DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and Myo81F

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_001303492.1 Gene:Myo81F / 26067052 FlyBaseID:FBgn0267431 Length:2082 Species:Drosophila melanogaster


Alignment Length:3108 Identity:622/3108 - (20%)
Similarity:1056/3108 - (33%) Gaps:1165/3108 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   156 GVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGS 220
            |..|||.:.::.|..:..||.:||:..:|||:.||||:||||||.. :.:..:...:|....||.
  Fly     9 GFADMTEMSEIDEIGINQNLNVRYNSDIIYTYTGSILLAVNPYKTI-NIFNKQTISEYHTCKLGD 72

  Fly   221 LPPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQIL 282
            |.||:||:..||:.::...   |..|||||||:|||||||.::|||..:.   .:.|:.:.:|||
  Fly    73 LSPHVFAVAEAAYTSIVDDNINQACVISGESGAGKTESTKFILQYLCTIT---SNVSSWVQQQIL 134

  Fly   283 EAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVF 346
            ||..:|||||||:|.||||||||||:::|.| .:..|.|..|..||||:|||..|:.||||||:.
  Fly   135 EANTILEAFGNAKTTRNDNSSRFGKFMQVCFDDNNCIKGCVILDYLLEQSRITFQSEGERNYHIM 199

  Fly   347 YELLG------GLSETERSKYGLLEADKYFYLNQGATDCASGRVD---WESLQGAMQVLGVSEGE 402
            |:|:.      |::.|    :.|..|:.|.|||...::..:..::   ::::..|..||.:.:..
  Fly   200 YQLVAQGQKNIGIANT----FHLRPAEFYKYLNTSNSEKINMNLESKKFDAVTMAFTVLQIPQFV 260

  Fly   403 REGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVG--------SDAE-IKWAAHLLHISADGLHRA 458
            .:|:.:|::::|.|||:.|           ::|.        ||.| |...:.||.:|.....:.
  Fly   261 IDGVFKVISSILWLGNIEF-----------IDVDGEVTDLTRSDQEAISIISMLLGLSRCDFKKV 314

  Fly   459 LTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDI 523
            |..|....|......||.|.:||:.|.|.|||||:.:|.||||:||:.... |..||..:.:|||
  Fly   315 LLIRQINVRGNITEIPLKIKEALENRHALAKALYSKMFTWLVSKINNCTNP-GQDDAKFLGVLDI 378

  Fly   524 FGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKP 588
            ||||:.:.||||||||||.||.|..:||.:||.|||:.|..|.:.:..:.:.||.|.:.:|.|.|
  Fly   379 FGFENFSHNSFEQLCINYTNEKLHKFFNHYVFALEQSIYEHEGIYFNHVEFTDNTPCLEILEKPP 443

  Fly   589 VGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARP--------RIGAQEFGVTHYAGQVWYC 645
            ..:..||.::.:.|:.:||:||...|     :|..:.|        |....|||:.||||.|.|.
  Fly   444 RCVFKLLTEQCHMPQGSDLAFLSNMH-----TEFESHPNYIKGSDRRHWETEFGIKHYAGLVIYA 503

  Fly   646 VDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRD---AGKTLPKGSNGRFVTMKPRTPT 707
            |.||::||||..:..:.|.::.|:...:    |.|...:|   ...:.|:||:      |.:. |
  Fly   504 VGGFVEKNRDVQQDVMFEYMSYSKDVFI----KDLSTYQDIQFINSSYPRGSS------KSKC-T 557

  Fly   708 VAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPV 772
            |:..|.:.||.|:..:....||:|||||||.:|.....:...||.||:|||::|.|:||:.|:|:
  Fly   558 VSDNFRNQLQSLIDVLQNTKPWYVRCIKPNLQKRPNNYNSSLVLDQLKYLGVVDIIRIRREGFPI 622

  Fly   773 RLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALES 837
            .|..:.|:.||:.|:.:   :...|.:  :.|...:.:.|:...::|:|.:::|||.|.:..||:
  Fly   623 HLSHKDFIVRYKCLIKN---KSFEYPQ--KYLTNILEKNGMPTTEWQIGKSKIFLRNAAYELLET 682

