DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and Myo9a

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	XP_006511271.1	Gene:	Myo9a / 270163	MGIID:	107735	Length:	2633	Species:	Mus musculus

Alignment Length:	3007	Identity:	696/3007 - (23%)
Similarity:	1097/3007 - (36%)	Gaps:	967/3007 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PIPGEIQEVHRAAQVIVVQALIKGKMRIVRFHLEPW--------QRGGGGSVTPSPAQSP-SLAL 73
            |||.  ::...||:||  .:||.      |.||:..        :..||.....:|...| ...:
Mouse    33 PIPA--RKNSTAAEVI--DSLIN------RLHLDKTKCYVLAEVKEFGGEEWILNPTDCPVQRMM 87

  Fly    74 LSPHVLRRQRPASLEDFEDL---PNLSAK-HPALPSSRLRRLKCRYPQVVKRLSTLCSDVIARHP 134
            |.|.:....| .|.||:..|   .||... |.....|.||..:.|     :|:.          .
Mouse    88 LWPRMALENR-LSGEDYRFLLREKNLDGSIHYGSLQSWLRVTEER-----RRMM----------E 136

  Fly   135 QTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYK 199
            :.|..||.:           ...:|:..|.||:|.:||.|||.|:....|||:.||||||:||:|
Mouse   137 RGFLPQPQQ-----------KDFDDLCSLPDLNEKTLLENLRNRFKHEKIYTYVGSILIAINPFK 190

  Fly   200 MFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQ 261
            ..| .|..:..|.|....||.|.||::|:...|:.|:   ...|.:|||||||||||:||..::.
Mouse   191 FLP-IYNPKYVKMYDNHQLGKLEPHIYAVADVAYHAMLQRKKNQCIVISGESGSGKTQSTNFLIH 254

  Fly   262 YLAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEV-YFKSGAIVGAKITQ 325
            :|.|:...|.::.  :.:.||.|.|:|||||||:||.|:|||||||:::| |.::|.::||.:.:
Mouse   255 HLTALSQKGFASG--VEQIILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYQETGTVLGAYVEK 317

  Fly   326 YLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQ---------------- 374
            |||||||:|.|...||||||||.||.|.||.||..:.|.:.::|.:|||
Mouse   318 YLLEKSRLVYQEHNERNYHVFYYLLAGASEEERLAFHLKQPEEYHFLNQITKKPLRQSWDDYCYD 382

  Fly   375 -GATDC--ASG---RVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGV 433
             ...||  ..|   |.|:|.||.||:::|.....|..|..:|:|:|||||:.:.::..|  .:.:
Mouse   383 SEPQDCFTVEGEDLRHDFERLQLAMEMVGFLPKTRRQIFSLLSAILHLGNISYKKKTYR--DDSI 445

  Fly   434 EVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNW 498
            ::.:...:...:.||.:..:.|..||.:|.|....|:|..|..:.:|:..|::.||:||:.||:|
Mouse   446 DICNPEVLPIVSELLEVKEEMLFEALVTRKTVTVGEKLILPYKLAEAVTVRNSMAKSLYSALFDW 510

  Fly   499 LVSRINSIV--QKGGTHDAHRISI--LDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQ 559
            :|.|||..:  .|....|...:||  ||||||||...|||||.|||:|||.||.|||:|:|||||
Mouse   511 IVFRINHALLNSKDLEQDTKTLSIGVLDIFGFEDYENNSFEQFCINFANERLQHYFNQHIFKLEQ 575

  Fly   560 AEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYA 624
            .||..|.:.|..:.:.||...|:|::|||.|:.||||:|||||:||:.:.|:|..:.|..:....
Mouse   576 EEYRTEGISWHNIDYIDNTCCINLISKKPTGLLHLLDEESNFPQATNQTLLDKFKHQHEENSYIE 640

  Fly   625 RPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELT------------ 677
            .|.:....|.:.||||:|.|.|..|.:||.|.:|.|::.||.|||...|..:|
Mouse   641 FPAVMEPAFIIKHYAGKVKYGVKDFREKNTDHMRPDIVALLRSSRNAFVSGMTGIDPVAVFRWAV 705

