DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and myo7aa

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_021323248.1 Gene:myo7aa / 252846 ZFINID:ZDB-GENE-020709-1 Length:2185 Species:Danio rerio


Alignment Length:3419 Identity:696/3419 - (20%)
Similarity:1078/3419 - (31%) Gaps:1525/3419 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 EGDLVWFDPGMGH----PIPGEIQEVHRAAQVIVVQALIKGKMRIVRFHLEPWQRGGGGSVTPSP 65
            :||.||.|...||    || |.:.::..:.|:.|:..  :|.        |.|            
Zfish     6 QGDYVWLDLKTGHEFEVPI-GAVVKLCDSGQIQVLDD--EGN--------EHW------------ 47

  Fly    66 AQSPSLALLSPHVLRRQRPASLEDFEDLPNLSAKHPALPSSRLRRLKCRYPQVVKRLSTLCSDVI 130
                    :||              ::..|:...||.                            
Zfish    48 --------ISP--------------QNATNIKPMHPT---------------------------- 62

  Fly   131 ARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIY------TFAG 189
                                  ...|||||..|.||:||.:|.||.:||.:.|||      |:.|
Zfish    63 ----------------------SIHGVEDMIRLGDLNEAGILRNLLIRYREHLIYTNCGGRTYTG 105

  Fly   190 SILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALP---SPQVVVISGESGSG 251
            |||:|||||::.| .|..:..:.|..:.:|.:|||:|||....:..:.   ..|..:||||||:|
Zfish   106 SILVAVNPYQLLP-IYTADQIRLYTNKKIGEMPPHIFAIADNCYFNMQRNNKDQCCIISGESGAG 169

  Fly   252 KTESTKLVMQYLAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KS 315
            |||||||::|:|||:    ....:.|.:|:|||.|:|||||||:|.|||||||||||::::| |.
Zfish   170 KTESTKLILQFLAAI----SGQHSWIEQQVLEANPILEAFGNAKTIRNDNSSRFGKYIDIHFNKR 230

  Fly   316 GAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCA 380
            |||.||||.||||||||:..||..|||||:||.:|.|::..::.:.||.:|..|.||..|.....
Zfish   231 GAIEGAKIEQYLLEKSRVCRQARDERNYHIFYCMLKGMTPDQKKQLGLSKATDYTYLTIGNCTVC 295

  Fly   381 SGRVD---WESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIK 442
            .||.|   :.:::.||:||..::.|...|.::|||:||:||:.:..|.. ...:..||...:.:.
Zfish   296 DGRDDQKEYSNIRSAMKVLMFTDKENWEISKLLAAILHMGNLRYEARTY-DNLDACEVVRCSALT 359

  Fly   443 WAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIV 507
            .||.||.:....|...|||||...|.|.:.|||.|:||||.||||.|.:|..||.|:|.:||:.:
Zfish   360 TAAVLLEVDLKDLMNCLTSRTIITRGETVSTPLSIEQALDVRDAFVKGIYGRLFVWIVEKINAAI 424

  Fly   508 QKGGTHD----AHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLE 568
            .|..:.:    ...|.:|||||||:...|||||||||:||||||.:|.:|||||||.||..|.:.
Zfish   425 YKPPSLELKAVRRSIGLLDIFGFENFMVNSFEQLCINFANENLQQFFVRHVFKLEQEEYNLENIN 489

  Fly   569 WTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQ-E 632
            |..:.:.||...:.::|.||:.|..|:|:||.||:.||.:.|.|.:..|.|:..|..|:...: :
Zfish   490 WQHIEFTDNQDALDMIAIKPMNIISLIDEESKFPKGTDTTMLNKLNSQHKLNTNYIPPKNTYETQ 554

  Fly   633 FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGR 697
            ||:.|:||.|:|...|||:||||.|.||:::|:.||:    .:..||: .|.|    :..|:..|
Zfish   555 FGIQHFAGVVYYETRGFLEKNRDTLHGDIIQLVHSSK----NKFIKQI-FQAD----VAMGAETR 610

  Fly   698 FVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDT 762
                 .|:||::::|..||:.|::::..|.|:||||||||:.|..:..|....::||||.||::|
Zfish   611 -----KRSPTLSSQFKRSLELLMRTLSVCQPFFVRCIKPNEYKKPMLFDRELCVRQLRYSGMMET 670

  Fly   763 IQIRQRGYPVRLRFQHFVERYRHLLP--SPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRV 825
            |:||:.|||:|..|..||:|||.|:|  .|..:....|..|:.:.||:  .| ...|:|:|.|::
Zfish   671 IRIRRAGYPIRYTFVEFVDRYRVLMPGVKPAYKQEDLRGTCQRIAEAV--LG-RDDDWQMGKTKI 732

