Protein Alignment Myo10A and myo-2

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_510092.2
• Gene: myo-2 / 181404
• WormBaseID: WBGene00003514
• Length: 1947
• Species: Caenorhabditis elegans
• Alignment Length: 2162
• Identity: 499/2162 - (23%)
• Similarity: 846/2162 - (39%)
• Gaps: 490/2162 - (22%)

  Fly   158 EDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLP 222
            |||:.|..|::||:|:||:.||...||||::|...:.:||||..| .|...||:.:.|:....:|
 Worm    84 EDMSNLTFLNDASVLYNLKARYAAMLIYTYSGLFCVVINPYKRLP-IYTDSVARMFMGKRRTEMP 147

  Fly   223 PHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSA----------- 273
            |||||:...|:..:   ...|.::|:||||:||||:||.|:.|.|||    |:|
 Worm   148 PHLFAVSDEAYRNMLQNHENQSMLITGESGAGKTENTKKVISYFAAV----GAAQQETFGAKKAA 208

  Fly   274 --------SAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLE 329
                    ...:.:||::..|:|||||||:|.||:|||||||::.::| |.|.:....|..||||
 Worm   209 TEEDKNKKKVTLEDQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRIHFSKQGRVASCDIEHYLLE 273

  Fly   330 KSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADK-YFYLNQG--ATDCASGRVDWESLQG 391
            |||::.||||||.||:||::........:....|.:..| |:::.|.  ..|..:.:.:.:....
 Worm   274 KSRVIRQAPGERCYHIFYQVFSDYLPNLKKDLLLNKPVKDYWFIAQAELIIDGINDKEEHQLTDE 338

  Fly   392 AMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLH 456
            |..:|..:..|:....|::||::|:||:.|.:|. |..|...:...|||  .||....|.::...
 Worm   339 AFDILKFTPTEKMECYRLVAAMMHMGNMKFKQRP-REEQAEPDGTDDAE--RAAKCFGIDSEEFL 400

  Fly   457 RALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISIL 521
            :|||....:...|.::....|:|...|..|.||.||:.:|||||.:.|..:.:.|....|.|.:|
 Worm   401 KALTRPRVKVGNEWVNKGQNIEQVNWAVGAMAKGLYSRIFNWLVKKCNQTLDQKGISRDHFIGVL 465

  Fly   522 DIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAK 586
            ||.|||....||||||.||:.||.||.:||.|:|.|||.|||||.::||.:.:..:|.....|.:
 Worm   466 DIAGFEIFDFNSFEQLWINFVNEKLQQFFNHHMFVLEQEEYAREGIQWTFIDFGLDLQACIELIE 530

  Fly   587 KPVGICHLLDDESNFPRATDLSFLEKC---HYNHALSELYARPRIGAQ---EFGVTHYAGQVWYC 645
            ||:||..:||:|...|:||||:..:|.   |.....:....:|..|.|   .|.:.||||.|.|.
 Worm   531 KPLGIIAMLDEECIVPKATDLTLAQKLIDQHLGKHPNFEKPKPPKGKQAEAHFAMRHYAGTVRYN 595

  Fly   646 VDGFLDKNRDALRGDVLELL-ASSRLPLVGELTKQLRAQRDAGKTLPKGS--------NGRFVTM 701
            ...:|:||:|.|...|:.:: ||....|:.|:.:....|.:|.....||:        :|.|:
 Worm   596 CLNWLEKNKDPLNDTVVTVMKASKEHALIVEVWQDYTTQEEAAAAAAKGTAGAKKKGKSGSFM-- 658

  Fly   702 KPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIR 766
                 ||:..:.:||.:|:..:...||.|:|||.||::|.:..:|...||.||...|:|:.|:|.
 Worm   659 -----TVSMLYRESLNKLMTMLHSTHPHFIRCIIPNEKKASGVIDAGLVLNQLTCNGVLEGIRIC 718

