DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and hum-4

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_001359540.1 Gene:hum-4 / 181335 WormBaseID:WBGene00002037 Length:2577 Species:Caenorhabditis elegans


Alignment Length:3124 Identity:737/3124 - (23%)
Similarity:1248/3124 - (39%) Gaps:710/3124 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPY--KMFPDAYGLEVAKQYAGRPLG 219
            ::::..|.|..||.:..||..|:.||:.||.|.::|:.||.:  |...|....|.:.        
 Worm     1 MDNLIELPDQSEAGIAQNLHERFKKGVTYTKASNVLVFVNDFNDKDSEDQLSWETSS-------- 57

  Fly   220 SLPPHLFAIGAAAHAAL-------PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVI 277
                 ...:.|.|..||       .:.:.:|..|||||||:.:.....:||.:     ...|.|.
 Worm    58 -----TSGVNAVAKNALNKIFNMSSNAESIVFGGESGSGKSYNVFKAFKYLTS-----QPKSKVS 112

  Fly   278 TEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKSGAIVGAKITQYL-LEKSRIVTQAPGER 341
            |:.......:.::||.|:|.:||.::|||..:::.:|...:.|..:...: ||..|:::|.||||
 Worm   113 TKHSSSIEFVFKSFGCAKTLKNDEATRFGCSIDLLYKRNVLTGLNLKYTVPLEVPRVISQKPGER 177

  Fly   342 NYHVFYELLGGLSETERSKYGLLEADKYFYLNQG-ATDCASGRVD-WESLQGAMQVLGVSEGERE 404
            |:::|||:..|||:..::|:|:....|:||:||| :::.....|: ::.|:.|:.|||.|:....
 Worm   178 NFNIFYEVYHGLSDEMKAKFGIKGLQKFFYINQGNSSENIQHDVNRFKHLESALHVLGFSDDHCM 242

  Fly   405 GIVRVLAAVLHLGNVYFH-RRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARA 468
            .|.::::.:||:||:||. :|.....|:.||:|:.||:||.|.||.:..|.|.:.|...:.:.  
 Worm   243 SIYKIISTILHIGNIYFRTKRNPNVEQDVVEIGNLAELKWIAFLLEVDFDQLVKFLLPTSEDG-- 305

  Fly   469 ERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENS 533
                :.:.::.|||.||:||..:|..||.|:::|| .:..|...|.. .|||||.:|||....|.
 Worm   306 ----STIELNAALDNRDSFAMMIYEELFKWVLNRI-GLQLKCSLHTG-VISILDHYGFEKYNNNG 364

  Fly   534 FEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLP-------VIHLLAKKPVGI 591
            .|:..||..||.::..|.||.|..:..:||::     .::.|..:|       .:.||.|||.|:
 Worm   365 VEEFLINSVNERIENLFVKHCFHDQLIDYAKD-----GISVDYKVPNSIENGKTVELLFKKPYGL 424

  Fly   592 CHLLDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQ-EFGVTHYAGQVWYCVDGFLDKNRD 655
            ..||.||..||:.|..::||.|:.||.....|.:.|...: ||||.|..|..||.|..|..:|:.
 Worm   425 LSLLTDECKFPKGTHETYLEHCNLNHTDRSAYGKARNKERLEFGVRHCIGTTWYNVTDFFARNKR 489

  Fly   656 ALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFA-DSLQQL 719
            .:....::|:.:|:.|::|.|.:..            |.|...:.:.      .|:|. ...|.:
 Worm   490 IISLSAVQLMRNSKNPIIGLLFESY------------GGNTSDIIVS------QAQFVLRGAQDI 536

  Fly   720 LQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYR 784
            ...:...|..||||||.|.|:.:.:.|:|.|.:|::.|.:.:.:..|.:||||::....|..:||
 Worm   537 ADKINVSHVHFVRCIKSNNERQSTKFDIPLVNRQIKNLLLAELLSFRVKGYPVKISKTTFARQYR 601

