DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and Myh11

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_006245904.1 Gene:Myh11 / 24582 RGDID:3136 Length:1979 Species:Rattus norvegicus


Alignment Length:1971 Identity:505/1971 - (25%)
Similarity:826/1971 - (41%) Gaps:386/1971 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 SGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            |.||||..|..|:|||:|.|||.||..|||||::|...:.|||||..| .|..::...|.|:...
  Rat    85 SKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLP-IYSEKIVDMYKGKKRH 148

  Fly   220 SLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLA------------AVVPG 269
            .:|||::||...|:.::   ...|.::.:||||:||||:||.|:||||            ::..|
  Rat   149 EMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDSSITQG 213

  Fly   270 GGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRI 333
            ...|...:.:|:|:|.|:|||||||:|.:|||||||||::.:.|. :|.||||.|..|||||||.
  Rat   214 PSFAYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRA 278

  Fly   334 VTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVD---WESLQGAMQV 395
            :.||..||.:|:||.|:.|..|..|:...|...:.|.:|:.|.....:.:.|   .|:|: ||.:
  Rat   279 IRQARDERTFHIFYYLIAGAKEKMRNDLLLESFNSYTFLSNGFVPIPAAQDDEMFQETLE-AMSI 342

  Fly   396 LGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRA-L 459
            :|.||.|:..|::|:::||.|||:.|.:.:   ..:...:..:...:...||:.|:.....|| |
  Rat   343 MGFSEEEQLAILKVVSSVLQLGNIVFKKER---NTDQASMPDNTAAQKVCHLVGINVTDFTRAIL 404

  Fly   460 TSRTTEAR--AERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILD 522
            |.|....|  .::..|.   :||..|.:|.|||.|..||.|::||:|..:.|.....|..:.|||
  Rat   405 TPRIKVGRDVVQKAQTK---EQADFAIEALAKATYERLFRWILSRVNKALDKTHRQGASFLGILD 466

  Fly   523 IFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWD-DNLPVIHLLAK 586
            |.|||....||||||||||.||.||..||..:|.|||.||.||.:||..:.:. |..|.|.|:.:
  Rat   467 IAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIER 531

  Fly   587 --KPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPR--IGAQEFGVTHYAGQVWYCVD 647
              .|.|:..|||:|..||:|||.||:||..........:.:|:  ....||.:.||||:|.|...
  Rat   532 PNNPPGVLALLDEECWFPKATDKSFVEKLCSEQGNHPKFQKPKQLKDKTEFSIIHYAGKVDYNAS 596

  Fly   648 GFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAG---------KTLPKGSNGRFVTMKP 703
            .:|.||.|.|..:|..||.:|....|.:|.|.:  .|..|         .:||..|.    |.|.
  Rat   597 AWLTKNMDPLNDNVTSLLNASSDKFVADLWKDV--DRIVGLDQMAKMTESSLPSASK----TKKG 655

  Fly   704 RTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQR 768
            ...||...:.:.|.:|:.::....|.|||||.||.||.:.::|...||:|||..|:|:.|:|.::
  Rat   656 MFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQ 720

  Fly   769 GYPVRLRFQHFVERYRHLLPSPLARG-TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALH 832
            |:|.|:.||.|.:||..|..:.:.:| ...::.|..:::|:.   ::...|::|.:::|.|..:.
  Rat   721 GFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALE---LDPNLYRIGQSKIFFRTGVL 782

  Fly   833 RALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQ 897
            ..||..|..::....::.|...||.|.|:...:||...|.::..   ||....|.:||.      
  Rat   783 AHLEEERDLKITDVIMAFQAMCRGYLARKAFTKRQQQLTAMKVI---QRNCAAYLKLRN------ 838

  Fly   898 RLWRGRQARRRVQQLRSDHRRRQEAR---EAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYS 959
              |:..:...:|:.|....|:.:|.:   |..|:.:|.::..::.|:..:..:..:..|...:..
  Rat   839 --WQWWRLFTKVKPLLQVTRQEEEMQAKEEEMQKIKERQQKAESELKELEQRHTQLAEEKTLLQE 901

  Fly   960 KLQGWSPPHGDRHLVKV--------LGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRR 1016
            :||..:..:.:...::|        |..:.....:.::..||..|              :||..|
  Rat   902 QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRSQ--------------QLQAER 952

  Fly  1017 EPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILV 1081
            :.:...:|        |.::.|            :..|.|::||..:.:..:| ..:.|.|:|||
  Rat   953 KKMAQQML--------DLEEQL------------EEEEAARQKLQLEKVTAEA-KIKKLEDDILV 996

  Fly  1082 Q-------------LCNQVHGLPPNSGE----ATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEA 1129
            .             |..:|..|..|..|    |..|.:|..      :..:..|:..:|...:|.
  Rat   997 MDDQNNKLSKERKLLEERVSDLTTNLAEEEEKAKNLTKLKS------KHESMISELEVRLKKEEK 1055

  Fly  1130 PESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAV 1194
            .......|.|:|              .|....|.....:.:|  :..::.:.|...:|..|    
  Rat  1056 SRQELEKLKRKL--------------EGDASDFHEQIADLQA--QIAELKMQLAKKEEELQ---- 1100

