DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and hum-6

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_508420.1 Gene:hum-6 / 180539 WormBaseID:WBGene00002039 Length:2098 Species:Caenorhabditis elegans


Alignment Length:3162 Identity:695/3162 - (21%)
Similarity:1070/3162 - (33%) Gaps:1245/3162 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   139 LQPGE----------------GSLRARQDLGS------------------SGVEDMTLLDDLHEA 169
            ::||:                |.|:...|||:                  .|||||..|.|.||:
 Worm    12 IEPGKTEGSIPIGARVIDQDHGRLKVIDDLGNEQWLSADRRVRLMHPTSVQGVEDMCQLGDFHES 76

  Fly   170 SLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHA 234
            ::|.||.:||.:.|||.:.|||||||||| |....|..:..:.|..:.:|.||||:|||...|:.
 Worm    77 AILRNLFIRYREKLIYAYTGSILIAVNPY-MDIAIYTADEIRMYKRKRIGELPPHIFAIADNAYT 140

  Fly   235 AL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQILEAAPLLEAFGNART 296
            .:   ...|.|:||||||:|||||||||:|:||.:    ....:.|.:|:|||.|:|||||||:|
 Worm   141 NMRREKKNQSVIISGESGAGKTESTKLVLQFLATI----SGQHSWIEQQVLEANPVLEAFGNAKT 201

  Fly   297 ARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSK 360
            .|||||||||||::|:| :||:|.||||.||||||||||||:..|||||:||.||.|||..|:|:
 Worm   202 IRNDNSSRFGKYIDVHFNESGSIEGAKIEQYLLEKSRIVTQSENERNYHIFYCLLAGLSREEKSE 266

  Fly   361 YGLLEADKYFYLNQGATDCASGR---VDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFH 422
            ..|..|..|:||.||.|..|.||   .|...::.||:||.::|.|...|.::||::||:||:.| 
 Worm   267 LELGTAADYYYLIQGKTLTAEGRDDAADLAEIRSAMRVLMINEQEIGSIFKLLASLLHIGNIRF- 330

  Fly   423 RRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAF 487
            |:......|.|:|...:.:...|.||.:....|..|:|:::...|.||:.:.|...||:|||||.
 Worm   331 RQNTNDNMESVDVADPSTLVRIAKLLQLHEQNLLDAITTKSLVTREERVISRLNGQQAVDARDAL 395

  Fly   488 AKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNK 552
            |||:|..||..:|.|:|..:.|........|.||||||||:...|||||||||:|||.||.:|..
 Worm   396 AKAIYGKLFIHIVRRVNDAIYKPSQSRRTSIGILDIFGFENFESNSFEQLCINFANETLQQFFVH 460

  Fly   553 HVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH 617
            ||||:||.||..|.:.|..:.:.||...:.|:|::|:.|..|:|:||.||:.||.:.|.|.|..|
 Worm   461 HVFKMEQKEYDEEHINWRHIKFVDNQATVDLIAQRPLNILSLIDEESIFPKGTDKTMLLKLHSTH 525

  Fly   618 ALSELYARPRIGAQE-FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLR 681
            ..:|||.:|:...|. |||||:||.|:|...|||:||||:...|:..|::||::|.:..|...: 
 Worm   526 GRNELYLQPKSELQRAFGVTHFAGNVFYNTRGFLEKNRDSFSADLSVLISSSKMPFLARLFDDI- 589

  Fly   682 AQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMD 746
                           .:.|...:..||..:|..||:||:..:.:.||:|:||||||:.|.||.||
 Worm   590 ---------------EYDTSSRKKVTVGNQFRRSLEQLMSQLTQTHPFFIRCIKPNEMKRALVMD 639

  Fly   747 MPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPS---PLAR---GTPYRELCRALL 805
            ...||:||||.||::||:||:.|||:|..:..||.|||.|:.|   |:.|   ....:::|..:|
 Worm   640 RDLVLRQLRYSGMMETIKIRRSGYPIRHDYYPFVFRYRVLVSSIQGPVNRIDLHDAAKKICHMIL 704

  Fly   806 EAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAA 870
            ..       ..|||||.|:|||::.....||......|:..|:.:|::||..|||:...:::.||
 Worm   705 GT-------NADYQLGKTKVFLKDKHDLVLEQEYYRILKDKAIVIQKNVRRWLVRKDFEKQRQAA 762

