DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and Myo5a

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_038936774.1 Gene:Myo5a / 25017 RGDID:3143 Length:1880 Species:Rattus norvegicus


Alignment Length:1705 Identity:460/1705 - (26%)
Similarity:731/1705 - (42%) Gaps:401/1705 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   116 PQVVKRLSTLCSD------VIARHPQTFALQPGEGSLRARQDLGSS------------GVEDMTL 162
            |:.|.:.:.|..|      |:..|     |:.|: .|..|.|..:|            |..|:|.
  Rat    18 PEEVWKSAELLKDYKPGDKVLLLH-----LEEGK-DLEYRLDPKTSELPHLRNPDILVGENDLTA 76

  Fly   163 LDDLHEASLLWNLRLRY-DKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLF 226
            |..|||.::|.|||:|: |..||||:.|.:|:|:|||:..| .||.::...|:|:.:|.:.||:|
  Rat    77 LSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLP-IYGEDIINAYSGQNMGDMDPHIF 140

  Fly   227 AIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQILEAAPLL 288
            |:...|:..:...   |.:::|||||:|||.|.|..|:|.|.|  .|.::.|.:.|::|.:.|::
  Rat   141 AVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATV--SGSASEANVEEKVLASNPIM 203

  Fly   289 EAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGG 352
            |:.|||:|.|||||||||||:|:.| |...|:||.:..|||||||:|.||..|||||:||:|...
  Rat   204 ESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCAS 268

  Fly   353 LSETERSKYGLLEADKYFYLNQGATDCASGRVDWESL---QGAMQVLGVSEGEREGIVRVLAAVL 414
            ....|.....|..||.:.|..||.:....|..|.:.:   :.|..:||:||..:.||.|:||.:|
  Rat   269 AKLPEFKMLRLGNADSFHYTKQGGSPMIEGVDDAKEMAHTRQACTLLGISESYQMGIFRILAGIL 333

  Fly   415 HLGNVYFHRRQL-------RHGQEGVEVGSD---AEIKWAAHLLHISADGLHRALTSRTTEARAE 469
            |||||.|..|..       :|  |.:.:..|   .:.:...|.|      .||.|.:.|     |
  Rat   334 HLGNVGFASRDSDSCTIPPKH--EPLIIFCDLMGVDYEEMCHWL------CHRKLATAT-----E 385

  Fly   470 RLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR----ISILDIFGFEDLA 530
            ....|:...||.:||||.||.:||.||||:|..:|..:     |.|.:    |.:|||:|||...
  Rat   386 TYIKPISKLQATNARDALAKHIYAKLFNWIVGHVNQAL-----HSAVKQHSFIGVLDIYGFETFE 445

  Fly   531 ENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLL 595
            .|||||.|||||||.||..||.|||||||.||.:|::.||.:.:.||.|.|:|:..| :||..||
  Rat   446 INSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESK-LGILDLL 509

  Fly   596 DDESNFPRATDLSFLEKCHYNHALSE--LYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALR 658
            |:|...|:.||.::.:|. ||..|::  |:.:||:..:.|.:.|:|.:|.|..:|||:||:|.:.
  Rat   510 DEECKMPKGTDDTWAQKL-YNTHLNKCALFEKPRMSNKAFIIKHFADKVEYQCEGFLEKNKDTVF 573

  Fly   659 GDVLELLASSRLPLVGELTK------QLRAQRDAGKT----LP----KGSNGRFVTMKPRTPTVA 709
            .:.:::|.||:..::.||.:      ...:...:|:|    :|    ||..|:  |.|....||.
  Rat   574 EEQIKVLKSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRVPVKPTKGRPGQ--TAKEHKKTVG 636

  Fly   710 ARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRL 774
            .:|.:||..|::::....|.:|||||||..|.....|....:||||..|:|:||:|...|:|.|.
  Rat   637 LQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRW 701

  Fly   775 RFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGR 839
            .:|.|..|||.|:......| ..::.|:.:||.:.   ::...||.|.|::|.|......||..|
  Rat   702 TYQEFFSRYRVLMKQKDVLG-DRKQTCQNVLEKLI---LDKDKYQFGKTKIFFRAGQVAYLEKLR 762

  Fly   840 TERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQ--QRYERLRKGALTAQRLWRG 902
            .::||.|.:.:|:.:||.|:|::....|.||..:|...||.:|:  .::.|..|.|.|.|:.||.
  Rat   763 ADKLRAACIRIQKTIRGWLLRKRYLCMQRAAITVQRYVRGYQARCYAKFLRRTKAATTIQKYWRM 827

