DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and Myh15

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_038944797.1 Gene:Myh15 / 303965 RGDID:1565858 Length:1987 Species:Rattus norvegicus


Alignment Length:2147 Identity:495/2147 - (23%)
Similarity:846/2147 - (39%) Gaps:493/2147 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   142 GEGSLRARQD-------LGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYK 199
            || |||.|:|       .....:||:::|..::|.|:|..||.|||..:|||::|...:|:||||
  Rat    64 GE-SLRIREDEIQQMNPAELEMIEDLSMLLYINEGSVLHTLRKRYDHWMIYTYSGLFCVAINPYK 127

  Fly   200 MFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALP-----SPQVVVISGESGSGKTESTKLV 259
            ..| .|..||...|..:.....|||:||:  |.||...     ..|.::.:||||||||.:||::
  Rat   128 WLP-VYQKEVMAAYKRKRRSEAPPHIFAV--ANHAFQDMLRNGENQSILFTGESGSGKTVNTKMI 189

  Fly   260 MQYLAAVVPGGGSASAV--ITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGA 321
            :||.|.:.........:  :.:||::..|:|||||||:|.||||||||||::.:|| ..|.:..|
  Rat   190 IQYFATMAATSEPKKKLGNLEDQIVQMNPILEAFGNAKTLRNDNSSRFGKFIRMYFGVRGTLSFA 254

  Fly   322 KITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATD---CASGR 383
            .|..|.|||||:|.|.|||||||:||::|.|..|.:          ....::...:|   |:.|.
  Rat   255 DIQIYFLEKSRVVYQQPGERNYHIFYQILSGKQELQ----------DMLLVSTNPSDFHICSCGV 309

  Fly   384 VDWESL---------QGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDA 439
            |..|:|         :.|:.|||....|:.|..:::.|::|.||:.| |:..|  :|.:|.....
  Rat   310 VAVENLDDAKGFLATEKAIDVLGFLPDEKFGCYKLVGAIMHFGNLKF-RQNPR--EEQLEADGTE 371

  Fly   440 EIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRIN 504
            ....||.|:.|:|..|.:.|.....:...|.:.....|.|...|..|.:|::|..:|.|||:|:|
  Rat   372 NADKAALLMGINASELLKGLIYPRIKVGNEYVTRSQNIQQVTYAVGALSKSIYERMFKWLVARMN 436

  Fly   505 SIVQ-KGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLE 568
            .::. |..:|  ..|.||||.|||.|..||.||||||:.||.||.:||:.:|.|||.|..:|.|:
  Rat   437 QVLDAKVTSH--FFIGILDITGFEILDYNSLEQLCINFTNEKLQQFFNQQLFVLEQEECRKEGLD 499

  Fly   569 WTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARPRIGAQE 632
            |..:.:..:|.....|.:||:||..:|::|...|:|||.:|..|...:| ..|..:.:|....:.
  Rat   500 WMSIDYGLDLQACIDLIEKPMGILSILEEECMLPKATDNTFKTKLFAHHFGKSAYFQKPTAPEKN 564

  Fly   633 FGV----THYAGQVWYCVDGFLDKNRDALRGDVLELL-ASSRLPLVGELTKQLRAQRDAGKTLPK 692
            |.|    .||||.|.|.:.|::.||::.|...|:.|| .||...|....|....|......::..
  Rat   565 FEVHFELAHYAGVVPYDISGWIGKNKELLNETVVALLQKSSNKVLASLFTNNTIAGSGELDSIEF 629

  Fly   693 GSNGRFVTMKPRTPT-----VAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQ 752
            |.       |||...     :.:...:|:.:|:..:....|.|||||.||:.|....||...|||
  Rat   630 GE-------KPRRKATSFQLITSLHKESINKLMADLKSTAPHFVRCINPNENKIPGVMDPFWVLQ 687

