Protein Alignment Myo10A and Myo1a

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_062197.1
• Gene: Myo1a / 299509
• RGDID: 3135
• Length: 1043
• Species: Rattus norvegicus
• Alignment Length: 792
• Identity: 295/792 - (37%)
• Similarity: 440/792 - (55%)
• Gaps: 65/792 - (8%)

  Fly   153 GSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRP 217
            ||.||||:.||:.|.|.||:.||:|||:|..|||:.|:::|::|||:..| .||.|...:|....
  Rat     6 GSVGVEDLILLEPLDEESLIKNLQLRYEKKEIYTYIGNVVISMNPYQQLP-IYGPEFIAKYRDYT 69

  Fly   218 LGSLPPHLFAIGAAAHAALPS---PQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITE 279
            ...|.||::|:...|:.:|..   .|.::|:||||:||||::||||.|:|||. |.|.....:.|
  Rat    70 FYELKPHIYALANVAYQSLKDRDRDQCILITGESGAGKTEASKLVMSYVAAVC-GKGEQVNSVKE 133

  Fly   280 QILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVTQAPGERNY 343
            |:|::.|:|||||||:|.|||||||||||:::.|. .|:.:|..||.|||||||:|.|..||||:
  Rat   134 QLLQSNPVLEAFGNAKTIRNDNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRVVKQLKGERNF 198

  Fly   344 HVFYELLGGLSETERSKYGLLEADK--YFYLNQGATDCASGRVD---WESLQGAMQVLGVSEGER 403
            |:||:||.| ::|:..|...||.|.  |.||| |.....:|..|   :.::|.||.|:|.||.|.
  Rat   199 HIFYQLLAG-ADTQLLKALKLEEDARGYAYLN-GEVSRVNGMDDASNFRAVQNAMAVIGFSEEEI 261

  Fly   404 EGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARA 468
            ..::.|.|.||.||||........:|.....|.....|:....::.:::..|.:||.|||.|...
  Rat   262 RQVLEVTALVLKLGNVKLADEFQANGLPASGVCDGKGIQEIGEMMGLNSAELEKALCSRTMETGK 326

  Fly   469 ERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRI-SILDIFGFEDLAEN 532
            |::.|.|.:.||..||||.||.:|:.||:|:|:|||..: |.||.:..:: .:|||:|||.|.:|
  Rat   327 EKVVTVLNVIQAQYARDALAKNIYSRLFDWIVNRINESI-KVGTGEKRKVMGVLDIYGFEILEDN 390

  Fly   533 SFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDD 597
            ||||..|||.||.||..|.:...|.||.||.||.:.||.:.:.||..:..|:.....||..:||:
  Rat   391 SFEQFVINYCNEKLQQVFIELTLKEEQEEYKREGIPWTKVEYFDNGIICDLIEHSQRGILAMLDE 455

  Fly   598 ESNFPR-ATDLSFLEK--------CHYNHALSELYARP---RIGAQEFGVTHYAGQVWYCVDGFL 650
            |...|. .:|.:||.|        .||...:::...|.   .:|...|.:.||||:|.|.|..|:
  Rat   456 ECLRPGVVSDTTFLAKLNQLFSKHSHYESKVTQNAQRQYDRTMGLSCFRICHYAGKVTYNVTSFI 520

  Fly   651 DKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADS 715
            |||.|.|..|:.:.:..::.||:..|             .|:| |.:..::| |.||...:|.:|
  Rat   521 DKNNDLLFRDLSQTMWKAQHPLLHSL-------------FPEG-NPKEASLK-RPPTAGTQFKNS 570

  Fly   716 LQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFV 780
            :..|::::...:|.::||||||.::...|.....|:.|.||||:|:.:::|:.||..|..::.|:
  Rat   571 VAILMKNLYSKNPNYIRCIKPNDQQQQGRFTSELVMVQARYLGLLENVRVRRAGYAFRQAYKPFL 635

  Fly   781 ERYRHLLPSPLARGTPYRELCRALLEAMPRTGVE---------GPDYQLGATRVFLR--EALHRA 834
            ||||.|..|...|           .....|.|||         ..:...|.|::|:|  :.|. .
  Rat   636 ERYRLLSRSTWPR-----------WNGEDREGVEKVLGSLILSSEELAYGRTKIFIRSPKTLF-Y 688

  Fly   835 LESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRL 899
            ||..|..||::.|..:|:..||...|....:.:.:...:.|.:||.:.::.|.::|...|..|..
  Rat   689 LEEQRRLRLQQLATLIQKVYRGWRCRTHYQQMRKSQILISAWFRGNKQKKHYGKIRSSVLLIQAF 753

  Fly   900 WRGRQARRRVQQ 911
            .||.:||:..::
  Rat   754 VRGWKARKNYRK 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	262/689 (38%)
		PTZ00121	<828..>943	CDD:173412	23/86 (27%)
		MyTH4	1014..1171	CDD:470587
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myo1a	NP_062197.1	MYSc_Myo1	22..681	CDD:276829	262/689 (38%)
		IQ	742..764	CDD:197470	7/21 (33%)
		Myosin_TH1	847..1042	CDD:461801