Protein Alignment Myo10A and Myo1d

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_037115.2
• Gene: Myo1d / 25485
• RGDID: 621321
• Length: 1006
• Species: Rattus norvegicus
• Alignment Length: 1076
• Identity: 340/1076 - (31%)
• Similarity: 510/1076 - (47%)
• Gaps: 175/1076 - (16%)

  Fly   148 ARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQ 212
            |.|:....|..|..|:|.:.....:.|||||::||.||||.|.::::|||||:. :.||.:..:|
  Rat     2 AEQESLEFGKADFVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKVL-NIYGRDTIEQ 65

  Fly   213 YAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVV-PGGGSA 273
            |.||.|...|||||||..||:.|:   .....::||||||:||||::|.:|||:||:. |...:.
  Rat    66 YKGRELYERPPHLFAIADAAYKAMKRRSKDTCIMISGESGAGKTEASKYIMQYIAAITNPSQRAE 130

  Fly   274 SAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVTQA 337
            ...:...:|::..:|||||||:|.|||||||||||:::.|. .|..:|..|..|||||||::.|.
  Rat   131 IERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQ 195

  Fly   338 PGERNYHVFYELLGGLSETERSKYGLLEA-DKYFYLNQGA------TDCASGRVDWESLQGAMQV 395
            ||||::|.||:||.|.||.......|.:: ..|.|:..||      .|.|..:|    :..||:|
  Rat   196 PGERSFHSFYQLLQGGSEQMLHSLHLQKSLSSYNYIRVGAQLKSSINDAAEFKV----VADAMKV 256

  Fly   396 LGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEG-VEVGSDAEIKWAAHLLHISADGLHRAL 459
            :|....|.:.:.::|||:|||||:.|    :..|... :|.|....:  .|.||...||.:.:||
  Rat   257 IGFKPEEIQTVYKILAAILHLGNLKF----IVDGDTPLIENGKVVSV--IAELLSTKADMVEKAL 315

  Fly   460 TSRTTEAR---AERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQ-KGGTHDAHR--- 517
            ..||....   .::.||.   .:|...|||||||:|..||.|:|:|||.|:: |......|.
  Rat   316 LYRTVATGRDIIDKQHTE---QEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTVHGKNT 377

  Fly   518 -ISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVI 581
             |.:|||:|||....|||||.||||.||.||..|.:.|.|.||.||.||.:.|..:.:.:|..::
  Rat   378 VIGVLDIYGFEIFDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIV 442

  Fly   582 HLLAKKPVGICHLLDDE-SNFPRATDLSFLEKC------HYNHALSELYARPRI--GAQEFGVTH 637
            .|:.::..||..:|||. .|..:.||..|||..      |.:.:..:..|..:|  ..::|.:.|
  Rat   443 DLVEQQHKGIIAILDDACMNVGKVTDGMFLEALNSKLGKHGHFSSRKTCASDKILEFDRDFRIRH 507

  Fly   638 YAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGS-NGRFVTM 701
            |||.|.|.|.||:|||:|.|..|...|:.:|..|::..:             .|:|. :...||.
  Rat   508 YAGDVVYSVIGFIDKNKDTLFQDFKRLMYNSSNPVLKNM-------------WPEGKLSITEVTK 559

  Fly   702 KPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIR 766
            :|.  |.|..|.:|:..|:.::....|::|||||||.:|.....|......|:.|||:|:.:::|
  Rat   560 RPL--TAATLFKNSMIALVDNLASKEPYYVRCIKPNDKKSPQIFDDERCRHQVEYLGLLENVRVR 622

  Fly   767 QRGYPVRLRFQHFVERYR---------HLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGA 822
            :.|:..|..::.|:.||:         |.|||.       :|..:.|:|   |.|.: .|...|.
  Rat   623 RAGFAFRQTYEKFLHRYKMISEFTWPNHDLPSD-------KEAVKKLIE---RCGFQ-DDVAYGK 676

  Fly   823 TRVFLREALHRALESGRT----ERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQ 883
            |::|:|        :.||    |.||..          ||||..|.        ||..|||..|:
  Rat   677 TKIFIR--------TPRTLFTLEELRAQ----------MLVRVVLF--------LQKVWRGTLAR 715

  Fly   884 QRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRA---------REAREAKQAV 939
            .||:| .|.|||..|.:|..:.:..:.::.......:..|:..:..         |...||.|::
  Rat   716 MRYKR-TKAALTIIRYYRRYKVKSYIHEVARRFHGVKNMRDYGKHVKWPTPPKVLRRFEEALQSI 779

  Fly   940 LERSQLSYL--DIPA-ELAFIYSKLQGWSPPHGDRHLV--------KVLGTVPGPPSSA---VQL 990
            ..|.:.|.|  .||| :|..:.:|:.......|.|..:        ..|.:.|..|.::   |.:
  Rat   780 FNRWRASQLIKTIPASDLPQVRAKVAAMEMLKGQRADLGLQRAWEGNYLASKPDTPQTSGTFVPV 844

  Fly   991 PEDLGQ--------FS-----FGKFSSVYCNGL--------RLQPRRE---PITAPLLTRAASRD 1031
            ..:|.:        ||     ..:||.|....:        ::.|.::   ..|.||........
  Rat   845 ANELKRKDKYMNVLFSCHVRKVNRFSKVEDRAIFVTDRHLYKMDPTKQYKVMKTIPLYNLTGLSV 909

  Fly  1032 QDFQDALAVFK-------LILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHG 1089
            .:.:|.|.||.       ::..:|.....|....:|:...:.|.....|.|:..:...:...:||
  Rat   910 SNGKDQLVVFHTKDNKDLIVCLFSKQPTHESRIGELVGVLVNHFKSEKRHLQVNVTNPVQCSLHG 974

  Fly  1090 LPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFV 1125
            ........|||          .||...|:|....|:
  Rat   975 KKCTVSVETRL----------NQPQPDFTKNRSGFI 1000

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	259/698 (37%)
		PTZ00121	<828..>943	CDD:173412	31/127 (24%)
		MyTH4	1014..1171	CDD:470587	24/122 (20%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myo1d	NP_037115.2	MYSc_Myo1	24..682	CDD:276829	259/697 (37%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	572..594		8/21 (38%)
		Interaction with calmodulin. /evidence=ECO:0000269|PubMed:8034741	776..896		22/119 (18%)
		Myosin_TH1	803..996	CDD:461801	36/202 (18%)