  Fly   678 -----KQLRAQRDAGK-----------TLP----------------------------------- 691
                 :.:.|.|:|||           |.|
Mouse   706 LRAFFRAVVAFREAGKRHIQRKSGHDDTTPCAILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSI 770

  Fly   692 ------------KGSN-------------------------------------GRF--------- 698
                        :|.|                                     |.|
Mouse   771 TRKNPRTPLSDLQGMNTLNEKNQHDTFDIAWNVRTGIRQSRLPASNTSLLDKDGIFAHSASSKLL 835

  Fly   699 ----------------------------------VTM-------------KPRTPTVAARFADSL 716
                                              :|:             |.:.|:::|:|..||
Mouse   836 ERAHGILTRNKNFRSKPVLPKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKKKPPSISAQFQASL 900

  Fly   717 QQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVE 781
            .:|::::|:..|:||:||:.|.||..||.....||:||||.|||:|::|||.||..:..||.||.
Mouse   901 SKLMETLGQAEPYFVKCIRSNAEKLPLRFSDALVLRQLRYTGMLETVRIRQSGYSSKYSFQDFVS 965

  Fly   782 RY-----RHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTE 841
            .:     :|::||.......:|::           .:...:||:|.|.|||:|...:.|:....:
Mouse   966 HFHVLLPQHIIPSKFNIQDFFRKI-----------NINSDNYQVGKTMVFLKEHERQHLQDLLHQ 1019

  Fly   842 RLRRAAVSVQRHVRGMLVRRQ-LARRQA-------------------------------AATRLQ 874
            .:.|..|.:||..|.:|.|:| |..|||                               ||:.||
Mouse  1020 EVLRRIVLLQRWFRVLLSRQQFLHLRQASIIIQRFWRNYLNQKQVRNAAVEKDAFIMASAASLLQ 1084

  Fly   875 ARWRGQRAQQRYERLRKGALTAQRLWR-----GRQARRRVQQLRSDHRRRQEARE---------A 925
            |.||....:|||..||..|:..|:.||     ..:|...:|.....:|:|::.:|         :
Mouse  1085 ASWRAHLERQRYLELRAAAVIIQQRWRELYRCRHKAATCIQSRWRGYRQRKKYKEQRNKIILLQS 1149

  Fly   926 AQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQL 990
            ..|...||:...|:.|                 .||:.....||..| ||..|.:....|.
Mouse  1150 IYRGFRARQRCNALKE-----------------EKLREAKLEHGLVH-VKACGPLEIQGSD---- 1192

  Fly   991 PEDLGQFSFGKFSSVYCNGLR-LQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALE 1054
            |.:....||.       |.:: ::..:..|.:..::|.:|.|            ..:.|.||..|
Mouse  1193 PSEWEDRSFD-------NRVKAIEECKYVIESNRISRESSMD------------FSKESPDKQQE 1238

  Fly  1055 GAKEK----LLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSA 1115
            ..:.:    |..|.||.:       |.:.|..|..:..|....  |:.|:.:|
Mouse  1239 RGRRQSGTDLQEDVIVRQ-------RPKSLEDLHQKKVGRAKR--ESRRMREL------------ 1282

  Fly  1116 AFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGC---D 1177
                       ::|..||..|.:|.|     ||.|..               |.|.|:...   .
Mouse  1283 -----------EQAIFSLELLKVRSL-----GGMSPS---------------EERRWSTELMPEG 1316

  Fly  1178 MALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIA 1242
            :..|...||..|...:::..| |:|         ...|:..:|:||:|:
Mouse  1317 LQSPHGTPDSESSQGSLELLT-CDE---------NQKSKPESLILDEGE---------------- 1355

  Fly  1243 EKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSS 1307
                                  .:.:.|:....|                    :|....||.||
Mouse  1356 ----------------------LKISSPNTFTNP--------------------KSQDNALSASS 1378

  Fly  1308 ALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDR 1372
            ..:        |...|:|:|:.....::.:..:.|.         | |.||:    ..:.:|.|.
Mouse  1379 ETS--------STLAGKGASSDSEHLKNGTAKEKLV---------C-SSEPI----TCKPQLRDS 1421

  Fly  1373 YHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASH 1437
            :.|:..         |.:....|                     :.|.::|:..|||
Mouse  1422 FVSSSL---------PTFFYIPH---------------------QEALKTSSHLDTS-------- 1448