  Fly   785 HLLPSPLARGTPYRELCRALLEAMPRTGVE-GPDYQLGATRVFLREALHRALESGRTERLRRAAV 848
            .|||..:|:....:|:.:.:|:..   ||: ..|:::|...|||||.|....:..:.:....||:
 Worm   602 CLLPGDIAQCQNEKEIIQDILQGQ---GVKYEDDFKIGTEYVFLRERLAERYDGLQNKICGDAAI 663

  Fly   849 SVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLR 913
            .:|::::..:.::...|.:||..:||:..||.:|::.|...|:....|    .||..:|      
 Worm   664 IIQKNMKSFVAQKVYKRMRAAIIKLQSGLRGWKARRDYIIKREEMFKA----IGRTMKR------ 718

  Fly   914 SDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLG 978
               .:|.:|...|.....:.:     |:::.:.|:||..:......:      |..|....:.|.
 Worm   719 ---NKRLDAYHQALGTENSGQ-----LQQTLVGYIDINEDAKKFLER------PTSDSDATETLT 769

  Fly   979 ---TVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAV 1040
               |||     ......::...:..:|:.....|..|:||||||..|.|.:.:  |.||:.::.:
 Worm   770 HYLTVP-----MKNFLSNMNSITLEQFAEENFKGHLLEPRREPIMTPFLHKES--DYDFRLSVEI 827

  Fly  1041 FKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLG 1105
            |||||::.||..|...:.:.|..|||.:.:|:...|||||||..||::.....:. :...|:|:.
 Worm   828 FKLILKYMNDIKLTKKQREDLGRYIVQQGISNPCQRDEILVQTINQINKNQDKTA-SDNGWKLVH 891

  Fly  1106 QCLCCFQPSAAFSKYLMRFVDDEA---PESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWL 1167
            ..:..|.|:......|:.|.:.|:   .|.|...|.|:|          ....:...|...|:.|
 Worm   892 MAISVFPPTENIIPMLIGFFNKESVPMKEQLFATLQRRL----------KIYDSEIARELPPSNL 946

  Fly  1168 EWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVA-SRGWTLVLDDGQQLTDS 1231
            |..|.....:....:...|.....|.:..|::..|.|...:...||. :.|||:.::...::...
 Worm   947 ELIATPNIPNTVAEINCYDGLCCDVHLSPWSTTSEIAERILKQRGVGIALGWTVEVETPNRVFAP 1011

  Fly  1232 CGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRER 1296
            .|..::.|:.::.|      ....|.......|........||:|.|             ||:|.
 Worm  1012 TGNHFIHDVFSQIE------GANMDSENQQNIFFNFPPEKLVKKPPV-------------VPKEV 1057

  Fly  1297 RSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHT 1361
            ...:|::|:::                .|:....|::             .|.|.:..:|.|..|
 Worm  1058 VQEQEIVSQNT----------------NGTIPKAART-------------YPTPEEWINQPPQRT 1093

  Fly  1362 LGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMS 1426
                |||...|.|                       ::....|..|...:|.::|.||       
 Worm  1094 ----ESRNTPRDH-----------------------QKPDEESDESLVREYNEEAGYA------- 1124

  Fly  1427 DTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENE-A 1490
                          ..:|.:.....|.::|                               || :
 Worm  1125 --------------YTLPRKNKPAPQAVED-------------------------------NETS 1144

  Fly  1491 ESEIDDLDDYINDI-FQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINE 1554
            |||.|| :|..|.: ::.:...:|::.:.:....:.|:|...:..|...|:|:.|     :|...
 Worm  1145 ESEEDD-EDAANRVGYETVRPEENMKMMETIQDHSHILKSPVLPRKTYSRNEQHE-----EYTPM 1203

