DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and Myo9b

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	XP_038950134.1	Gene:	Myo9b / 25486	RGDID:	3146	Length:	2156	Species:	Rattus norvegicus

Alignment Length:	2314	Identity:	571/2314 - (24%)
Similarity:	891/2314 - (38%)	Gaps:	705/2314 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 EDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLP 222
            :|:..|.:|:||:||.:|:||:.:..|||:|||||:|:||:|..| .|..:..|.|..:.||.|.
  Rat   149 DDLCNLPELNEANLLQSLKLRFVQQKIYTYAGSILVAINPFKFLP-IYNPKYVKMYENQQLGKLE 212

  Fly   223 PHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQILEA 284
            ||:||:...|:..:...   |.:|||||||||||:||..::..|.|:...|.::.  :...||.|
  Rat   213 PHVFALADVAYYTMLRKHVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGYASG--VERTILGA 275

  Fly   285 APLLEAFGNARTARNDNSSRFGKYLEV-YFKSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYE 348
            .|:|||||||:||.|:|||||||:::| |.:||.:.||.:.:|||||||:|:|...||||||||.
  Rat   276 GPVLEAFGNAKTAHNNNSSRFGKFIQVNYLESGIVRGAVVEKYLLEKSRLVSQEKDERNYHVFYY 340

  Fly   349 LLGGLSETERSKYGLLEADKYFYLNQGATDCASG---RVDWESLQGAMQVLGVSEGEREGIVRVL 410
            ||.|:||.||.::.|.:...||||||...:...|   :.|:|.||.||:::|.....::.|..||
  Rat   341 LLLGVSEEERQEFQLKQPQDYFYLNQHNLNIEDGEDLKHDFERLQQAMEMVGFLPATKKQIFSVL 405

  Fly   411 AAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPL 475
            :|:|:||||.:.:|.... .||:|||....:...:.||.:..:.|...||.|.|....::|..|.
  Rat   406 SAILYLGNVTYKKRATGR-DEGLEVGPPEVLDTLSQLLKVKRETLVEVLTKRKTITVNDKLILPY 469

  Fly   476 GIDQALDARDAFAKALYAGLFNWLVSRIN-SIVQKGGTHDA---HRISILDIFGFEDLAENSFEQ 536
            .:.:|:.|||:.||:||:.||:|:|.||| :::.|....:|   ..|.:||||||||...|||||
  Rat   470 SLSEAITARDSMAKSLYSALFDWIVLRINHALLNKKDMEEAVSCLSIGVLDIFGFEDFERNSFEQ 534

  Fly   537 LCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNF 601
            .|||||||.||.||.:|:|||||.||..|.:.|..:.:.||:..|||::|||.|:.:|||:||||
  Rat   535 FCINYANEQLQYYFTQHIFKLEQEEYQGEGISWHNIDYTDNVGCIHLISKKPTGLFYLLDEESNF 599

  Fly   602 PRATDLSFLEKCHYNHALSELYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLA 666
            |.||..:.|.|....|..::.:....:....|.:.|:||:|.|.:..|.:||.|.:|.|::.||.
  Rat   600 PHATSHTLLAKFKQQHEDNKYFLGTPVLEPAFIIQHFAGRVKYQIKDFREKNMDYMRPDIVALLR 664

  Fly   667 SSRLPLVGEL--------------------------TKQLRAQR----DAG----------KTLP 691
            .|....|.:|                          ..:|||:|    :||          :.||
  Rat   665 GSDSSYVRQLIGMDPVAVFRWAVLRAAIRAMAVLREAGRLRAERAEKAEAGVSSPVTRSHVEELP 729

  Fly   692 KGSN-----------------------------------GRFV---------------------- 699
            :|:|                                   .|.|
  Rat   730 RGANTPSEKLYRCAGLDFSFERSEELDVNAFEDIMAFYESRKVRERSDLHNQIIKSLKGLPWQGE 794

  Fly   700 -----------TMKPRT------------------------------------------------ 705
                       ..||||
  Rat   795 DPRRLLQSLSRLQKPRTFFLKSKGIKQKQIIPKNLLDSKSLRLIISMTLHDRTTKSLLHLHKKKK 859

  Fly   706 -PTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRG 769
             |:::|:|..||.:||:::|:..|:|:|||:.|.||..|..|...|||||||.|||:|::||:.|
  Rat   860 PPSISAQFQTSLNKLLEALGKAEPFFIRCIRSNAEKKELCFDDELVLQQLRYTGMLETVRIRRSG 924

