DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and myh7

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_001106204.1 Gene:myh7 / 30616 ZFINID:ZDB-GENE-991123-5 Length:1938 Species:Danio rerio


Alignment Length:2242 Identity:509/2242 - (22%)
Similarity:831/2242 - (37%) Gaps:689/2242 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.:...|||.::|:||:.||...:|||::|...:.|||||..| .|..||...|.|:.....
Zfish    87 IEDMAMFTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNQEVVVAYRGKKRSEA 150

  Fly   222 PPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGGGS------ASAVI 277
            |||:|:|...|:..:.:.   |.::|:||||:|||.:||.|:||.|::..||.:      ....:
Zfish   151 PPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAGGSAKKEGAEKKGTL 215

  Fly   278 TEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGER 341
            .:||::|.|.|||||||:|.||||||||||::.::| .||.:..|.|..|||||||:..|...||
Zfish   216 EDQIIQANPALEAFGNAKTIRNDNSSRFGKFIRIHFGASGKLASADIETYLLEKSRVTFQLKAER 280

  Fly   342 NYHVFYELLGGLSETERSKYGLLE-------ADKYFYLNQGATDCASGRVDWESL---QGAMQVL 396
            :||:||::|      .:.|..|||       ...|.|::||.|..||.. |.|.|   ..|..||
Zfish   281 DYHIFYQIL------SQRKPELLEMLLITNNPYDYAYISQGETTVASIN-DGEELLATDEAFDVL 338

  Fly   397 GVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQE--GVEVGSDAEIKWAAHLLHISADGLHRAL 459
            |.::.|:.||.:::.|::|.||:.|.::|.....|  |.|.|..     .|:|:.:::..|.:.|
Zfish   339 GFTQEEKNGIYKLIGAIMHFGNMKFKQKQREEQAEADGTEDGDK-----VAYLMGLNSADLIKGL 398

  Fly   460 TSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR--ISILD 522
            .....:...|.:.....:.|...|..|.||::|..:|.|:|.|||   |...|....:  |.:||
Zfish   399 CHPRVKVGNEWVTKGQNVQQVYYAIGALAKSVYEKMFLWMVVRIN---QSLDTKQPRQYFIGVLD 460

  Fly   523 IFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKK 587
            |.|||....|:|||||||:.||.||.:||.|:|.|||.||.:|.:||..:.:..:|.....|.:|
Zfish   461 IAGFEIFDFNTFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIDLIEK 525

  Fly   588 PVGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARPRI--GAQE--FGVTHYAGQVWYCVD 647
            |:||..:|::|..||:|:|.:|..|.:.|| ..|..:.:||.  |..|  |.:.||||.|.|.::
Zfish   526 PMGIMSILEEECMFPKASDSTFKAKLYDNHLGKSNNFQKPRAIKGKPESHFSLVHYAGTVDYNIN 590

  Fly   648 GFLDKNRDALRGDVLELLASSRLPLVGEL-TKQLRAQRDAGK------TLPKGSNGRFVTMKPRT 705
            .:|.||:|.|...|:.|...|.:.|:..| ......:.|.||      :..|||:.:        
Zfish   591 NWLVKNKDPLNETVVGLFQKSTVKLLSMLFANYAGTESDNGKGGKGGGSKKKGSSFQ-------- 647

  Fly   706 PTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGY 770
             ||:|...::|.:|:.::...||.|||||.||:.|....|:.|.|:.|||..|:|:.|:|.::|:
Zfish   648 -TVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMENPLVMHQLRCNGVLEGIRICRKGF 711

  Fly   771 PVRLRFQHFVERYRHLLPSPLARG--TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHR 833
            |.|:.:..|.:|||.|.|:.:..|  ...|:....||.::   .::...|:.|.|:||.:..|..
Zfish   712 PNRILYGDFKQRYRILNPAAIPEGQFIDSRKGAEKLLGSL---DIDHNQYKFGHTKVFFKAGLLG 773