  Fly  1555 LFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFL 1619
            .|.|.|......::...:::.|.:.....|      |.:.....:||:.   .|:..||:.....
 Worm  1204 NFAPPPTFTYPQQMPMMQYVPVMMTSSMMT------PSMMTPSMMPGQQ---IAMVPQQMMMQPH 1259

  Fly  1620 QSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSI--SPPPPQSPMRM 1682
            .|.:.|..||.|..                           |..||||..|:  ..||..:|:..
 Worm  1260 FSYVPQYPQIPQYC---------------------------PPEPILSPQSVRSEVPPMMAPVMH 1297

  Fly  1683 K---ATRSS--LVVMESLQPPPPPPPPPMPPP----------------LECKDPSETRHFLDPYG 1726
            .   :|||.  .::.....|........||.|                :..||.....|| :...
 Worm  1298 DGHGSTRSRDYRIMKRGEVPSQYSTIRNMPVPEHGKDVDQFLDAVFDQVLSKDEQRAAHF-NSNQ 1361

  Fly  1727 RAKTVRIGKWRWPPPQDEPQFQT--------------EEDFFAFKMRQHQRKTTPQAQH------ 1771
            .|.|::.||.| |....||..||              ::.....:.:...|..:|:.:|      
 Worm  1362 LANTIKGGKLR-PEGYYEPPVQTYSPVPPRYPTLRRVDDSPLRSRAKSLPRIISPRHEHFVRRPH 1425

  Fly  1772 ------HQMTSNGGMMESGPGARGASATAIEWE---EFEIESPT---PPPMSGQLMRSSIRLETT 1824
                  ::.||:...|.....:|..|.......   .::...|.   |..|:|.  ...|.|...
 Worm  1426 SRNSYSNESTSSDDQMNYRTRSRERSLPRFHSNNGYNYDPSQPVYMMPVQMNGH--GEMILLSPV 1488

  Fly  1825 TTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQV 1889
            .:...:...:|..||..:   ..:.|.|...:||:|..:...:||                    
 Worm  1489 ASEHKAQSRHRTHDRSHR---HHVPSGVERYMAKRSPSVDILKPP-------------------- 1530

  Fly  1890 TAGHSVRSTVSTKSEQRAP-AKLEDT--RKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQI 1951
                         ..:|.| |.:|.|  |..:.|..:|...:.....::.|.|  ||.|.     
 Worm  1531 -------------MSRRTPDAMVEQTYVRPHLAQSPVGRQTSRFEEFSALPRG--DSRAR----- 1575

  Fly  1952 ERMEGKLSPPPAPPSGGWP---GVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPE 2013
            ||||..|.....|.:  :|   |.::||.||                          :.|:|.|.
 Worm  1576 ERMENPLLARQIPRA--YPYQNGNVVPPPPS--------------------------SYRAPSPA 1612

  Fly  2014 PDYRTSSSQVVKEHVPAFIQRQERDTFGAVR----QQQMISSHHLHLEDHSASSSPAVAAWEQAE 2074
            |   ||..:.....:|     ||..|..||:    ..:.:|.|..:|::..|..        :.|
 Worm  1613 P---TSGDRRGLNRLP-----QESYTEPAVKNTKNNSEYLSPHRFNLDEQKAVI--------RHE 1661

  Fly  2075 RERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLYEIRQVERERESHKVY 2139
            :|.:::                       |....|::.| |.....:.:..||.:          
 Worm  1662 KETAKN-----------------------AINMLSDRLR-KLPPPVDNVRLIRPI---------- 1692

  Fly  2140 QPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEHERKRKSSASSGMREELDSMHMTTPP 2204
            .||.|.:.|:.:.:                                          :.:.:.||.
 Worm  1693 TPAQPPITQSPVPS------------------------------------------EPVVVRTPS 1715

