Protein Alignment Myo10A and Myo16

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_006508841.1
• Gene: Myo16 / 244281
• MGIID: 2685951
• Length: 1941
• Species: Mus musculus
• Alignment Length: 1936
• Identity: 459/1936 - (23%)
• Similarity: 708/1936 - (36%)
• Gaps: 564/1936 - (29%)

  Fly    20 PGEIQEVHRAAQVIVVQALIKGKMRIVRFHLEPWQRGGGGSVTPSPAQSPSLALLSPHVLRRQRP 84
            |.:|     ||...:.:.|:|.::        .|:.    .:..||: :||||          :.
Mouse   313 PSDI-----AASESIEEMLLKAEI--------AWEE----KMKESPS-APSLA----------QE 349

  Fly    85 ASLEDFEDLPNLSAK-HP-ALPSSRLRRLKCRYPQVVKRLSTLCSDVIARHPQTFALQPGEGSLR 147
            ...|...|||:||:| .| .||.::...|..:..........||.......|...::....|...
Mouse   350 ELYEILHDLPDLSSKLSPLVLPIAKQDSLLEKDIMFKDTTKGLCKQESQDGPPETSMTSNCGKPE 414

  Fly   148 ARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQ 212
            ..|.:..:..:|:..|.:|:::|||:.::.|:....|:||.|.|.:.|||:|..| .|...|::.
Mouse   415 QVQVMPPAPSDDLATLSELNDSSLLYEIQKRFGNDQIHTFIGDIFLLVNPFKELP-IYSTMVSQM 478

  Fly   213 Y---AGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGG 271
            |   .|:...|||||||:....|...|   ..||.:::|||.|||||:::|.:|:||.:   ...
Mouse   479 YLSPTGQRSPSLPPHLFSCAERAFHRLFQERKPQNIILSGERGSGKTQASKQIMKYLTS---RAS 540

  Fly   272 SASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF--KSGAIVGAKITQYLLEKSRIV 334
            |:..:...::..|..::||||:|:|..|:.||...:|.|:..  :...|.||:|:.|:|||||:|
Mouse   541 SSCTMFDSRLRHAIYIVEAFGHAKTTLNNVSSCLIQYWELQCCQRRKHITGARISTYMLEKSRVV 605

  Fly   335 TQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCAS------GRVDWESLQGAM 393
            .|.||:..:.:|..|:.|||..|:....|.....:.|::||..:..|      .:....:|:.|:
Mouse   606 AQPPGQGTFLIFSWLMDGLSSEEKCGLHLNNFCAHRYVSQGMREDVSTAEHSLNKERLAALKHAL 670

  Fly   394 QVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAE-IKWAAHLLHISADGLHR 457
            .|:|.|..|.|.:..:|:|:||:|::.|  ..|........  ||.: ::..|.:|.:|.|.|..
Mouse   671 NVIGFSTLEVENLFVILSAILHIGDIQF--TALTEADSAFV--SDLQLLEQVAGMLQVSTDELAS 731

  Fly   458 ALTSRTTEARAE---RLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR-- 517
            |||:.....:.:   |.||   |..|...||..||:||:.||.:|::.:|..:|   ..|.::
Mouse   732 ALTTDIQYFKGDVIIRRHT---IQMAAFYRDLLAKSLYSRLFGFLINTVNCCLQ---NQDEYKSL 790

  Fly   518 ----ISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEW-TPLAWDDN 577
                |.||||||||:..:|.|||||:|..||.:..|..:.:|..||.|..:|.:.. |..:..:.
Mouse   791 QTLDIGILDIFGFEEFQKNEFEQLCVNLTNEKMHHYIQEVLFLQEQTECVQEGVAMETACSPGNQ 855

