Protein Alignment Myo10A and Myo16

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_008769606.1
• Gene: Myo16 / 192253
• RGDID: 621561
• Length: 1934
• Species: Rattus norvegicus
• Alignment Length: 2022
• Identity: 461/2022 - (22%)
• Similarity: 735/2022 - (36%)
• Gaps: 648/2022 - (32%)

  Fly     6 GDLVWFDPGMGHPI-------------------------------PGEIQEVHRAAQVIVVQALI 39
            |||...|.|...|:                               |.:|     ||...:.:.|:
  Rat   268 GDLNGMDDGYWTPLHLAAKYGQTTLVKLLLAHQANPHLVNCNGEKPSDI-----AASESIEEMLL 327

  Fly    40 KGKMRIVRFHLEPWQRGGGGSVTPSPAQSPSLALLSPHVLRRQRPASLEDFEDLPNLSAK-HP-A 102
            |.::        .|:.    .:..||: .||||         |.....|...|||.||:| .| .
  Rat   328 KAEI--------AWEE----RMKESPS-VPSLA---------QEELYEEILHDLPELSSKLSPLV 370

  Fly   103 LPSSRLRRLKCRYPQVVKRLSTLCSDVI-------------------------ARHPQTFALQPG 142
            ||             :.|:.|.|..|::                         :..|:...|.|.
  Rat   371 LP-------------IAKQDSLLEKDIMFKDTTKGLCNQESQDGPPETSMVSSSSKPEQVQLTPP 422

  Fly   143 EGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGL 207
            ..|            :|:..|.:|:::|||:.::.|:....|:||.|.|.:.|||:|..| .|..
  Rat   423 APS------------DDLATLSELNDSSLLYEIQKRFGNDQIHTFIGDIFLLVNPFKELP-IYST 474

  Fly   208 EVAKQY---AGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAV 266
            .|::.|   .|:...|||||||:....|...|   ..||.:::|||.|||||:::|.:|::|.:
  Rat   475 VVSQMYLSPTGQRSPSLPPHLFSCAERAFHRLFQERRPQNIILSGERGSGKTQASKQIMKHLTS- 538

  Fly   267 VPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF--KSGAIVGAKITQYLLE 329
              ...|:..:...:...|..:|||||:|:|..|:.||...:|.|:.|  :...:.||:|:.|:||
  Rat   539 --RASSSCTMFDSRFKHAICILEAFGHAKTTLNNVSSCLIQYWELQFCQRRKHVTGARISTYMLE 601

  Fly   330 KSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCAS------GRVDWES 388
            |.|:|.|.||:.::.:|..|:.|||..|:....|.....:.|::||..:..|      .:.....
  Rat   602 KPRLVAQPPGQGSFLIFSWLMDGLSAEEKCGLHLSNFCAHRYVSQGMREDVSTAERSLNKERLAD 666

  Fly   389 LQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAE-IKWAAHLLHISA 452
            |:.|:.|:|.|..|.|.:..:|:|:||:|::.|  ..|........  ||.: ::..|.:|.:|.
  Rat   667 LKHALNVIGFSALEVENLFAILSAILHIGDIQF--TALTEADSAFV--SDLQLLEQVADMLQVST 727

  Fly   453 DGLHRALTSRTTEARAE---RLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHD 514
            |.|..|||:.....:.:   |.||   ...|...||..||:||:.||.:|::.:|..:|   :.|
  Rat   728 DELASALTTDIQYFKGDVIIRRHT---TQIAAFYRDLLAKSLYSRLFGFLINTVNCCLQ---SQD 786

  Fly   515 AHR------ISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEW-TPL 572
            .::      |.||||||||:..:|.|||||:|..||.:..|..:.:|..||.|..:|.:.. |..
  Rat   787 EYKSLQTLDIGILDIFGFEEFQKNEFEQLCVNLTNEKMHHYIQEVLFLQEQTECVQEGVAMETAC 851

