DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and Myo5c

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	XP_006510998.1	Gene:	Myo5c / 208943	MGIID:	2442485	Length:	1749	Species:	Mus musculus

Alignment Length:	844	Identity:	301/844 - (35%)
Similarity:	457/844 - (54%)	Gaps:	74/844 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 GVEDMTLLDDLHEASLLWNLRLRY-DKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            |..|:|.|..|||.::|.|||:|: :..||||::|.||:|:||||..| .||..:...|:|:.:|
Mouse    68 GENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLP-IYGDAIIHAYSGQNMG 131

  Fly   220 SLPPHLFAIGAAAHAALP---SPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQI 281
            .:.||:||:...|:..:.   ..|.:::|||||:|||.|.:..|:|.|.|  ...|::|.:.:::
Mouse   132 DMDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATV--SKSSSNAHVEDKV 194

  Fly   282 LEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHV 345
            |.:.|:.||.|||:|.|||||||||||.|:.| :...|:||.:..|||||||:|.|:..|||||:
Mouse   195 LASNPITEAVGNAKTTRNDNSSRFGKYTEISFDERNQIIGANMRTYLLEKSRVVFQSENERNYHI 259

  Fly   346 FYELLGGLSETERSKYGLLEADKYFYLNQGATDCASG---RVDWESLQGAMQVLGVSEGEREGIV 407
            ||:|.....::|.....|..|:::.|...|......|   |.|....|....:||..:..:..:.
Mouse   260 FYQLCASAQQSEFKHLKLGSAEEFNYTRMGGNTVIEGVNDRADMVETQKTFTLLGFKKDFQMDVF 324

  Fly   408 RVLAAVLHLGNVYFHRRQLRHGQEGVEVG-SDAEIKWAAHLLHISADGLHRALTSRTTEARAERL 471
            ::|||:||||||    :....|.|...|. .|:.:|....||.:....:.:.|.:|.....:|.:
Mouse   325 KILAAILHLGNV----QVTTVGNERSSVSEDDSHLKVFCELLGLETSKVAQWLCNRKIVTSSETV 385

  Fly   472 HTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQ 536
            ..|:...||::||||.||.:||.||:::|.:||..:...|..... |.:|||:|||....|||||
Mouse   386 VKPMTRPQAINARDALAKKIYAHLFDFIVEQINQALHFSGKQHTF-IGVLDIYGFETFDVNSFEQ 449

  Fly   537 LCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNF 601
            .|||||||.||..||.|||||||.||.:|.:.||.:.:.||.|||.|:..| :||..|||:|...
Mouse   450 FCINYANEKLQQQFNLHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAK-MGILELLDEECLL 513

  Fly   602 PRATDLSFLEKCHYNHALSE--LYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLEL 664
            |..||.::|:|. ||:.:::  |:.:||:....|.:.|:|.:|.|..:|||:||||.:...::|:
Mouse   514 PHGTDENWLQKL-YNNFVNKNSLFEKPRMSNSSFIIQHFADKVEYQCEGFLEKNRDTVYDMLVEI 577

  Fly   665 LASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVT-------MKPRT----PTVAARFADSLQQ 718
            |.:|:..|.....::        ..:|....|..:|       :||.|    .||..:|..||..
Mouse   578 LRASKFHLCAAFFQE--------SPVPSSPFGAMITVKSAKQVIKPNTKHFRTTVGNKFRSSLYL 634

  Fly   719 LLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERY 783
            |::::....|.:|||||||.||.....|...::||||..|:|:||:|..:.||.|..:..|..||
Mouse   635 LMETLNATTPHYVRCIKPNDEKMPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYLEFYSRY 699

  Fly   784 RHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAV 848
            ..|:.......:..:|:|:.:|..:.:   :...||.|.|::|.|......||..|.::||:..:
Mouse   700 GILMTQQELSLSDKKEVCKVVLHRLIQ---DSNQYQFGRTKIFFRAGQVAYLEKLRLDKLRQDCI 761

  Fly   849 SVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQR---------------------------- 885
            .:|:||||.|.||:..|.:.||..:|..:|||:..::
Mouse   762 MIQKHVRGWLQRRKFLRERQAALTIQRYFRGQQTVRKAITATALKEAWAAIILQKYCRGYLVRNL 826

  Fly   886 YERLRKGALTAQRLWRGRQARRRVQQLRSDHRR--RQEAREAAQRAREAREAKQAVLERSQLSY 947
            |:.:|...:|.|...||..||||.::|..:|:.  .|:...|....|..:..::.|| ..||:|
Mouse   827 YQLIRVATITIQAHTRGFLARRRYRKLLQEHKAVILQKYARAWLARRRFQNIRRFVL-NIQLTY 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	261/701 (37%)
		MYSc_Myo15	169..828	CDD:276838	253/680 (37%)
		MyTH4	1014..1171	CDD:295320
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myo5c	XP_006510998.1	MYSc_Myo5	81..741	CDD:276831	253/680 (37%)
		DUF3584	<767..>1043	CDD:378817	33/124 (27%)
		SMC_prok_A	<922..1276	CDD:274009
		ERM	1220..>1354	CDD:366293
		Myo5c_CBD	1376..1743	CDD:271260
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810