  Fly   753 QLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPD 817
            |||..|:|:..::..:.:|:|:.:..|.:||..|.|...:: :.:..:.:|..|.:....::...
  Rat   688 QLRCNGVLEGTRVCCKAFPIRMLYDDFKQRYCILNPRIFSK-SKFVNIRKATEEVLALLEIDQSQ 751

  Fly   818 YQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVR---RQLARRQAAATRLQARWRG 879
            ||.|.|:||.:..:...||..|.|::.:.....|...||.|:|   :::...:.|...:|     
  Rat   752 YQCGVTKVFFKARILDRLEERRDEKISKVFTLFQARARGKLMRITFQKILEERDALALIQ----- 811

  Fly   880 QRAQQRYERLRKGALTAQRLW-------------RGRQARRRVQQLRSDHRRRQEAREAAQRARE 931
                   |.:|  |..|.:.|             :...|...:..|:.:..:.|::.|.::..||
  Rat   812 -------ENIR--AFIAVKTWPWMGLFFKVKPLAKSVGAGEEIAGLKEECAQLQKSLETSESQRE 867

  Fly   932 AREAKQA--VLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDL 994
            ..:.||.  |.||:.| .|.:.||...:.:..:..      ..|:|          |.::|...:
  Rat   868 ELKTKQVSLVQERNDL-LLQLQAEQETLANSEELC------ESLIK----------SKIELEAKI 915

  Fly   995 GQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEK 1059
            .:.|            |.....|.|.:.|..|.                  |...|:..|..||.
  Rat   916 KELS------------RRVEEEEEINSELTARG------------------RKLEDECSELKKEI 950

  Fly  1060 LLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRF 1124
            ...:.|:.|:..::...:..:..|..:||.|..:..:.||..|      ...:......::|  .
  Rat   951 YDLEAILAKSEKAKCAAEHKVRNLTEEVHSLHEDVSKLTRAMQ------AAQEAQQQTQEHL--H 1007

  Fly  1125 VDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEAS 1189
            :::|...::..  :.|.|.||..                               ||...|..|..
  Rat  1008 IEEEKLSNVSK--VNQKLSQQVD-------------------------------ALEGDLERERK 1039

  Fly  1190 QTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPR 1254
            ..:      .||.........|.:...|...:....|||         ::.:.:||.        
  Rat  1040 ARM------KCEREKHKLEGELKLNQEGAENLESSRQQL---------IEQLRKKEF-------- 1081

  Fly  1255 SDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPS 1319
             ::.:..:|                     ..:.|..|.:.:::.:||.::...|.|..      
  Rat  1082 -EMGQMNSK---------------------VENEKNLVSQLQKTVKELQTQILNLKEEL------ 1118

  Fly  1320 PGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSA--ERLA-- 1380
                :...|.:||...:..|  ||.|:                    ..||:|...|  ..||  
  Rat  1119 ----ESERTIRAKVERERGD--LAQDL--------------------EDLNERLEEAGGTSLAQM 1157

  Fly  1381 PVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVR--V 1443
            .:.:....|:||.:|         ....::::.:....:.:.....:.:|......|:::||  :
  Rat  1158 EITRQQEARFQKLRH---------DMEETTRHFEATSVSLKRRHAENVAELEGQVEHLQQVRQVL 1213

  Fly  1444 PSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQE-NEAESEIDDLDDYINDIFQP 1507
            ..:.||:...:|||.:.|     |:::.|::.|..: .|.||:. |||.:::|:......|:...
  Rat  1214 DQEKSDLQLQVDDLLTRV-----DQMARAKANAEKL-CGLYERRLNEANTKLDEATQLAKDLTSQ 1272

  Fly  1508 IPLVQN-----LEKLTSKDQLAAII---KGGGVASKPEER---DEESEIEDL---------DDY- 1551
            ...:||     .::|..|:.|.:.:   |...:....|.|   :|||:.:..         .|| 
  Rat  1273 RTKLQNESGEFFKRLEEKEALISQLSREKSNLILQVEELRVQLEEESKSQSALAHALQSTKHDYD 1337

