Protein Alignment Myo10A and MYO16

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_001185879.1
• Gene: MYO16 / 23026
• HGNCID: 29822
• Length: 1880
• Species: Homo sapiens
• Alignment Length: 1794
• Identity: 459/1794 - (25%)
• Similarity: 702/1794 - (39%)
• Gaps: 457/1794 - (25%)

  Fly    74 LSPHVLRRQRPASLEDFEDLPNLSAK-----HPALPSSRLRRLKCRYPQVVKRLSTLCS-DVIAR 132
            ||...|.::.|.. |...|||.||:|     .|......|......:....|.|....| |.|..
Human   341 LSASTLAQEEPYE-EIIHDLPVLSSKLSPLVLPIAKQDSLLEKDIMFKDATKGLCKQQSQDSIPE 404

  Fly   133 HPQTFALQPGEGSLRARQD--LGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAV 195
            :|..      .||.:..|.  :..:..:|:..|.:|::.|||:.::.|:....||||.|.||:.|
Human   405 NPMM------SGSTKPEQVKLMPPAPNDDLATLSELNDGSLLYEIQKRFGNNQIYTFIGDILLLV 463

  Fly   196 NPYKMFPDAYGLEVAKQY---AGRPLGSLPPHLFA-IGAAAHAAL--PSPQVVVISGESGSGKTE 254
            ||||..| .|...|::.|   :|:...|||||||: :..|.|...  ..||..::|||.||||:|
Human   464 NPYKELP-IYSSMVSQLYFSSSGKLCSSLPPHLFSCVERAFHQLFREQRPQCFILSGERGSGKSE 527

  Fly   255 STKLVMQYLAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF--KSGA 317
            ::|.::::|..   ..|::.|.:..:......:|||||:|:|..||.||.|.||.|:.|  :...
Human   528 ASKQIIRHLTC---RAGASRATLDSRFKHVVCILEAFGHAKTTLNDLSSCFIKYFELQFCERKQQ 589

  Fly   318 IVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGL----LEADKYFYLNQGATD 378
            :.||:|..|||||||:|:|..|:.|:.:||.|:.|||..|  ||||    |.|.:  ||||...|
Human   590 LTGARIYTYLLEKSRLVSQPLGQSNFLIFYLLMDGLSAEE--KYGLHLNNLCAHR--YLNQTIQD 650

  Fly   379 CAS------GRVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGS 437
            .||      .|.....|:.|:.|:|.|..|.|.:..:|||:||||::.|  ..|..|.....  |
Human   651 DASTGERSLNREKLAVLKRALNVVGFSSLEVENLFVILAAILHLGDIRF--TALNEGNSAFV--S 711

  Fly   438 DAE-IKWAAHLLHISADGLHRALTSRTTEARAE---RLHTPLGIDQALDARDAFAKALYAGLFNW 498
            |.: ::..|.:|.:|.|.|..|||:.....:.:   |.||   |..|...||..||:||:.||::
Human   712 DLQLLEQVAGMLQVSTDELASALTTDIQYFKGDMIIRRHT---IQIAEFFRDLLAKSLYSRLFSF 773

  Fly   499 LVSRINSIVQKGGTHDAHR------ISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKL 557
            ||:.:||.:.   :.|..:      |.||||||||:..:|.|||||:|..||.:..|.|:.:|..
Human   774 LVNTMNSCLH---SQDEQKSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLH 835

  Fly   558 EQAEYARERLEW-TPLAWDDNLPVIHLLAKKPVGICHLLDD--------ESNFPRATDLSFLEKC 613
            ||.|..:|.:.. |..:..:...|:....:||.|...|||:        |||||:... |.||..
Human   836 EQVECVQEGVTMETAYSPGNQNGVLDFFFQKPSGFLTLLDEESQMIWSVESNFPKKLQ-SLLESS 899

  Fly   614 HYNHALSELY-ARPRIGAQEFG----VTHYAGQVWYCVDGFLDKNRDALRGD-----------VL 662
            :.|...|.:. ....:..::.|    :.||||:|.|.|.|.::||:|:|..:           |:
Human   900 NTNAVYSPMKDGNGNVALKDHGTAFTIMHYAGRVMYDVVGAIEKNKDSLSQNLLFVMKTSENVVI 964

  Fly   663 ELLASSRLPLVGE-----------------LTKQLRAQRDAG---------KTLPKGSNGRFVTM 701
            ..|..|:|...|.                 |:|::.|....|         |.|.|.....|:..
Human   965 NHLFQSKLSQTGSLVSAYPSFKFRGHKSALLSKKMTASSIIGENKNYLELSKLLKKKGTSTFLQR 1029

  Fly   702 KPR--TPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQ 764
            ..|  ..|:|::...||..::..:.:|.|.|:.||:||..|.....|...|..||:|:|:|:.::
Human  1030 LERGDPVTIASQLRKSLMDIIGKLQKCTPHFIHCIRPNNSKLPDTFDNFYVSAQLQYIGVLEMVK 1094

  Fly   765 IRQRGYPVRLRFQHFVERYRHLLPSPLA-------RGTPYRELCRALLEAMPRTGVEGPDYQLGA 822
            |.:.||||||.|..|:.||:     |||       :.....|.||.:|:.....|     :|:|.
Human  1095 IFRYGYPVRLSFSDFLSRYK-----PLADTFLREKKEQSAAERCRLVLQQCKLQG-----WQMGV 1149