  Fly   767 QRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEA--MPRTGVEGPDYQLGATRVFLRE 829
            ::|:|.|.....||:||..|.......|....:...||:.|  :....:|..::::|.|:||.:.
 Worm   719 RKGFPNRTLHPDFVQRYALLAADESIIGKTDAKKGSALMLARLVKEKKLEEENFRVGLTKVFFKA 783

  Fly   830 ALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRA------------ 882
            .:...||..|.:.|.:....:|..:|......:..||....|.|:...|..|:
 Worm   784 GIVAHLEDLRDQSLAQLITGLQAQIRWYYQTIERKRRVEKITALKIIQRNIRSWAELRTWVWFKL 848

  Fly   883 -------------QQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREARE 934
                         :.:||:|::...|.:            ..:..:..::::.:|.|:|..:...
 Worm   849 YGKVKPLVNSGKIEAQYEKLQETVATLK------------DTVVQEEEKKRQLQEGAERLNKETA 901

  Fly   935 AKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSF 999
            ...|.||.|:.|..::...:..:            :...|.:.|.: ...|..:::.|
 Worm   902 DLLAQLEASKGSTREVEERMTAM------------NEQKVALEGKL-ADASKKLEVEE------- 946

  Fly  1000 GKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDA-LAVFKLILRWSNDKALEGAKE---KL 1060
                   ...:.:..:::.:.|    ..|...::.||. |::.|:       :|.:.|||   :.
 Worm   947 -------ARAVEINKQKKLVEA----ECADLKKNCQDVDLSLRKV-------EAEKNAKEHQIRA 993

  Fly  1061 LADYI------VHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSK 1119
            |.|.:      :.|....|..::|...:|...:......:..|.:|...|.|.|...:.:....|
 Worm   994 LQDEMRQQDENISKLNKERKNQEEQNKKLTEDLQAAEEQNLAANKLKAKLMQSLEDSEQTMEREK 1058

  Fly  1120 YLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTL 1184
            .....:|....::...|.:.|...::...:.|.|..|...:       |....|.|      :.|
 Worm  1059 RNRADMDKNKRKAEGELKIAQETLEELNKSKSDAENALRRK-------ETELHTLG------MKL 1110

  Fly  1185 PDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGL--------------- 1234
            .||.:....:......:||.                |.|...||.|....
 Worm  1111 EDEQAAVAKLQKGIQQDEAR----------------VKDLHDQLADEKDARQRADRSRADQQAEY 1159

  Fly  1235 --------DYVMDLIAEKELCPAFPAP----RSDLLRSGAKFAR--TTL----PDAVKRPAVPPP 1281
                    |......|:.||.....|.    |.||..||.||..  |.|    .||::.  :...
 Worm  1160 DELTEQLEDQARATAAQIELGKKKDAELTKLRRDLEESGLKFGEQLTVLKKKGSDAIQE--LSDQ 1222

  Fly  1282 APPTSSGKEDVPRER-RSSRELLSRSSALNERYFEREPSPGPGQGSSTG------QAKSRSKSLD 1339
            .......|..:.:|: ...||....|:||::....|.......:|....      :|..:|:.|.
 Worm  1223 IEQLQKQKGRIEKEKGHMQREFDESSAALDQEAKLRADQERIAKGYEVRLLELRLKADEQSRQLQ 1287

  Fly  1340 DLLAGDIVPVPTDCDSQEPLHTLGLSESRLN----DRYHSAERLAPVGKDTGPRYQKSQHAGRRS 1400
            |.::                     |:.|||    |.....|.|.  .|.......|.|.:....
 Worm  1288 DFVS---------------------SKGRLNSENSDLARQVEELE--AKIQAANRLKLQFSNELD 1329

  Fly  1401 HAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHV----RRVRVPSQAS-DVDQFLDDLFSP 1460
            ||.......|:........:::.|........|:...|    ...|..|:|| ::||:.....:.
 Worm  1330 HAKRQAEEESRERQNLSNLSKNLARELEQLKESIEDEVAGKNEASRQLSKASVELDQWRTKFETE 1394

  Fly  1461 VLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNL-EKLTSK---D 1521
            .|.|: ||..:.:           :::|:..|||.|..|..|   ..|..::|. .:||::   :
 Worm  1395 GLIGA-DEFDEVK-----------KRQNQKTSEIQDALDACN---AKIVALENARSRLTAEADAN 1444

