DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and Myo5b

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_008770307.1 Gene:Myo5b / 25132 RGDID:621347 Length:1854 Species:Rattus norvegicus


Alignment Length:1563 Identity:423/1563 - (27%)
Similarity:676/1563 - (43%) Gaps:330/1563 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   156 GVEDMTLLDDLHEASLLWNLRLRY-DKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            |..|:|.|..|||.::|.||::|: :...|||:.|.:|:|:|||:..| .||.:|...|:|:.:|
  Rat    78 GENDLTALSHLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLP-IYGQDVIYAYSGQNMG 141

  Fly   220 SLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAV-ITEQ 280
            .:.||:||:...|:..:   ...|.:::|||||:|||.|.|..|:|.|.|   |||||.. |.|:
  Rat   142 DMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATV---GGSASDTNIEEK 203

  Fly   281 ILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYH 344
            :|.::|::||.|||:|.|||||||||||:|:.| |...|:||.:..|||||||:|.||..|||||
  Rat   204 VLASSPIMEAIGNAKTTRNDNSSRFGKYIEIGFDKKYHIIGANMRTYLLEKSRVVFQADDERNYH 268

  Fly   345 VFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASG---RVDWESLQGAMQVLGVSEGEREGI 406
            :||:|....|..|..:..|..|:.:||...|......|   ..|:|..:.|:.:|||.|..:..|
  Rat   269 IFYQLCAAASLPEFKELALTCAEDFFYTAHGGNTTIEGVDDAEDFEKTRQALTLLGVRESHQISI 333

  Fly   407 VRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERL 471
            .:::|::||||:|.....  |.|........|..:.....||.|....:...|..|.....:|..
  Rat   334 FKIIASILHLGSVEIQAE--RDGDSCSISPQDEHLSNFCRLLGIEHSQMEHWLCHRKLVTTSETY 396

  Fly   472 HTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQ 536
            ...:.:.|.::||:|.||.:||.||:|:|..||..:|......:. |.:|||:|||....|||||
  Rat   397 VKTMSLQQVVNARNALAKHIYAQLFSWIVEHINKALQTSLKQHSF-IGVLDIYGFETFEINSFEQ 460

  Fly   537 LCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNF 601
            .|||||||.||..||.|||||||.||.:|::.||.:.:.||.|.|.|:..| :||..|||:|...
  Rat   461 FCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAK-LGILDLLDEECKV 524

  Fly   602 PRATDLSFLEKCHYNHALSELYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLA 666
            |:.||.::.:|.:..|:.|:.:.:||:....|.|.|:|.:|.|..||||:||||.:..:.:.:|.
  Rat   525 PKGTDQNWAQKLYERHSNSQHFQKPRMSNTAFIVIHFADKVEYLSDGFLEKNRDTVYEEQINILK 589

  Fly   667 SSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTP-----------TVAARFADSLQQLL 720
            :|:.|||.:|.:..:....|..|....|:.: :.::...|           :|..:|..||..|:
  Rat   590 ASKFPLVADLFRDDKDSVPATNTAKSRSSSK-INVRSSRPLMKAPNKEHKKSVGYQFRTSLNLLM 653

  Fly   721 QSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRH 785
            :::....|.:|||||||.||.....|....:||||..|:|:||:|...|||.|..:..|..|||.
  Rat   654 ETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWTYHDFFNRYRV 718

  Fly   786 LLPS-PLARGTPYRELCRALLEAMPRTGVEGPD-YQLGATRVFLREALHRALESGRTERLRRAAV 848
            |:.. .||..|..:.:|:::||::    ::.|| :|.|.|::|.|......||..|.::.|.|.:
  Rat   719 LMKKRELANTTDKKNICKSVLESL----IKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFREATI 779

  Fly   849 SVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLR 913
            .:|:.|||.|.|                       .:|.|||...||.||..||..|||     .
  Rat   780 MIQKTVRGWLQR-----------------------VKYRRLRAATLTLQRFCRGYLARR-----L 816

  Fly   914 SDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLG 978
            ::|.||..|                                |.::.|                  
  Rat   817 TEHLRRTRA--------------------------------AIVFQK------------------ 831

  Fly   979 TVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKL 1043
                             |:...|....||     :.||..:.....|||....:.::..|...|.
  Rat   832 -----------------QYRMLKARRAYC-----RVRRAAVIIQSYTRAMCVRRSYRQVLTEHKA 874

