Protein Alignment Myo10A and MYH15

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_011510861.1
• Gene: MYH15 / 22989
• HGNCID: 31073
• Length: 1946
• Species: Homo sapiens
• Alignment Length: 2175
• Identity: 511/2175 - (23%)
• Similarity: 851/2175 - (39%)
• Gaps: 544/2175 - (25%)

  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.:|..|:|||:|..|:.||.:.:|||::|...:.:||||..| .|..||...|.|:.....
Human   105 IEDMAMLTHLNEASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLP-VYQKEVMAAYKGKRRSEA 168

  Fly   222 PPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQY---LAAVVPGGGSASAVITEQ 280
            |||:||:...|...:   ...|.::.:||||:|||.::|.::||   :||::.......| :.:|
Human   169 PPHIFAVANNAFQDMLHNRENQSILFTGESGAGKTVNSKHIIQYFATIAAMIESRKKQGA-LEDQ 232

  Fly   281 ILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKS-GAIVGAKITQYLLEKSRIVTQAPGERNYH 344
            |::|..:|||||||:|.||||||||||::.::|.: |.:....|..|||||||::.|..||||||
Human   233 IMQANTILEAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDIDIYLLEKSRVIFQQAGERNYH 297

  Fly   345 VFYELLGGLSETERSKYGLL-----EADKYFYLNQGATDCASGRVDWESL---------QGAMQV 395
            :||::|.|    ::..:.||     .:|.:|        |:.|.|..|||         :.||.:
Human   298 IFYQILSG----QKELHDLLLVSANPSDFHF--------CSCGAVTVESLDDAEELLATEQAMDI 350

  Fly   396 LGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALT 460
            ||....|:.|..::..|::|.||:.|.::.   .:|.:|.........||.|:.|::..|.:.|.
Human   351 LGFLPDEKYGCYKLTGAIMHFGNMKFKQKP---REEQLEADGTENADKAAFLMGINSSELVKCLI 412

  Fly   461 SRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR-----ISI 520
            ....:...|.:.....|:|...|..|.:|::|..:|.|||:|||..:      ||..     |.|
Human   413 HPRIKVGNEYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRAL------DAKLSRQFFIGI 471

  Fly   521 LDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLA 585
            |||.|||.|..||.||||||:.||.||.:||.|:|.|||.||.:|.:||..:.:..:|.....|.
Human   472 LDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGLDLQACIDLI 536

  Fly   586 KKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELY-ARPRIGAQE----FGVTHYAGQVWYC 645
            :||:||..:|::|..||:||||:|..|...||....:: .:|:...::    |.:.||||.|.|.
Human   537 EKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKKKFEAHFELVHYAGVVPYN 601

  Fly   646 VDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAA 710
            :.|:|:||:|.|...|:.:...|...|:..|.:...:...|   :|.|...|  .......|||:
Human   602 ISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSA---IPFGEKKR--KKGASFQTVAS 661

  Fly   711 RFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLR 775
            ...::|.:|:.::....|.|||||.||..|....:|...||||||..|:|:..:|.:.|:|.||:
Human   662 LHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREGFPNRLQ 726

  Fly   776 FQHFVERYRHLLPS--PLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESG 838
            :..|.:||..|.|.  |.::....|:....||.::.   ::...|:.|.|:||.:......||:.
Human   727 YADFKQRYCILNPRTFPKSKFVSSRKAAEELLGSLE---IDHTQYRFGITKVFFKAGFLGQLEAI 788

  Fly   839 RTERLRRAAVSVQRHVRGMLVR---RQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLW 900
            |.|||.:.....|...:|.|:|   :::...:.|...:|...|...|.:.:..:|. ....:.|.
Human   789 RDERLSKVFTLFQARAQGKLMRIKFQKILEERDALILIQWNIRAFMAVKNWPWMRL-FFKIKPLV 852

  Fly   901 RGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVL--ERSQLSYLDIPAE---LA----- 955
            :..:....|..|:.:..:.|:|.|.::..||..:|||..|  |::.| .|.:.||   ||
Human   853 KSSEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDL-ILQLQAEQETLANVEEQ 916

  Fly   956 ---FIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPR-- 1015
               .|.||:|       ....||.|       |..|:..|::.       |.:...|.:|:..
Human   917 CEWLIKSKIQ-------LEARVKEL-------SERVEEEEEIN-------SELTARGRKLEDECF 960

  Fly  1016 -------------------------------------REPITAPLLTRAA-----SRDQDFQD-- 1036
                                                 .|.|:.  |.|||     :..|...|
Human   961 ELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISK--LNRAAKVVQEAHQQTLDDLH 1023

  Fly  1037 -------ALAVFKLILRWSNDKALEGA-----KEKLLADYIVHK---------------ALSSRG 1074
                   :|:...|.|....|: ||||     |.::..:..:||               ..|.|.
Human  1024 MEEEKLSSLSKANLKLEQQVDE-LEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRH 1087

  Fly  1075 LRDEI------LVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDD-----E 1128
            |.:|:      |.|:.::|..   ..|...:|.:.:              |.|...:.|     |
Human  1088 LAEELRKKELELSQMNSKVEN---EKGLVAQLQKTV--------------KELQTQIKDLKEKLE 1135

