DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and Myh6

DIOPT Version :10

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_058935.2 Gene:Myh6 / 29556 RGDID:62029 Length:1939 Species:Rattus norvegicus


Alignment Length:2092 Identity:507/2092 - (24%)
Similarity:840/2092 - (40%) Gaps:421/2092 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 ASLEDFEDLPNLSAKHPALPSSRLRRLKCRYPQVVKRLSTLCSDVIARHPQTFALQPGEGSLRAR 149
            |.:.||      .|..|.|..|...||:.:......|......|....:.:...:....|.:.|.
  Rat     4 AQMADF------GAAAPYLRKSEKERLEAQTRPFDIRTECFVPDDKEEYVKAKIVSREGGKVTAE 62

  Fly   150 QDLGSS-----------------GVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNP 197
            .:.|.:                 .:|||.:|..|||.::|:||:.||...:|||::|...:.|||
  Rat    63 TENGKTVTVKEDQVMQQNPPKFDKIEDMAMLTFLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNP 127

  Fly   198 YKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLV 259
            ||..| .|..||...|.|:.....|||:|:|...|:..:.:.   |.::|:||||:|||.:||.|
  Rat   128 YKWLP-VYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRV 191

  Fly   260 MQYLAAVVPGG--------GSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KS 315
            :||.|::...|        .:....:.:||::|.|.|||||||:|.||||||||||::.::| .:
  Rat   192 IQYFASIAAIGDRSKKDNPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGAT 256

  Fly   316 GAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLE-------ADKYFYLN 373
            |.:..|.|..|||||||::.|...|||||:||::|      ...|..||:       ...|.:::
  Rat   257 GKLASADIETYLLEKSRVIFQLKAERNYHIFYQIL------SNKKPELLDMLLVTNNPYDYAFVS 315

  Fly   374 QGATDCASGRVDWESL---QGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEV 435
            ||....|| ..|.|.|   ..|..|||.:..|:.|:.::..|::|.||:.|.::|   .:|..|.
  Rat   316 QGEVSVAS-IDDSEELLATDSAFDVLGFTAEEKAGVYKLTGAIMHYGNMKFKQKQ---REEQAEP 376

  Fly   436 GSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLV 500
            ....:...:|:|:.:::..|.:.|.....:...|.:.....:.|...:..|.||::|..:|||:|
  Rat   377 DGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMV 441

  Fly   501 SRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARE 565
            :|||:.::...... :.|.:|||.|||....|||||||||:.||.||.:||.|:|.|||.||.:|
  Rat   442 TRINATLETKQPRQ-YFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKE 505

  Fly   566 RLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARPR-- 627
            .:||..:.:..:|.....|.:||:||..:|::|..||:|||::|..|.:.|| ..|..:.:||  
  Rat   506 GIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNV 570

  Fly   628 IGAQE--FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTL 690
            .|.||  |.:.||||.|.|.:.|:|:||:|.|...|:.|...|.|.|:..|.... |..|.|.: 
  Rat   571 KGKQEAHFSLVHYAGTVDYNILGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTY-ASADTGDS- 633

  Fly   691 PKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLR 755
            .||..|:  .......||:|...::|.:|:.::...||.|||||.||:.|....||.|.|:.|||
  Rat   634 GKGKGGK--KKGSSFQTVSALHRENLNKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLR 696

  Fly   756 YLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARG--TPYRELCRALLEAMPRTGVEGPDY 818
            ..|:|:.|:|.::|:|.|:.:..|.:|||.|.|:.:..|  ...|:....||.::   .::...|
  Rat   697 CNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDSRKGAEKLLGSL---DIDHNQY 758

  Fly   819 QLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVR---RQLARRQAAATRLQ------ 874
            :.|.|:||.:..|...||..|.|||.|....:|...||.|:|   :::..|:.|...:|      
  Rat   759 KFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQARGQLMRIEFKKMVERRDALLVIQWNIRAF 823

  Fly   875 ---ARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQL--RSDHRRRQ-------------- 920
               ..|...:...:.:.|.|.|.|.:.:...::...||:..  :|:.||::              
  Rat   824 MGVKNWPWMKLYFKIKPLLKSAETEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKND 888

  Fly   921 -------------------------------EAREAAQRAREARE------AKQAVLERSQLSYL 948
                                           :.:|..:|..:..|      ||:..|| .:.|.|
  Rat   889 LQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLE-DECSEL 952

  Fly   949 --DIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGK--FSSVYCNG 1009
              ||. :|....:|::  ...|...:.||.|      ......|.|.:.:.:..|  ....:...
  Rat   953 KKDID-DLELTLAKVE--KEKHATENKVKNL------TEEMAGLDEIIAKLTKEKKALQEAHQQA 1008

  Fly  1010 L-RLQPRREPITAPLLTRAASRDQ--DFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALS 1071
            | .||...:.:...:.::.....|  |.:.:|...|.:     ...||.||.||..|.       
  Rat  1009 LDDLQAEEDKVNTLIKSKVKLEQQVDDLEGSLEQEKKV-----RMDLERAKRKLEGDL------- 1061

  Fly  1072 SRGLRDEILVQLCN------------------QVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFS 1118
              .|..|.::.|.|                  |...:......|.:|.:.|       :.:.|..
  Rat  1062 --KLTQESIMDLENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQLQKKL-------KENQARI 1117