  Fly   578 LPVIHLLAKKPVGICHLLDDES--------NFPRATDLSFLEKCHYNHALSELYARPRIG----- 629
            ..|:....:||.|...|||:||        |.||... ..||..:.|    .:|:..:.|
Mouse   856 AGVLDFFFQKPSGFFSLLDEESQVIWSGEPNLPRKLQ-GLLESSNTN----AVYSPVKDGNGNVA 915

  Fly   630 ----AQEFGVTHYAGQVWYCVDGFLDKNRDALRGD-----------VLELLASSRLPLVGELTKQ 679
                ...|.|.||||:|.|.:.|.:::|:|:|..:           |:..|..|:|...|.|...
Mouse   916 FKGQGAAFTVMHYAGRVMYEMGGAVERNKDSLSQNLLFVMKTSENVVISHLFQSKLSQTGSLISS 980

  Fly   680 ------------LRAQRDA-------------GKTLPKGSNGRFVTMKPR--TPTVAARFADSLQ 717
                        |.::|.|             .|.|.|.....|:....|  ..|.|::...||.
Mouse   981 YPSFKFGGHKSTLLSKRTASSMVGVNKNYLELSKLLKKKGTSTFLQRLERGEPATAASQLTKSLA 1045

  Fly   718 QLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVER 782
            .:...:.|..|.|:.|||||..:.....|...|..||:|||:|..:::.:.|||||..|:.|:.|
Mouse  1046 DITAKLQRGSPHFILCIKPNTSQLPGVFDHFYVSAQLQYLGVLGLVRLFRSGYPVRPSFEDFLSR 1110

  Fly   783 YRHLLPSPLA-------RGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRT 840
            |     .|||       :|....|.||.:|:   |..::|  :|:|..:|||: ..|....|...
Mouse  1111 Y-----EPLASVLLGETKGQAAEERCRLVLQ---RCKLQG--WQIGVHKVFLK-YWHVDQLSDLW 1164

  Fly   841 ERLRRAAVSVQRHVRGMLVRRQLARR----QAAATRLQARWRG--------------QRAQ---Q 884
            .:|:|..|:.|:.:||.|.|:.|.:|    |...|.:::..:.              |.|.   :
Mouse  1165 LQLQRKIVTCQKVIRGFLARQHLLQRMSIKQQEVTSIKSFLQSTEDMALKTYDALVIQNASDIAR 1229

  Fly   885 RYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLD 949
            .::||||...||.                  ||.|||  |..:||.:     |........:.:.
Mouse  1230 EHDRLRKEVHTAY------------------HRNRQE--EGTKRAED-----QGGCRHVHSNSVP 1269

  Fly   950 IPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQP 1014
            :|..:..:...|.|.|......|.|..:....|.||...|.|.                    :|
Mouse  1270 VPMVVDSLAQALTGPSTRPPSLHSVFSMDDSTGLPSPRKQPPP--------------------KP 1314

  Fly  1015 RREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLA------DYIVHKALSSR 1073
            :|:|     .||.::..:.....|:..|           :.|.|.|..      ||...|.:..|
Mouse  1315 KRDP-----NTRLSASYEAVSACLSAAK-----------DAAGEALTRPRPHSDDYSTMKKIPPR 1363

  Fly  1074 GLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLL 1138
            ..:.....:|          ||....:|
Mouse  1364 KPKRSPHTKL----------SGSYEEIW------------------------------------- 1381

  Fly  1139 RQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTR-----GCDMALPLTLP------DEASQTV 1192
                   |....||.:|.|. |...|..|..: |.|     .|...|||.||      |:.::.|
Mouse  1382 -------GPPRPSGTMGQGG-RHQAPGTLSVQ-WARPDSVPQCTPQLPLHLPLPQGDYDDDAEPV 1437

  Fly  1193 AVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQL---------TDSCGLDYVMDLIA------ 1242
            .::...:...|......|           .|.|:.:         .:.|||..:..|.|
Mouse  1438 YIEMVGNAARAGGSETDS-----------PDQGESVYEEMKYILPEEGCGLGMLTFLPASPPLFL 1491

