Protein Alignment Myo10A and Myo5c

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_006510998.1
• Gene: Myo5c / 208943
• MGIID: 2442485
• Length: 1749
• Species: Mus musculus
• Alignment Length: 844
• Identity: 301/844 - (35%)
• Similarity: 457/844 - (54%)
• Gaps: 74/844 - (8%)

  Fly   156 GVEDMTLLDDLHEASLLWNLRLRY-DKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            |..|:|.|..|||.::|.|||:|: :..||||::|.||:|:||||..| .||..:...|:|:.:|
Mouse    68 GENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLP-IYGDAIIHAYSGQNMG 131

  Fly   220 SLPPHLFAIGAAAHAALP---SPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQI 281
            .:.||:||:...|:..:.   ..|.:::|||||:|||.|.:..|:|.|.|  ...|::|.:.:::
Mouse   132 DMDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATV--SKSSSNAHVEDKV 194

  Fly   282 LEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHV 345
            |.:.|:.||.|||:|.|||||||||||.|:.| :...|:||.:..|||||||:|.|:..|||||:
Mouse   195 LASNPITEAVGNAKTTRNDNSSRFGKYTEISFDERNQIIGANMRTYLLEKSRVVFQSENERNYHI 259

  Fly   346 FYELLGGLSETERSKYGLLEADKYFYLNQGATDCASG---RVDWESLQGAMQVLGVSEGEREGIV 407
            ||:|.....::|.....|..|:::.|...|......|   |.|....|....:||..:..:..:.
Mouse   260 FYQLCASAQQSEFKHLKLGSAEEFNYTRMGGNTVIEGVNDRADMVETQKTFTLLGFKKDFQMDVF 324

  Fly   408 RVLAAVLHLGNVYFHRRQLRHGQEGVEVG-SDAEIKWAAHLLHISADGLHRALTSRTTEARAERL 471
            ::|||:||||||    :....|.|...|. .|:.:|....||.:....:.:.|.:|.....:|.:
Mouse   325 KILAAILHLGNV----QVTTVGNERSSVSEDDSHLKVFCELLGLETSKVAQWLCNRKIVTSSETV 385

  Fly   472 HTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQ 536
            ..|:...||::||||.||.:||.||:::|.:||..:...|..... |.:|||:|||....|||||
Mouse   386 VKPMTRPQAINARDALAKKIYAHLFDFIVEQINQALHFSGKQHTF-IGVLDIYGFETFDVNSFEQ 449

  Fly   537 LCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNF 601
            .|||||||.||..||.|||||||.||.:|.:.||.:.:.||.|||.|:..| :||..|||:|...
Mouse   450 FCINYANEKLQQQFNLHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAK-MGILELLDEECLL 513

  Fly   602 PRATDLSFLEKCHYNHALSE--LYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLEL 664
            |..||.::|:|. ||:.:::  |:.:||:....|.:.|:|.:|.|..:|||:||||.:...::|:
Mouse   514 PHGTDENWLQKL-YNNFVNKNSLFEKPRMSNSSFIIQHFADKVEYQCEGFLEKNRDTVYDMLVEI 577

  Fly   665 LASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVT-------MKPRT----PTVAARFADSLQQ 718
            |.:|:..|.....::        ..:|....|..:|       :||.|    .||..:|..||..
Mouse   578 LRASKFHLCAAFFQE--------SPVPSSPFGAMITVKSAKQVIKPNTKHFRTTVGNKFRSSLYL 634

  Fly   719 LLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERY 783
            |::::....|.:|||||||.||.....|...::||||..|:|:||:|..:.||.|..:..|..||
Mouse   635 LMETLNATTPHYVRCIKPNDEKMPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYLEFYSRY 699

  Fly   784 RHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAV 848
            ..|:.......:..:|:|:.:|..:.:   :...||.|.|::|.|......||..|.::||:..:
Mouse   700 GILMTQQELSLSDKKEVCKVVLHRLIQ---DSNQYQFGRTKIFFRAGQVAYLEKLRLDKLRQDCI 761

  Fly   849 SVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQR---------------------------- 885
            .:|:||||.|.||:..|.:.||..:|..:|||:..::
Mouse   762 MIQKHVRGWLQRRKFLRERQAALTIQRYFRGQQTVRKAITATALKEAWAAIILQKYCRGYLVRNL 826

  Fly   886 YERLRKGALTAQRLWRGRQARRRVQQLRSDHRR--RQEAREAAQRAREAREAKQAVLERSQLSY 947
            |:.:|...:|.|...||..||||.::|..:|:.  .|:...|....|..:..::.|| ..||:|
Mouse   827 YQLIRVATITIQAHTRGFLARRRYRKLLQEHKAVILQKYARAWLARRRFQNIRRFVL-NIQLTY 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	253/680 (37%)
		PTZ00121	<828..>943	CDD:173412	38/144 (26%)
		MyTH4	1014..1171	CDD:470587
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myo5c	XP_006510998.1	MYSc_Myo5	81..741	CDD:276831	253/680 (37%)
		IQ	831..851	CDD:459869	9/19 (47%)
		SMC_prok_B	<850..>1385	CDD:274008	10/41 (24%)
		Myo5c_CBD	1376..1743	CDD:271260