  Fly  1119 KYLMRFVDDEAP-----ESLRPLLLRQLLR-----QQGGGTSSGAVGAGACRSFVPAWLEWRAWT 1173
            :.|...::.|..     |.||..|.|:|..     ::.||.:|..:.....|.     .|::...
  Rat  1118 EELEEELEAERTARAKVEKLRSDLTRELEEISERLEEAGGATSVQIEMNKKRE-----AEFQKMR 1177

  Fly  1174 RGCDMALPLTLPDEASQTVAVDSWTSCEEAAAL------AVSSLG--------------VASRGW 1218
            |..:.|   ||..||:             ||||      :|:.||              .....:
  Rat  1178 RDLEEA---TLQHEAT-------------AAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEF 1226

  Fly  1219 TLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAP 1283
            .|.|||   :|.:  ::.::...|..|........:::..|...:.|:.:|.|...:.|    ..
  Rat  1227 KLELDD---VTSN--MEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRA----KL 1282

  Fly  1284 PTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDD------LL 1342
            .|.:|  ::.|:......|:|:.:.              |:.|.|.|.:...:.|::      .|
  Rat  1283 QTENG--ELARQLEEKEALISQLTR--------------GKLSYTQQMEDLKRQLEEEGKAKNAL 1331

  Fly  1343 AGDIVPVPTDCD------------SQEPLHTLGLSESRL--------NDRYHSAERLAPVGKDTG 1387
            |..:.....|||            ..|....|..:.|.:        .|.....|.|....|...
  Rat  1332 AHALQSARHDCDLLREQYEEEMEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1396

  Fly  1388 PRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQ 1452
            .|.|.::.|....:|.......:|:..:.|.   ...|.|...:.:.|:     .:..:..:.|:
  Rat  1397 QRLQDAEEAVEAVNAKCSSLEKTKHRLQNEI---EDLMVDVERSNAAAA-----ALDKKQRNFDK 1453

  Fly  1453 FLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDY----------INDIFQP 1507
            .|.: :....:.|..||..::..|.|:....::.:|..|..::.|:.:          |:|:.:.
  Rat  1454 ILAE-WKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQ 1517

  Fly  1508 I----PLVQNLEKLTSK---------------------------------DQLAAIIKGGGVASK 1535
            :    ..|..|||:..:                                 :|:.|.|:     .|
  Rat  1518 LGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE-----RK 1577

  Fly  1536 PEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLP 1600
            ..|:|||.|    ....|.|.....:...||..|...:.|:.::.....|.|..:..|.|..::.
  Rat  1578 LAEKDEEME----QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIA 1638

  Fly  1601 GETESGPALYQQQVQRAFLQ--------SAMAQNLQIQQQ----LLAQNQALQTLLSQ--QAAAA 1651
            .|.:......|..::...||        ..:.:|:.|.::    |.|:.:.|:.::.|  ::...
  Rat  1639 SEAQKHLKNAQAHLKDTQLQLDDAVRANDDLKENIAIVERRNTLLQAELEELRAVVEQTERSRKL 1703

  Fly  1652 AANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPS 1716
            |............:|.|.:.|....:..|....::....|.|::|              ||::..
  Rat  1704 AEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ--------------ECRNAE 1754

  Fly  1717 ETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAF--KMRQHQRKTTPQAQH-----HQM 1774
            |         :||     |..........:.:.|:|..|.  :|:::..:|....||     .|:
  Rat  1755 E---------KAK-----KAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQI 1805

  Fly  1775 TSNGGMMESGPGARGASATAIEWE-EFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRD 1838
            ...||..:    .:...|...|.| |.|.|..........:.:|..|::..|..|.....|..| 
  Rat  1806 ALKGGKKQ----LQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLVR- 1865

  Fly  1839 RETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKL-KLSSEMRQRLEQVTAGHSVRSTVSTK 1902
              .||:...:|  :..|..|:..| .|:.....::.|. |:..|:.:..|:.....|..:.:..|
  Rat  1866 --LQDLVDKLQ--LKVKAYKRQAE-EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1925

  Fly  1903 SEQ-RAPAKLED 1913
            |.. .|..|:.|
  Rat  1926 SRDIGAKQKMHD 1937

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc_Myo15 169..828 CDD:276838 250/687 (36%)
PTZ00121 <828..>943 CDD:173412 33/179 (18%)
MyTH4 1014..1171 CDD:470587 33/186 (18%)
Ubl1_cv_Nsp3_N-like 1178..>1245 CDD:475130 18/86 (21%)
MyTH4 2704..2810 CDD:459939
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
Myh6NP_058935.2 Myosin_N 32..76 CDD:460670 5/43 (12%)
MYSc_class_II 99..768 CDD:276951 250/687 (36%)
Actin-binding 657..679 10/21 (48%)
Actin-binding 759..773 5/13 (38%)
Calmodulin-binding. /evidence=ECO:0000250 790..807 5/16 (31%)
Calmodulin-binding. /evidence=ECO:0000250 816..833 2/16 (13%)
Myosin_tail_1 848..1925 CDD:460256 210/1209 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1908..1939 7/30 (23%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.