  Fly  1552 -INELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGP---ALYQQ 1612
             :.|.:|.      ..::.|:.|.|:|  .|............|..||...:.|...   |:..|
  Rat  1338 LLREQYEE------EQEVKSELHRALS--KGNKETVQWRTKYEHDAMQRTEDLEEAKKKLAIRLQ 1394

  Fly  1613 QVQRAFLQSAMAQNLQIQQQ----LLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISP 1673
            :...| ::.:.|:|..:::.    .|....||..|...::.|||......  .:...|:|.....
  Rat  1395 EAAEA-MEVSNAKNASLERARHRLQLELGDALSDLGKARSVAAALGQKQQ--HSDKALASWKQKQ 1456

  Fly  1674 PPPQ-----SPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGR------ 1727
            ...|     |....:|..|.::::..                .|::.:|.:..|....:      
  Rat  1457 EEAQELLQASQKEARALSSEVLMLRQ----------------ACEESNEAQETLKRQNQDLQERI 1505

  Fly  1728 ---AKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARG 1789
               ...||.|            .:...:....|....|.||..||:          :|...|   
  Rat  1506 CCLTNQVREG------------IKNLTEVEKAKKLIEQEKTEIQAR----------LEEAEG--- 1545

  Fly  1790 ASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVN-NRDRDRETQDVGQPMQS--- 1850
                |:|..|.:|       :..||..|..:.|.....:..... .|.|::..|.:|....|   
  Rat  1546 ----ALERNESKI-------LRFQLDLSEAKAELGRKLSEKEDEAGRLREKHQQALGSLQSSLDS 1599

  Fly  1851 -----VVTTKLAK------KSFEI---GADRPPPGSVGKL-KLSSEMRQRLEQVTAGHSVRSTVS 1900
                 :..||:.|      |..||   .|:|....:...| :|.|:|:. |:|     .:..::.
  Rat  1600 EASSRIEATKMRKKIEGDLKEMEIQLCTANRQVSQTTRALGQLQSQMKD-LQQ-----HLDDSIY 1658

  Fly  1901 TKSEQRAPAKLEDTRKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPP 1965
            ...:.:....|.:.|.::||.:|..|                  .:::.|.||.. ||:...   
  Rat  1659 QNKDLKDQVALAEQRNILLQSELEEL------------------RSLQEQTERGR-KLAEKE--- 1701

  Fly  1966 SGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPA 2030
                   ||.....:..                                 :.|.::.::.:.   
  Rat  1702 -------LLEATERISL---------------------------------FHTQNASLLSQK--- 1723

  Fly  2031 FIQRQERDTFGAVRQQ-QMISSHHLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESV 2094
              ::.|.|...|.::. :|:.:.....|....:::.|...||:.::|:..:....|.|::..:::
  Rat  1724 --KKLEADVAQAQKEAGEMLQACQKAEEKAKKTAAEAANMWEELKKEQDTNAHLERTRKNMEQTI 1786

  Fly  2095 WD---RAEVEGPASGSGSEKEREK-----RERERERLYEIRQ-VERERESHKVYQPAPPRVIQAS 2150
            .|   |.:.....:..||:|:.:|     |:.|.|...|:|: .|.:||:.::.:.......||.
  Rat  1787 KDLQKRLDEAEQTAVVGSKKQIQKLESRVRDLEGELESEVRRSAEAQREARRLERGIKELTYQAE 1851

  Fly  2151 MD 2152
            .|
  Rat  1852 ED 1853

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 244/711 (34%)
MYSc_Myo15 169..828 CDD:276838 240/690 (35%)
MyTH4 1014..1171 CDD:295320 24/156 (15%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
Myh15XP_038944797.1 Myosin_N 31..70 CDD:397036 5/6 (83%)
Motor_domain 98..762 CDD:419868 240/689 (35%)
Myosin_tail_1 843..1919 CDD:396244 227/1327 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.000

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