DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and myhz2

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_694514.2 Gene:myhz2 / 246275 ZFINID:ZDB-GENE-020604-1 Length:1935 Species:Danio rerio


Alignment Length:2159 Identity:485/2159 - (22%)
Similarity:848/2159 - (39%) Gaps:522/2159 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.::..|:|.|:|:||:.||...:|||::|.....|||||..| .|..||...|.|:.....
Zfish    89 IEDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLP-VYDAEVVAAYRGKKRMEA 152

  Fly   222 PPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAV-VPGG--------GSAS 274
            |||:|::...|:..:.:.   |.|:|:||||:|||.:||.|:||.|.| |.||        |...
Zfish   153 PPHIFSVSDNAYQFMLTDRENQSVLITGESGAGKTVNTKRVIQYFATVAVQGGDKKKEQAAGKMQ 217

  Fly   275 AVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAP 338
            ..:.:||:.|.|||||:|||:|.||||||||||::.::| .||.:..|.|..|||||||:..|.|
Zfish   218 GSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSGKLASADIETYLLEKSRVTFQLP 282

  Fly   339 GERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRV------DWESL---QGAMQ 394
            .||.||:||:::.. .:.|..:..|:..:.|.:     ..|:.|::      |.|.|   ..|:.
Zfish   283 DERGYHIFYQMMTN-HKPELIEMTLITTNPYDF-----PMCSQGQITVASIDDKEELVATDTAID 341

  Fly   395 VLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRAL 459
            :||.:..|:.||.:...||||.||:.|.::|   .:|..|.....|....|:||.:::..:.:||
Zfish   342 ILGFTGEEKMGIYKFTGAVLHHGNMKFKQKQ---REEQAEPDGTEEADKIAYLLGLNSADMLKAL 403

  Fly   460 TSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIF 524
            .....:...|.:.....:.|..::..|.:|::|..:|.|:|.|||.::......:.. |.:|||.
Zfish   404 CYPRVKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVIRINQMLDTKQQRNFF-IGVLDIA 467

  Fly   525 GFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPV 589
            |||....||.||||||:.||.||.:||.|:|.|||.||.:|.:.|..:.:..:|.....|.:||:
Zfish   468 GFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMDLAACIELIEKPL 532

  Fly   590 GICHLLDDESNFPRATDLSFLEKCHYNHALSELYA----RPRIGAQE--FGVTHYAGQVWYCVDG 648
            ||..:|::|..||:|||.||..|.:..| |.:..|    :|..|..|  |.:.||||.|.|.:.|
Zfish   533 GIFSILEEECMFPKATDTSFKNKLYDQH-LGKCNAFQKPKPAKGKAEAHFSLVHYAGTVDYNISG 596

  Fly   649 FLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFA 713
            :||||:|.|...|::|...|.:.|:..|...:..:...||   ||...:..:|:    ||:::|.
Zfish   597 WLDKNKDPLNESVVQLYQKSSVKLLATLYPPVVEETGGGK---KGGKKKGGSMQ----TVSSQFR 654

  Fly   714 DSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQH 778
            ::|.:|:.::...||.||||:.||:.|....|:...|:.|||..|:|:.|:|.::|:|.|:.:..
Zfish   655 ENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYGD 719

  Fly   779 FVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERL 843
            |.:||:.|..|.:..| .:.:..:|..:.:....|...:|:.|.|:||.:..|...||..|.|:|
Zfish   720 FKQRYKVLNASVIPEG-QFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFKAGLLGTLEEMRDEKL 783

  Fly   844 RRAAVSVQRHVRGMLVRRQ----LARRQAAATRLQ---------ARWRGQRAQQRYERLRKGALT 895
            .......|...|..|:||:    :.||::..| :|         ..|...:...:.:.|.|.|.|
Zfish   784 ATLVTMTQALCRAYLMRREFVKMMERRESIYT-IQYNIRSFMNVKHWPWMKVYYKIKPLLKSAET 847

  Fly   896 AQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVL--ERSQLSYLDIPAE---LA 955
            .:.|          ..::.|..:.:||...|:..::..|.|...|  |::.|. |.:.:|   |:
Zfish   848 EKEL----------ATMKEDFVKCKEALAKAEAKKKELEEKMVALLQEKNDLQ-LAVASESENLS 901

  Fly   956 FIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPIT 1020
            ....:.:|         |:|          |.:||...|.:.:           .||:...| |.
Zfish   902 DAEERCEG---------LIK----------SKIQLEAKLKETT-----------ERLEDEEE-IN 935

  Fly  1021 APLLTRAASRDQDFQDALAVFKLILRWSNDKALEGA---KEKLLADYIVHKALSSRGLRDEILVQ 1082
            |.|    .::.:..:|..:..|..:   :|..|..|   |||...:..|.........:||.:.:
Zfish   936 AEL----TAKKRKLEDECSELKKDI---DDLELTLAKVEKEKHATENKVKNLTEEMASQDESIAK 993

  Fly  1083 LCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGG 1147
            |..:...|                                                 |...||  
Zfish   994 LTKEKKAL-------------------------------------------------QEAHQQ-- 1007

  Fly  1148 GTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLG 1212
                                               ||.|..::...|::.|..:....       
Zfish  1008 -----------------------------------TLDDLQAEEDKVNTLTKSKTKLE------- 1030

  Fly  1213 VASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDL------LRSGAKFARTTLPD 1271
                         ||:.|..|     .|..||:|       |.||      |....|.|:.::.|
Zfish  1031 -------------QQVDDLEG-----SLEQEKKL-------RMDLERAKRKLEGDLKLAQESIMD 1070

