DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and Myh3

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_036736.1 Gene:Myh3 / 24583 RGDID:3138 Length:1940 Species:Rattus norvegicus


Alignment Length:2055 Identity:512/2055 - (24%)
Similarity:811/2055 - (39%) Gaps:472/2055 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   128 DVIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSIL 192
            ||.|.:|..|                 ..:|||.:|..|:|.::|:||:.||...:|||::|...
  Rat    76 DVYAMNPPKF-----------------DKIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFC 123

  Fly   193 IAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPSP---QVVVISGESGSGKTE 254
            :.|||||..| .|..||...|.|:.....|||:|:|...|:..:.:.   |.::|:||||:|||.
  Rat   124 VTVNPYKWLP-VYTPEVVDGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTV 187

  Fly   255 STKLVMQYLAAVVPGGGSA-------SAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVY 312
            :||.|:||.|.:...|..|       ...:.:||:.|.|||||||||:|.||||||||||::.::
  Rat   188 NTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIH 252

  Fly   313 F-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFY--LNQ 374
            | .:|.:..|.|..|||||||:..|...||:||:||::|.. .:.|..:..|:..:.|.|  ::|
  Rat   253 FGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSN-KKPELIELLLITTNPYDYPFISQ 316

  Fly   375 GATDCAS--GRVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQE--GVEV 435
            |....||  .|.:..:...|:.:||.:..|:.|:.::..||:|.||:.|.::|.....|  |.||
  Rat   317 GEILVASIDDREELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEV 381

  Fly   436 GSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLV 500
            ...     .|:|:.:::..|.:||.....:...|.:.....:||...|.:|.:|::|..||.|:|
  Rat   382 ADK-----TAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMV 441

  Fly   501 SRINSIVQKGGTH--DAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYA 563
            :|||   |:..|.  ..|.|.:|||.|||....||.||||||:.||.||.:||.|:|.|||.||.
  Rat   442 TRIN---QQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYK 503

  Fly   564 RERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARPR 627
            :|.:|||.:.:..:|.....|.:||:||..:|::|..||:|||.||..|.:..| ..|..:.:|:
  Rat   504 KEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPK 568

  Fly   628 I--GAQE--FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQL-RAQRDAG 687
            :  |..|  |.:.||||.|.|.|.|:|:||:|.|...|:.|...|...|:..|.... ....|.|
  Rat   569 VVKGKAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATTDADGG 633

  Fly   688 K---TLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPC 749
            |   ...|||:.:         ||:|.|.::|.:|:.::...||.|||||.||:.|....|:...
  Rat   634 KKKVAKKKGSSFQ---------TVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSL 689

  Fly   750 VLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARG--TPYRELCRALLEAMPRTG 812
            ||.|||..|:|:.|:|.::|:|.|:.:..|.:|||.|..|.:..|  ...::.|..||.::   .
  Rat   690 VLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDSKKACEKLLASI---D 751

  Fly   813 VEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVR----RQLARRQA----- 868
            ::...|:.|.|:||.:..|...||..|.|||.:.....|...||.|:|    :.:.||::     
  Rat   752 IDHTQYKFGHTKVFFKAGLLGTLEEMRDERLAKLITRTQAVCRGFLMRVEFQKMMQRRESIFCIQ 816

  Fly   869 ---AATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQ-QLRSDHRRRQEARE----- 924
               .|......|...:...:.:.|.|.|.|.:.:...::..::.: :|.....:|:|..|     
  Rat   817 YNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTL 881

  Fly   925 --------------------AAQRAREAREAK-------QAVLERSQLSYLDIPAELAFIYSKLQ 962
                                |.:|..:..:||       :.|.||:: ...:|.|||.....||:
  Rat   882 VQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAE-DEEEINAELTAKKRKLE 945

  Fly   963 G-------------------WSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGK--FSSVY 1006
            .                   ....|...:.||.|      ......|.|.:.:.:..|  ....:
  Rat   946 DECSELKKDIDDLELTLAKVEKEKHATENKVKNL------TEELAGLDETIAKLTREKKALQEAH 1004

  Fly  1007 CNGL-RLQPRREPIT--APLLTRAASRDQDFQDALAVFK----------------------LILR 1046
            ...| .||...:.:.  :.|.::...:..|.:.:|...|                      .||.
  Rat  1005 QQTLDDLQAEEDKVNSLSKLKSKLEQQVDDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILD 1069

  Fly  1047 WSNDKALEGAKEKLLADYIVHKALSSRGLRDE--ILVQLCNQVHGLPPNSGE---------ATRL 1100
            ..|||  :...|:|......:..|.|: :.||  :.:||..::..|.....|         |||.
  Rat  1070 LENDK--QQLDERLKKKDFEYSQLQSK-VEDEQTLSLQLQKKIKELQARIEELEEEIEAERATRA 1131

  Fly  1101 WQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPA 1165
                       :.....|.|....  :|..|.|          ::.||.:|..:.....|.    
  Rat  1132 -----------KTEKQRSDYAREL--EELSERL----------EEAGGVTSTQIELNKKRE---- 1169

