DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and Myh6

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_058935.2 Gene:Myh6 / 29556 RGDID:62029 Length:1939 Species:Rattus norvegicus


Alignment Length:2092 Identity:507/2092 - (24%)
Similarity:840/2092 - (40%) Gaps:421/2092 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 ASLEDFEDLPNLSAKHPALPSSRLRRLKCRYPQVVKRLSTLCSDVIARHPQTFALQPGEGSLRAR 149
            |.:.||      .|..|.|..|...||:.:......|......|....:.:...:....|.:.|.
  Rat     4 AQMADF------GAAAPYLRKSEKERLEAQTRPFDIRTECFVPDDKEEYVKAKIVSREGGKVTAE 62

  Fly   150 QDLGSS-----------------GVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNP 197
            .:.|.:                 .:|||.:|..|||.::|:||:.||...:|||::|...:.|||
  Rat    63 TENGKTVTVKEDQVMQQNPPKFDKIEDMAMLTFLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNP 127

  Fly   198 YKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLV 259
            ||..| .|..||...|.|:.....|||:|:|...|:..:.:.   |.::|:||||:|||.:||.|
  Rat   128 YKWLP-VYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRV 191

  Fly   260 MQYLAAVVPGG--------GSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KS 315
            :||.|::...|        .:....:.:||::|.|.|||||||:|.||||||||||::.::| .:
  Rat   192 IQYFASIAAIGDRSKKDNPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGAT 256

  Fly   316 GAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLE-------ADKYFYLN 373
            |.:..|.|..|||||||::.|...|||||:||::|      ...|..||:       ...|.:::
  Rat   257 GKLASADIETYLLEKSRVIFQLKAERNYHIFYQIL------SNKKPELLDMLLVTNNPYDYAFVS 315

  Fly   374 QGATDCASGRVDWESL---QGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEV 435
            ||....|| ..|.|.|   ..|..|||.:..|:.|:.::..|::|.||:.|.::|   .:|..|.
  Rat   316 QGEVSVAS-IDDSEELLATDSAFDVLGFTAEEKAGVYKLTGAIMHYGNMKFKQKQ---REEQAEP 376

  Fly   436 GSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLV 500
            ....:...:|:|:.:::..|.:.|.....:...|.:.....:.|...:..|.||::|..:|||:|
  Rat   377 DGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMV 441

  Fly   501 SRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARE 565
            :|||:.::...... :.|.:|||.|||....|||||||||:.||.||.:||.|:|.|||.||.:|
  Rat   442 TRINATLETKQPRQ-YFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKE 505

  Fly   566 RLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARPR-- 627
            .:||..:.:..:|.....|.:||:||..:|::|..||:|||::|..|.:.|| ..|..:.:||  
  Rat   506 GIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNV 570

  Fly   628 IGAQE--FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTL 690
            .|.||  |.:.||||.|.|.:.|:|:||:|.|...|:.|...|.|.|:..|.... |..|.|.: 
  Rat   571 KGKQEAHFSLVHYAGTVDYNILGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTY-ASADTGDS- 633

  Fly   691 PKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLR 755
            .||..|:  .......||:|...::|.:|:.::...||.|||||.||:.|....||.|.|:.|||
  Rat   634 GKGKGGK--KKGSSFQTVSALHRENLNKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLR 696

  Fly   756 YLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARG--TPYRELCRALLEAMPRTGVEGPDY 818
            ..|:|:.|:|.::|:|.|:.:..|.:|||.|.|:.:..|  ...|:....||.::   .::...|
  Rat   697 CNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDSRKGAEKLLGSL---DIDHNQY 758

  Fly   819 QLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVR---RQLARRQAAATRLQ------ 874
            :.|.|:||.:..|...||..|.|||.|....:|...||.|:|   :::..|:.|...:|      
  Rat   759 KFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQARGQLMRIEFKKMVERRDALLVIQWNIRAF 823

  Fly   875 ---ARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQL--RSDHRRRQ-------------- 920
               ..|...:...:.:.|.|.|.|.:.:...::...||:..  :|:.||::              
  Rat   824 MGVKNWPWMKLYFKIKPLLKSAETEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKND 888

  Fly   921 -------------------------------EAREAAQRAREARE------AKQAVLERSQLSYL 948
                                           :.:|..:|..:..|      ||:..|| .:.|.|
  Rat   889 LQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLE-DECSEL 952

  Fly   949 --DIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGK--FSSVYCNG 1009
              ||. :|....:|::  ...|...:.||.|      ......|.|.:.:.:..|  ....:...
  Rat   953 KKDID-DLELTLAKVE--KEKHATENKVKNL------TEEMAGLDEIIAKLTKEKKALQEAHQQA 1008

  Fly  1010 L-RLQPRREPITAPLLTRAASRDQ--DFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALS 1071
            | .||...:.:...:.::.....|  |.:.:|...|.:     ...||.||.||..|.       
  Rat  1009 LDDLQAEEDKVNTLIKSKVKLEQQVDDLEGSLEQEKKV-----RMDLERAKRKLEGDL------- 1061

