Protein Alignment Myo10A and Myo1h

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_001158045.1
• Gene: Myo1h / 231646
• MGIID: 1914674
• Length: 1022
• Species: Mus musculus
• Alignment Length: 796
• Identity: 308/796 - (38%)
• Similarity: 447/796 - (56%)
• Gaps: 80/796 - (10%)

  Fly   143 EGSLRARQDLGSSGVEDMTLLDD-LHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYG 206
            ||:|.||..:   ||:|..|||. ..|::.|.|||.|:.:.||||:.|::|::||||:    ..|
Mouse     2 EGALTARDKV---GVQDFVLLDAYTSESAFLENLRKRFRENLIYTYIGTLLVSVNPYQ----ELG 59

  Fly   207 LEVAKQ---YAGRPLGSLPPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAA 265
            :..|.|   |.|.....||||::||...|:..:.|.   ..::||||||:||||::|.::||.|.
Mouse    60 IYTASQMELYQGVNFFELPPHVYAIADNAYRMMCSELNNHFILISGESGAGKTEASKKILQYFAV 124

  Fly   266 VVPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLE 329
            ..|...|.. :..:::|.:.|:|||||||:|.|||||||||||:::.|. .|..||..|..||:|
Mouse   125 TCPMTESLQ-IARDRLLLSIPVLEAFGNAKTLRNDNSSRFGKYMDIQFDFQGVPVGGHIISYLIE 188

  Fly   330 KSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADK--YFYLNQGATDCA-----SGRVDWE 387
            |||:|.|..||||:|:||:||.|......:..| ||.|.  |.||:||  .||     |.:.|||
Mouse   189 KSRVVYQNHGERNFHIFYQLLAGGGSERLASLG-LERDPQLYKYLSQG--HCARESPISDKNDWE 250

  Fly   388 SLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEG-VEVGSDAEIKWAAHLLHIS 451
            ::.||..|:|.:|.:.|.:..::|:|||||||.|     :..::| ..|....||||.|.||.:.
Mouse   251 TVCGAFSVIGFTEADLENLFGIIASVLHLGNVCF-----KGDKQGCASVPDTHEIKWIAKLLGVC 310

  Fly   452 ADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRIN-SIVQKGGTHDA 515
            ...|..|||.|..||:.|.:..||.::.::.||||.|||:|...|.|||:||| |:|.|..|...
Mouse   311 PAVLLEALTHRKIEAKTEEVICPLTVELSVYARDAMAKAVYGRTFTWLVNRINSSLVNKDFTQKT 375

  Fly   516 HRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPV 580
             .|.:|||:|||...:|.|||.||||.||.||....:...|.|||||..|.:||..:.:.:|..:
Mouse   376 -VIGLLDIYGFEVFDKNGFEQFCINYCNEKLQQLLIERTLKAEQAEYESEGIEWETVQYFNNKII 439

  Fly   581 IHLLAKKPVGICHLLDDESNFP-RATDLSFLEK--------CHY-NHALSELYARPRIGAQEFGV 635
            ..|:.::..||..:||:|...| .|||||||||        .|: ...|:....|.|||..||.:
Mouse   440 CDLVEERHRGIISILDEECIRPGPATDLSFLEKLEEKVGKHAHFQTRKLAGPKGRKRIGWLEFCL 504

  Fly   636 THYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGE--LTKQLRAQRDAGKTLPKGSNGRF 698
            .||||:|.||..|||:||.|.|...:.|:|.||:..::.|  |..:|..:|
Mouse   505 LHYAGEVTYCTKGFLEKNNDLLYRHLKEVLCSSKNSILRECFLVAELENRR-------------- 555

  Fly   699 VTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTI 763
                 |.|||..:|.:||..||:.:....|.::||||||:.|...:.|...:..|::|||:::.:
Mouse   556 -----RPPTVGTQFKNSLSSLLEILISKEPSYIRCIKPNERKEPSKFDDFLISHQIKYLGLMEHL 615

  Fly   764 QIRQRGYPVRLRFQHFVERYRHLLPS--PLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVF 826
            ::|:.|:..|.:::||::||:.|.|.  |...|.|...:.|.:    ...|.:..||:||.|::|
Mouse   616 RVRRAGFAYRRKYEHFLQRYKSLCPDTWPHWHGPPGEGVERLI----KYIGYQPQDYKLGKTKIF 676

  Fly   827 LR-----EALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRY 886
            :|     .|...|.|..:.:.:.|    :|...:|.|.||:..:::.|||:|:|.|||..|::..
Mouse   677 IRFPRTLFATEDAFEFSKHQLVSR----IQATYKGCLGRREYMKKRQAATKLEAHWRGVLARKEI 737

  Fly   887 ERLRKGALTAQRLWRG 902
            :|.|......:|..:|
Mouse   738 KRRRWAVQIIRRFVKG 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	273/688 (40%)
		PTZ00121	<828..>943	CDD:173412	23/80 (29%)
		MyTH4	1014..1171	CDD:470587
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myo1h	NP_001158045.1	MYSc_Myo1	26..678	CDD:276829	273/688 (40%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	568..590		9/21 (43%)
		IQCD	711..741	CDD:467745	12/29 (41%)
		Myosin_TH1	834..1015	CDD:461801