Protein Alignment Myo10A and Myo7a

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_006229804.1
• Gene: Myo7a / 266714
• RGDID: 628830
• Length: 2276
• Species: Rattus norvegicus
• Alignment Length: 3251
• Identity: 713/3251 - (21%)
• Similarity: 1089/3251 - (33%)
• Gaps: 1368/3251 - (42%)

  Fly   156 GVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGS 220
            |||||..|.||:||.:|.||.:||...||||:.||||:|||||::. ..|..|..:||..:.:|.
  Rat   127 GVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLL-SIYSSEHIRQYTNKKIGE 190

  Fly   221 LPPHLFAIGAAAHAALP---SPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQIL 282
            :|||:|||....:..:.   ..|..:||||||:||||||||::|:|||:    ....:.|.:|:|
  Rat   191 MPPHIFAIADNCYFNMKRNNRDQCCIISGESGAGKTESTKLILQFLAAI----SGQHSWIEQQVL 251

  Fly   283 EAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVF 346
            ||.|:|||||||:|.|||||||||||::::| |.|||.||||.||||||||:..|||.|||||||
  Rat   252 EATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQAPDERNYHVF 316

  Fly   347 YELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVD---WESLQGAMQVLGVSEGEREGIVR 408
            |.:|.|::|.|:.|.||.:|..|.||..|......||||   :.:::.||:||..::.|...|::
  Rat   317 YCMLEGMNEEEKKKLGLGQAADYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDTENWEILK 381

  Fly   409 VLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHT 473
            :|||:||:||:.:..|...: .:..||.....:..||..|.::...|...|||||...|.|.:.|
  Rat   382 LLAAILHMGNLQYEARTFEN-LDACEVLFSPSLATAASHLEVNPPDLMSCLTSRTLITRGETVST 445

  Fly   474 PLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGG----THDAHRISILDIFGFEDLAENSF 534
            ||..:||||.||||.|.:|..||.|:|.:||:.:.|..    |:....|.:|||||||:...|||
  Rat   446 PLSREQALDVRDAFVKGIYGRLFVWIVEKINAAIYKPPSQEVTNSRRSIGLLDIFGFENFTVNSF 510

  Fly   535 EQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDES 599
            ||||||:|||:||.:|.:|||||||.||..|.::|..:.:.||...:.::|.:|:.:..|:|:||
  Rat   511 EQLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQEALDMIANRPMNVISLIDEES 575

  Fly   600 NFPRATDLSFLEKCHYNHALSELYARPRIGAQ-EFGVTHYAGQVWYCVDGFLDKNRDALRGDVLE 663
            .||:.||.:.|.|.:..|.|:..|..|:...: :||:.|:||.|:|...|||:||||.|.||:::
  Rat   576 KFPKGTDATMLHKLNSQHRLNANYVPPKNSHETQFGINHFAGIVYYESQGFLEKNRDTLHGDIIQ 640

  Fly   664 LLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHP 728
            |:.|||    .:..||: .|.|    :..|:..|     .|:||::::|..||:.|::::|.|.|
  Rat   641 LVHSSR----NKFVKQI-FQAD----VAMGAETR-----KRSPTLSSQFKRSLELLMRTLGACQP 691

  Fly   729 WFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLP--SPL 791
            :||||||||:.|..:..|....::||||.||::||:||..|||:|..|..||||||.|||  .|.
  Rat   692 FFVRCIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRHAGYPIRYSFVEFVERYRVLLPGVKPA 756

  Fly   792 ARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRG 856
            .:....:..|:.:.||:..|   ..|:|:|.|::||::.....||..|.:.:....:.:|:.:||
  Rat   757 YKQDDLQGTCQRMAEAVLGT---HDDWQIGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRG 818

  Fly   857 MLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQ------------------------ 897
            ...|....|.::|||.:|..|||...::.||.:|.|.|..|
  Rat   819 FKDRSNFLRLKSAATLIQRHWRGHHCRKNYELIRLGFLRLQALHRSRKLHKQYRLARQRIIKFQA 883

  Fly   898 -------------RLW---------RGRQARRRVQQLRSDHRRRQEARE-------------AAQ 927
                         |||         ||..|||..::||.::.||.||..             :|:
  Rat   884 RCRAYLVRRAFRHRLWAVITVQAYARGMIARRLHRRLRVEYWRRLEAERMRLAEEEKLRKEMSAK 948