  Fly   834 ALESGRTERLRRAAVSVQRHVRGMLVR---RQLARRQAAATRLQ---------ARWRGQRAQQRY 886
            .||..|.:||......:|...||:|.|   :::..|:.|...:|         ..|...:...:.
Zfish   774 QLEEMRDDRLSLIISGIQARSRGLLARVEFQKIVERRDALLVIQWNVRAFMGVKNWPWMKLFFKI 838

  Fly   887 ERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIP 951
            :.|.|.|          :|.:.:..::.:..:.:||...:       ||::..||...:|.|...
Zfish   839 KPLLKSA----------EAEKEMANMKDEFAKLKEAYAKS-------EARRKELEEKMVSLLQEK 886

  Fly   952 AELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRR 1016
            .:|     :||                         ||..:|....:..:...:..|.::|:.:.
Zfish   887 NDL-----QLQ-------------------------VQAEQDNLCDAEERCDQLIKNKIQLEAKA 921

  Fly  1017 EPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILV 1081
            :.:|..|           :|                    :|::.|:....|    |.|.||   
Zfish   922 KELTERL-----------ED--------------------EEEMNAELTAKK----RKLEDE--- 948

  Fly  1082 QLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQG 1146
              |::                                  |.:.:||                   
Zfish   949 --CSE----------------------------------LKKDIDD------------------- 958

  Fly  1147 GGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTS--CEEAAALAVS 1209
                                             |.|||.....:..|.::...  .||.|||.  
Zfish   959 ---------------------------------LELTLAKVEKEKHATENKVKNLTEEMAALD-- 988

  Fly  1210 SLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVK 1274
                                     |.:..|..||:                      .|.:|.:
Zfish   989 -------------------------DIIAKLTKEKK----------------------ALQEAHQ 1006

  Fly  1275 RPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLD 1339
            :..            :|:..|......|....:.|.::..:.|           |..:...|...
Zfish  1007 QTL------------DDLQSEEDKVNTLTKAKAKLEQQVDDLE-----------GSLEQEKKLRM 1048

  Fly  1340 DL------LAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGR 1398
            ||      |.||:..      :||.|..|.      ||:....|||..  ||    ::.||..| 
Zfish  1049 DLERAKRKLEGDLKL------TQESLMDLE------NDKQQLEERLKK--KD----FEISQLNG- 1094

  Fly  1399 RSHAASHGSHSSKYADK-----------AEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQ 1452
                        |..|:           .|...|...:.:..||...|    |.:|..|.:|   
Zfish  1095 ------------KIEDEQTICIQLQKKLKELQARIEELEEELEAERAA----RAKVEKQRAD--- 1140

  Fly  1453 FLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKL 1517
                     |...|:|:|:....|........|...:.|:|           ||  .|.::||:.
Zfish  1141 ---------LARELEEISERLEEAGGATAAQIEMNKKREAE-----------FQ--KLRRDLEEA 1183

  Fly  1518 TSKDQLAAII----KGGGVASKPEERD-----------EESEIE-DLDDYINELFEPIPVAEGLD 1566
            |.:.:..|..    :...||...|:.|           |:||:. :|||.::.:...:.....|:
Zfish  1184 TLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELRLELDDVVSNMEHVVKTKANLE 1248

  Fly  1567 KLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGP-ALYQQQVQRAFLQSAMAQNLQIQ 1630
            |:|..                    |..|:.:...:.|.|. .:....:|::.|||   :|.::.
Zfish  1249 KMTRS--------------------LEDQMNEYKTKYEEGQRCINDFTMQKSKLQS---ENGELS 1290

  Fly  1631 QQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRM-KATRSSLVVMES 1694
            :||    :...:|:||...                 |.:|.:........:: :.|::...:..:
Zfish  1291 RQL----EEKDSLVSQLTR-----------------SKMSYTQQIEDLKRQLEEETKAKSALAHA 1334

  Fly  1695 LQPPPPPPPPPMPPPLECKDPSETRHFLD----------------PYGRAK-TVRIGKWRWPPPQ 1742
            :|                    ..||..|                ..|.:| ...:.:||.....
Zfish  1335 VQ--------------------SARHDTDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYET 1379