  Fly  1166 WLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTD 1230
             .|:....|..:.|   ||..||  |||.......:.||.||..            :|:.|::..
  Rat  1170 -AEFLKLRRDLEEA---TLQHEA--TVATLRKKHADSAAELAEQ------------IDNLQRVKQ 1216

  Fly  1231 SCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFART---------TLPDAVKRPAVPPPAPPTS 1286
            .          .|||. ..|.....||..|....:::         ||.|.:..          :
  Rat  1217 K----------LEKEK-SEFKLEIDDLSSSVESVSKSKANLEKICRTLEDQLSE----------A 1260

  Fly  1287 SGKEDVPRERRSSRELLSRSSALN------ERYFEREPS----PGPGQGSSTGQAKSRSKSLDD- 1340
            .||.:  ..:||..||.::.|.|.      .|..|.:.|    ....:.:.|.|.:...:.|:: 
  Rat  1261 RGKNE--ETQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQIEELKRQLEEE 1323

  Fly  1341 -----LLAGDIVPVPTDCD--------SQEPLHTLGLSESRLN------------DRYHSAERLA 1380
                 .||..:.....|||        .||....|..:.|:.|            |.....|.|.
  Rat  1324 NKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELE 1388

  Fly  1381 PVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPS 1445
            ...|....|.|.|:......:|.......:|...:.|.   ...|.|...|.|||:     .:..
  Rat  1389 EAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEV---EDLMVDVERANSLAA-----ALDK 1445

  Fly  1446 QASDVDQFLDDLFSPVLDGSLD---ELSDARSLAASI--RGGSYEQ----------ENE-AESEI 1494
            :..:.|:.|.:..:...:...:   .|.::|||:..:  ...:||:          ||: .|.||
  Rat  1446 KQRNFDKVLAEWKTKCEESQAELEAALKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEI 1510

  Fly  1495 DDLDDYINDIFQPIPLVQNLEKLTSKDQL--------------------AAIIK--------GGG 1531
            .||.:.|.:..:.|   ..|||...:.:|                    |.|::        ...
  Rat  1511 ADLTEQIAENGKSI---HELEKSRKQMELEKADIQMALEEAEAALEHEEAKILRIQLELTQVKSE 1572

  Fly  1532 VASKPEERDEESE---------IED----LDDYINELFEPIPVAEGLD--------KLT-SKEHL 1574
            :..|..|:|||.|         :|.    ||..:....|.|.:.:.::        :|: :....
  Rat  1573 IDRKIAEKDEEIEQLKRNYQRTVETMQGALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQA 1637

  Fly  1575 AVSIRGGGSTDSNGADPLLHQLMQLPGE---------TESGPALYQQQVQ--RAFLQSAMAQNLQ 1628
            |.:|:...|......|..||....|.|:         .|....|.|.:|:  ||.|:........
  Rat  1638 AETIKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKL 1702

  Fly  1629 IQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVME 1693
            .:|:||..|:.:|.|.:|..:.....                            |...:.|..::
  Rat  1703 AEQELLDSNERVQLLHTQNTSLIHTK----------------------------KKLETDLTQLQ 1739

  Fly  1694 SLQPPPPPPPPPMPPPLECKDPS-ETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAF- 1756
            |                |.:|.| :.|:..:...:|.|        .......:.:.|:|..|. 
  Rat  1740 S----------------EVEDASRDARNAEEKAKKAIT--------DAAMMAEELKKEQDTSAHL 1780

  Fly  1757 -KMRQHQRKTTPQAQH-----HQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLM 1815
             :|:::..:|....||     .|:...||..:.     ....|.|...|||:|        |:..
  Rat  1781 ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQI-----QKLETRIRELEFELE--------GEQK 1832

  Fly  1816 RS--SIR-LETTTTTTTSAVNNRDRDRET----QDVGQPMQSVVTTKLAKKSFEIGADRPPPGSV 1873
            |:  |:: |..............:.||:.    ||:...:|  |..|..|:..| .||......:
  Rat  1833 RNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQ--VKVKSYKRQAE-EADEQANVHL 1894

  Fly  1874 GKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLED 1913
            .|.:.:....:..|:       |:.::.....:..||..|
  Rat  1895 TKFRKAQHELEEAEE-------RADIAESQVNKLRAKTRD 1927

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 261/709 (37%)
MYSc_Myo15 169..828 CDD:276838 254/688 (37%)
MyTH4 1014..1171 CDD:295320 32/191 (17%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
Myh3NP_036736.1 Myosin_N 36..73 CDD:280832
Myosin_head 88..767 CDD:278492 260/700 (37%)
MYSc_Myh3 100..767 CDD:276878 254/688 (37%)
Actin-binding 656..678 10/21 (48%)
Actin-binding 758..772 5/13 (38%)
GrpE 843..>962 CDD:295646 19/119 (16%)
Myosin_tail_1 847..1924 CDD:279860 224/1240 (18%)
RILP-like 962..1095 CDD:304877 23/141 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1260..1289 8/30 (27%)
MIT_CorA-like <1296..>1408 CDD:294313 21/111 (19%)
COG6 1373..>1506 CDD:303003 26/140 (19%)
TMPIT 1739..>1828 CDD:285135 22/117 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

Return to query results.
Submit another query.