  Fly   838 GRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRG 902
            .|.:.|.:.||.:|::.:...:::...|.:.|..|:|..:||.|.:.|:.|:|:.|:..|...||
  Fly   683 NRKDTLYKNAVIIQKNWKKYYIQKSFLRNKQAVLRIQHAYRGWRLRIRFMRMRRSAIVIQSRLRG 747

  Fly   903 RQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPP 967
                             ..|||.|...||.:...:.:.:|..            ||.:|..    
  Fly   748 -----------------VFAREVAAALREMKRVDEELKKRDG------------IYEQLTS---- 779

  Fly   968 HGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQ 1032
                                                               ||...|   |..::
  Fly   780 ---------------------------------------------------ITTKTL---ADCER 790

  Fly  1033 DFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEA 1097
            ..|:.|:|...|    :|.....||.  |:|.....:.::|....:..|.|.|....|..:.|  
  Fly   791 SIQEELSVLAHI----SDNIRASAKP--LSDKNDSDSNTARSSIKQNTVNLDNMFDFLCESKG-- 847

  Fly  1098 TRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSF 1162
                              ||...|::.::|                                   
  Fly   848 ------------------AFENALIKEIND----------------------------------- 859

  Fly  1163 VPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQ 1227
                 .|....:..|..:.|.:..|       ||:                              
  Fly   860 -----NWNNLVKNLDEEIGLCIHTE-------DSF------------------------------ 882

  Fly  1228 LTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFAR---TTLPDAVKRPAVPPPAPPTSSGK 1289
                                        |..::|..|..   .|||:    |.||||.||     
  Fly   883 ----------------------------DSQKTGKLFTTKTVRTLPE----PTVPPPPPP----- 910

  Fly  1290 EDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCD 1354
                         :|.|:.||                                            
  Fly   911 -------------VSISANLN-------------------------------------------- 918

  Fly  1355 SQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYA 1419
             .||::. .::..:|.                                      ::|...|.:|.
  Fly   919 -SEPIYE-AINLYKLT--------------------------------------TTKEIKKEKYM 943

  Fly  1420 TRS-SAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGS 1483
            ... .::.|.|:.||.:|    |.|..|                   :||..:.|          
  Fly   944 LLDYKSIKDNSKKPSTSS----VFVKYQ-------------------IDERENRR---------- 975

  Fly  1484 YEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDL 1548
               :...|.:|.:|.  :.||.:.|.:..:...:.                  |..:......||
  Fly   976 ---KQRVEKKIHELT--LIDIHKDIHIDNSFYNIL------------------EFAENYFNTHDL 1017

  Fly  1549 DDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQ- 1612
            ....|.:..|....:..|| |:|..:.:       ...:...|..|..|..|.......::::: 
  Fly  1018 SSDCNFISTPTQKGKSSDK-TAKHEMTM-------FSKSDKIPTSHIHMYDPENVVLSCSMFREL 1074

  Fly  1613 -QVQRAFLQSAMAQNLQIQQQLLA---QNQALQTLLSQQAAAAAANNSTSPPPAPPI-------- 1665
             :..|..|.:  .:.|||.|.::.   :.:.|:..:..|....:.||       |.|        
  Fly  1075 CKYMRGELNA--ERELQIIQYIVGLGIEREELRDEIFIQCIRQSRNN-------PNIDWTDRIWI 1130

  Fly  1666 ---LSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGR 1727
               ||.::..|             |.|:.                           |:|:....:
  Fly  1131 ILCLSIVAFQP-------------SKLLF---------------------------RYFVSFIKK 1155

  Fly  1728 AKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASA 1792
            :.....|                      |:||:.                              
  Fly  1156 SMIELDG----------------------KLRQYS------------------------------ 1168

  Fly  1793 TAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLA 1857
               :|                                                 ...:..:||::
  Fly  1169 ---QW-------------------------------------------------CFDNCKSTKVS 1181

  Fly  1858 KKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQ 1922
            .:.:       ||.||              :|.|...:.:.|.......|..|            
  Fly  1182 TRMY-------PPSSV--------------EVAAMRRLGTIVCRFFFLDARTK------------ 1213

  Fly  1923 LGGLFASVSGGNSGPGGVVDSHA--TVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPP 1985
                             .:|.|.  |....::::..||:   ...:.||                
  Fly  1214 -----------------AIDVHPTDTAGDAVQKLAEKLN---LTTTDGW---------------- 1242

