Protein Alignment Myo10A and myo52

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_588492.1
• Gene: myo52 / 2538846
• PomBaseID: SPCC1919.10C
• Length: 1516
• Species: Schizosaccharomyces pombe
• Alignment Length: 1113
• Identity: 343/1113 - (30%)
• Similarity: 539/1113 - (48%)
• Gaps: 166/1113 - (14%)

  Fly   154 SSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPL 218
            :|..:|:|.|..|:|.|:|..|..||::..|||::|.:||||||::..|:.|..|:.:.|:.:..
pombe    72 NSDADDLTDLSYLNEPSVLDALSTRYNQLQIYTYSGIVLIAVNPFQRLPNLYTHEIVRAYSEKSR 136

  Fly   219 GSLPPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASA----- 275
            ..|.|||:||...::..:...   |.::||||||:|||.|.:.:|:|.|:|.....|..:
pombe   137 DELDPHLYAIAEDSYKCMNQEHKNQTIIISGESGAGKTVSARYIMRYFASVQALIQSTDSNFHEA 201

  Fly   276 ----VITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKSGA-IVGAKITQYLLEKSRIVT 335
                .:..:||...|::|||||::|:|||||||||||:::.|...| |:||||..||||:||:|.
pombe   202 PQLTAVENEILATNPIMEAFGNSKTSRNDNSSRFGKYIQILFDGNATIIGAKIQTYLLERSRLVF 266

  Fly   336 QAPGERNYHVFYELLGGLSETERSKYGLLEADKYF-YLNQGATDCASGRVDWESLQG---AMQVL 396
            |...|||||:||::|.|.|..:..|:.|:|..:.| ||.||......|..|.|..:.   |::.:
pombe   267 QPNQERNYHIFYQILAGSSSEQLEKWKLVENSQEFNYLKQGNCSTIEGVNDKEEFKATVDALKTV 331

  Fly   397 GVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAE-IKWAAHLLHISADGLHRALT 460
            |:.....|.|..:|||:||:||:     :::|.:....:.|..| :..|..||.:....|.:.||
pombe   332 GIDNDTCECIFSLLAALLHIGNI-----EVKHSRNDAYIDSKNENLINATSLLGVDPSSLVKWLT 391

  Fly   461 SRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIV----QKGGTHDAHRISIL 521
            .|..:..:|.:..||...||:.|||:.||.|||.||:|||:.||..:    .|........|.:|
pombe   392 KRKIKMASEGILKPLNEFQAVVARDSVAKFLYASLFDWLVATINKALMYSADKSNQTAKSFIGVL 456

  Fly   522 DIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAK 586
            ||:|||...:|||||.|||||||.||..|.:|||||||.|||.|.|.|:.:.:.||...|.::..
pombe   457 DIYGFEHFKKNSFEQFCINYANEKLQQEFYRHVFKLEQEEYAAEGLNWSYIDYQDNQQCISMIES 521

  Fly   587 KPVGICHLLDDESNFPRATDLSFLEKCHYNHALSE-----LYARPRIGAQEFGVTHYAGQVWYCV 646
            : :||..|||:|...|..:|.:::.|  .|.|.|:     .|.:.|.|.:||.:.|||..|.||.
pombe   522 R-LGILSLLDEECRMPTNSDENWVSK--LNDAFSKPEFKNSYQKSRFGNKEFTIKHYALDVVYCA 583

  Fly   647 DGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAAR 711
            :||:|||||.:..::|||..:|.:|.|.:|. ..|.:    :|.|.....:..| ||::.|:.:.
pombe   584 EGFIDKNRDTISDELLELFTNSDVPFVKDLV-LFRLE----QTAPPADTKKIKT-KPKSNTLGSM 642

  Fly   712 FADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRF 776
            |..||..|:.::...:..::||||||:||.|.:.|...|:.|||..|:|:||:|...|:|.|..|
pombe   643 FKSSLVSLMSTINETNAHYIRCIKPNEEKEAWKFDNQMVVSQLRACGVLETIKISCAGFPSRWTF 707

  Fly   777 QHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTE 841
            ..||.||..|:||.: |.|......:|:||    ...:...||:|.|::|.|..:...|||.|.:
pombe   708 DEFVSRYYMLVPSAV-RTTESLTFSKAILE----KHADPTKYQIGKTKIFFRSGVTPLLESARDK 767

  Fly   842 RLRRAA----------------------------------------------------------- 847
            .|:.||
pombe   768 ALKHAAHLLYEAFAVNYYRTRFLLSRKRVRSFQAVAHGFLSRRHTEYELLSSNIIKLQSLWRTAL 832

  Fly   848 ------------VSVQRHVRGMLVRRQLAR--RQAAATRLQARWRGQRAQQRYERLRKGALTAQR 898
                        :.||..:||.|:|:.|..  :..|...:|:.|...:|.:.|:.|:..|:..|.
pombe   833 KRKEFIQTKNSILKVQSIIRGFLLRQTLEEKTKHDATLIIQSLWLTFKAHKHYKELQYYAVRIQS 897

  Fly   899 LWRGRQARRRVQQLRSDHRRRQEAREAAQR--AREAREAKQAVLERSQLSYLDIPAELAFIYSKL 961
            |||.:.|:|::.:|:.:..:....::.:.|  :|....:||  |:.|:.........:|.:.|.|
pombe   898 LWRMKLAKRQLTELKIESTKASHLKQVSYRLESRLFEISKQ--LDNSEQENNKFRERIAELESHL 960

  Fly   962 QGW------------------SPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCN 1008
            ..:                  |....|..|.::|   ....::.:.:.|::.|.:......:..|
pombe   961 SNYAEAKLAQERELEQTRVLISDQSQDGELKELL---EEKENALIMMEEEMRQVNDANTELLRVN 1022

  Fly  1009 G-LRLQPRR-EPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALS 1071
            . |:.|.:. :.|.....::...:::.........|::...|:.:....::||...|    .:|.
pombe  1023 ATLKSQLKNYDMIIVEQTSQLKEKNRIIASLTKATKILNSASSIEQSRNSEEKSRRD----SSLM 1083

  Fly  1072 SRGLRDEILVQLCNQ--VHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLR 1134
            ....:.|:||.|.|.  .|.|...:..|.|.:..|              |.|:...:|...:.|.
pombe  1084 EMRTQKEMLVLLMNDGLKHDLDKLTEYAGRTFTTL--------------KTLLLKDNDVEAQKLD 1134

  Fly  1135 PLLLRQLL 1142
            .|.|.:||
pombe  1135 HLFLAKLL 1142

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	265/685 (39%)
		PTZ00121	<828..>943	CDD:173412	34/189 (18%)
		MyTH4	1014..1171	CDD:470587	25/132 (19%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
myo52	NP_588492.1	COG5022	1..1501	CDD:227355	343/1113 (31%)