  Fly  2205 PVIVPAPVPPPS------------STSPGLGVVSGVLMGSGSG-------------GSTACLTYN 2244
            ||..|.|.|||.            ...|   |..|.:.||...             .....:.:.
 Worm  1716 PVPQPTPPPPPPPVREEWVIRDSVERDP---VTQGRIRGSFRKEPLVPQPPRPPVVAEKPAVKFV 1777

  Fly  2245 RVPWKLRVRKEVFQPHEPIGPPVALDLLFAQVLGDVFGVTPCLRITPQEKSSALNMLHGHGVSVD 2309
            :.||||.:|||:|.|.|.:.....:|.:|||::.|.....| .||..|::.....:|..:.:...
 Worm  1778 KAPWKLTIRKEMFYPGEVLNDIQIIDQVFAQIVEDCKKSYP-YRIREQDRKQVETVLRQYEIPPS 1841

  Fly  2310 TLSNRNGSGAGGGGNGGQVRALVKRHLVDMARDWPLYFARLFAVQGAPLYPDVS---IMGVSHSG 2371
            .|:|::           .:...||..::::||.|||||.:::.|  ....||.|   |..:|..|
 Worm  1842 DLNNQS-----------NIHPDVKVAVIELARLWPLYFNQVYEV--VEKRPDESVSTIFAISEHG 1893

  Fly  2372 LYL---ARRDADYLIVVQAISFGEIQSAVTLPRPAALQLNLRN-GKHLALHAARAAAIQSMVTTF 2432
            :.|   ...|.:..:.:|.....|..:.|:|.....|.:::|: .:..|..|.|      :.|..
 Worm  1894 IRLIVHTPHDLENPLKIQDFFPFETIADVSLEANDILSVHVRHEDEENAYSAVR------IKTNQ 1952

  Fly  2433 VQEFRKSQSKASTLSSGARAAAQTLNVPLERLESRQAHAQRNEHGVDGGSRQNEQLQQSELHHHL 2497
            ..:.:|:..:.  ||.|.        ||..:.                 .|..|....||::|  
 Worm  1953 APQIKKTLDRC--LSGGV--------VPKRKF-----------------VRALEDYVTSEVNH-- 1988

  Fly  2498 QQQQQQQQQQQHHQQQQQQQQLEDAMEEQHMATDHQQQQQQQLGQQQGQQQRFLKQQSYLHSARK 2562
                                                      |..:||.....|::..       
 Worm  1989 ------------------------------------------LSFKQGDVIELLQEPE------- 2004

  Fly  2563 SNAGQQP--SSLTNGQVHHQEQMLQQQQQQS-----------QSLPHHDLDANYLQDESNGGTPP 2614
               |:.|  .:...|::.::...|..|...|           ::....|....:..||    .|.
 Worm  2005 ---GETPPVGNWLYGKIENRFGFLLAQYVDSTDGDNVPPIRHETSEDRDERVRFFDDE----VPF 2062

  Fly  2615 SVTKYSLLQFAMQHFRNDQLRDADRHHERHQSAANRSYAELVKWQGHAIRLPLLR-LPNDLAPLA 2678
            |..:|:::.||.::||.      .:..::.::.|....:::|::....|...||. |.|:.:..|
 Worm  2063 SSERYTMIDFATKYFRK------PKDKKKQETWAWEDISQIVRFSEKPISQSLLADLGNEESKYA 2121

  Fly  2679 LECFDCILRYCGDIPLDPDLTEVKCVYTVLMHCHKYLALRDEVYCQLMKQTTANRSPCPDSSQRA 2743
            :|.|..|:::.||.||....:....|:.||:.||:...|||||||||:||||:|.|..|:|:.||
 Worm  2122 VETFHAIMKFMGDEPLKKSESMTDVVFKVLLICHRQPTLRDEVYCQLIKQTTSNISQKPNSALRA 2186