  Fly   871 TRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQ-------ARRRVQQLRSDHRRRQEAREAAQR 928
            ..:|..|||...::||.::..|....|.:.|.||       .|:.:.|.::..|.....|:..::
 Worm   763 VTIQTAWRGFDQRKRYRQIISGFSRLQAVLRSRQLVSHYQTLRKTIIQFQAVCRGSLVRRQVGEK 827

  Fly   929 AREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGD-------------RHLVKVLGTV 980
            .:...:|....:..:.....|...||.   ..|..:.|..|.             |.....|.|.
 Worm   828 RKRGEKAPLTEVSSTASVISDSHEELV---GHLFDFLPSDGKDSGNENDSADSSRRGSYSRLHTS 889

  Fly   981 PGPPSSAV-----QLPEDLGQFSFGKFSSVYCNGLRLQPR-REPITAPLLTRAASRDQDFQDALA 1039
            |..|.:.:     .:.|||.::.|||:::.:......... ::|:...|||......|  ..||.
 Worm   890 PVMPPANIPRVDSYVDEDLSKYQFGKYAATFFQAQATATHVKKPLKTALLTHTEPSAQ--LAALT 952

  Fly  1040 VFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLL 1104
            .:..|||:..|          |||                          :.|.|...:.::   
 Worm   953 AWTTILRFMGD----------LAD--------------------------VKPGSTNGSEVY--- 978

  Fly  1105 GQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEW 1169
                                  |:.|..::                                   
 Worm   979 ----------------------DKTPVMIK----------------------------------- 986

  Fly  1170 RAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGL 1234
                      |..||                                                  
 Worm   987 ----------LYATL-------------------------------------------------- 991

  Fly  1235 DYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSS 1299
                                      |.||:...|.:|:                          
 Worm   992 --------------------------GKKFSAHDLEEAM-------------------------- 1004

  Fly  1300 RELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGL 1364
                     |:..|               |.||:..|.:...|.                     
 Worm  1005 ---------LSSEY---------------GGAKTLKKGMGRKLI--------------------- 1024

  Fly  1365 SESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTS 1429
                       :..|...||..|                                      ||||
 Worm  1025 -----------SMTLKRKGKING--------------------------------------SDTS 1040

  Fly  1430 EAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEI 1494
            ...|                     |.::|              |..|.:       ||      
 Worm  1041 SISS---------------------DSVYS--------------SFNAML-------EN------ 1057

  Fly  1495 DDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPI 1559
                                :.:||.|:|..|| |.|:..           |||.|   |::   
 Worm  1058 --------------------KPMTSLDKLHYII-GLGILR-----------EDLRD---EIY--- 1084

  Fly  1560 PVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMA 1624
                                                                             
 Worm  1085 ----------------------------------------------------------------- 1084

  Fly  1625 QNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSL 1689
              .|:.:||                   :||                       |.::.|.|..:
 Worm  1085 --CQLCKQL-------------------SNN-----------------------PSKLSAARGWI 1105

  Fly  1690 VVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFF 1754
            ::  ||             .:.|..|||              |..|:                .|
 Worm  1106 LL--SL-------------CVGCFAPSE--------------RFIKY----------------LF 1125

  Fly  1755 AFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRSSI 1819
            .|                       :.|.||...|.|.        .||                
 Worm  1126 CF-----------------------IRERGPAGTGYSK--------YIE---------------- 1143

  Fly  1820 RLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQ 1884
                            ||.|.||                    :...|..|.|..:|:.:...:.
 Worm  1144 ----------------DRLRRTQ--------------------VNGTRHQPPSYVELQANKSQKP 1172

  Fly  1885 RLEQVT-AGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLG-----GLFASVSGGNSGPGGVVDS 1943
            .:..|| ...||::..:..:...|....:...|:.|....|     .||..||...||...|:| 
 Worm  1173 VVLAVTFMDGSVKTLCADSATTAAELCKQLAEKVGLTNSFGFSLYIALFDKVSSLGSGTDHVMD- 1236

  Fly  1944 HATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTAR 2008
                                                                             
 Worm  1237 ----------------------------------------------------------------- 1236

  Fly  2009 SPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLEDHSASSSPAVAAWEQA 2073
                                                                     |::..||.
 Worm  1237 ---------------------------------------------------------AISQCEQY 1244