  Fly   826 FLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLR 890
            ||::.....||..|.:.:....:.:|:.|||...|....:.:.:|..:|..|||...::.|..:|
Zfish   733 FLKDHHDMLLEIERDKAITDKVILIQKVVRGFKDRSNFLKMKKSAMLIQKTWRGYYCRKNYGAMR 797

  Fly   891 KGALTAQ-------------------------------------RLW---------RGRQARRRV 909
            .|....|                                     |||         ||..|||..
Zfish   798 GGFSRLQALYRSRKLYQTYHVARQRIMLFQGRCRGFLVRRAFRHRLWAVITIQAYTRGMIARRLY 862

  Fly   910 QQLRSDHRRRQEARE-------------AAQRAREAREAKQAVLER-SQLSYLDIPAE------- 953
            ::|:.::|||.||.:             :|::|:|  ||::...|| :||:..|...|       
Zfish   863 KRLKGEYRRRLEAEKLRLAEEQKLRNQMSARKAKE--EAEKMHQERLAQLAREDAEREKKERQEA 925

  Fly   954 ---LAFIYSKLQGWSPPHGDRHLVK----VLGTVPGPPSSAVQLP-------------------- 991
               :..:....:....|..|..:|.    .|||....|....|.|                    
Zfish   926 RRKMEMLDQMEKARQEPVNDSDMVDKMFGFLGTTNSFPGQEGQAPAGFEDLERTHRELEVEDLDE 990

  Fly   992 ---------EDLGQFSFGKFSSVYCNGLRLQP-RREPITAPLLTRAASRDQDFQDALAVFKLILR 1046
                     |||.::.|.|||:.|..|..... .|.|:..|||......||  ..||||:..:||
Zfish   991 SLPLPEDDLEDLSEYKFAKFSATYFQGTSTHTYMRRPLKQPLLFHEDEGDQ--LAALAVWITVLR 1053

  Fly  1047 WSND------------------------------------KALEG--------------AKEKLL 1061
            :..|                                    :||:|              .:.||:
Zfish  1054 FMGDLPEPKYHTAISDGSEKIPVMTKIYETLGKKTYKRELQALQGEGENTNIESHKKSSVRHKLV 1118

  Fly  1062 A--------------------DYIVH--KALSSR-------------------GLRDEILVQLCN 1085
            :                    :|.||  ..|..|                   ||||||..|:|.
Zfish  1119 SLTLKKKSKITEEVTKRLNDGEYTVHGNSMLEDRPTSNLEKLHFIIGNGILRPGLRDEIYCQICK 1183

  Fly  1086 QVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTS 1150
            |::..|..|..| |.|.|:..|:.||.||..|.|||..|: .|.|....|....:|.|....|| 
Zfish  1184 QLNQNPSKSSHA-RGWILMSLCVGCFAPSEKFVKYLRNFI-SEGPPGYAPYCEERLRRTFVNGT- 1245

  Fly  1151 SGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVAS 1215
                     |:..|:|||.:|......:.||:|..|..::|:..||.|:.               
Zfish  1246 ---------RTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTA--------------- 1286

  Fly  1216 RGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPP 1280
                                        ||||.|                               
Zfish  1287 ----------------------------KELCNA------------------------------- 1292

  Fly  1281 PAPPTSSGKEDVPRERRSSRELLSRSSALNERY--------FEREPSPGPGQGSSTGQAKSRSKS 1337
                                  ||...:|.:|:        |::..|.|.|.             
Zfish  1293 ----------------------LSDKISLQDRFGFSLYIALFDKVSSLGSGN------------- 1322

  Fly  1338 LDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHA 1402
                  ..::...:.|:                                  :|.|.|.|..|:  
Zfish  1323 ------DHVMDAVSQCE----------------------------------QYAKEQGAQERN-- 1345

  Fly  1403 ASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLD 1467
                                        ||....                |..::|:|..|    
Zfish  1346 ----------------------------APWRLF----------------FRKEIFTPWHD---- 1362

  Fly  1468 ELSDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGV 1532
                                                                             
Zfish  1363 ----------------------------------------------------------------- 1362

  Fly  1533 ASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLM 1597
                                                                             
Zfish  1363 ----------------------------------------------------------------- 1362

  Fly  1598 QLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPA 1662
                     ||           :.|:|.|| |.||::                            
Zfish  1363 ---------PA-----------EDAVATNL-IYQQIV---------------------------- 1378