  Fly   573 AWDDNLPVIHLLAKKPVGICHLLDDES--------NFPRATDLSFLEKCHYNHALSEL------Y 623
            :..:...|:....:||.|...|||:||        |.||... ..||..:.|...|.:      .
  Rat   852 SPGNQAGVLDFFFQKPSGFFSLLDEESQAIWSVEPNLPRKLQ-GLLESSNTNAVYSPMKDGNGNV 915

  Fly   624 ARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGK 688
            |....|| .|.|.||||:|.|.:.|.:::|:|:|..::|.::.:|...::..|.:        .|
  Rat   916 AFKGQGA-AFTVMHYAGRVTYEIRGAVERNKDSLSQNLLFVMKTSENVVISHLFQ--------SK 971

  Fly   689 TLPKGSNGRFVTMKP-------RTPTVAARFADS----------LQQLLQSMGRC---------- 726
            ..|.||   .::..|       ::..::.|.|.|          |.:||:..|.|
  Rat   972 LSPTGS---LISSYPSFKFGGHKSSLLSKRIASSMVGVNKNYLELSKLLKKKGTCTFLQRLERGD 1033

  Fly   727 ----------------------HPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRG 769
                                  .|.|:.|:|||..:.....|...|..||:|||:|..:::.:.|
  Rat  1034 PATTASQLTKSLADITAKLQKGSPHFILCVKPNTSQLPGVFDHFYVSAQLQYLGVLGLVRLFRYG 1098

  Fly   770 YPVRLRFQHFVERYRHLLPSPLA-------RGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFL 827
            ||||..|:.|:.||     .|||       :|.|..|.||.:|:   |..::|  :|:|..:|||
  Rat  1099 YPVRPSFEDFLSRY-----EPLASVLLGEKKGQPAEERCRLVLQ---RCKLQG--WQMGVHKVFL 1153

  Fly   828 REALHRALESGRTERL-------RRAAVSVQRHVRGMLVRRQLARR----QAAATRLQARWRG-- 879
            :        ..:.::|       :|..|:.|:.:||.|.|:.|.:|    |...|.:::..:.
  Rat  1154 K--------YWQVDQLGDLWLQMQRKIVTCQKVIRGFLARQHLLQRMSIKQQEVTSIKSFLQSTE 1210

  Fly   880 QRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSD-----HRRRQEAREAAQRAREAREAKQAV 939
            ..|.:.|:     ||..|   ......|...:||.:     ||.|||  |..:||.:     |..
  Rat  1211 DMALKTYD-----ALVIQ---NASDIAREHDRLRKEVHAAYHRNRQE--EGTKRAED-----QGG 1260

  Fly   940 LERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSS 1004
            ...:..:.:.:|..:..:...|.|.|......|.|..:....|.||...|.|.
  Rat  1261 CRHAHSNSVPVPMAVDSLAQALAGPSSRSPSLHSVFSMDDSTGLPSPRKQPPP------------ 1313

  Fly  1005 VYCNGLRLQPRREP----------------ITAPLLTRAASRDQDFQDALAVFKLI----LRWSN 1049
                    :|:|:|                .|....:.|.:|.:...|..:..|.|    .:.|.
  Rat  1314 --------KPKRDPNTRLSASYEAVSACLSATKDAASEALTRPRPHSDDYSTMKKIPPRKPKRSP 1370

  Fly  1050 DKALEGAKEKL--------LADYIVHKALSSRGLR---DEILVQLCNQV-------------HGL 1090
            ...|.|:.|::        :.....|.|..:.|::   .:.:.|...|:             .|.
  Rat  1371 HTKLSGSYEEIWGPRPSGTMGQVGKHHAPGTLGVQWASPDSMPQCTPQLPLHLPLPQGDYDDDGE 1435

  Fly  1091 P-------------------PNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAP---ESL 1133
            |                   |:.||:  :::.:...|    |.......::.|:....|   |:.
  Rat  1436 PVYIEMVGNAARAGGSETDSPDQGES--VYEEMKYVL----PEEGCGPGMLTFLPASPPLFLETR 1494

