DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and hum-2

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	NP_001317742.1	Gene:	hum-2 / 179321	WormBaseID:	WBGene00002036	Length:	1811	Species:	Caenorhabditis elegans

Alignment Length:	1756	Identity:	471/1756 - (26%)
Similarity:	717/1756 - (40%)	Gaps:	489/1756 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 GVEDMTLLDDLHEASLLWNLRLRYDKG-LIYTFAGSILIAVNPYKMFPDAYGLEVAKQY--AGRP 217
            |.:|:|||..|||.::|.||::|:.|| .|||:.|.:|:|:|||......||.|:.:.|  ||:.
Worm    80 GKDDLTLLSYLHEPAVLHNLQVRFVKGSSIYTYCGIVLVAINPYADCSHIYGEEIIQVYRGAGKS 144

  Fly   218 LGSLPPHLFAIGAAAH---AALPSPQVVVISGESGSGKTESTKLVMQYLAAVVP----GGGSASA 275
            ...:.||:||:...||   .|....|.:::|||||:|||.|.|.||:|||:|..    .||:.|
Worm   145 AREMDPHIFAVAEEAHFDMGAFGKSQSIIVSGESGAGKTVSAKFVMRYLASVAASKTRNGGTTS- 208

  Fly   276 VITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF--KSGAIVGAKITQYLLEKSRIVTQAP 338
             |..::|.:.|::|:.|||:|.||||||||||::::.|  :...||||::..|||||||:|.|||
Worm   209 -IEARVLASNPIMESIGNAKTIRNDNSSRFGKFIQINFCERGRRIVGAEMKTYLLEKSRLVFQAP 272

  Fly   339 GERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASG---RVDWESLQGAMQVLGVSE 400
            ||||||:||:|....:........|...:.|.||.||......|   :.|:|:|..|:|:||..|
Worm   273 GERNYHIFYQLCAARNHQVLKDLHLGPCESYSYLTQGGDSRIPGVDDKADFEALLKALQLLGFDE 337

  Fly   401 GEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEI-KWAAHLLHISADGLHRALTSRTT 464
            .:...:.|:||.:|.||||:|...:   |...|...|..|| :.......||...|...||.|..
Worm   338 KQMSDVFRLLAGLLLLGNVHFENGE---GSSAVSASSCQEISRLCREFWKISESDLRIWLTRREI 399

  Fly   465 EARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQK----GGTHDAHR----ISIL 521
            .|..|.:..||..::|:.:|||..|.||:.||.|||.:||..:.:    .||:...|    |.:|
Worm   400 RAVNEIVTKPLTKNEAVRSRDALTKMLYSHLFGWLVDKINEALNEKDKLDGTNQKKRPDRFIGVL 464

  Fly   522 DIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAK 586
            ||:|||....|||||..||||||.||..||:|||||||.||.||.:||..:.:.||.|.|.|: :
Worm   465 DIYGFETFDVNSFEQFSINYANEKLQQQFNQHVFKLEQEEYIREEIEWVRVDFHDNQPAIDLI-E 528

  Fly   587 KPVGICHLLDDESNFPRATDLSFLEKCHYNHAL--SELYARPRIGAQEFGVTHYAGQVWYCVDGF 649
            .|||:.:|||::......:|..:|.:...:..|  :...|.|::.:.:|.|.|:|..|.|..|||
Worm   529 GPVGMINLLDEQCKRLNGSDADWLSQLQNSTELKRNPQLAFPKVRSNDFIVRHFAADVTYSTDGF 593

  Fly   650 LDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPK--GSNGRFVTMKPRT--PTVAA 710
            ::|||||:...:|:::.:|:.|.:..:         .|.|.|.  .|:....|...||  .|||:
Worm   594 VEKNRDAIGEQLLDVVVASKFPFIRTV---------IGSTAPTSVSSSSSSSTPGKRTIKKTVAS 649

  Fly   711 RFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLR 775
            :|.|||::|:..:....|.:|||||||..|.:...:....:||||..|:|:|::|...|:|.|..
Worm   650 QFRDSLKELMSVLCSTRPHYVRCIKPNDSKISFDFEPKRAIQQLRACGVLETVRISAAGFPSRYP 714

  Fly   776 FQHFVERYR--HLLPSPLARGTP--YREL-CRALLEAMPRTGVEGPDYQLGATRVFLREALHRAL 835
            ::.|..|||  :...:.|.|..|  :.|| |:..||       || .|.:|.|::|||......|
Worm   715 YEEFARRYRVIYTKEAALWRDKPKQFAELACQQCLE-------EG-KYAVGKTKIFLRTGQVAVL 771

  Fly   836 ESGRTERLRRAAVSVQRHVRGMLVRRQ-------------------------------------- 862
            |..|.:.|..||..:|:..:|.|.||:
Worm   772 ERVRLDTLAAAATVIQKMWKGFLARRKYETMRRSLLIVQASLKAFLAFRRIKYLQMHRAVIVMQS 836

  Fly   863 -----LARRQAAATR-----LQARWRGQRAQQRYERLR--KGALTAQRLWRGRQAR--------- 906
                 |.||:....|     :||.::..|.::..|:||  |.|:|.|..|||..||
Worm   837 AVRGYLERRKYEQIRDSIIGIQAMFKANRVRRYVEKLRYEKSAITIQAAWRGYLARREQIANRKK 901