  Fly  1663 PPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGR 1727
                                                                             
Zfish  1379 ----------------------------------------------------------------- 1378

  Fly  1728 AKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASA 1792
             :.|:.|::|                                                       
Zfish  1379 -RGVKFGEYR------------------------------------------------------- 1387

  Fly  1793 TAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLA 1857
                                                                             
Zfish  1388 ----------------------------------------------------------------- 1387

  Fly  1858 KKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQ 1922
                   .||                                            ||..:|..||.
Zfish  1388 -------CDR--------------------------------------------EDLAELASQQY 1401

  Fly  1923 LGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPI 1987
                                                                             
Zfish  1402 ----------------------------------------------------------------- 1401

  Fly  1988 RPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSH 2052
                                        |....|:::.|.:.:.|..                  
Zfish  1402 ----------------------------YVDYGSEILVERLLSLIPS------------------ 1420

  Fly  2053 HLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRE 2117
              ::.|...||:..|..|.|                                             
Zfish  1421 --YIPDREISSAKTVERWAQ--------------------------------------------- 1438

  Fly  2118 RERERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEHERK 2182
                                        .|.|:      |::                       
Zfish  1439 ----------------------------FIMAA------HKK----------------------- 1446

  Fly  2183 RKSSASSGMREELDSMHMTTPPPVIVPAPVPPPSSTSPGLGVVSGVLMGSGSGGSTACLTYNRVP 2247
                                                                             
Zfish  1447 ----------------------------------------------------------------- 1446

  Fly  2248 WKLRVRKEVFQPHEPIGPPVALDLLFAQVLGDVFGVTPCLRITPQEKSSALNMLHGHGVSVDTLS 2312
                                              ||....|:.||:                   
Zfish  1447 ----------------------------------GVYTQKRVDPQK------------------- 1458

  Fly  2313 NRNGSGAGGGGNGGQVRALVKRHLVDMAR-DWPLYFARL---FAVQGAPLYPDVSIMGVSHSGLY 2373
                               ||..:||.|| .|||.|:|.   |...|..|..:..|:.|:.:|:|
Zfish  1459 -------------------VKEEVVDFARYKWPLLFSRFYEAFKFSGPSLPKNDVIVAVNWTGVY 1504

  Fly  2374 LARRDADYLIVVQAISFGEIQSAVTLPRPAALQ-----LNLRNGKHLALHAARAAAIQSMVTTFV 2433
            ........|:   .:||.|| :||:..:...||     |...........:..|..|:.:|.||:
Zfish  1505 FVDEQEQVLL---ELSFPEI-TAVSSSKGGKLQAQSFTLATIKADEFTFTSNNAEDIRDLVVTFL 1565

  Fly  2434 QEFRKSQSKASTLSSGARAAAQTLN---------VPLERLESRQAHAQRNEHGVDGGSRQNEQLQ 2489
            :..||.......|......||....         :.|::....|.......||.:..::|.....
Zfish  1566 EGLRKRSKFVVALQDNPSPAADDSTFLSFLKGDLIVLDQDTGEQVMTSGWAHGTNDRTKQRGDFP 1630

  Fly  2490 QSELHHHLQQQQQQQQQQQHHQQQQQQQQLEDAMEEQH----MATDHQQQQQQQLGQQQGQQQRF 2550
            ...::                       .|...:...|    ..|....|:|:.|          
Zfish  1631 ADCVY-----------------------VLPTVVRPPHDVVAFVTMTPDQRQESL---------- 1662

  Fly  2551 LKQQSYLHSARKSNAGQQPSSLTNGQVHHQEQMLQQQQQQSQSLPHHDLDANYLQDESNGGTPPS 2615
                                     ::.|...:.:.:::                          
Zfish  1663 -------------------------RISHVPALTETEER-------------------------- 1676

  Fly  2616 VTKYSLLQFAMQHFRNDQLRDADRHH-ERHQSAANRSYAELVKWQGHAIRLPLLRL---PNDLAP 2676
            |..|:|.:|:..:|     |...:|. .|.....||...:|.......|:..||:.   ..:|:.
Zfish  1677 VKPYTLEEFSYDYF-----RPPPKHTLSRVMITKNRGKDKLWCCTREPIKQALLKKCGGHEELSQ 1736

  Fly  2677 LALECFDCILRYCGDIPLDPDLTEVKCVYTVLMHCHKYLALRDEVYCQLMKQTTANRSPCPDSSQ 2741
            .|...|..:::|.||.|.....:..:....:.....|...|:||:|||::||.|.|.  ...|.:
Zfish  1737 EACMAFIAVMKYMGDYPSKRTRSVNELTDQIFEGALKAEPLKDEIYCQILKQLTENH--IKYSEE 1799