  Fly   770 YPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRA 834
            |..:..||.|.|:::.|||..:   .|.||...||||.:.   |:..:||:|.|:|||:|...:|
  Rat   925 YSAKYTFQDFTEQFQVLLPKDV---QPCREAIAALLEKLQ---VDRQNYQIGKTKVFLKETERQA 983

  Fly   835 LESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRL 899
            |:......:.|..:.:|...|.:|.||...:.:.||..:||.||..|.::..||.| .|:..|..
  Rat   984 LQERLHGEVLRRILLLQSWFRMVLERRHFVQMKHAALTIQACWRSYRVRRTLERTR-AAVYLQAA 1047

  Fly   900 WRG---RQARR-------RVQQLRSDHRRRQEARE---AAQRAREAREAKQAVLERSQLSYLDIP 951
            |||   |||..       |:|.|...|.:|:...:   ..|:|.:|||...|.:...:      |
  Rat  1048 WRGYLQRQAYHHQRHSIIRLQSLCRGHLQRRSFSQMMLEKQKAEQARETAGAEMSEGE------P 1106

  Fly   952 AELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRR 1016
            :.:|            .|::           |....|:.||.||..:....:|...||  |.|::
  Rat  1107 SPVA------------AGEQ-----------PSEHPVEDPESLGVETETWMNSKSPNG--LSPKK 1146

  Fly  1017 EPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGL----RD 1077
            | |.:|.:...|.            |.:...|::| :..::||       .::...|||    |.
  Rat  1147 E-IPSPEMETPAQ------------KTVPAESHEK-VPSSREK-------RESRRQRGLEHVERQ 1190

  Fly  1078 EILVQLCNQVHG-LPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQL 1141
            ...:|.|.:.:. |...|.:|:            .:...:|.:      |.:.|
  Rat  1191 NKHIQSCREENSTLREPSRKAS------------LETGESFPE------DTKEP----------- 1226

  Fly  1142 LRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLT-------LPDEASQTVAVDSWTS 1199
             |:.|                :..|.|..|  ..|...:|:.       .|.:...::.:||..|
  Rat  1227 -REDG----------------LETWTETAA--PSCPKQVPIVGDPPRSPSPLQRPASLDLDSRVS 1272

  Fly  1200 CEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPA-------FPAPRSDL 1257
                ..|..|||......     |.|:..|.          :.:|...|:       :..|.::.
  Rat  1273 ----PVLPSSSLESPQDE-----DKGENSTK----------VQDKPESPSGSTQIQRYQHPDTER 1318

  Fly  1258 LRS------GAKFARTTLPDAVKRPAVPPPA----PPT-----SSGKEDV----PRERRSSREL- 1302
            |.:      |.|.|...|..::.....|..|    .||     |....||    |.:.::|.|:
  Rat  1319 LATAVEIWRGKKLASAMLSQSLDLSEKPRTAGAALTPTEERRISFSTSDVSKLSPVKVQTSTEVD 1383

  Fly  1303 --LSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLS 1365
              ||.......:....:||.||..|..||                     :..||:.....|.|.
  Rat  1384 GDLSAKKPAGHKKKSEDPSAGPDAGLPTG---------------------SQGDSKSAFKRLFLH 1427

  Fly  1366 ESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSE 1430
            :::  |:..|.|   .|.:..|...|.:|.|..|.......|...::.              |.|
  Rat  1428 KAK--DKKPSLE---GVEETEGSGGQAAQEAPARKTLDVPSSQQHRHT--------------TGE 1473

  Fly  1431 APSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGS---------LDELSDARSLAASIRGGSYEQ 1486
            .| |.....|.|...|.:..:::.:.:|..:.:.:         |::::|.||....|.....|.
  Rat  1474 KP-LKGKKNRNRKVGQITVSEKWRESVFRKITNANELKFLDEFLLNKVNDLRSQKTPIESLFIEA 1537

  Fly  1487 ENEAESEI----------------DDLDDY------------------INDIFQPIPLVQNLEKL 1517
            .....|.|                |.:::|                  :.::||  .|:....:.
  Rat  1538 TERFRSNIKTMYSVPNGKIHVGYKDLMENYQIVVSNLAAERGEKDTNLVLNVFQ--SLLDEFTRS 1600

