DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and Myh8

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_001093955.1 Gene:Myh8 / 252942 RGDID:620356 Length:1937 Species:Rattus norvegicus


Alignment Length:2173 Identity:485/2173 - (22%)
Similarity:855/2173 - (39%) Gaps:507/2173 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   132 RHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVN 196
            :..|.|.:.|.:          ...:|||.::..|||..:|:||:.||...:|||::|...:.||
  Rat    75 KEDQVFPMNPPK----------YDKIEDMAMMTHLHEPGVLYNLKERYAAWMIYTYSGLFCVTVN 129

  Fly   197 PYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKL 258
            |||..| .|..||...|.|:.....|||:|:|...|:..:.:.   |.::|:||||:|||.:||.
  Rat   130 PYKWLP-VYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKR 193

  Fly   259 VMQYLAAVVPGG-------GSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KS 315
            |:||.|.:...|       |.....:.:||:.|.|||||||||:|.||||||||||::.::| .:
  Rat   194 VIQYFATIAVTGEKKKEESGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTT 258

  Fly   316 GAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLE-------ADKYFYLN 373
            |.:..|.|..|||||||:..|...||:||:||::      |...|..|:|       ...|.:::
  Rat   259 GKLASADIETYLLEKSRVTFQLKAERSYHIFYQI------TSNKKPELIEMLLITTNPYDYAFVS 317

  Fly   374 QGATDCASGRVDWESL---QGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQE--GV 433
            ||.....| ..|.|.|   ..|:.:||.|..|:..|.::..||:|.||:.|.::|.....|  |.
  Rat   318 QGEITVPS-IDDQEELMATDSAIDILGFSPEEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGT 381

  Fly   434 EVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNW 498
            ||...     ||:|..:::..|.:||.....:...|.:.....:.|..:|..|.|||:|..:|.|
  Rat   382 EVADK-----AAYLQSLNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNAVGALAKAVYEKMFLW 441

  Fly   499 LVSRINSIVQKGGTHDAHR--ISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAE 561
            :|:|||   |:..|....:  |.:|||.|||....||.||||||:.||.||.:||.|:|.|||.|
  Rat   442 MVTRIN---QQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEE 503

  Fly   562 YARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYAR 625
            |.:|.:|||.:.:..:|.....|.:||:||..:|::|..||:|||.||..|.:..| ..|..:.:
  Rat   504 YKKEGIEWTFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQK 568

  Fly   626 PR--IGAQE--FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGEL-TKQLRAQRD 685
            |:  .|..|  |.:.||||.|.|.:.|:||||:|.|...|:.|...|.:..:..| :....|:.|
  Rat   569 PKPTKGKAEAHFSLIHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTLASLFSTYASAEAD 633

  Fly   686 AGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCV 750
            .|  ..||:..:..:.:    ||:|.|.::|.:|:.::...||.|||||.||:.|....|:...|
  Rat   634 GG--AKKGAKKKGSSFQ----TVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELV 692

  Fly   751 LQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEG 815
            |.|||..|:|:.|:|.::|:|.|:.:..|.:||:.|..|.:..| .:.:..:|..:.:....::.
  Rat   693 LHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEG-QFIDSKKASEKLLGSIDIDH 756

  Fly   816 PDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVR----RQLARRQA-------- 868
            ..|:.|.|:||.:..|...||..|.|:|.:.....|...||.|:|    :.|.||::        
  Rat   757 TQYKFGHTKVFFKAGLLGLLEEMRDEKLAQIITRTQAVCRGYLMRVEYQKMLLRRESIFCIQYNI 821

  Fly   869 AATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAR 933
            .|......|...:...:.:.|.|.|          :..:.:..::.:.::.::....::..|:..
  Rat   822 RAFMNVKHWPWMKLFFKIKPLLKSA----------ETEKEMATMKEEFQKTKDELAKSEAKRKEL 876

  Fly   934 EAKQAVL--ERSQLSYLDIPAE---LAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPED 993
            |.|...|  |::.|. |.:.:|   ||....:.:         .|:|                  
  Rat   877 EEKMVTLLKEKNDLQ-LQVQSEADSLADAEERCE---------QLIK------------------ 913

  Fly   994 LGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKE 1058
                          |.::|:.:.:.:|        .|.:|.::..|......|...|:..|..|:
  Rat   914 --------------NKIQLEAKIKEVT--------ERAEDEEEINAELTAKKRKLEDECSELKKD 956

  Fly  1059 KLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMR 1123
            ....:..:.|....:...:..:..|..::.||.....:.|:             ...|..:...:
  Rat   957 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK-------------EKKALQEAHQQ 1008

  Fly  1124 FVDD-EAPE-SLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPD 1186
            .:|| :|.| .:..|...:...:|......|::                                
  Rat  1009 TLDDLQAEEDKVNTLTKAKTKLEQQVDDLEGSL-------------------------------- 1041

  Fly  1187 EASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFP 1251
            |..:.:.:|    .|.|.......|.:|......:.:|.|||.:.         :.:||      
  Rat  1042 EQEKKLRMD----LERAKRKLEGDLKLAQESTMDIENDKQQLDEK---------LKKKE------ 1087

  Fly  1252 APRSDLLRSGAKFARTTLPDAVK-RPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFE 1315
                        |..:.|...:: ..||            ::..::: .:||.:|...|.|. .|
  Rat  1088 ------------FEISNLISKIEDEQAV------------EIQLQKK-IKELQARIEELEEE-IE 1126