  Fly  2074 ERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLYEIRQVERERESHKV 2138
            .:|:.|                                                   :||.:   
 Worm  1245 AKEQGR---------------------------------------------------QERNA--- 1255

  Fly  2139 YQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEHERKRKSSASSGMREELDSMHMTTP 2203
                                                                             
 Worm  1256 ----------------------------------------------------------------- 1255

  Fly  2204 PPVIVPAPVPPPSSTSPGLGVVSGVLMGSGSGGSTACLTYNRVPWKLRVRKEVFQP-HEPIGPPV 2267
                                                       ||:|..|||:|.| |:|...||
 Worm  1256 -------------------------------------------PWRLFFRKEIFSPWHDPRDDPV 1277

  Fly  2268 ALDLLFAQVL-GDVFGVTPCLRITPQEKSSAL----NMLHGHGVSVDTLSNRNGSGAGGGGNGGQ 2327
            :.:|::.||: |..:|...|   ...|:.:|:    ..:....:.|:.|.|...|........|:
 Worm  1278 STNLIYQQVIRGIKYGEYRC---DKDEELAAICAQQYYIDEGTMDVNKLENNLPSYLPDFEMSGK 1339

  Fly  2328 VRAL------------------------VKRHLVDMAR-DWPLYFARLFAV---QGAPLYPDVSI 2364
            ..||                        ||.::|.:|: .|||.|:|.:..   .|.||..:..|
 Worm  1340 EMALEKWTQTIMHQYRKKFTGRLPSQIEVKENVVSVAKTKWPLLFSRFYEALKFAGPPLPKNEVI 1404

  Fly  2365 MGVSHSGLYLARRDADYLIVVQAISFGEIQSAV--TLPRPAALQLNLRN--GKHLALHAARAAAI 2425
            :.|:.:|:|:. .|.::  |:...||.||.:|.  ...|.......:|.  |......:..|..|
 Worm  1405 IAVNWTGVYVV-DDREH--VMLEFSFPEISTAYYGKGKRSTTDTCTVRTVVGDEYTFQSPNADDI 1466

  Fly  2426 QSMVTTFVQEFRKSQSKASTLSSGARAAAQTLNVPLERLESRQAHAQRNEHGVDGGSRQNEQLQQ 2490
            .:::..|::..:|                          .||...|.:::.|             
 Worm  1467 TNLIVMFLEGLKK--------------------------RSRYLVAIKSQKG------------- 1492

  Fly  2491 SELHHHLQQQQQQQQQQQHHQQQQQQQQLEDAMEEQHMATDHQQQQQQQLGQQQGQQQRFLKQQS 2555
            .|.::.|:.::                  .|.:...:..|.:....:..:   :|:..|    ..
 Worm  1493 DEKNNFLEFEK------------------GDLLILVNEFTGNTLLTESVV---KGENSR----TC 1532

  Fly  2556 YLHSARKSNAGQQPSSLTNGQVHHQEQMLQQQQQQSQSLPHHDLDANYLQDESNGGTPPSVTKYS 2620
            .....|..|....|:            :::..:...|..| .|:|.:.  |..|.....:|..|:
 Worm  1533 LFGLIRAENVYVLPT------------LVKPSKNTLQIFP-KDMDLSL--DLFNNNKQVTVVDYN 1582

  Fly  2621 LLQFAMQHFR----NDQLRDADRHHERHQSAANRSYAELVKWQGHAIRLPLLRLPN---DLAPLA 2678
            ...:.:::|.    |.|::...............|..|..::....|..|||:..|   |....|
 Worm  1583 AEPYTLENFAEDNFNSQVKRVGSQISLMTLRKKESQIECWRFSREHIDQPLLKKLNGREDACRGA 1647

  Fly  2679 LECFDCILRYCGDIP-----LDPDLTEVKCVYTVLMHCHKYLALRDEVYCQLMKQTTANRSPCPD 2738
            :|.|..|::|.||.|     |...||:......:.|.     |||||:||||:||.|.|  |...
 Worm  1648 IEIFAAIMKYMGDEPSKRSRLGTHLTDHIFKLPISME-----ALRDELYCQLVKQLTLN--PSIM 1705