  Fly   907 --------------RRVQQLR-----------------------------SDHRRRQEAREAAQR 928
                          ||:::|:                             ::.|.::||.:.|..
Worm   902 VVMVQCAVRKWLAKRRLRELKIEARSVGHLQKLNTGLENKIIELQMRLDIANARTKEEAEKFATA 966

  Fly   929 AREAREAKQ--AVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVL-------------- 977
            ::..::.|.  |::|..:|:.|:.                    |:.|:||
Worm   967 SKNLQKTKADLAMMEAERLTLLEA--------------------RNRVEVLQEEVERLETECDLK 1011

  Fly   978 -GTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQ------------PRREPITAPLLTRAAS 1029
             ....|..:..|:|...|.||.....|......|..|            ..|:.:.|.|.|..::
Worm  1012 EAQRGGMETKMVELQSRLDQFQMQSESGQTIVELTEQLEKAKADRVLWDEERQRMEAALNTERSA 1076

  Fly  1030 RDQDFQDALAVFKLILRWSNDKALEGAKEKLLADY------IVHKALSSRGLRDE---------- 1078
            |     :||           |..:...:|:|:.:.      ...|..|.:..||:
Worm  1077 R-----NAL-----------DAEMAAMREQLMKNVDLFESSTFQKRPSQKKNRDDDSCSRTTSNL 1125

  Fly  1079 ------ILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLL 1137
                  ...:..|.||.....|.|.     ||......|:.        :|.::|
Worm  1126 SQLTGSFTAETINGVHSTSRGSPEV-----LLDNMASTFEQ--------LRMIND---------- 1167

  Fly  1138 LRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTV-AVDSWTSCE 1201
                |||:.          ..|:         |...|       :....|||..: .:|..||.:
Worm  1168 ----LRQRN----------EHCQ---------RETER-------MKAIIEASTLIETLDKKTSLK 1202

  Fly  1202 EAAALAVSSL-GVASRGWTLVLDDGQQLT--DSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAK 1263
            ...::.|..| |..:|    :.:|.::|.  ::.....|.:.|.|:          ::.||..|.
Worm  1203 AFESIRVGELEGAYNR----LKNDMERLVSGENGATHSVFERIMEE----------NERLREEAV 1253

  Fly  1264 FARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSST 1328
            ..|:.|....::.:|     ..|||      .|||.|                 |..|...|:.:
Worm  1254 ELRSMLSSHFEKQSV-----AGSSG------YRRSPR-----------------PDSGHCSGADS 1290

  Fly  1329 GQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSES---RLNDRYHSAERLAPVGKDTGPRY 1390
            ....|.:...:||           |..::..|...|:|:   .|.::....|||     ....|:
Worm  1291 EDGSSGADLEEDL-----------CIERQCRHLKNLAENLTKMLTNQNLEIERL-----QQQLRF 1339

  Fly  1391 QKSQHAGRRSHA----ASHGSH------SSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPS 1445
            .:||...|.|..    |..|:|      :.:..|..:..||.|
Worm  1340 SESQTVFRPSDCSLDEAVRGAHKQTQLLAQQNMDLNDKLTRQS---------------------- 1382

  Fly  1446 QASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRG--GSYEQENEAESEIDDLDDY-------- 1500
                                 :||::||   |.:||  |....||.::.||..|:.:
Worm  1383 ---------------------EELAEAR---AQLRGYSGPLGLENASDEEIIRLEAFEKGSIKHS 1423

  Fly  1501 -INDIFQPIP---------LVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINEL 1555
             ..:::. :|         |...|.:|.:|: |.|.:......:..|:|||.:
Worm  1424 GFLEVYN-VPEFARIIVCELKPTLARLLTKN-LPAYLLVAAFRNHDEKRDETA------------ 1474

  Fly  1556 FEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGAD------------PLLHQLMQLPGETESGPA 1608
                     |..|.|..||.:.     .|.|...|            .|.:.|.|..|| :|.|.
Worm  1475 ---------LTGLFSSVHLVLK-----DTISRSHDLDLLSLWLVNLWRLFNLLRQYSGE-DSQPE 1524

  Fly  1609 LY--QQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSI 1671
            .:  ..:.|.::...|. ....|:.||..:.:...|.|.::    |..:..||...|.||...|.
Worm  1525 WHVANTETQNSYRFKAY-DVAPIRDQLKLRIEECYTSLMKK----AIEHVLSPKIVPGILQHESS 1584

  Fly  1672 S 1672
            |
Worm  1585 S 1585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	278/714 (39%)
		MYSc_Myo15	169..828	CDD:276838	268/693 (39%)
		MyTH4	1014..1171	CDD:295320	28/178 (16%)
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
hum-2	NP_001317742.1	MYSc_Myo5	93..764	CDD:276831	268/693 (39%)
		IQ	779..799	CDD:197470	8/19 (42%)
		IQ	826..847	CDD:197470	3/20 (15%)
		CCDC158	<864..1473	CDD:318193	145/803 (18%)
		Myo5_CBD	1429..1803	CDD:271254	41/191 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810