  Fly  1272 AVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSK 1336
            ...         .....:|.:.::...:.:|||:        .|.|.|.|........:.::|.:
Zfish  1071 LEN---------DKQQSEEKIKKKDFETAQLLSK--------IEDEQSLGAQLQKKIKELQARIE 1118

  Fly  1337 SLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQ--KSQHAG-- 1397
            .|::.:..:.. .....:.|....:..|.|        .:|||...|..|..:.:  |.:.|.  
Zfish  1119 ELEEEIEAERA-ARAKVEKQRADLSRELEE--------ISERLEEAGGATAAQIEMNKKREAEFQ 1174

  Fly  1398 --RRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRV--RVPSQASDVDQFLDDLF 1458
              ||....|...|.:..|     |.|.......:|......:::||  ::..:.|:....:|||.
Zfish  1175 KLRRDLEESTLQHEATAA-----ALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEIDDLS 1234

  Fly  1459 SPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQ--NLE---KLT 1518
            |     :::.::.|::....:.....:|.:|.:|:.|:....|||:......:|  |.|   :|.
Zfish  1235 S-----NMEAVAKAKANLEKMCRTVEDQLSEIKSKNDENLRQINDLSAQRARLQTENGEFGRQLE 1294

  Fly  1519 SKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGS 1583
            .|:.|.:.:..|..|.       ..:||:|...|.|            ::.:|..||.:::..  
Zfish  1295 EKEALVSQLTRGKQAF-------TQQIEELKRQIEE------------EVKAKNALAHAVQSA-- 1338

  Fly  1584 TDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQ--------NLQIQQQLLAQNQAL 1640
              .:..|.|..|.    .|.:...|..|:.:.:|  .|.:||        .:|..::|....:.|
Zfish  1339 --RHDCDLLREQF----EEEQEAKAELQRGMSKA--NSEVAQWRTKYETDAIQRTEELEESKKKL 1395

  Fly  1641 QTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPP 1705
            ...|.:......|.||.        .:||.      ::..|::.....|::              
Zfish  1396 AQRLQEAEEQIEAVNSK--------CASLE------KTKQRLQGEVEDLMI-------------- 1432

  Fly  1706 MPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQ----------TEEDFFAFKMRQ 1760
                 :.:..:.....||...|.....:.:|:....:.:.:.:          ||    .|||:.
Zfish  1433 -----DVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTE----LFKMKN 1488

  Fly  1761 HQRKTTPQAQHHQMTSNGGMMESGP-----GARGAS-------ATAIEWEEFEIESP------TP 1807
            ...:|..|.:..:..:.....|...     |..|.|       ...:|.|:.||::.      |.
Zfish  1489 SYEETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKAKKTVETEKAEIQTALEEAEGTL 1553

  Fly  1808 PPMSGQLMRSSIRLETTTTTTTSAVNNRDRD-----RETQDVGQPMQSVVTTKLAKKSFEIGADR 1867
            .....:::|..:.|..........:..:|.:     |.:|.|.:.|||.:.:::..::..:...:
Zfish  1554 EHEESKILRVQLELNQVKGEIDRKLAEKDEEMEQIKRNSQRVTEAMQSTLDSEVRSRNDALRIKK 1618

  Fly  1868 PPPGSVGKLKL--------SSEMRQRLEQVTAG------HSVRSTVSTKSEQRAPAKLEDTRKLM 1918
            ...|.:.::::        ::|.:::|..|.|.      | :...|..:.:.:....:.:.|..:
Zfish  1619 KMEGDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLH-LDDAVRGQEDMKEQVAMVERRNTL 1682

  Fly  1919 LQQQLGGLFASVSGGNSGPG-------------GVVDSHAT--------VRTQIERMEGKLSPPP 1962
            :|.::..|.|::.....|..             |::.|..|        :.|.:.:::.::.   
Zfish  1683 MQSEIEELRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLETDLVQIQSEVE--- 1744

  Fly  1963 APPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEH 2027
                                                   .:...||:.|.:.....:.:.::.|.
Zfish  1745 ---------------------------------------DTVQEARNAEEKAKKAITDAAMMAEE 1770

  Fly  2028 VPAFIQRQERDTF------------------------------GAVRQQQMISSHHLHLED---- 2058
            :     ::|:||.                              |..:|.|.:.|....||.    
Zfish  1771 L-----KKEQDTSAHLERMKKNLEVTVKDLQHRLDEAENLAMKGGKKQLQKLESRVRELESEVEA 1830

  Fly  2059 ---HSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERER 2120
               ..|.:...|..:|:..:|.:......:...:..:.:.|:.:::..|....||   |..|:..
Zfish  1831 EQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAYKRQSE---EAEEQAN 1892

  Fly  2121 ERLYEIRQVERERE 2134
            ..|.::|:|:.|.|
Zfish  1893 SHLSKLRKVQHELE 1906

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 251/706 (36%)
MYSc_Myo15 169..828 CDD:276838 245/686 (36%)
MyTH4 1014..1171 CDD:295320 20/159 (13%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
myhz2NP_694514.2 Myosin_N 36..74 CDD:280832
Myosin_head 89..768 CDD:278492 250/698 (36%)
MYSc_class_II 101..768 CDD:276951 245/686 (36%)
SPEC 881..1043 CDD:295325 45/311 (14%)
Myosin_tail_1 882..1925 CDD:279860 208/1335 (16%)
RILP-like <1002..1096 CDD:304877 27/179 (15%)
MIT_CorA-like <1297..>1409 CDD:294313 25/140 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
22.000

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