  Fly  2739 SSQRAWRLLSILAAYFGCSDALRPYLMEHLTSAASDRRRSCHGTAAVCLTNLRKTARCGGRKNVP 2803
            |.:|.|.||.:....|..|.||...:...|.|..       |..|..|...::|.|:.|.||..|
 Worm  1706 SEERGWELLWMATGLFAPSAALAKEISHFLKSRP-------HPIALDCQNRMQKLAKGGSRKYPP 1763

  Fly  2804 SVEEVTAVSAGRSARRQIYR---LPGGAERVVNTRCSTVVADVIAELCALLGVESEAEQQEFSLY 2865
            .:.||.|:   :....||:.   .|...:..:....:|...|...::...||::|   ...|||:
 Worm  1764 HLVEVEAI---QHKTTQIFHKVFFPDNTDEAIEVDSATRARDFCHKIGYRLGLKS---SDGFSLF 1822

  Fly  2866 CIVQGDAFTMPLAADEYILDVTTEL----------LKSGQ----PFYLIFCRSVWH-FALKREPA 2915
            ..::.....:|  ..|:..|....|          .|...    .:.:.|.|.:|: |....:| 
 Worm  1823 VKIKDKVLAVP--ESEFFFDYVRSLSDWVHTNHATQKDATMIPINYQVYFMRKLWYNFVAGADP- 1884

  Fly  2916 PMPLYVEVLF--NQVAPDYLEGLLLELPGNGVPVPEMVRDMARIAALLHRA-------ADLSHVP 2971
                ..:::|  :|.:..||.|.          ......|:..:|||:.|:       |.|:.:|
 Worm  1885 ----QADIIFHYHQESQKYLLGY----------HKTTKNDVIELAALILRSMTKDGKNAPLAQIP 1935

  Fly  2972 AMKEIKFLLPKPALGIREIRPAQWVGLVQSAWPQVANLSPGQVKAQFLNVLATWPLFGSSFFAVK 3036
            .:  :..::||.:|  :....::|...:.:|:.::.:|...|.|.:|||.:..||.|||:||.|.
 Worm  1936 QL--LDEIIPKDSL--KMYSASEWRKTISNAYARIEHLKSDQAKIEFLNYICRWPTFGSAFFPVS 1996

  Fly  3037 RIWAEEGPHVEDNHSPMWRDLILALNRRGVLFLDPNTHETLQHWSFMEVISTRKVRSEDGALFLD 3101
            :        ..|.:.|  ..|:||:|:.||.....:|...|..:.|..:.:.     ..|..:.:
 Worm  1997 Q--------YSDLNLP--DRLLLAINQTGVNIYHLDTKNLLVQYPFNVICNW-----TSGNTYFN 2046

  Fly  3102 MKVGNLM---QQRVIRVQTEQAHEISRLVRQYITMAQISQRD 3140
            |.|||::   :.:.:.:.|...:::..|:..||::...:|.:
 Worm  2047 MTVGNMLKGNEGKKLLLDTTVGYKMDDLLTSYISLLISNQNN 2088

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 313/693 (45%)
MYSc_Myo15 169..828 CDD:276838 303/672 (45%)
MyTH4 1014..1171 CDD:295320 18/157 (11%)
MyTH4 2704..2810 CDD:279165 37/105 (35%)
B41 2823..3033 CDD:214604 48/236 (20%)
FERM_B-lobe 2920..3025 CDD:271216 24/113 (21%)
FERM_C_MyoXV 3029..3138 CDD:270022 25/111 (23%)
hum-6NP_508420.1 MYSc 57..731 CDD:214580 315/702 (45%)
MYSc_Myo7 76..720 CDD:276832 303/672 (45%)
IQ 757..779 CDD:197470 7/21 (33%)
MyTH4 929..1168 CDD:214535 95/865 (11%)
B41 1174..1388 CDD:214604 59/501 (12%)
FERM_B-lobe 1278..1378 CDD:271216 19/102 (19%)
FERM_C1_MyoVII 1382..1480 CDD:270019 24/126 (19%)
SH3 1481..1544 CDD:302595 12/100 (12%)
MyTH4 1624..1772 CDD:214535 55/164 (34%)
B41 1779..1993 CDD:214604 48/237 (20%)
FERM_B-lobe 1890..1985 CDD:271216 24/108 (22%)
FERM_C2_MyoVII 1989..2087 CDD:270020 25/112 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.710

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