Protein Alignment Myo10A and Myo1g

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_006514763.1
• Gene: Myo1g / 246177
• MGIID: 1927091
• Length: 1039
• Species: Mus musculus
• Alignment Length: 1000
• Identity: 334/1000 - (33%)
• Similarity: 481/1000 - (48%)
• Gaps: 187/1000 - (18%)

  Fly   177 LRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PS 238
            |:::||.|||:.|.:|::||||:..| .||.|...:|.||.|...||||:|:..||:.|:   ..
Mouse    52 LKFEKGRIYTYIGEVLVSVNPYQELP-LYGPEAIAKYQGRELYERPPHLYAVANAAYKAMKRRSR 115

  Fly   239 PQVVVISGESGSGKTESTKLVMQYLAAVV-PGGGSASAVITEQILEAAPLLEAFGNARTARNDNS 302
            ...:|||||||:||||::|.:|||:|||. |...:....:...:|::..:|||||||||.||.||
Mouse   116 DTCIVISGESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKNVLLKSTCVLEAFGNARTNRNHNS 180

  Fly   303 SRFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGL-LE 365
            ||||||:::.|. .|..||..|..|||||||::.|..||||:|.||:||.|..:.|..  || ||
Mouse   181 SRFGKYMDINFDFKGDPVGGHIHSYLLEKSRVLKQHVGERNFHAFYQLLRGSEDQELQ--GLHLE 243

  Fly   366 ADKYFY--------LNQGATDCASGRVDWESLQG---AMQVLGVSEGEREGIVRVLAAVLHLGNV 419
            .:...|        ||.|..:....  |.:|.||   ||:::|.|..|.|.|.|:|||:|||||:
Mouse   244 RNPAVYNFTRQGAGLNMGVHNALDS--DEKSHQGVMEAMRIIGFSPDEVESIHRILAAILHLGNI 306

  Fly   420 YFHRRQLRHGQE-GVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARA----ERLHTPLGIDQ 479
            .|...:....|: |:||..:|.:.:.|.|.....|.:.|.|.:||..:..    |:.||   :.:
Mouse   307 EFVETEENGPQKGGLEVADEALVGYVAKLTATPRDLVLRTLLARTVASGGREVIEKSHT---VAE 368

  Fly   480 ALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR----------ISILDIFGFEDLAENSF 534
            |..||||.|||:|..||.|:|::||||::     ..:|          |.:|||:|||....|||
Mouse   369 ASYARDACAKAMYQRLFEWVVNKINSIME-----PRNRDPRCDGKDTVIGVLDIYGFEVFPVNSF 428

  Fly   535 EQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDE- 598
            ||.||||.||.||..|.:.:.|.||.||.||.:.|..:.:.:|..::.|:.:...||..:||:.
Mouse   429 EQFCINYCNEKLQQLFIQLILKQEQEEYEREGIAWQTIEYFNNATIVELVEQPHRGILAVLDEAC 493

  Fly   599 SNFPRATDLSFLEKCHYNHALSELYAR----PRIGAQEFG----VTHYAGQVWYCVDGFLDKNRD 655
            |.....||..||:....:|.....|:.    |.....|||    :.||||.|.|.|:||:|||||
Mouse   494 STAGPITDRIFLQTLDTHHRHHPHYSSRQLCPTDKTMEFGRDFQIKHYAGDVTYSVEGFIDKNRD 558

  Fly   656 ALRGDVLELLASSRLPLVGELTKQLRA-----QRDAGKTLPKGSNGRFVTMKPRTPTVAARFADS 715
            :|..|...||.:|..|       .|||     |:|..:          ||.:|.  |....|.:|
Mouse   559 SLFQDFKRLLYNSVDP-------TLRAMWPDGQQDITE----------VTKRPL--TAGTLFKNS 604

  Fly   716 LQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFV 780
            :..|::::....|::|||||||::|.|.|:|......|:.|||:|:.:::|:.|:..|..:..|:
Mouse   605 MVALVENLASKEPFYVRCIKPNEDKVAGRLDEAHCRHQVEYLGLLENVRVRRAGFASRQPYPRFL 669

  Fly   781 ERYR---------HLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALE 836
            .||:         |||.|.       |:...||||   :.|::| |...|.:::|:|..  |.|.
Mouse   670 LRYKMTCEYTWPNHLLGSD-------RDAVSALLE---QHGLQG-DVAFGHSKLFIRSP--RTLV 721

  Fly   837 SGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWR 901
            :....|.|...:.|                    ..||..|||..|:....||| ...|..|.:|
Mouse   722 TLEQSRARLIPIIV--------------------LLLQKAWRGTLARWHCRRLR-AIYTIMRWFR 765

  Fly   902 GRQARRRVQQLRSDHRRRQEAREAAQRARE-AREAKQAVLERSQLSYLDIPAELAFIYSKLQGWS 965
            ..:.|..:.:|:   ||.|.||:.....|: ......|||:..|       .....::|:   |.
Mouse   766 RHKVRAHLIELQ---RRFQAARQPPLYGRDLVWPTPPAVLQPFQ-------DTCRVLFSR---WR 817

  Fly   966 PPHGDRHLVKVLGTVPGPPSSAVQ-------------LPEDLG-QFSFGK-----------FSSV 1005
            .    |.|||.:     |||..:|             |.:|.| |.::.:           .|.:
Mouse   818 A----RQLVKNI-----PPSDMIQIKAKVAAMGALQGLRQDWGCQRAWARDYLSSDTDNPTASHL 873

  Fly  1006 YCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKAL 1070
            :...|:....::...:.|.:....:...|           |.|.|:||      ||.|..::|..
Mouse   874 FAEQLKALREKDGFGSVLFSSHVRKVNRF-----------RKSRDRAL------LLTDRYLYKLE 921

  Fly  1071 SSRGLRDEILVQLCNQVHGLPPNSG 1095
            ..|..|....|.| ..|.||...||
Mouse   922 PGRQYRVMRAVPL-EAVTGLSVTSG 945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	268/705 (38%)
		PTZ00121	<828..>943	CDD:173412	29/115 (25%)
		MyTH4	1014..1171	CDD:470587	19/81 (23%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myo1g	XP_006514763.1	MYSc_Myo1	52..715	CDD:276829	268/705 (38%)
		Myosin_TH1	836..1007	CDD:461801	25/127 (20%)