  Fly   903 RQARRRVQQLRSDHRRRQEAREAAQ---RAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGW 964
            ...||:       ::.|:.|....|   |...||...:.:|...         :...|..:::||
  Rat   828 YVVRRK-------YKIRRAATIVLQSYLRGYLARNRYRKILREH---------KAVIIQKRVRGW 876

  Fly   965 -SPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAA 1028
             :..|..|.:..::                          .:.|...|:..:||.....:..|:.
  Rat   877 LARTHYKRTMKAII--------------------------YLQCCFRRMMAKRELKKLKIEARSV 915

  Fly  1029 SRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPN 1093
            .|          :|        |...|.:.|::.   :.:.:..:....:.|::....:.|    
  Rat   916 ER----------YK--------KLHIGMENKIMQ---LQRKVDEQNKDYKCLMEKLTNLEG---- 955

  Fly  1094 SGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGA 1158
                                           |.:...|.||..:.|..|.::....::|.|    
  Rat   956 -------------------------------VYNSETEKLRNDVERLQLSEEEAKVATGRV---- 985

  Fly  1159 CRSFVPAWLEWRAWTRGCDMALPLTLPDEAS-------QTVAVDSWTSCEEAAALAVSSLGVASR 1216
                                   |:|.:|.:       ||.:...  |.||.|            
  Rat   986 -----------------------LSLQEEIAKLRKDLEQTRSEKK--SIEERA------------ 1013

  Fly  1217 GWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPP 1281
                  |..:|.|:    ..|.:|..|..|........:.|:...||    .:.:.::|..|   
  Rat  1014 ------DKYKQETE----QLVSNLKEENTLLKQEKETLNHLMVEQAK----EMTETMERKLV--- 1061

  Fly  1282 APPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDI 1346
             ..|...:.|:..||...:.||:..|.|.|||                         |||     
  Rat  1062 -EETKQLELDLNDERLRYQNLLNEFSRLEERY-------------------------DDL----- 1095

  Fly  1347 VPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSK 1411
                     :|.: ||.|:..:                           .|.:...::|.|:.|:
  Rat  1096 ---------KEEM-TLMLNVPK---------------------------PGHKRTDSTHSSNESE 1123

  Fly  1412 YADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFL------------DDLFSPVLDG 1464
            |...:|:| .:..::..:|.|:      ..:||   .|:..||            ..|....||.
  Rat  1124 YTFSSEFA-ETEDIAPRTEEPT------EKKVP---LDMSLFLKLQKRVTELEQEKQLMQDELDR 1178

  Fly  1465 SLDELSDARSLA-----ASIRGGSYEQEN----EAESEIDDLDDYINDIFQPI-----PLVQN-- 1513
            ..:::  .||.|     ..|||...|.|:    |.|||...|.:.:|::.:.:     |.|..  
  Rat  1179 KEEQV--LRSKAKEEERPQIRGAELEYESLKRQELESENKKLKNELNELRKALSEKSAPEVTAPG 1241

  Fly  1514 -------LEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSK 1571
                   :|:||:..:...:.|...:..:.:...::..|:..||. |.:.:...:.|.:.|:..|
  Rat  1242 APAYRVLMEQLTAVSEELDVRKEEVLILRSQLVSQKEAIQPKDDK-NTMTDSTILLEDVQKMKDK 1305

  Fly  1572 EHLAVSIRGGGSTDSNGADPLLHQLMQLPGE-------TESGPALYQQQVQ-------------R 1616
            ..:|.:..  |..::|.:..:.:|.:...||       .:....|.:.|:|             |
  Rat  1306 GEIAQAYI--GLKETNRSSAMDYQELNEDGELWLVYEGLKQANRLLESQLQSQKRSHENEAEALR 1368

  Fly  1617 AFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMR 1681
            ..:||...:|.: ||||||||  ||.....:..|:..:..|...........|....|......|
  Rat  1369 GEIQSLKEENNR-QQQLLAQN--LQLPPEARIEASLQHEITRLTNENLYFEELYADDPKKYQSYR 1430

  Fly  1682 MKATRSSLVVMESLQ 1696
            :...:..:.:||.|:
  Rat  1431 ISLYKRMIDLMEQLE 1445

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 275/717 (38%)
MYSc_Myo15 169..828 CDD:276838 267/696 (38%)
MyTH4 1014..1171 CDD:295320 18/156 (12%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
Myo5aXP_038936774.1 COG5022 7..1275 CDD:227355 422/1527 (28%)
MYSc_Myo5 83..751 CDD:276831 267/696 (38%)
Smc 1157..>1484 CDD:224117 61/297 (21%)
Myo5a_CBD 1506..1880 CDD:271262
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.810

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