DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and Myh9

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_037326.2 Gene:Myh9 / 25745 RGDID:3140 Length:1960 Species:Rattus norvegicus


Alignment Length:1940 Identity:504/1940 - (25%)
Similarity:804/1940 - (41%) Gaps:344/1940 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 SGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            |.||||..|..|:|||:|.||:.||..|||||::|...:.:||||..| .|..|:...|.|:...
  Rat    81 SKVEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLP-IYSEEIVDMYKGKKRH 144

  Fly   220 SLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSA--SAVITE 279
            .:|||::||...|:.::   ...|.::.:||||:||||:||.|:||||.|.....|.  ...:..
  Rat   145 EMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKSKKDQGELER 209

  Fly   280 QILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVTQAPGERNY 343
            |:|:|.|:|||||||:|.:|||||||||::.:.|. :|.||||.|..|||||||.:.||..||.:
  Rat   210 QLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTF 274

  Fly   344 HVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVDWESLQ---GAMQVLGVSEGEREG 405
            |:||.||.|..|..::...|...:||.:|:.|.. ...|:.|.:..|   .||:::|:.|.|:.|
  Rat   275 HIFYYLLSGAGEHLKTDLLLEPYNKYRFLSNGHV-TIPGQQDKDMFQETMEAMRIMGIPEDEQMG 338

  Fly   406 IVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRA-LTSRTTEAR-- 467
            ::||::.||.|||:.|.:.:   ..:...:..:...:..:|||.|:.....|. ||.|....|  
  Rat   339 LLRVISGVLQLGNIVFKKER---NTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDY 400

  Fly   468 AERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAEN 532
            .::..|.   :||..|.:|.|||.|..:|.|||.|||..:.|.....|..|.||||.|||....|
  Rat   401 VQKAQTK---EQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLN 462

  Fly   533 SFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWD-DNLPVIHLLAKK--PVGICHL 594
            |||||||||.||.||..||..:|.|||.||.||.:||..:.:. |..|.|.|:.|.  |.||..|
  Rat   463 SFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILAL 527

  Fly   595 LDDESNFPRATDLSFLEKCHYNHALSELYARPR--IGAQEFGVTHYAGQVWYCVDGFLDKNRDAL 657
            ||:|..||:|||.||:||..........:.:|:  ....:|.:.||||:|.|..|.:|.||.|.|
  Rat   528 LDEECWFPKATDKSFVEKVVQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPL 592

  Fly   658 RGDVLELLASSRLPLVGELTKQ----LRAQRDAGKT---LPKGSNGRFVTMKPRTPTVAARFADS 715
            ..::..||..|....|.||.|.    :...:.||.:   ||    |.|.|.|....||...:.:.
  Rat   593 NDNIATLLHQSSDKFVSELWKDVDRIIGLDQVAGMSETALP----GAFKTRKGMFRTVGQLYKEQ 653

  Fly   716 LQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFV 780
            |.:|:.::...:|.|||||.||.||.|.::|...||.|||..|:|:.|:|.::|:|.|:.||.|.
  Rat   654 LAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFR 718

  Fly   781 ERYRHLLPSPLARG-TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLR 844
            :||..|.|:.:.:| ...::.|..:::|:.   ::...|::|.::||.|..:...||..|..::.
  Rat   719 QRYEILTPNSIPKGFMDGKQACVLMIKALE---LDSNLYRIGQSKVFFRAGVLAHLEEERDLKIT 780

  Fly   845 RAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRV 909
            ...:..|...||.|.|:..|:||...|.::..   ||....|.|||.        |:..:...:|
  Rat   781 DVIIGFQACCRGYLARKAFAKRQQQLTAMKVL---QRNCAAYLRLRN--------WQWWRLFTKV 834

  Fly   910 QQLRSDHRRRQE--AREA-AQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDR 971
            :.|.:..|...|  |:|| ..:.||...|.:..|...:.....:.||...:..:||..:....:.
  Rat   835 KPLLNSIRHEDELLAKEAELTKVREKHLAAENRLTEMETMQSQLMAEKLQLQEQLQAETELCAEA 899

  Fly   972 HLVKV--------LGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCN------------GLRLQPRR 1016
            ..::.        |..:.....:.|:..|:..|:...:...:..|            ..|.:.:.
  Rat   900 EELRARLTAKKQELEEICHDLEARVEEEEERCQYLQAEKKKMQQNIQELEEQLEEEESARQKLQL 964

  Fly  1017 EPITAPLLTRAASRDQD---------------FQDALAVFKLILRWSNDKA-----LEGAKEKLL 1061
            |.:|.....:....||.               .:|.:|.|...|....:|:     |:...|.::
  Rat   965 EKVTTEAKLKKLEEDQIIMEDQNCKLAKEKKLLEDRVAEFTTNLMEEEEKSKSLAKLKNKHEAMI 1029