  Fly  1518 TSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLD---------------- 1566
            .:|.....:.:|   .::.::|.:|..:::.:.::...:: :.:.:..:
  Rat  1601 YNKTDFEPVKQG---KAQKKKRKQERAVQEHNGHVFASYQ-VNIPQSCEQCLSYIWLMDKALLCS 1661

  Fly  1567 --KLTSKEHLAVSIRG-----GGSTDSNGADP-------------------LLHQLM---QLPG- 1601
              |:|..:.....|:.     |......||:|                   :|.:|:   ::.|
  Rat  1662 VCKMTCHKKCVHKIQSYCSYTGRRKSELGAEPGHFGVCVDSLTSDKASVPIVLEKLLEHVEMHGL 1726

  Fly  1602 ETE-----SGPALYQQQVQRAFLQSAMAQNLQ----------IQQQLLAQNQALQTLL------- 1644
            .||     ||.|...:::::|.........|:          ::|.|....:.|.|..
  Rat  1727 YTEGLYRKSGAANRTRELRQALQTDPATVKLEDFPIHAITGVLKQWLRELPEPLMTFAQYGDFLR 1791

  Fly  1645 -------SQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPP 1702
                   .:|.||..|           :|..|     |..:...::.....||.:..|:......
  Rat  1792 AVELPEKQEQLAAIYA-----------VLDHL-----PEANHTSLERLIFHLVKVALLEDVNRMS 1840

  Fly  1703 PPPM-----PPPLECKDPSETRHFLDPYGRAKTV-------------RIGKWRWPPPQDEPQFQT 1749
            |..:     |..|.|.|.|      ||....|.|             ::.|::  ...:|.....
  Rat  1841 PGALAIIFAPCLLRCPDNS------DPLTSMKDVLKITTCVEMLIKEQMRKYK--VKMEEINHLE 1897

  Fly  1750 EEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQL 1814
            ..:..||:.....|:..|                .|...|.|:   .:|....:||..|.:..
  Rat  1898 AAESIAFRRLSLLRQNAP----------------WPLKLGFSS---PYEGVRTKSPRTPVVQD-- 1941

  Fly  1815 MRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKLS 1879
                  ||........|... |.|||.:.:.:.:||:   |..|:..........|....:..|.
  Rat  1942 ------LEELGALPEEAAGG-DEDREKEILMERIQSI---KEEKEDITYRLPELDPRGSDEENLD 1996

  Fly  1880 SEMRQRLEQVTAGHSVRSTVSTKS--EQRAPAKLEDTRKLMLQQQLGGLFASVSGGNSGPGGVVD 1942
            ||               ::.||:|  |:||                      |.|...|
  Rat  1997 SE---------------TSASTESLLEERA----------------------VRGAAEG------ 2018

  Fly  1943 SHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPA-PQSPPT 2006
                                            ||||::|.|..|...|..|..|||.. |.|..|
  Rat  2019 --------------------------------PPAPALPCPISPTPNPLPAATAPPRGRPTSFVT 2051

  Fly  2007 ARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLEDHSASSSPAVAAWE 2071
            .|...|.   ||....:....:|..:.                    |||           .:|.
  Rat  2052 VRVKTPR---RTPIMPMANIKLPPGLP--------------------LHL-----------TSWA 2082

  Fly  2072 QAERERS---RSRSRSRDREDYSESVWDRAEVEGPASGS 2107
            .|.:|.:   :.|.....|:|...||:.....:.|:.|:
  Rat  2083 PALQEAAVPVKRREPPARRQDQVHSVYIAPGADLPSQGT 2121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	305/845 (36%)
		MYSc_Myo15	169..828	CDD:276838	298/826 (36%)
		MyTH4	1014..1171	CDD:295320	26/161 (16%)
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myo9b	XP_038950134.1	Ubiquitin_like_fold	16..112	CDD:421700
		MYSc_Myo9	160..977	CDD:276836	298/826 (36%)
		IQ	1014..1033	CDD:197470	7/18 (39%)
		IQ	1036..1058	CDD:197470	11/22 (50%)
		PTZ00449	<1145..1493	CDD:185628	87/476 (18%)
		C1_Myosin-IXb	1626..1683	CDD:410434	3/57 (5%)
		RhoGAP	1696..1881	CDD:413382	34/206 (17%)
		MCP_Sipho	1941..>2064	CDD:411416	43/212 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810