DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and unc-54

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_493596.1 Gene:unc-54 / 259839 WormBaseID:WBGene00006789 Length:1963 Species:Caenorhabditis elegans


Alignment Length:2080 Identity:499/2080 - (23%)
Similarity:813/2080 - (39%) Gaps:487/2080 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    79 LRRQRPASLEDFEDLPNLSAKHPALPSSRLRRLKCRYPQVVKRLSTLCSDVIARHPQTFALQPGE 143
            |||.|...||| :..|..|.|:..:|.          |:.    ..|..::.|.......:....
 Worm    12 LRRTREQVLED-QSKPYDSKKNVWIPD----------PEE----GYLAGEITATKGDQVTIVTAR 61

  Fly   144 GS-LRARQDLGS-------SGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKM 200
            |: :..:::|..       ...|||:.|..|::||:|.|||.||...||||::|...:.:||||.
 Worm    62 GNEVTLKKELVQEMNPPKFEKTEDMSNLSFLNDASVLHNLRSRYAAMLIYTYSGLFCVVINPYKR 126

  Fly   201 FPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQY 262
            .| .|....|:.:.|:....:||||||:...|:..:   ...|.::|:||||:||||:||.|:.|
 Worm   127 LP-IYTDSCARMFMGKRKTEMPPHLFAVSDEAYRNMLQDHENQSMLITGESGAGKTENTKKVICY 190

  Fly   263 LAAV----VPGGGSA-----SAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGA 317
            .|||    ..||...     ...:.:||::..|:|||||||:|.||:|||||||::.::| |.|.
 Worm   191 FAAVGASQQEGGAEVDPNKKKVTLEDQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRIHFNKHGR 255

  Fly   318 IVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLE--ADKYFYLNQGATDCA 380
            :....|..|||||||::.||||||.||:||::.... ..|..|..||:  ...|:::.| |....
 Worm   256 LASCDIEHYLLEKSRVIRQAPGERCYHIFYQIYSDF-RPELKKELLLDLPIKDYWFVAQ-AELII 318

  Fly   381 SGRVDWESLQ---GAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIK 442
            .|..|.|..|   .|..:|..|..|::...|:::|.:|:||:.|.:|.   .:|..|.....|.:
 Worm   319 DGIDDVEEFQLTDEAFDILNFSAVEKQDCYRLMSAHMHMGNMKFKQRP---REEQAEPDGTDEAE 380

  Fly   443 WAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIV 507
            .|:::..|..:...:|||....:...|.:......:|...|..|.||.||:.:|||||.:.|..:
 Worm   381 KASNMYGIGCEEFLKALTKPRVKVGTEWVSKGQNCEQVNWAVGAMAKGLYSRVFNWLVKKCNLTL 445

  Fly   508 QKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPL 572
            .:.|....:.|.:|||.|||....||||||.||:.||.||.:||.|:|.|||.|||||.::|..:
 Worm   446 DQKGIDRDYFIGVLDIAGFEIFDFNSFEQLWINFVNEKLQQFFNHHMFVLEQEEYAREGIQWVFI 510

  Fly   573 AWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKC-------HYNHALSELYARP---- 626
            .:..:|.....|.:||:||..:||:|...|:||||:...|.       |.|      :.:|    
 Worm   511 DFGLDLQACIELIEKPLGIISMLDEECIVPKATDLTLASKLVDQHLGKHPN------FEKPKPPK 569

  Fly   627 -RIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSR-LPLVGELTKQLRAQRDA--- 686
             :.|...|.:.||||.|.|....:|:||:|.|...|:..:..|: ..|:.|:.:....|.:|   
 Worm   570 GKQGEAHFAMRHYAGTVRYNCLNWLEKNKDPLNDTVVSAMKQSKGNDLLVEIWQDYTTQEEAAAK 634

  Fly   687 -----GKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMD 746
                 |....||.:|.|:       ||:..:.:||..|:..:.:.||.|:|||.||::|.:..:|
 Worm   635 AKEGGGGGKKKGKSGSFM-------TVSMLYRESLNNLMTMLNKTHPHFIRCIIPNEKKQSGMID 692