  Fly  1062 ADYIVHKALSSRGLRDEILVQLCNQVHGLPPN----SGEATRLWQLLGQCLCCFQPSAAFSKYLM 1122
            .|      |..|..|:|      .|...|...    .|::|.|...:.:.      .|..::..|
  Rat  1030 TD------LEERLRREE------KQRQELEKTRRKLEGDSTDLSDQIAEL------QAQIAELKM 1076

  Fly  1123 RF-------------VDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTR 1174
            :.             |::||.:....|...:.|..|............|||:        :|..:
  Rat  1077 QLAKKEEELQAALARVEEEAAQKNMALKKIRELETQISELQEDLESERACRN--------KAEKQ 1133

  Fly  1175 GCDM-----ALPLTLPDEASQTVAVDSWTS-CEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCG 1233
            ..|:     ||...|.|....|.|.....| .|:..::...:|...::.....:.:.:|..... 
  Rat  1134 KRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVSILKKTLEDEAKTHEAQIQEMRQKHSQA- 1197

  Fly  1234 LDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRS 1298
               |.:|..:.|               ..|..:.||..|                |:.:..||  
  Rat  1198 ---VEELAEQLE---------------QTKRVKATLEKA----------------KQTLENER-- 1226

  Fly  1299 SRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDL-------------LAGDIVPVP 1350
             .||.:...||.:           |:|.|..:.|.....|.:|             ||..:..:.
  Rat  1227 -GELANEVKALLQ-----------GKGDSEHKRKKVEAQLQELQVKFSEGERVRTELADKVSKLQ 1279

  Fly  1351 TDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADK 1415
            .:.||...|  |..|:|:.:........|....:||....|:...                  .|
  Rat  1280 VELDSVTGL--LNQSDSKSSKLTKDFSALESQLQDTQELLQEENR------------------QK 1324

  Fly  1416 AEYATRSSAMSDTSEAPSLASHVRR------------VRVPSQASDVDQFLDDLFSPVLDGSLDE 1468
            ...:|:...|.|  |..|....:..            ..:.:|.:|:.:.::|..     |.|:.
  Rat  1325 LSLSTKLKQMED--EKNSFREQLEEEEEAKRNLEKQIATLHAQVTDMKKKMEDGV-----GCLET 1382

  Fly  1469 LSDA-RSLAASIRG---------GSYEQENEAESEI-DDLDDYINDIFQPIPLVQNLEKLTSK-D 1521
            ..:| |.|...:.|         .:|::..:.::.: .:|||.:.|:......|.||||...| |
  Rat  1383 AEEAKRRLQKDLEGLSQRLEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSVSNLEKKQKKFD 1447

  Fly  1522 QLAAIIKGGGVASK-PEERD--------EESEIEDLDDYINELFEPIPVAEGLDK---------L 1568
            ||.|..|  .:::| .||||        :|::...|...:.|..|.....|.|:|         :
  Rat  1448 QLLAEEK--TISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLM 1510

  Fly  1569 TSKEHLAVSIRGGGSTD---SNGADPLLHQLMQLPGE---TESGPALYQ---QQVQRAF---LQS 1621
            :||:.:..|:.....:.   ....:.:..||.:|..|   ||......:   |.::..|   ||.
  Rat  1511 SSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQG 1575

  Fly  1622 AMAQNLQIQQQLLAQNQALQTLL----SQQAAAAAANNSTSPPPAPPILSSLS--ISPPPPQSPM 1680
            ...|:.:.::||:.|.:.::..|    .|::.|.||.......     |..|.  |.........
  Rat  1576 RDEQSEEKKKQLVRQVREMEAELEDERKQRSIAMAARKKLEMD-----LKDLEAHIDTANKNREE 1635

  Fly  1681 RMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEP 1745
            .:|..|.....|:...             .|..|...:|..:....:....::      ...:..
  Rat  1636 AIKQLRKLQAQMKDCM-------------RELDDTRASREEILAQAKENEKKL------KSMEAE 1681

  Fly  1746 QFQTEEDFFAFK--MRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPP 1808
            ..|.:|:..|.:  .||.|::....|.....:|..|.:......|..:..|...||.|.|.....
  Rat  1682 MIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTE 1746

  Fly  1809 PMSGQLMRSSIRLETTTT----TTTSAVNNRDR----DRETQDVGQPMQSVVTTKLAKKSFEIGA 1865
            .::.:|.:::::::...|    ..:.|..|.:.    :|:.:::...:|.:.:...:|....|.|
  Rat  1747 LINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKAKLQEMESAVKSKYKASIAA 1811

  Fly  1866 DRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQ 1920
                        |.:::.|..||:......|...| |..:||..||:|   ::||
  Rat  1812 ------------LEAKIAQLEEQLDNETKERQAAS-KQVRRAEKKLKD---VLLQ 1850

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 275/704 (39%)
MYSc_Myo15 169..828 CDD:276838 267/683 (39%)
MyTH4 1014..1171 CDD:295320 32/193 (17%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
Myh9NP_037326.2 Myosin_N 29..68 CDD:397036
Motor_domain 95..764 CDD:419868 267/683 (39%)
Myosin_tail_1 842..1921 CDD:396244 207/1153 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.000

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