  Fly  1438 VRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYIN 1502
            ::|.::|                                          |.||
Mouse  1449 IQRNKLP------------------------------------------EREA------------ 1459

  Fly  1503 DIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDK 1567
              .....|.|::.:...|.|.:.                                        |:
Mouse  1460 --ILKTTLTQDINREARKCQFSG----------------------------------------DQ 1482

  Fly  1568 LTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQ 1632
            :|..           :|||:..  :|.:|.:|..|.|......|||.::..::       ||:||
Mouse  1483 MTPL-----------NTDSSCT--VLKKLEKLNIEKEKRQKQLQQQNEKEMME-------QIRQQ 1527

  Fly  1633 ---LLAQNQALQTL-LSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQ-------SPMRMKATR 1686
               |..:.:|.:|: .|:..|:..|.:...|........||.|...|.:       ||..:....
Mouse  1528 TDILEKERKAFKTIEQSRTEASVLAPSFYQPRQKVERPCSLYIQNTPSKGEAGVLGSPSAVTKRD 1592

  Fly  1687 SSLVVMESLQPPPPPPPPPMPPPLECK-DPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTE 1750
            ::|...:|.....||...|:....|.| .|.::|...:   ..||.|.|              |:
Mouse  1593 AALATKDSPSIHLPPKDRPVTLFFEKKGSPCQSRTVKE---LPKTERTG--------------TQ 1640

  Fly  1751 EDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEI------------- 1802
            .| .|:|: .:.|.|  :..|.:.|.........|...|:|.......:..|
Mouse  1641 HD-AAYKL-SNNRST--ERDHFKSTHFYSHRSDDPSREGSSRAIFFTPKDNITPLVHSGNPQAHK 1701

  Fly  1803 --ESPTPPPMSG-----QLMRSSIRLETTTTTTTSAVNNR------DRDRETQDVGQPMQSVVTT 1854
              ||...|.::|     |:.|.:.:.:.....|.|....|      :.|.|..|....::.:::.
Mouse  1702 QDESAWKPKLAGPGQQEQVARPAHKKKARMARTRSDFLTRGTFAEGEGDTEEDDYDDIIEPLLSL 1766

  Fly  1855 KLAKKSFEIGADRPPPGSVGKLKLS-SEM-RQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKL 1917
            ..|..| |:|    |..|:|:...| ||| .||.          |:|..:::........:..||
Mouse  1767 DQASHS-ELG----PVSSLGQASHSDSEMTSQRF----------SSVDEQAKLHKAMSQGEITKL 1816

  Fly  1918 MLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPA 1982
            .::|:...|            .:....|.:|...:..:|:.......|:.........|.|.|..
Mouse  1817 AVRQKASDL------------DIRPQRAKMRFWAKGKQGEKKTTRVKPASQSEISSFFPGPDVTP 1869

  Fly  1983 PPPPIRPPSMAPPAPPPAPQSPPTAR-----SPEPEP------------------DYRTSSSQVV 2024
            ..|.....:...|.||.:|:.|.:.|     :.||.|                  .::..|.|::
Mouse  1870 AHPFSDELTQYHPTPPLSPELPGSCRKEFKENKEPSPKAKRKRGVKISSVALDSMHWQNDSVQII 1934

  Fly  2025 K-----EHVPAFIQRQ---------ERDTF------GAVRQ--QQMISSHH--LHLED-HSASSS 2064
            .     :.:..|:.::         ::||.      .|:::  |.:.||:.  |.::| .|....
Mouse  1935 ASASDLKSMDEFLLKKMNDLDNEDSKKDTLVDVVFKKALKEFRQNIFSSYSSALAMDDGKSIRYK 1999

  Fly  2065 PAVAAWEQAERERSRSRSRSRDREDYSES---VW--------DRAEVEGPASGSGSEK----ERE 2114
            ...|.:||...:..|...|     |::||   ||        |....|.....|.:.|    ||:
Mouse  2000 DLYALFEQILEKTMRLEQR-----DWNESPVRVWVNTFKVFLDEYMNEFKTLDSTAPKVLKTERK 2059