  Fly  1129 APESLRPLL-------------LRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMAL 1180
            |..:.|..:             |.:.|.:.||.:.:                           .|
Human  1136 AERTTRAKMERERADLTQDLADLNERLEEVGGSSLA---------------------------QL 1173

  Fly  1181 PLTLPDEAS-QTVAVDSWTSCEEAAA-LAVSSLGVASRGWTLV------LDDGQQLTDSCGLD-- 1235
            .:|...|.. |.:..|    .|||.. ...:|..:..|....:      :::.||:......|
Human  1174 EITKKQETKFQKLHRD----MEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKS 1234

  Fly  1236 ----YVMDLI------------AEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPP 1284
                .|.||:            ||| ||..:   ...|..:.||.      |.|.:.|....|..
Human  1235 DLQLEVDDLLTRVEQMTRAKANAEK-LCTLY---EERLHEATAKL------DKVTQLANDLAAQK 1289

  Fly  1285 TSSGKEDVPRERR-SSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVP 1348
            |....|.....|| ..:|.|....:..:..|.|:..      ...||.:..:|| ...||..:..
Human  1290 TKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIE------DLRGQLEKETKS-QSALAHALQK 1347

  Fly  1349 VPTDCD--------SQEPLHTLGLSESRLND-------RYHS-----AERLAPVGKDTGPRYQKS 1393
            ...|||        .||....|..:.|::|.       :|.:     .|.|....|:...|.|::
Human  1348 AQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEA 1412

  Fly  1394 QHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLF 1458
            ..|...::|.:.....:::..:.|.   ..|:||..            :|.|.|:.:||
Human  1413 AEAMGVANARNASLERARHQLQLEL---GDALSDLG------------KVRSAAARLDQ------ 1456

  Fly  1459 SPVLDGSLDELSDARSLAASIRGGSYEQEN-EAESEIDDLDDYINDIFQPIPLVQNL--EKLTSK 1520
                    .:|...::||      .::|:: |:::.:|.....:..:...:..::|.  |.:..:
Human  1457 --------KQLQSGKALA------DWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQ 1507

  Fly  1521 DQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSI---RGGG 1582
            :.|           :.|.::.:.||.:|.:.:.|..:.:...|.:.||..:|...|.:   ...|
Human  1508 ETL-----------RRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEG 1561

  Fly  1583 STDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQ 1647
            :.:.|.:..|..||..|..:.|....|.::..:        .:|.:.:||...  .:||:.|..:
Human  1562 ALERNESKILHFQLELLEAKAELERKLSEKDEE--------IENFRRKQQCTI--DSLQSSLDSE 1616

  Fly  1648 AAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLEC 1712
            |.:                              |::.||....:.|.|.        .|...|.|
Human  1617 AKS------------------------------RIEVTRLKKKMEEDLN--------EMELQLSC 1643

  Fly  1713 --KDPSETRHFLDPYG-RAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQM 1774
              :..||....|.... :.|.:::        |.:...|...|.........:|.:..|::...:
Human  1644 ANRQVSEATKSLGQLQIQIKDLQM--------QLDDSTQLNSDLKEQVAVAERRNSLLQSELEDL 1700

  Fly  1775 TSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDR-- 1837
            .|   :.|.....|..|      ||             :|:.::.|:....|..||.::.:.:
Human  1701 RS---LQEQTERGRRLS------EE-------------ELLEATERINLFYTQNTSLLSQKKKLE 1743

  Fly  1838 ------DRETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVR 1896
                  .:|.::|.|..|:  ..:.|||:           ::....||.|::::  |.|..|..|
Human  1744 ADVARMQKEAEEVVQECQN--AEEKAKKA-----------AIEAANLSEELKKK--QDTIAHLER 1793

  Fly  1897 STVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPP 1961
                  :.:.....:.|.:|.:.:.:...|..|                  |.||:::|.::...
Human  1794 ------TRENMEQTITDLQKRLAEAEQMALMGS------------------RKQIQKLESRVREL 1834

  Fly  1962 PAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKE 2026
            .....|                  .||                   ||.|.:...| ...:.:||
Human  1835 EGELEG------------------EIR-------------------RSAEAQRGAR-RLERCIKE 1861

  Fly  2027 HVPAFIQRQERDTFGAVRQQQMISSHHLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYS 2091
                ...:.|.|.....|.|..:....|.::::....       |.||.:.::..|:.:.::...
Human  1862 ----LTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQV-------EVAETQANQYLSKYKKQQHEL 1915

  Fly  2092 ESVWDRAEVEGPASGSGSEKEREKRERERE 2121
            ..|.:||||..........|.||..::.:|
Human  1916 NEVKERAEVAESQVNKLKIKAREFGKKVQE 1945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	242/691 (35%)
		PTZ00121	<828..>943	CDD:173412	28/119 (24%)
		MyTH4	1014..1171	CDD:470587	38/253 (15%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	18/92 (20%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
MYH15	XP_011510861.1	COG5022	53..1460	CDD:227355	400/1505 (27%)
		MYSc_Myh15_mammals	117..778	CDD:276892	242/691 (35%)
		SMC_prok_B	1093..1932	CDD:274008	189/1115 (17%)