  Fly  1316 REPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLA 1380
            .|.:   .:..:..|....|:.|:::                        ..||.:...:.....
  Rat  1127 AERA---SRAKAEKQRSDLSRELEEI------------------------SERLEEAGGATSAQV 1164

  Fly  1381 PVGKDTGPRYQKSQ---HAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVR 1442
            .:.|.....:||.:   ......|.|:..:...|:||         :|::..|.......|:: :
  Rat  1165 ELNKKRETEFQKLRRDLEEATLQHEATSAALRKKHAD---------SMAELGEQIDNLQRVKQ-K 1219

  Fly  1443 VPSQASDVDQFLDDLFSPV-----LDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYIN 1502
            :..:.|::...:|||.|..     ..|:|:::  .|:|.        :|.:|.:|:.::....||
  Rat  1220 LEKEKSELKMEIDDLSSNAEAIAKAKGNLEKM--CRTLE--------DQVSELKSKEEEQQRLIN 1274

  Fly  1503 DIFQPIPLVQN-----LEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVA 1562
            ::......:|.     ..:|..||.|.:.:          .|.:::..:.:::...:|.|.....
  Rat  1275 ELTAQRARLQTEAGEYSRQLDEKDALVSQL----------SRSKQASTQQIEELKRQLEEETKAK 1329

  Fly  1563 EGL-DKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQ-QQVQRA-FLQSA-- 1622
            ..| ..|.|..|....:|.....:..|...|...|.:...|.......|: ..:||. .|:.|  
  Rat  1330 NALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK 1394

  Fly  1623 -MAQNLQIQQQLL----------------AQNQALQTLLS-QQAAAAAANNSTSPPPAPPILSSL 1669
             :||.||..::.:                .||:....:|. ::..||.|...........:||  
  Rat  1395 KLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKVLS-- 1457

  Fly  1670 SISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSET---------RHFLDPY 1725
                   :...:.:.|::.|   ||                 |:..|.|         ..:.:..
  Rat  1458 -------EWRQKYEETQAEL---ES-----------------CQKESRTLSTELFKVKNAYEESL 1495

  Fly  1726 GRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGA 1790
            .:.:|:|......   |.|....||:.....|......|...|.:..:......:.|        
  Rat  1496 DQLETLRRENKNL---QQEISDLTEQIAEGGKHIHELEKIKKQVEQEKCEIQAALEE-------- 1549

  Fly  1791 SATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRD-----RETQDVGQPMQS 1850
            :..::|.||            |:::|..:.|....:.....:..:|.:     |....|.:.|||
  Rat  1550 AEASLEHEE------------GKILRIQLELNQVKSEIDRKIAEKDEEIDQLKRNHIRVVETMQS 1602

  Fly  1851 VVTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTR 1915
            .:..::..::..:...:...|.:.::::......||    |..|:|:..:|:      ..|:||:
  Rat  1603 TLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRL----AAESLRNYRNTQ------GILKDTQ 1657

  Fly  1916 KLM---------LQQQLGGLFASVSGGNSGPGGVVDSHAT-VRTQIERMEGKLSPPPAPPSGGWP 1970
            ..:         |::||               .:|:..|. ::.:||.:...|.           
  Rat  1658 LHLDDALRGQEDLKEQL---------------AIVERRANLLQAEIEELRATLE----------- 1696

  Fly  1971 GVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPE-PEPDYRTSSSQVVKEHV--PAFI 2032
                                              .|.||.: .|.:...:|.:|...|.  .:.|
  Rat  1697 ----------------------------------QTERSRKIAEQELLDASERVQLLHTQNTSLI 1727

  Fly  2033 ---QRQERDTFGAVRQQQMISSHHLHLEDHS--ASSSPAVAAWEQAERERSRSRSRSRDREDYSE 2092
               ::.|.|......:.:.:.....:.|:.:  |.:..|:.| |:.::|:..|....|.:::..:
  Rat  1728 NTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMA-EELKKEQDTSAHLERMKKNLEQ 1791

  Fly  2093 SVWD---RAEVEGPASGSGSEKEREKRERERERLYEIRQVERERESHKVYQPAPPRVIQASMDTT 2154
            :|.|   |.:.....:..|.:|:.:|.|.      .:|::|.|.|:.:          :.:.:..
  Rat  1792 TVKDLQHRLDEAEQLALKGGKKQIQKLEA------RVRELEGEVENEQ----------KRNAEAV 1840

  Fly  2155 GGHRREDRTGGLATFRTHMAQKYEHERK 2182
            .|.|:.:|.....|::|      |.:||
  Rat  1841 KGLRKHERRVKELTYQT------EEDRK 1862

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 258/710 (36%)
MYSc_Myo15 169..828 CDD:276838 251/689 (36%)
MyTH4 1014..1171 CDD:295320 21/158 (13%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
Myh8NP_001093955.1 Myosin_N 38..75 CDD:280832 485/2173 (22%)
Myosin_head 90..769 CDD:278492 257/701 (37%)
Motor_domain 102..769 CDD:277568 251/689 (36%)
Myosin_tail_1 849..1926 CDD:279860 206/1356 (15%)
RILP-like 964..1097 CDD:304877 27/208 (13%)
eIF-4B <1042..1099 CDD:283846 14/87 (16%)
COG6 1375..>1510 CDD:303003 26/166 (16%)
TMPIT 1456..>1584 CDD:285135 25/179 (14%)
TMPIT 1741..>1828 CDD:285135 17/93 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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