  Fly   928 RAREAREAKQAVLER-SQLSYLDIPAEL----------AFIYSKLQGWSPP--HGDR--HLVKVL 977
            :|:|..|.|..  || :||:..|...||          ..:....:....|  |.|.  .:...|
  Rat   949 KAKEEAERKHQ--ERLAQLAREDAERELKEKEEARRKKELLQQMERARHEPINHSDMVDKMFGFL 1011

  Fly   978 GTVPGPPSSAVQLP-----------------------------EDLGQFSFGKFSSVYCNGLRLQ 1013
            ||..|.|....|.|                             |||.::.|.||::.|..|....
  Rat  1012 GTSSGLPGQEGQAPSGFEDLERGRREMVEEDVDAALPLPDEDEEDLSEYKFAKFAATYFQGTTTH 1076

  Fly  1014 P-RREPITAPLLTRAASRDQDFQDALAVFKLILRWSND--------------------------- 1050
            . .|.|:..|||......||  ..||||:..|||:..|
  Rat  1077 SYTRRPLKQPLLYHDDEGDQ--LAALAVWITILRFMGDLPEPKYHTAMSDGSEKIPVMTKIYETL 1139

  Fly  1051 ---------KALEGAKEKLLAD---------YIVHKALSSR------------------------ 1073
                     :||:|..|..|::         .:||..|..:
  Rat  1140 GKKTYKRELQALQGEGEAQLSEGQKKTSVKHKLVHLTLKKKSKLTEEVTKRLHDGESMVQGNSML 1204

  Fly  1074 ----------------------GLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAA 1116
                                  .|||||..|:..|:...|..|..| |.|.|:..|:.||.||..
  Rat  1205 EDRPTSNLEKLHFIIGNGILRPALRDEIYCQISKQLTHNPSKSSYA-RGWILVSLCVGCFAPSEK 1268

  Fly  1117 FSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALP 1181
            |.|||..|:.. .|....|....:|.|....||          |:..|:|||.:|......:.||
  Rat  1269 FVKYLRNFIHG-GPPGYAPYCEERLRRTFVNGT----------RTQPPSWLELQATKSKKPIMLP 1322

  Fly  1182 LTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASR-GWTL---VLDDGQQLTDSCGLDYVMDLIA 1242
            :|..|..::|:..||.|:.:|........:.:..| |::|   :.|....|  ..|.|:|||.|:
  Rat  1323 VTFMDGTTKTLLADSATTAKELCNALADKISLKDRFGFSLYIALFDKVSSL--GSGSDHVMDAIS 1385

  Fly  1243 EKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSS 1307
            :   |..:                                     .||...:||.:...|
  Rat  1386 Q---CEQY-------------------------------------AKEQGAQERNAPWRL----- 1405

  Fly  1308 ALNERYFERE---PSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRL 1369
                 :|.:|   |...|.:.:                      |.|:...|:.:..:...|.|
  Rat  1406 -----FFRKEVFTPWHNPSEDN----------------------VATNLIYQQVVRGVKFGEYR- 1442

  Fly  1370 NDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSL 1434
                                                   ..|..|.||.|::
  Rat  1443 ---------------------------------------CEKEDDLAELASQ------------- 1455

  Fly  1435 ASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDD 1499
                            ..|:|                            |..|...|..:..:..
  Rat  1456 ----------------QYFVD----------------------------YGSEMILERLLSLVPT 1476

  Fly  1500 YINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEG 1564
            ||.|  :.|..::||||..   |||......|:.:  :.|.:..:::  .|.:|......|:
  Rat  1477 YIPD--REITPLKNLEKWA---QLAIAAHKKGIYA--QRRTDAQKVK--QDVVNYARFKWPL--- 1529

  Fly  1565 LDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQN--- 1626
               |.|:.:.|...                          |||.|.:..|       .:|.|
  Rat  1530 ---LFSRFYEAYKF--------------------------SGPPLPKSDV-------IVAVNWTG 1558

  Fly  1627 ---LQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSS 1688
               :..|:|:|                                  |.:|.|   ..|.:.::|..
  Rat  1559 VYFVDEQEQVL----------------------------------LELSFP---EIMAVSSSREC 1586

  Fly  1689 LVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDF 1753
            .|::.                |.|.|                  :|
  Rat  1587 RVLLS----------------LGCSD------------------LG------------------- 1598