  Fly  1986 PIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMIS 2050
                                                                    |:.|.:...
  Fly  1243 --------------------------------------------------------AIYQNRPDG 1251

  Fly  2051 SHHLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREK 2115
            ..|:...|:...   .:::||..:                             |:.:|::|    
  Fly  1252 EEHIKSYDYLYD---VISSWEMKQ-----------------------------ATYAGTKK---- 1280

  Fly  2116 RERERERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEHE 2180
                                                 ||.|                        
  Fly  1281 -------------------------------------TTNG------------------------ 1284

  Fly  2181 RKRKSSASSG------MREELDSMHMTTPPPVIVPAPVPPPSSTSPGLGVVSGVLMGSGSGGSTA 2239
                  :|||      .:....|.|..:..||.|                               
  Fly  1285 ------SSSGENQFVFKKRLFKSTHELSQDPVEV------------------------------- 1312

  Fly  2240 CLTYNRVPWKLRVRKEVFQPHEPIGPPVALDL--LFAQV-LGDVFGVTPCLRITPQEKSSALNML 2301
            .:.|::....: |:|:.|    |:...|||.|  |.||| |||     |..:..|:..|...:.|
  Fly  1313 SMLYSQAVHSV-VKKDEF----PVSEKVALQLAGLQAQVALGD-----PSNQPKPEYYSDINSFL 1367

  Fly  2302 ---------HGHGVSVDTLSNRNGSGAGGGGNGGQVRALVKRHL-VDMARDWPLYFARLFAVQGA 2356
                     ....:.:...::|.        .|....||..:.| :.....:|||...:|.|...
  Fly  1368 PIRISKTREQQFWIPILAQAHRQ--------YGSSRNALTAKVLYLSCVMQYPLYGTTMFKVNYK 1424

  Fly  2357 PLYPDVS--IMGVSHSGLYLARRDADYLIVVQAISFGEIQSAVTLPRPAALQLNLRNGKHLALHA 2419
            ..:...|  |:|:.:.|:.....: |..:|.| ..:.:|:|.:..|..:.:.::|.....|...:
  Fly  1425 GYWNLASNIILGIHYDGIMFINPE-DKSVVFQ-FKYVDIESILLDPSDSFITISLNRSAQLLKTS 1487

  Fly  2420 ARAAAIQSMVTTFVQEFRKSQSKASTLSSGARAAAQTLNVPLERLESRQAHAQRNEHGVDGGSRQ 2484
            ...:::......||.|..:.....|.:.|...|.:   |..|..||..:.:.         |:.:
  Fly  1488 LYGSSLIESQKCFVFETPQKNDIGSLIISYYPALS---NWILNNLECSKKYK---------GTTK 1540

  Fly  2485 NEQLQQSELHHHLQQQQQQQQQQQHHQQQQQQQQLEDAMEEQHMATDHQQQQQQQLGQQQGQQQR 2549
            .::|:.                                                           
  Fly  1541 EDRLRL----------------------------------------------------------- 1546

  Fly  2550 FLKQQSYLHSARKSNAGQQPSSLTNGQVHHQEQMLQQQQQQSQSLPHHDLDANYLQDESNGGTPP 2614
                                         :|..:|.::         |.:|.|.::...:.|...
  Fly  1547 -----------------------------YQNVVLCRR---------HLVDMNIVKKPHDFGGFL 1573

  Fly  2615 SVTKYSLLQFAMQHFRNDQLRDADRHHERHQSAANRSYAELVKWQGHAIRLPLLRLPNDLAPLAL 2679
            ..|...|.:..::..|::...:...|.|.::..::..:|    :....|...:..:.:....|.:
  Fly  1574 RNTLRRLSKHRLEKLRSEVGSNTQEHGETYKGFSHTFWA----FSKQQIPFCISTISDQEEALMI 1634

  Fly  2680 ECFDCILRYCG------DIPLDPDLTEVKCVYTVLMHCHKYLALRDEVYCQLMKQTTANRSPCPD 2738
            :.||.||.|.|      .|....| ..::.:.:::..|.|..:|.:|:|.||:||||.:    ||
  Fly  1635 QVFDSILTYSGLGSSGESISRAED-EHIRIIQSIMDKCMKKESLLNELYLQLIKQTTDH----PD 1694