  Fly  2744 WRLLSILAAYFGCSDALRPYLMEHLTSAASDRRRSCHGTAAVCLTNLRKTARCGGRKNVPSVEEV 2808
            ||||:|:.|||..|..|:||::::|...|.:.:|..||||.:|.||:.:|.:.||||.:.:..||
 Worm  2187 WRLLTIITAYFPSSLTLKPYVLQYLGDNADEWQRPFHGTARICQTNMIQTFKYGGRKVLLNALEV 2251

  Fly  2809 TAVSAGRSARRQIYRLPGGAERVVNTRCSTVVADVIAELCALLGVESEAEQQEFSLYCIVQGDAF 2873
            ..::.|...|||.:.:..........|..||..::|.|||.||.|.|..|||||||...|..|..
 Worm  2252 QQITDGCQLRRQAFYISKDHNVSQTLRPITVAEEMIQELCNLLNVRSLHEQQEFSLCYTVGKDKH 2316

  Fly  2874 TMPLAADEYILDVTTELLKSGQPFYLIFCRSVWHFALKREPAPMPLYVEVLFNQVAPDYLEGLLL 2938
            ......|.|::|:.||......||.....|:||...|:.:.|   .|::.:|:||..|||.|.|:
 Worm  2317 LNYCKNDNYLMDIITESEHKKLPFQFYLKRTVWVHPLRYDNA---AYIDSMFDQVIDDYLRGSLI 2378

  Fly  2939 ELPGNGVPVPEMVRDMARIAALLHRAADLSHVPA---MKEIKFLLPKPALGIREIRPAQWVGLVQ 3000
            .....|........::.::||.|...  |...|.   .|.:..::||..:..:.....:.|..:.
 Worm  2379 STNSLGQLTAATTEEIIKLAAYLFLL--LPDNPKGLNAKTLPQIVPKSVIEPKHRHQEEMVTRIS 2441

  Fly  3001 SAWPQV-ANLSPGQVKAQFLNVLATWPLFGSSFFAVKRIWAEEGPHVEDNHS-PMWRDLILALNR 3063
            ...... ..:.|.:.|:.||.:|:|||.||...:.:|.:       ||:.|. |   ::||.:|:
 Worm  2442 RQLKMFGGRMRPAEAKSHFLELLSTWPTFGVLHYRLKSV-------VENGHQLP---EVILTINK 2496

  Fly  3064 RGVLFLDPNTHETLQHWSFMEVISTRKVRSEDGALFLDMKVGNLMQ-QRVIRVQTEQAHEISRLV 3127
            .|:..|.|.:.|..:..::.:::|...:|..  |..:...|.|.|| :..:.::|::|.|||.|:
 Worm  2497 SGIQLLQPKSKEVFKERNYDQIVSVESIRKT--AYKIVRLVINTMQGEETLDIKTDEADEISHLI 2559

  Fly  3128 RQYI 3131
            .||:
 Worm  2560 GQYM 2563

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 214/701 (31%)
MYSc_Myo15 169..828 CDD:276838 207/681 (30%)
MyTH4 1014..1171 CDD:295320 49/159 (31%)
MyTH4 2704..2810 CDD:279165 53/105 (50%)
B41 2823..3033 CDD:214604 61/213 (29%)
FERM_B-lobe 2920..3025 CDD:271216 24/108 (22%)
FERM_C_MyoXV 3029..3138 CDD:270022 28/105 (27%)
hum-4NP_001359540.1 MYSc_Myo12 13..643 CDD:276841 207/681 (30%)
IQ 680..701 CDD:197470 8/20 (40%)
MyTH4 803..952 CDD:214535 50/161 (31%)
PRK10263 <1162..>1357 CDD:236669 42/235 (18%)
SH3 1974..2030 CDD:388381 14/126 (11%)
MyTH4 2100..2255 CDD:214535 66/154 (43%)
B41 2262..2475 CDD:214604 63/217 (29%)
PH-like 2489..2563 CDD:388408 21/75 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 109 1.000 Domainoid score I4019
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52622
OrthoDB 1 1.010 - - D10566at33208
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.930

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