  Fly  1072 SRGLRDEILVQLCN------------------QVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFS 1118
              .|..|.::.|.|                  |...:......|.:|.:.|       :.:.|..
  Rat  1062 --KLTQESIMDLENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKL-------KENQARI 1117

  Fly  1119 KYLMRFVDDEAP-----ESLRPLLLRQLLR-----QQGGGTSSGAVGAGACRSFVPAWLEWRAWT 1173
            :.|...::.|..     |.||..|.|:|..     ::.||.:|..:.....|.     .|::...
  Rat  1118 EELEEELEAERTARAKVEKLRSDLTRELEEISERLEEAGGATSVQIEMNKKRE-----AEFQKMR 1177

  Fly  1174 RGCDMALPLTLPDEASQTVAVDSWTSCEEAAAL------AVSSLG--------------VASRGW 1218
            |..:.|   ||..||:             ||||      :|:.||              .....:
  Rat  1178 RDLEEA---TLQHEAT-------------AAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEF 1226

  Fly  1219 TLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAP 1283
            .|.|||   :|.:  ::.::...|..|........:::..|...:.|:.:|.|...:.|    ..
  Rat  1227 KLELDD---VTSN--MEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRA----KL 1282

  Fly  1284 PTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDD------LL 1342
            .|.:|  ::.|:......|:|:.:.              |:.|.|.|.:...:.|::      .|
  Rat  1283 QTENG--ELARQLEEKEALISQLTR--------------GKLSYTQQMEDLKRQLEEEGKAKNAL 1331

  Fly  1343 AGDIVPVPTDCD------------SQEPLHTLGLSESRL--------NDRYHSAERLAPVGKDTG 1387
            |..:.....|||            ..|....|..:.|.:        .|.....|.|....|...
  Rat  1332 AHALQSARHDCDLLREQYEEEMEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1396

  Fly  1388 PRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQ 1452
            .|.|.::.|....:|.......:|:..:.|.   ...|.|...:.:.|:     .:..:..:.|:
  Rat  1397 QRLQDAEEAVEAVNAKCSSLEKTKHRLQNEI---EDLMVDVERSNAAAA-----ALDKKQRNFDK 1453

  Fly  1453 FLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDY----------INDIFQP 1507
            .|.: :....:.|..||..::..|.|:....::.:|..|..::.|:.:          |:|:.:.
  Rat  1454 ILAE-WKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQ 1517

  Fly  1508 I----PLVQNLEKLTSK---------------------------------DQLAAIIKGGGVASK 1535
            :    ..|..|||:..:                                 :|:.|.|:     .|
  Rat  1518 LGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE-----RK 1577

  Fly  1536 PEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLP 1600
            ..|:|||.|    ....|.|.....:...||..|...:.|:.::.....|.|..:..|.|..::.
  Rat  1578 LAEKDEEME----QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIA 1638

  Fly  1601 GETESGPALYQQQVQRAFLQ--------SAMAQNLQIQQQ----LLAQNQALQTLLSQ--QAAAA 1651
            .|.:......|..::...||        ..:.:|:.|.::    |.|:.:.|:.::.|  ::...
  Rat  1639 SEAQKHLKNAQAHLKDTQLQLDDAVRANDDLKENIAIVERRNTLLQAELEELRAVVEQTERSRKL 1703

  Fly  1652 AANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPS 1716
            |............:|.|.:.|....:..|....::....|.|::|              ||::..
  Rat  1704 AEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ--------------ECRNAE 1754

  Fly  1717 ETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAF--KMRQHQRKTTPQAQH-----HQM 1774
            |         :||     |..........:.:.|:|..|.  :|:::..:|....||     .|:
  Rat  1755 E---------KAK-----KAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQI 1805

  Fly  1775 TSNGGMMESGPGARGASATAIEWE-EFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRD 1838
            ...||..:    .:...|...|.| |.|.|..........:.:|..|::..|..|.....|..| 
  Rat  1806 ALKGGKKQ----LQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLVR- 1865

  Fly  1839 RETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKL-KLSSEMRQRLEQVTAGHSVRSTVSTK 1902
              .||:...:|  :..|..|:..| .|:.....::.|. |:..|:.:..|:.....|..:.:..|
  Rat  1866 --LQDLVDKLQ--LKVKAYKRQAE-EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1925

  Fly  1903 SEQ-RAPAKLED 1913
            |.. .|..|:.|
  Rat  1926 SRDIGAKQKMHD 1937

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 258/708 (36%)
MYSc_Myo15 169..828 CDD:276838 250/687 (36%)
MyTH4 1014..1171 CDD:295320 33/186 (18%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
Myh6NP_058935.2 Myosin_N 34..72 CDD:397036 5/37 (14%)
MYSc_class_II 99..768 CDD:276951 250/687 (36%)
Actin-binding 657..679 10/21 (48%)
Actin-binding 759..773 5/13 (38%)
Calmodulin-binding. /evidence=ECO:0000250 790..807 5/16 (31%)
Calmodulin-binding. /evidence=ECO:0000250 816..833 2/16 (13%)
Myosin_tail_1 848..1925 CDD:396244 210/1209 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1908..1939 7/30 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.000

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