  Fly  2742 RAWRLLSILAAYFGCSDALRPYLMEHLTSAASDRRRSCHGTAAVCLTNLRKTARCGGRKNVPSVE 2806
            :.|.||.:....|..|:.|.|::...|.|      :..|..|..|:..|:|..|.|.||..|.:.
Zfish  1800 KGWELLWLCVGLFPPSNVLLPHVQRFLQS------KKHHPLALDCMQRLQKALRNGSRKYPPHLV 1858

  Fly  2807 EVTAVSAGRSARRQIYR---LPGGAERVVNTRCSTVVADVIAELCALLGVESEAEQQEFSLYCIV 2868
            ||.|:   :....||:.   .|...:.......||...|....:.:.|.:::   .:.|||:..:
Zfish  1859 EVEAI---QHKTTQIFHKVYFPDDTDEAFEVESSTKAKDFCLNISSRLLLKT---PEGFSLFVKI 1917

  Fly  2869 QGDAFTMPLAADEYILDVT---TELLKSGQP----------FYLIFCRSVWHFALKREPAPMPLY 2920
            .....::|  ..::..|..   |:.:|..:|          :.:.|.:.:|...:..:.:    :
Zfish  1918 SDKVISVP--EGDFFFDFVRHLTDWIKKARPAKDGIVPSLTYQVFFMKKLWTTTVPGKDS----F 1976

  Fly  2921 VEVLFN--QVAPDYLEGLLLELPGNGVPVPEMVR-DMARIAALLHRAA---DLSHVPAM-KEIKF 2978
            .:.:|:  |..|.||.|           ..:..| ::.::.||::|..   |.||.|:: |.:|.
Zfish  1977 ADSIFHYYQELPKYLRG-----------YHKCSREEVFQLGALIYRVKFEDDKSHFPSIPKMLKE 2030

  Fly  2979 LLPKPALGIREIRPAQWVGLVQSAWPQVANLSPGQVKAQFLNVLATWPLFGSSFFAVKRIWAEEG 3043
            ::|:..  ||::.|..|...:.:.:.:.|..|..:.|..||.::..||.|||:||.||:......
Zfish  2031 MIPQDL--IRQLSPDDWKRSIVAYFNRHAGKSREEAKLMFLKIIFKWPTFGSAFFEVKQTTEPHF 2093

  Fly  3044 PHVEDNHSPMWRDLILALNRRGVLFLDPNTHETLQHWSFMEVISTRKVRSEDGALFLDMKVGNLM 3108
            |.:          |::|:|:.||..:||...:.|..:.|.::.:.     ..|..:..:.:|||:
Zfish  2094 PEI----------LLIAINKYGVSLIDPKNKDILTTYPFTKISNW-----SSGNTYFHITIGNLV 2143

  Fly  3109 QQRVIRVQTEQAHEISRLVRQYI-----TMAQISQRDKR 3142
            |...:..:|...:::..|:..||     ||::  ||:.|
Zfish  2144 QGSKLLCETSLGYKMDDLLTSYISQMLTTMSK--QRNSR 2180

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 303/699 (43%)
MYSc_Myo15 169..828 CDD:276838 293/678 (43%)
MyTH4 1014..1171 CDD:295320 61/248 (25%)
MyTH4 2704..2810 CDD:279165 33/105 (31%)
B41 2823..3033 CDD:214604 46/232 (20%)
FERM_B-lobe 2920..3025 CDD:271216 26/111 (23%)
FERM_C_MyoXV 3029..3138 CDD:270022 27/113 (24%)
myo7aaXP_021323248.1 MYSc_Myo7 79..735 CDD:276832 293/678 (43%)
IQ 772..793 CDD:197470 5/20 (25%)
MAP7 <863..941 CDD:310345 17/79 (22%)
UFD1 893..>1160 CDD:332114 52/270 (19%)
MyTH4 1023..1259 CDD:214535 62/249 (25%)
B41 1265..1479 CDD:214604 81/1180 (7%)
FERM_C1_MyoVII 1473..1571 CDD:270019 26/101 (26%)
SH3 1572..1636 CDD:327375 8/86 (9%)
MyTH4 1716..1864 CDD:214535 44/158 (28%)
B41 1871..2083 CDD:214604 46/233 (20%)
FERM_C2_MyoVII 2079..2174 CDD:270020 26/109 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.