  Fly  1134 RPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDM--ALPLTLPDEASQTVAVDS 1196
            :.::|.              .|.|:|:.....          ||:  ..|..||......|...:
  Rat  1495 KAIILE--------------AGEGSCQPLKDT----------CDIPPPFPNLLPHRPPLLVFPPT 1535

  Fly  1197 WTSCEEAA------ALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPR- 1254
            ..:|..|:      .|.|..|.|.                ...|.|.:.......|.|.:...:
  Rat  1536 PVTCSPASDESPLTPLEVKKLPVL----------------ETNLKYPVQSEGSSPLSPQYSKAQK 1584

  Fly  1255 --SDLLRSGAKFARTTLPDAVKRPAVPPP-----------------APPTSSGKEDVPRERRSSR 1300
              :|.|.|.. |.....|..:..||.|||                 .||...|...||
  Rat  1585 GENDQLTSPG-FPVFNGPSRISPPATPPPPPGPPPAPCGPPSAPCGPPPAPCGPPPVP------- 1641

  Fly  1301 ELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDS-----QEPLH 1360
                           ..|.|.|                    .|   |.|..|.:     :.|.|
  Rat  1642 ---------------CGPPPAP--------------------CG---PPPAPCGAAPAPCRPPTH 1668

  Fly  1361 ------------TLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYA 1413
                        ...|:.|.| .|.......|||   .||                    .|.:.
  Rat  1669 FAFPPDSVLVTAAKALTNSDL-PRTQPKPSSAPV---LGP--------------------CSPFV 1709

  Fly  1414 DKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAAS 1478
             ||.|:...:|.:|..:|.|..|      .||..|..:       |..|...||||:...:...|
  Rat  1710 -KAPYSPGRTARADLRKASSTFS------PPSPYSPPN-------SRPLSSPLDELASLFNSGRS 1760

  Fly  1479 I--RGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDE 1541
            :  |.....:..|||....:::                  |:|:|:.::    ..:||:.::|:.
  Rat  1761 VLRRSAVGRRIREAEGFETNMN------------------LSSRDEPSS----SEMASETQDRNA 1803

  Fly  1542 ESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESG 1606
            .:....|...::.    :..||..:.:|:           |..:.:|...|.     |.|   .|
  Rat  1804 NNHGTQLSSSLSS----VVAAENGNPVTN-----------GLAEDDGCSRLC-----LSG---MG 1845

  Fly  1607 PALYQQQVQRAFLQSAMAQNLQIQQQL-LAQNQ--ALQTLLSQQAAAAAANNSTSPPPAPPILSS 1668
            .:.:|:..:        :...|:..|| |::|:  |||.||.
  Rat  1846 TSSFQRHRE--------SHTTQVIHQLRLSENESVALQELLD----------------------- 1879

  Fly  1669 LSISPPPPQSPMRMKATRSSLVVMESLQPPPP--PPPPPMPPPLECKDPSETRHFLDPYGRAKTV 1731
                       .|.|...|.....|::|.|.|  |||||      ||.|:..:   .|.|.:.|
  Rat  1880 -----------WRRKLCESREGWQEAMQHPEPRAPPPPP------CKKPTLLK---KPEGGSCT- 1923

  Fly  1732 RIGKWRW 1738
            |:....|
  Rat  1924 RLSSQLW 1930

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	228/753 (30%)
		PTZ00121	<828..>943	CDD:173412	29/132 (22%)
		MyTH4	1014..1171	CDD:470587	32/222 (14%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	12/74 (16%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myo16	XP_008769606.1	ANKYR	81..332	CDD:440430	12/76 (16%)
		ANK repeat	114..145	CDD:293786
		ANK repeat	147..178	CDD:293786
		ANK repeat	180..210	CDD:293786
		ANK repeat	243..274	CDD:293786	3/5 (60%)
		ANK repeat	276..307	CDD:293786	2/30 (7%)
		MYSc_Myo16	437..1154	CDD:276844	228/753 (30%)
		NYAP_N	1236..1603	CDD:464717	74/440 (17%)