  Fly  1743 DEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTP 1807
            |..| :|||      :.:.::|.   ||..|.|      |....|..|..:::|..:..:::...
Zfish  1380 DAIQ-RTEE------LEEAKKKL---AQRLQET------EEAVEAVNAKCSSLEKTKHRLQNEIE 1428

  Fly  1808 PPMSGQLMRSSIRLETTTTTTTSAVNNRDRD------------RETQ---DVGQPMQSVVTTKL- 1856
            ..|        :.|| .:....:|::.:.|:            .|:|   :..|.....::|:| 
Zfish  1429 DLM--------VDLE-RSNAAAAALDKKQRNFDKVLSEWKQKFEESQAELESSQKEARCLSTELF 1484

  Fly  1857 -AKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAG----HSV----RSTVSTKSE-----QRA 1907
             .|.|:|...|...........|..|:....||:..|    |.:    :.....|||     :.|
Zfish  1485 KLKNSYEEALDHLETMKRENKNLQEEISDLTEQLGEGGKSIHELEKMRKQLEQEKSEIQSALEEA 1549

  Fly  1908 PAKLEDTRKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGV 1972
            .|.||.....:|:.||.  |:.:.         .|....:..:.|.||                 
Zfish  1550 EASLEHEEGKILRAQLE--FSQIK---------ADIERKLAEKDEEME----------------- 1586

  Fly  1973 LLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTAR--------SPEPEPDYRTSSSQVVKEHVP 2029
                                         ||....:        |.|.|...|..:.: :|:.:.
Zfish  1587 -----------------------------QSKRNLQRTIDTLQSSLESETRSRNEALR-IKKKME 1621

  Fly  2030 AFIQRQERDTFGAVRQ----QQMISSHHLHLEDHSASSSPAVAAWE----------------QAE 2074
            ..:...|.....|.||    |:.:.|.|.|::|.......::...|                |||
Zfish  1622 GDLNEMEIQLSQANRQAAEAQKQLKSVHAHMKDAQLQLDDSLRTNEDLKENTAIVERRNNLLQAE 1686

  Fly  2075 RERSRS--RSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLYEIRQVERE----- 2132
            .|..|:  ....|.|:...:.:.|.:|.........:....:|::.|.    :|.|::.|     
Zfish  1687 LEELRAALEQTERGRKLAEQELLDTSERVQLLHSQNTSLLNQKKKLET----DISQLQTEVEEAV 1747

  Fly  2133 RESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQ---------------------- 2175
            :|.....:.|...:..|:|......:.:|.:..|...:.:|.|                      
Zfish  1748 QECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAMKGGKK 1812

  Fly  2176 --------------KYEHERKRKSSASSGMRE 2193
                          :.|.|:|:.|.|..|:|:
Zfish  1813 QVQKLEARVRELESEVESEQKKSSEAVKGIRK 1844

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 260/716 (36%)
MYSc_Myo15 169..828 CDD:276838 253/696 (36%)
MyTH4 1014..1171 CDD:295320 14/156 (9%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
myh7NP_001106204.1 Myosin_N 35..72 CDD:280832
Myosin_head 87..768 CDD:278492 259/708 (37%)
MYSc_class_II 99..768 CDD:276951 253/696 (36%)
MIT_CorA-like 780..>991 CDD:294313 56/410 (14%)
Myosin_tail_1 848..1925 CDD:279860 231/1443 (16%)
RILP-like 963..1096 CDD:304877 39/235 (17%)
MIT_CorA-like <1297..>1409 CDD:294313 25/164 (15%)
COG6 1374..>1536 CDD:303003 35/186 (19%)
GBP_C 1563..1825 CDD:303769 46/323 (14%)
TMPIT 1742..>1832 CDD:285135 10/89 (11%)
coiled coil 1795..1805 CDD:293879 0/9 (0%)
coiled coil 1814..1825 CDD:293879 0/10 (0%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.000

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