  Fly  1960 PPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPP-APQ 2002
            .......|..||                ..|:..|.|||| |||
  Rat  2014 SDEEEAEGAEPG----------------SAPTQEPEAPPPAAPQ 2041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	266/774 (34%)
		MYSc_Myo15	169..828	CDD:276838	258/733 (35%)
		MyTH4	1014..1171	CDD:295320	29/178 (16%)
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myh14	XP_038967907.1	Motor_domain	115..833	CDD:419868	258/733 (35%)
Myh14	XP_038967907.1	Myosin_tail_1	910..1990	CDD:396244	238/1295 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000