  Fly  1243 -----------------EKELC---PAFPAPRSDLLRSGAKFARTTLPDAVKRP--AVPPPAPPT 1285
                             .|:.|   |.||               ..||   .||  .|.||.|.|
Mouse  1492 ETRKAIILEAAEGNCQPSKDTCDIPPPFP---------------NLLP---HRPPLLVFPPTPVT 1538

  Fly  1286 SSGKED----VPRERRSSRELLSRSSALNERYFEREPSPGPGQGSS--TGQAKSRSKSLDDLLAG 1344
            .|...|    .|.|.:....|     ..|.:|      |...:|||  :.|.....|..:|.||.
Mouse  1539 RSPASDESPLTPLEVKKLPVL-----ETNLKY------PVQSEGSSPLSPQYSKAQKGDNDQLAS 1592

  Fly  1345 DIVPV----------------------------------PTDCDSQEPLHTLGLSESRLNDRYHS 1375
            ...||                                  |..|.  .|....|...
Mouse  1593 PGFPVFNGPSRISPPATPPPPPGPPPAPCGPPPAPCGPPPAPCG--PPPAPCGPPP--------- 1646

  Fly  1376 AERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSD-----TSEAPSLA 1435
                ||.|....|....|...|.........:|.: :..::...|.:.|:::     |...||.|
Mouse  1647 ----APCGPPPAPCGAASASCGVAPAPCRPPTHFA-FPPESVLVTAAKALTNSDLPRTQPKPSSA 1706

  Fly  1436 -------SHVRRVRVPSQASDVD-QFLDDLFSP----------VLDGSLDELSDARSLAASI--R 1480
                   |.|:....|.:.:..| :.....|||          .|...||||:...:...|:  |
Mouse  1707 PVPGPCSSFVKAPYSPGKTARADLRKTSSTFSPPSPYSPPNSRPLSSPLDELASLFNSGRSVLRR 1771

  Fly  1481 GGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEI 1545
            .....:..|||....:::                  |:|:|:.::    ..:||:.::|:..:..
Mouse  1772 SAVGRRIREAEGFETNMN------------------LSSRDEPSS----SEMASETQDRNANNHG 1814

  Fly  1546 EDLDDYINELFEPI------PVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETE 1604
            ..|.   :.|...:      ||..||.:......|.:|..|..|
Mouse  1815 TQLS---SSLSSDVTAENGNPVTNGLAEDDGCSRLCLSGMGTSS--------------------- 1855

  Fly  1605 SGPALYQQQVQRAFLQSAMAQNLQIQQQL-LAQNQ--ALQTLLSQQAAAAAANNSTSPPPAPPIL 1666
                         |.::..:...|:..|| |::|:  |||.||.
Mouse  1856 -------------FQRNRESHTTQVIHQLRLSENESVALQELLD--------------------- 1886

  Fly  1667 SSLSISPPPPQSPMRMKATRSSLVVMESLQPPPP--PPPPPMPPPLECKDP 1715
                         .|.|...:.....|:||.|.|  |||||...|...|.|
Mouse  1887 -------------WRRKLCEAREGWQEALQHPEPRAPPPPPCKKPTLLKKP 1924

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	231/745 (31%)
		PTZ00121	<828..>943	CDD:173412	31/135 (23%)
		MyTH4	1014..1171	CDD:470587	26/162 (16%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	16/104 (15%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myo16	XP_006508841.1	ANKYR	81..336	CDD:440430	7/39 (18%)
		ANK repeat	114..145	CDD:293786
		ANK repeat	147..178	CDD:293786
		ANK repeat	180..210	CDD:293786
		ANK repeat	243..274	CDD:293786
		ANK repeat	276..307	CDD:293786
		MYSc_Myo16	436..1153	CDD:276844	231/745 (31%)
		NYAP_N	1235..1605	CDD:464717	101/526 (19%)