  Fly   823 TRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLAR----RQAAATRLQARWRGQRAQ 883
            .:|||: ..|....:....:|:|..::.|:.:||.|.|:.|.:    ||...|.:.:      ..
Human  1150 RKVFLK-YWHADQLNDLCLQLQRKIITCQKVIRGFLARQHLLQRISIRQQEVTSINS------FL 1207

  Fly   884 QRYERLRKGALTAQRLWRGRQARRRVQQLRSD-----HRRRQEAREAAQRAREAREAKQAVLERS 943
            |..|.:......|..:.......|...:|||:     |:.:.|.|...:...:..:.|... ...
Human  1208 QNTEDMGLKTYDALVIQNASDIARENDRLRSEMNAPYHKEKLEVRNMQEEGSKRTDDKSGP-RHF 1271

  Fly   944 QLSYLDIPAELAFIYSKLQG---WSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSV 1005
            ..|.:.:.|.:..:...|.|   |||   ..|.|..:......||...|.|.
Human  1272 HPSSMSVCAAVDGLGQCLVGPSIWSP---SLHSVFSMDDSSSLPSPRKQPPP------------- 1320

  Fly  1006 YCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLA------DY 1064
                   :|:|:|     .||.::..:.....|:.           |.|.|.|.|..      ||
Human  1321 -------KPKRDP-----NTRLSASYEAVSACLSA-----------AREAANEALARPRPHSDDY 1362

  Fly  1065 IVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEA 1129
            ...|.:..|                 .|.....|:|             |.::.:     :....
Human  1363 STMKKIPPR-----------------KPKRSPNTKL-------------SGSYEE-----ISGSR 1392

  Fly  1130 PESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLP--DEASQTV 1192
            |...||               :||.|| |.|...|.       |..|  |||...|  ||
Human  1393 PGDARP---------------AGAPGA-AARVLTPG-------TPQC--ALPPAAPPGDE----- 1427

  Fly  1193 AVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELC---PAFPAPR 1254
                    :::..:.:..||.|:|..:  .|.|:.:.:            |.:.|   ...|...
Human  1428 --------DDSEPVYIEMLGHAARPDS--PDPGESVYE------------EMKCCLPDDGGPGAG 1470

  Fly  1255 SDLLRSGAK--FARTTLPDAVKRPA----VPPPAP--------------------PTSSGKEDVP 1293
            |.||...:.  ..|....:|...|.    :|||.|                    |.|......|
Human  1471 SFLLHGASPPLLHRAPEDEAAGPPGDACDIPPPFPNLLPHRPPLLVFPPTPVTCSPASDESPLTP 1535

  Fly  1294 RERRSSRELLSR---------SSALNERYF-------EREPSPGPGQGSSTGQAKSRSKSLDDLL 1342
            .|.:....|.:.         ||.|:.:|.       :|..|||....:.:|:|...|..
Human  1536 LEVKKLPVLETNLKYPVQPEGSSPLSPQYSKSQKGDGDRPASPGLALFNGSGRASPPSTP----- 1595

  Fly  1343 AGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERL------APV--GKDTGPRYQKSQHAGRR 1399
                 |.|.......|.            .|.....|      |||  || .||..:..:...:.
Human  1596 -----PPPPPPPGPPPA------------PYRPCAHLAFPPEPAPVNAGK-AGPSAEAPKVHPKP 1642

  Fly  1400 SHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDG 1464
            :.|...|..||  ..|..|:...:..:|..:|.|.||.......||             |..|..
Human  1643 NSAPVAGPCSS--FPKIPYSPVKATRADARKAGSSASPPAPYSPPS-------------SRPLSS 1692

  Fly  1465 SLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKG 1529
            .||||:   ||..|  |.|..:::.|..:|.:.:.:..::           .::|:|..:.
Human  1693 PLDELA---SLFNS--GRSVLRKSAAGRKIREAEGFETNM-----------NISSRDDPST---- 1737

  Fly  1530 GGVASKPEERDEESEIEDLDDYI---------NELFEPIPVAEGLDKLTSKEHLAVSIRGGGST- 1584
            ..:.|:.::|:..:....|.:.:         |.:...:|..:|..:|        ||.|.|::
Human  1738 SEITSETQDRNANNHGIQLSNSLSSAITAENGNSISNGLPEEDGYSRL--------SISGTGTST 1794

  Fly  1585 -----DSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTLL 1644
                 ||: ...::|||..  .|.||               .|:.:.|..:::|..:.|..|.:|
Human  1795 FQRHRDSH-TTQVIHQLRL--SENES---------------VALQELLDWRRKLCEEGQDWQQIL 1841

  Fly  1645 SQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMK 1683
            ..           :.|..||        |||.:.|..:|
Human  1842 HH-----------AEPRVPP--------PPPCKKPSLLK 1861

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	252/746 (34%)
		PTZ00121	<828..>943	CDD:173412	23/123 (19%)
		MyTH4	1014..1171	CDD:470587	29/162 (18%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	13/68 (19%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
MYO16	NP_001185879.1	ANKYR	67..347	CDD:440430	2/5 (40%)
		ANK repeat	86..112	CDD:293786
		ANK repeat	114..145	CDD:293786
		ANK repeat	147..178	CDD:293786
		ANK repeat	180..210	CDD:293786
		ANK repeat	243..274	CDD:293786
		ANK repeat	276..307	CDD:293786
		ANK repeat	309..335	CDD:293786
		MYSc_Myo16	437..1155	CDD:276844	252/746 (34%)
		NYAP_N	1243..1590	CDD:464717	87/473 (18%)
		NYAP_C	1652..1880	CDD:464724	59/290 (20%)