  Fly  1754 FAFKMRQHQRKTTPQAQHHQMTSNGGMMESGP-----GARGASATAIEWEEFEIESPTPPPMSGQ 1813
                          .|..|  :...|:..:||     ..|||                      :
  Rat  1599 --------------CASCH--SGRAGLTPAGPCSPCWSCRGA----------------------K 1625

  Fly  1814 LMRSSIRLETT-----TTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSV 1873
            ||..|..|.|.     |.|:::|.:.||              :|.|.|
  Rat  1626 LMAPSFTLATIKGDEYTFTSSNAEDIRD--------------LVVTFL----------------- 1659

  Fly  1874 GKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVSGGNSGPG 1938
                  ..:|:|.:.|.|                   |:|
  Rat  1660 ------EGLRKRSKYVVA-------------------LQD------------------------- 1674

  Fly  1939 GVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQS 2003
                                :|.||....|
  Rat  1675 --------------------NPNPAGEESG----------------------------------- 1684

  Fly  2004 PPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLEDHSASSSPAVA 2068
                                       |:...:.|               |.:.||........:
  Rat  1685 ---------------------------FLSFAKGD---------------LIILDHDTGEQVMNS 1707

  Fly  2069 AWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLYEIRQVERER 2133
            .|.....||::.|
  Rat  1708 GWANGINERTKQR---------------------------------------------------- 1720

  Fly  2134 ESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEHERKRKSSASSGMREELDSM 2198
                                          |...|                           |.:
  Rat  1721 ------------------------------GDFPT---------------------------DCV 1728

  Fly  2199 HMTTPPPVIVPAPVPPPSSTSPGLGVVSGVLMGSGSGGSTACLTYNRVPWKLRVRKEVFQPHEPI 2263
            :       ::|....||                                      :|:
  Rat  1729 Y-------VMPTVTLPP--------------------------------------REI------- 1741

  Fly  2264 GPPVALDLLFAQVLGDVFGVTPCLRITPQEKSSALNMLHGHGVSVDTLSNRNGSGAGGGGNGGQV 2328
               |||                 :.:||.::...:.:|                         |:
  Rat  1742 ---VAL-----------------VTMTPDQRQDVVRLL-------------------------QL 1761

  Fly  2329 RALVKRHLVDMARDWPLYFARLFAVQGAPLYPDVSIMGVSHSGLYLARRDADYLIVVQAISFGEI 2393
            |.                           ..|:|.
  Rat  1762 RT---------------------------AEPEVR------------------------------ 1769

  Fly  2394 QSAVTLPRPAALQLNLRNGKHLALHAARAAAIQSMVTTFVQEFRKSQSKASTLS----SGARAAA 2454
                  .:|..|:                        .|..::.:|..| .|||    |.||..
  Rat  1770 ------TKPYTLE------------------------EFSYDYFRSPPK-HTLSRVMVSKARGK- 1802

  Fly  2455 QTLNVPLERLESRQAHAQRNEHGVDGGSRQNEQLQQSELHHHLQQQQQQQQQQQHHQQQQQQQQL 2519
                   :||                .|...|.|:|:.|
  Rat  1803 -------DRL----------------WSHTREPLKQALL-------------------------- 1818

  Fly  2520 EDAMEEQHMATDHQQQQQQQLGQQQGQQQ---RFLKQQSYLHSARKSNAGQQPSSLTNGQVHHQE 2581
                             ::.:|.::..|:   .|:....|:        |..||..|.
  Rat  1819 -----------------KKIVGSEELSQEACMSFIAVLKYM--------GDYPSKRTR------- 1851

  Fly  2582 QMLQQQQQQSQSLPHHDLDANYLQDESNGGTPPSVTKYSLLQFAMQHFRNDQLRDADRHHERHQS 2646
                              ..|.|.|
  Rat  1852 ------------------SVNELTD---------------------------------------- 1858

  Fly  2647 AANRSYAELVKWQGHAIRLPLLRLPNDLAPLALECFDCILRYCGDIPLDPDLTEVKCVYTVLMHC 2711
                   ::.:|.                                :..:|
  Rat  1859 -------QIFEWA--------------------------------VKAEP--------------- 1869

  Fly  2712 HKYLALRDEVYCQLMKQTTANRSPCPDSSQRAWRLLSILAAYFGCSDALRPYLMEHLTSAASDRR 2776
                 |:||.|.|::||.|.|.  ...|.::.|.||.:....|..|:.|.|::...|.|     |
  Rat  1870 -----LKDEAYVQILKQLTDNH--IRYSEEKGWELLWLCTGLFPPSNILLPHVQRFLQS-----R 1922