  Fly  1195 DSWTSCEEAAALAVSSLGVASRGWTLV--------LDDGQQLTDSCGLDYVMDLIAEK---ELCP 1248
                     ||||.....:..:...|.        :.|.|:..||   :......|||   :|..
  Rat  1101 ---------AALARLDEEITQKNNALKKIRELEGHVSDLQEDLDS---ERAARNKAEKQKRDLGE 1153

  Fly  1249 AFPAPRSDL------------LRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRE 1301
            ...|.:::|            ||:..:...|.|..|:..        .|.|.:..|...|:...:
  Rat  1154 ELEALKTELEDTLDSTATQQELRAKREQEVTMLKKALDE--------ETRSHEAQVQEMRQKHTQ 1210

  Fly  1302 LLSRSSALNERY-------------FEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDC 1353
            .:...:...|::             .|:|.:...|:....||||...:.....|.|.:..:.:.|
  Rat  1211 AVEELTEQLEQFKRAKANLDKSKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEGQLQELQSKC 1275

  Fly  1354 DSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGR-RSHAASHGSHSSKYADKAE 1417
            ...|...|      .|:|:.|..:.  .|...||...:....|.: ....||.||......:..:
  Rat  1276 SDGERART------ELSDKVHKLQN--EVESVTGMLNEAEGKAIKLAKEVASLGSQLQDTQELLQ 1332

  Fly  1418 YATR-------------------SSAMSDTSEA-PSLASHVRRVRVPSQASDVDQFLDDLFSPV- 1461
            ..||                   ...:.:..|| .:|..||..:.:  |.||..:.|.||.|.: 
  Rat  1333 EETRQKLNVSTKLRQLEDERNSLQDQLDEEMEAKQNLERHVSTLNI--QLSDSKKKLQDLASTIE 1395

  Fly  1462 --------LDGSLDELSDARSLAASIRGGSYEQENEAESEID--------DLDDYINDIFQPIPL 1510
                    |...::.|           |..||::..|..:::        :|||.:.|:.....|
  Rat  1396 VMEEGKKRLQKEMEGL-----------GQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1449

  Fly  1511 VQNLEKLTSK-DQLAAIIKGGGVASK---------PEERDEESEIEDLDDYINELFE-------- 1557
            |.||||...| |||.|..|  .::||         .|.|::|::...|...:.|..|        
  Rat  1450 VSNLEKKQKKFDQLLAEEK--NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512

  Fly  1558 -PIPVAEGLDKLTSKEHLAVSI----RGGGSTDSNGADPLLHQLMQLPGE---TESGPALYQQQV 1614
             .:..||..|.::||:.:..::    :...:.::. .:.:..||.:|..|   ||......:..:
  Rat  1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ-MEEMRTQLEELEDELQATEDAKLRLEVNM 1576

  Fly  1615 Q------RAFLQSAMAQN----LQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSL 1669
            |      ...||:...||    .|:|:||......|:....|:|.||||.......     |..|
  Rat  1577 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD-----LKDL 1636

  Fly  1670 SISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKD---------PSETRHFL--- 1722
            .:     |:...:|....::..:..||             .:.||         .|....|.   
  Rat  1637 EL-----QADSAVKGREEAIKQLRKLQ-------------AQMKDFQRELDDARASRDEIFATSK 1683

  Fly  1723 DPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSN---GGMMESG 1784
            :...:||::           :....|.:||..|.:..:.|.....:....::.|:   ...::..
  Rat  1684 ENEKKAKSL-----------EAELMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNTLQDE 1737

  Fly  1785 PGARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTT----TTTTSAVNN----RDRDRET 1841
            .....|....:| ||.|.|......||.::.:::::.|..:    |..::|..|    :..:|:.
  Rat  1738 KRRLEARIAQLE-EELEEEQGNMEAMSDRVRKATLQAEQLSNELVTERSAAQKNESARQQLERQN 1801

  Fly  1842 QDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQR 1906
            :::...:|.|.....||....:.|            |.:::.|..||:.. .:.....:||..::
  Rat  1802 KELRSKLQEVEGAVKAKLKSTVAA------------LEAKIVQLEEQIEQ-EAREKQAATKLLKQ 1853

  Fly  1907 APAKL-------EDTRKLMLQ 1920
            ...||       ||.||::.|
  Rat  1854 KDKKLKEVLLQVEDERKMVEQ 1874

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 267/716 (37%)
MYSc_Myo15 169..828 CDD:276838 259/695 (37%)
MyTH4 1014..1171 CDD:295320 30/173 (17%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
Myh11XP_006245904.1 Myosin_N 34..71 CDD:280832
Myosin_head 87..778 CDD:278492 266/707 (38%)
MYSc_class_II 99..778 CDD:276951 259/695 (37%)
Myosin_tail_1 855..1935 CDD:279860 218/1173 (19%)
FAM76 <997..1089 CDD:292665 17/113 (15%)
UBAN 1049..1163 CDD:301588 25/145 (17%)
BAR <1166..>1295 CDD:299863 25/144 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

Return to query results.
Submit another query.