  Fly   747 MPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELC-RALLEAMPR 810
            ...||.||...|:|:.|:|.::|:|.|.....||:||. :|.:..|:....::.| .|::..:..
 Worm   693 AALVLNQLTCNGVLEGIRICRKGFPNRTLHPDFVQRYA-ILAAKEAKSDDDKKKCAEAIMSKLVN 756

  Fly   811 TGVEGPD-YQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVR---GMLVRRQLARRQAAAT 871
            .|....: :::|.|:||.:..:...||..|.|:|.......|..:|   |:..|::...::|...
 Worm   757 DGSLSEEMFRIGLTKVFFKAGVLAHLEDIRDEKLATILTGFQSQIRWHLGLKDRKRRMEQRAGLL 821

  Fly   872 RLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARR------RVQ----QLRSDHRRRQEAREAA 926
            .:|...|.....:.:|..:........|..|::|..      :|:    .|..:.:.|:|..|::
 Worm   822 IVQRNVRSWCTLRTWEWFKLYGKVKPMLKAGKEAEELEKINDKVKALEDSLAKEEKLRKELEESS 886

  Fly   927 QRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLP 991
            .:..|.:.:....||.::....|....||    ||:...                  ..::.||.
 Worm   887 AKLVEEKTSLFTNLESTKTQLSDAEERLA----KLEAQQ------------------KDASKQLS 929

  Fly   992 EDLGQFSFGKFSSVYCNGLRLQPRREPITAPL-------------LTRAASRDQDFQDALAVFKL 1043
            |...|.:..:..:.     .:|..::.|.|.:             |.:|.|..|           
 Worm   930 ELNDQLADNEDRTA-----DVQRAKKKIEAEVEALKKQIQDLEMSLRKAESEKQ----------- 978

  Fly  1044 ILRWSNDKALEGAKEKL-LADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQC 1107
                |.|..:...:::: ..|..:.|....:..::||..:|...:...........::...|.|.
 Worm   979 ----SKDHQIRSLQDEMQQQDEAIAKLNKEKKHQEEINRKLMEDLQSEEDKGNHQNKVKAKLEQT 1039

  Fly  1108 LCCFQPSAAFSKYLMRFVDDEAPESL------RPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAW 1166
            |                  |:..:||      |..|.:|..:.:|                    
 Worm  1040 L------------------DDLEDSLEREKRARADLDKQKRKVEG-------------------- 1066

  Fly  1167 LEWRAWTRGCDMA------LPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDG 1225
             |.:......|.:      |...|..:.|:..:|.|....|:|   .||.|       ...:.||
 Worm  1067 -ELKIAQENIDESGRQRHDLENNLKKKESELHSVSSRLEDEQA---LVSKL-------QRQIKDG 1120

  Fly  1226 QQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLR------------SGAKFA------------- 1265
            |....    :...:|..|::........:|||.|            .||..|             
 Worm  1121 QSRIS----ELEEELENERQSRSKADRAKSDLQRELEELGEKLDEQGGATAAQVEVNKKREAELA 1181

  Fly  1266 --RTTLPDA----------VKRPAVPPPAPPT------SSGKEDVPRER----RSSRELLSR--- 1305
              |..|.:|          :::......|..|      :..|..|.:::    |.:.:|.::   
 Worm  1182 KLRRDLEEANMNHENQLGGLRKKHTDAVAELTDQLDQLNKAKAKVEKDKAQAVRDAEDLAAQLDQ 1246

  Fly  1306 --SSALNE----RYFEREPSPGPGQGSSTGQAKSRSKSLDDLLA---------GDIVPVPTDCDS 1355
              |..||.    :.||.:.:      ....:|..:|:.|.|..:         ||:|....|.:|
 Worm  1247 ETSGKLNNEKLAKQFELQLT------ELQSKADEQSRQLQDFTSLKGRLHSENGDLVRQLEDAES 1305