  Fly  2777 RSCHGTAAVCLTNLRKTARCGGRKNVPSVEEVTAVSAGRSARRQIYR---LPGGAERVVNTRCST 2838
            :.| ..|..||..|:|..|.|.||..|.:.||.|:   :....||:.   .|...:.......||
  Rat  1923 KHC-PLAIDCLQRLQKALRNGSRKYPPHLVEVEAI---QHKTTQIFHKVYFPDDTDEAFEVESST 1983

  Fly  2839 VVADVIAELCALLGVESEAEQQEFSLYCIVQGDAFTMPLAADEYILDVT---TELLKSGQP---- 2896
            ...|....:.:.|.::|   .:.|||:..:.....::|  .:::..|..   |:.:|..:|
  Rat  1984 KAKDFCQNIASRLLLKS---SEGFSLFVKIADKVISVP--ENDFFFDFVRHLTDWIKKARPIKDG 2043

  Fly  2897 ------FYLIFCRSVWHFALKREPAPMPLYVEVL-FNQVAPDYLEGLLLELPGNGVPVPEMVR-D 2953
                  :.:.|.:.:|...:   |...|:...:. :.|..|.||.|           ..:..| :
  Rat  2044 IVPSLTYQVFFMKKLWTTTV---PGKDPMADSIFHYYQELPKYLRG-----------YHKCTREE 2094

  Fly  2954 MARIAALLHRA---ADLSHVPAM-KEIKFLLPKPALGIREIRPAQWVGLVQSAWPQVANLSPGQV 3014
            :.::.||::|.   .|.|:.|:: |.::.|:|:..  ||::.|..|...:.:.:.:.|..|..:.
  Rat  2095 VLQLGALIYRVKFEEDKSYFPSIPKLLRELVPQDL--IRQVSPDDWKRSIVAYFNKHAGKSKEEA 2157

  Fly  3015 KAQFLNVLATWPLFGSSFFAVKRIWAEEGPHVEDNHSPMWRDLILALNRRGVLFLDPNTHETLQH 3079
            |..||.::..||.|||:||.||:......|.:          |::|:|:.|:..:||.|.:.|..
  Rat  2158 KLAFLKLIFKWPTFGSAFFEVKQTTEPNFPEI----------LLIAINKYGISLIDPRTKDILTT 2212

  Fly  3080 WSFMEVISTRKVRSEDGALFLDMKVGNLMQQRVIRVQTEQAHEISRLVRQYITM---AQISQRDK 3141
            ..|.::.:.     ..|..:..:.:|||::...:..:|...:::..|:..||:.   |...||:.
  Rat  2213 HPFTKISNW-----SSGNTYFHITIGNLVRGSKLLCETSLGYKMDDLLTSYISQMLTAMSKQRNS 2272

  Fly  3142 R 3142
            |
  Rat  2273 R 2273

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	299/672 (44%)
		PTZ00121	<828..>943	CDD:173412	42/174 (24%)
		MyTH4	1014..1171	CDD:470587	57/248 (23%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	20/70 (29%)
		MyTH4	2704..2810	CDD:459939	33/105 (31%)
		FERM_B-lobe	2920..3025	CDD:271216	24/110 (22%)
		FERM_C_MyoXV	3029..3138	CDD:270022	25/111 (23%)
Myo7a	XP_006229804.1	MYSc_Myo7	140..790	CDD:276832	299/672 (44%)
		DUF5401	<835..>991	CDD:375164	36/157 (23%)
		MAP7	<918..>996	CDD:461709	18/79 (23%)
		MyTH4	1078..1314	CDD:214535	58/249 (23%)
		FERM1_F1_Myosin-VII	1318..1416	CDD:340612	29/149 (19%)
		B41	1320..1535	CDD:214604	63/400 (16%)
		FERM_C1_MyoVII	1529..1665	CDD:270019	45/339 (13%)
		SH3_MYO7A	1666..1730	CDD:212814	20/320 (6%)
		MyTH4	1808..1957	CDD:214535	51/334 (15%)
		FERM2_F1_Myosin-VII	1962..2059	CDD:340613	17/101 (17%)
		B41	1964..2176	CDD:214604	47/232 (20%)
		FERM_C2_MyoVII	2172..2267	CDD:270020	25/109 (23%)