  Fly  1522 QLAAIIKGGGVAS-KPEERDEESEIEDLDDYINELFEPIPVAE-GLDKLTSKEHLAVSIRGGGST 1584
            :|.|......|:| :.:::..:..|::....:::|:..:..|: ...:|:.:.|   .:||...|
 Worm  1445 RLEAEHHAQAVSSLEKKQKAFDKVIDEWKKKVDDLYLELDGAQRDARQLSGEAH---KLRGQHDT 1506

  Fly  1585 DSNGADPLLHQLMQLPGET--------ESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQ 1641
            .::..:.|..:...|..||        |.|.|.:           |:::||   ::|..:.:.||
 Worm  1507 LADQVEGLRRENKSLSDETRDLTESLSEGGRATH-----------ALSKNL---RRLEMEKEELQ 1557

  Fly  1642 TLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPM 1706
            ..|.:..||..:..|                          ||.|..:.|
 Worm  1558 RGLDEAEAALESEES--------------------------KALRCQIEV--------------- 1581

  Fly  1707 PPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQH 1771
                     |:.|..::.       ||.             :.||:|      ::.||.
 Worm  1582 ---------SQIRAEIEK-------RIA-------------EKEEEF------ENHRKV------ 1605

  Fly  1772 HQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNN-- 1834
            ||.|.:...      |...|.|..:.|.|.::.    .:...:....|.|:........|..|
 Worm  1606 HQQTIDSIQ------ATLDSETKAKSELFRVKK----KLEADINELEIALDHANKANEDAQKNIR 1660

  Fly  1835 --RDRDRETQDVGQPMQSVVTTKLAKKSFE---IGADRPPPGSVGKLKLSSEMRQ----RLEQV- 1889
              .|:.||.|      |:|...:..::.|.   :.|:|       ||.::.:.::    :||.:
 Worm  1661 RYLDQIRELQ------QTVDEEQKRREEFREHLLAAER-------KLAVAKQEQEELIVKLEALE 1712

  Fly  1890 TAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERM 1954
            .|...|.|:|....|.......::......:.||....|.::      ..:.::|..:....:|
 Worm  1713 RARRVVESSVKEHQEHNNELNSQNVALAAAKSQLDNEIALLN------SDIAEAHTELSASEDR- 1770

  Fly  1955 EGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTS 2019
             |:.:...|                          ..:|........||....|       ::..
 Worm  1771 -GRRAASDA--------------------------AKLAEDLRHEQEQSQQLER-------FKKQ 1801

  Fly  2020 SSQVVKEHVPAFIQRQERDTFGAV---------RQQQMISSHHLHLEDHSASSSPAVAAWEQAER 2075
            ....||:     :|.:......||         :.:|.:.:....||..|..:..|.....:|:|
 Worm  1802 LESAVKD-----LQERADAAEAAVMKGGAKAIQKAEQRLKAFQSDLETESRRAGEASKTLARADR 1861

  Fly  2076 E-RSRSRSRSRDREDY---SESVWDRAEVEGPASGSGSEKEREKRERERERLYEIRQVERERESH 2136
            : |......:.|:::|   .|.|               ||...|.:.::::|.|   .|.:..||
 Worm  1862 KVREFEFQVAEDKKNYDKLQELV---------------EKLTAKLKLQKKQLEE---AEEQANSH 1908

  Fly  2137 KVYQPAPPRVIQASMDT 2153
            .    :..|.:|.|::|
 Worm  1909 L----SKYRTVQLSLET 1921

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	247/701 (35%)
		PTZ00121	<828..>943	CDD:173412	22/139 (16%)
		MyTH4	1014..1171	CDD:470587	29/166 (17%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	12/89 (13%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
myo-2	NP_510092.2	COG5022	27..1478	CDD:227355	392/1527 (26%)
		MYSc_class_II	95..782	CDD:276951	247/701 (35%)
		SMC_prok_B	1097..1936	CDD:274008	191/1084 (18%)