  Fly  2115 KRERERERLYEIRQVERERESH--KVYQPAPPRVIQAS------MDTTGGHRREDRTGGLATFRT 2171
            ||.::...|.|      |...|  |..|.:.|...:..      ||.....:       |..:..
Mouse  2060 KRRKKETDLVE------EHNGHIFKATQYSIPTYCEYCSSLIWIMDRASVCK-------LCKYAC 2111

  Fly  2172 H----------MAQKYEHERKRKSSASSGMREELDSMHMTTPPPVIVPAPVPPPSSTSPGLGV-V 2225
            |          .::||:.|   .||...|:  ||..:   |.....||..|....:.....|: .
Mouse  2112 HKKCCLKTTAKCSKKYDPE---LSSRQFGV--ELSRL---TSEDRAVPLVVEKLINYIEMHGLYT 2168

  Fly  2226 SGVLMGSGSGGSTACLTYNRVPWKLRVRKEVFQPHEPIGPPVALDLLFAQVLGDVFGVTPCLRIT 2290
            .|:...|||        .|::       ||:.|..:.....|.||.....|:..||  ...||..
Mouse  2169 EGIYRKSGS--------TNKI-------KELRQGLDTDAESVNLDDYNIHVIASVF--KQWLRDL 2216

  Fly  2291 P------------------QEKSSALNMLHGHGVSVDTLSNRNGSGAGGGGNGGQVRALVKR--H 2335
            |                  ||:...:..::.   .:|.||..:            :..|.:.  |
Mouse  2217 PNPLMTFELYEEFLRAMGLQERKETIRGVYS---VIDQLSRTH------------LNTLERLIFH 2266

  Fly  2336 LVDMA--RDWPLYFARLFAVQGAPLY---PDV-----SIMGVSHSGLYLARRDADYLIVVQAIS- 2389
            ||.:|  .|.....|...|:..||..   ||.     |:..:|.:...:.      ||||:.::
Mouse  2267 LVRIALQEDTNRMSANALAIVFAPCILRCPDTTDPLQSVQDISKTTTCVE------LIVVEQMNK 2325

  Fly  2390 ----FGEIQSAVTLPRPAALQLNL-RNGKHLALHAARAAAIQSMVTTFVQEFRKSQSKASTLSSG 2449
                ..:|.|.......|..:|:| |......|.|.|          |:...|.|.|....:..|
Mouse  2326 YKARLKDISSLEFAENKAKTRLSLIRRSMKPVLIAVR----------FMSITRSSVSGKGRIHRG 2380

  Fly  2450 ----------ARAAAQTLNVPLERLESRQAHAQRNEHGVDGGSRQNEQLQQSELHHHLQQQQQQQ 2504
                      .|..:.: :||.|.|.|..|..      .|...:|...:||.|        :...
Mouse  2381 NYPSPSSPVIVRLPSMS-DVPEETLSSETAME------TDLTDQQQAAMQQEE--------KVLT 2430

  Fly  2505 QQQQHHQQQQQQQQLEDAMEEQHMATDHQQQQQQQLGQQQGQQQRFL--KQQSYLHSARKSNAGQ 2567
            :|.::.|:::::...|..:.|...:.|...:.:..:|.....:...:  :::|...|:.|:....
Mouse  2431 EQIENLQKEKEELTFEMLVLEPRASDDETLESEASIGTADSSENLNMDSEERSLALSSLKAAGKS 2495

  Fly  2568 QPSSLTNGQVHHQEQML 2584
            :|||.:..|:..|...|
Mouse  2496 EPSSKSRKQLRKQPDSL 2512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	294/882 (33%)
		MYSc_Myo15	169..828	CDD:276838	287/861 (33%)
		MyTH4	1014..1171	CDD:295320	29/160 (18%)
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myo9a	XP_006511271.1	RA_Myosin-IXa	15..110	CDD:340736	23/87 (26%)
		MYSc_Myo9	160..1006	CDD:276836	287/861 (33%)
		DUF5401	<968..>1283	CDD:375164	83/398 (21%)
		IQ	1117..1138	CDD:197470	4/20 (20%)
		PEHE	<1827..1891	CDD:373705	12/63 (19%)
		C1	2075..2123	CDD:237996	8/54 (15%)
		RhoGAP_myosin_IX	2136..2321	CDD:239842	47/227 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810