  Fly  2739 SSQRA----WRLLSILAAYFGCS------DALRPYLMEHLTSAASD---RRRSCHGTAAVCLTNL 2790
            ::.|.    |.|||:|     ||      .|:|.||:.||...:||   ........|..|....
  Fly  1695 ANSRVNLKNWALLSVL-----CSVILPSMKAVRKYLIAHLKRCSSDFLSEEGKYARYAENCFFRT 1754

  Fly  2791 RKTARCGGRKNVPSVEEVTAVSAGRSARRQIYRLPGGAERVVNTRCSTV--VADVIAELCALLGV 2853
            :.|.|   |:..||.||:...:..|....:.|.:.|....:.....||.  |.::|.:...||. 
  Fly  1755 QGTRR---RQWTPSREEILCTTNRRPCYSKFYFMDGQYYSIEFQPSSTANDVLEIIKKKIGLLD- 1815

  Fly  2854 ESEAEQQEFSLYCIVQGDAFTMPLAADEYILDVTTELLK----SGQPFY----LIFCRSVWHFAL 2910
                ..:.:|:|.:: |:: ...|:::|.:.||..:..|    |.|.|.    ||..::.:.|..
  Fly  1816 ----NAKGYSIYEVI-GNS-ERSLSSEEKVCDVMAKWEKYQITSQQGFQKNTTLISQQNQYMFLF 1874

  Fly  2911 KREPAPMPLYV------------EVLFNQVAPDYLEGLLLELPGNGVPVPEMVRDM-ARIAALLH 2962
            |:.     |:.            |:|::|:        |..|.....|:.||...| ..:.:.|.
  Fly  1875 KKH-----LFFDNYINLEDIVEKELLYHQI--------LHNLRSERYPITEMEAIMLTALQSQLE 1926

  Fly  2963 RAADLSHVPAMKEI-------KFL--LPKPALGIREIRPAQWVGLVQSAWPQVANLSPGQVKAQF 3018
            |......:...:.:       :|:  :|..|:.:..          ||    :..:.|.:.|..|
  Fly  1927 RGDCCESITDYRAVASHCLPPRFVPNIPHEAVAMHH----------QS----LRGMLPIEAKKAF 1977

  Fly  3019 LNVLATWPLFGSSFFAVKRIWAEEGPHVEDNHSPMWRDLILALNRRGVLFLDPNTHETLQHWSFM 3083
            ||::.:|||..::.|.|.:.:....|          |.|.||::::|:..|:..:...|..:.:.
  Fly  1978 LNLIKSWPLHRATIFDVMQSFTTNWP----------RTLWLAIDQKGIHLLEHRSRNVLCTYGYD 2032

  Fly  3084 EVIS-TRKVRSEDGALFLDMKVGNLMQQRVIRVQTEQAHEISRLVRQYITMAQ 3135
            .:|| :..:.|      |.:..|...:|..:.:.|.||::|:.|:|:|...|:
  Fly  2033 SIISFSPNLNS------LMIFTGTEKKQSKVILTTPQAYQITTLIREYSEAAK 2079

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 260/712 (37%)
MYSc_Myo15 169..828 CDD:276838 252/691 (36%)
MyTH4 1014..1171 CDD:295320 24/156 (15%)
MyTH4 2704..2810 CDD:279165 38/118 (32%)
B41 2823..3033 CDD:214604 47/241 (20%)
FERM_B-lobe 2920..3025 CDD:271216 21/126 (17%)
FERM_C_MyoXV 3029..3138 CDD:270022 24/108 (22%)
Myo81FNP_001303492.1 MYSc 8..685 CDD:214580 262/716 (37%)
Motor_domain 23..673 CDD:277568 252/690 (37%)
MyTH4 1091..1194 CDD:279165 26/274 (9%)
B41 1202..1419 CDD:214604 58/472 (12%)
UBQ 1202..1297 CDD:294102 25/301 (8%)
FERM_M 1307..1419 CDD:278785 31/160 (19%)
PH-like 1415..1523 CDD:302622 20/112 (18%)
MyTH4 1664..1771 CDD:279165 38/118 (32%)
UBQ 1780..1860 CDD:294102 19/86 (22%)
B41 1781..1992 CDD:214604 48/244 (20%)
FERM_B-lobe 1893..1984 CDD:271216 21/112 (19%)
PH-like 1988..2076 CDD:302622 23/103 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1389at50557
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR13140
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
33.020

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