  Fly  1356 QEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYAT 1420
            |  ::.|...:|:|..:...|.|.|            .:.|..|...|   :.:..|..:||...
 Worm  1306 Q--VNQLTRLKSQLTSQLEEARRTA------------DEEARERQTVA---AQAKNYQHEAEQLQ 1353

  Fly  1421 RSSAMSDTSEAPSLASHVRRVRVPSQA-SDVDQFLDDLFSPVLDG----SLDELSDARSLAASIR 1480
            .|  :.:..|..:     ..:|..|:| :|:.|     :....:|    ..|||.||:...|   
 Worm  1354 ES--LEEEIEGKN-----EILRQLSKANADIQQ-----WKARFEGEGLLKADELEDAKRRQA--- 1403

  Fly  1481 GGSYEQENEAESEID------------------DLDDYINDIFQPIPLVQNLEK----------- 1516
                ::.||.:..:|                  ||||...|:.:...:...|||           
 Worm  1404 ----QKINELQEALDAANSKNASLEKTKSRLVGDLDDAQVDVERANGVASALEKKQKGFDKIIDE 1464

  Fly  1517 -LTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRG 1580
             ....|.|||.:.|.       :||..:...||....|...|...|.|||    .:|:.::|...
 Worm  1465 WRKKTDDLAAELDGA-------QRDLRNTSTDLFKAKNAQEELAEVVEGL----RRENKSLSQEI 1518

  Fly  1581 GGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTLLS 1645
            ...||..|               |.|.::::.|              :|.::|..:.:.||..|.
 Worm  1519 KDLTDQLG---------------EGGRSVHEMQ--------------KIIRRLEIEKEELQHALD 1554

  Fly  1646 QQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKA-------TRSSLV-VMESLQPPPPPP 1702
            :..||..|..|      ..:.:.:.:|....:...|::.       ||.:.. .:||:|......
 Worm  1555 EAEAALEAEES------KVLRAQVEVSQIRSEIEKRIQEKEEEFENTRKNHARALESMQASLETE 1613

  Fly  1703 PPPMPPPLECK-----DPSETRHFLDPYGRA-----KTVRIGKWRWPPPQDEPQFQTEED----- 1752
            .......|..|     |.:|....||...:|     |.::    |:.....|.|.|.||:     
 Worm  1614 AKGKAELLRIKKKLEGDINELEIALDHANKANADAQKNLK----RYQEQVRELQLQVEEEQRNGA 1674

  Fly  1753 -----FFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSG 1812
                 ||    ...:|.|..|::..::..          |..|:..|.:..|:|...........
 Worm  1675 DTREQFF----NAEKRATLLQSEKEELLV----------ANEAAERARKQAEYEAADARDQANEA 1725

  Fly  1813 QLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLK 1877
            ....||:         |||  .|..:.|.|.:...:...:      ..::...:|.........:
 Worm  1726 NAQVSSL---------TSA--KRKLEGEIQAIHADLDETL------NEYKAAEERSKKAIADATR 1773

  Fly  1878 LSSEMRQR-------------LEQVTAGHSVR----STVSTKSEQRAPAKLEDTRKLMLQQQLGG 1925
            |:.|:||.             |||......||    ...:.|..::..||||. |...|:.:|.|
 Worm  1774 LAEELRQEQEHSQHVDRLRKGLEQQLKEIQVRLDEAEAAALKGGKKVIAKLEQ-RVRELESELDG 1837

  Fly  1926  1925
             Worm  1838  1837

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 251/720 (35%)
MYSc_Myo15 169..828 CDD:276838 246/699 (35%)
MyTH4 1014..1171 CDD:295320 24/176 (14%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
unc-54NP_493596.1 Myosin_N 31..68 CDD:280832 6/50 (12%)
Myosin_head 83..775 CDD:278492 251/711 (35%)
MYSc_class_II 95..775 CDD:276951 246/699 (35%)
Myosin_tail_1 855..1932 CDD:279860 217/1202 (18%)
Prefoldin 903..>969 CDD:298833 12/92 (13%)
YlqD 946..>1020 CDD:287979 14/88 (16%)
GluZincin 1649..>1784 CDD:301352 30/169 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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