  Fly  1044 IL------RWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQ 1102
            .:      .|...:..:..::..:......:.|.:|.....:.::..:..|....|.|...::.|
  Rat   875 TIIQKYARGWMARRHFQRQRDAAIVIQCAFRRLKARQALKALKIEARSAEHLKRLNVGMENKVVQ 939

  Fly  1103 LLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWL 1167
                              |.|.:||:..|      .:.|..|....||:.|:.....:..:..:.
  Rat   940 ------------------LQRKIDDQNKE------FKTLSEQLSAVTSTHAMEVEKLKKELARYQ 980

  Fly  1168 EWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDD------GQ 1226
            :    .:..|.:|.|   .|..|::..:...:..|..                ||:|      |:
  Rat   981 Q----NQEADPSLQL---QEEVQSLRTELQKAHSERR----------------VLEDTHNRENGE 1022

  Fly  1227 QLTDSCGLDYVMDLIA-EKELCPAFPAPRSDLLR-SGAKFARTTLPDAVKRPAVPPPAPPTSSGK 1289
            .......|::...|:. |||..      .:.:|| |.|:.:::::.:.:..             |
  Rat  1023 LRKRVADLEHENALLKDEKEHL------NNQILRQSKAESSQSSVEENLLI-------------K 1068

  Fly  1290 EDVPRERRSSRELLSRSSALNERYFE-REPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDC 1353
            :::..||...:.|:...|.|.:||.. |:....||...:    .|...||:.             
  Rat  1069 KELEEERSRYQNLVKEYSQLEQRYENLRDEQQTPGHRKN----PSNQSSLES------------- 1116

  Fly  1354 DSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPR----YQKSQHAGRRSHAASHGSHSSKYAD 1414
            ||..|    .:|.|.:.|...:.:::..:|.:....    :.|.|...|...     ....|...
  Rat  1117 DSNYP----SISTSEIGDTEDALQQVEEIGIEKAAMDMTVFLKLQKRVRELE-----QERKKLQV 1172

  Fly  1415 KAEYATRSSAMSDTSEAPSLASHVRRVRVPSQAS--DVDQFLDDLFSPVLDGSLDELSDARSLAA 1477
            :.|...:.|               ::|:|..|.:  ||||..|..::.:                
  Rat  1173 QLEKEQQDS---------------KKVQVEQQNNGLDVDQDADIAYNSL---------------- 1206

  Fly  1478 SIRGGSYEQENEAESEIDDLDDYINDIFQPI--PLVQNLEKLTSKDQLAAIIKGGGVASKP-EER 1539
                    :..|.|||...|.:.:|::.:.:  ..:|:....:|.|..:.::....:|::. |.|
  Rat  1207 --------KRQELESENKKLKNDLNELRKAVADQAMQDNSTHSSPDSYSLLLNQLKLANEELEVR 1263

  Fly  1540 DEE-----SEIEDLDD--YINELFEPIPVAEGLDKLT----SKEHLAVSIRGGGSTDSNGADPLL 1593
            .||     ::|.:.|.  ...:..||     .::..|    |::|:          |...|....
  Rat  1264 KEEVLILRTQIMNADQRRLSGKNMEP-----NINARTSWPNSEKHV----------DQEDAIEAY 1313

  Fly  1594 HQLMQLPGETESGPAL---------YQ--QQVQRAFLQSAMAQNLQIQQQ---LLAQNQALQTLL 1644
            |.:.|...:||....|         ||  :||.|.......||||:.:::   |.||.:|::..:
  Rat  1314 HGVCQTNSQTEDWGYLNEDGELGLAYQGLKQVARLLEAQLQAQNLKHEEEVEHLKAQVEAMKEEM 1378

  Fly  1645 SQQ 1647
            .:|
  Rat  1379 DKQ 1381

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 269/701 (38%)
MYSc_Myo15 169..828 CDD:276838 261/680 (38%)
MyTH4 1014..1171 CDD:295320 24/162 (15%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
Myo5bXP_008770307.1 MYSc 72..770 CDD:214580 271/704 (38%)
MYSc_Myo5 91..759 CDD:276831 261/680 (38%)
IQ 871..891 CDD:197470 2/19 (11%)
DUF1690 910..1002 CDD:285231 20/122 (16%)
Rab5-bind 919..1179 CDD:286404 59/351 (17%)
RILP-like <979..1069 CDD:304877 19/131 (15%)
Uso1_p115_C 1155..1267 CDD:282695 27/155 (17%)
GBP_C <1340..1416 CDD:303769 13/42 (31%)
coiled coil 1385..1396 CDD:293879
coiled coil 1405..1416 CDD:293879
Myo5b_CBD 1480..1851 CDD:271261
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.810

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