Protein Alignment Myo10A and Myo7b

DIOPT Version :9

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_115770.2
• Gene: Myo7b / 17922
• MGIID: 107709
• Length: 2113
• Species: Mus musculus
• Alignment Length: 3193
• Identity: 683/3193 - (21%)
• Similarity: 1028/3193 - (32%)
• Gaps: 1361/3193 - (42%)

  Fly   145 SLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEV 209
            :||......:.||:||..|.||:||.::.||.:||.:..|||:.||||:||||::|.| .|.||.
Mouse    55 TLRPMHPNSAQGVDDMIRLGDLNEAGVVHNLLIRYQQHKIYTYTGSILVAVNPFQMLP-LYTLEQ 118

  Fly   210 AKQYAGRPLGSLPPHLFAIGAAAHAALPS---PQVVVISGESGSGKTESTKLVMQYLAAVVPGGG 271
            .:.|..|.:|.||||:|||..:.:..:..   .|..:||||||:||||:|||::|:||.|    .
Mouse   119 VQIYYSRHMGELPPHIFAIANSCYFNMKKNKRDQCCIISGESGAGKTETTKLILQFLATV----S 179

  Fly   272 SASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVT 335
            ...:.|.:|:|||.|:|||||||:|.|||||||||||::::| .||.|.||.|..:||||||:..
Mouse   180 GQHSWIEQQVLEANPILEAFGNAKTIRNDNSSRFGKYIDIHFNSSGVIEGASIEHFLLEKSRVCR 244

  Fly   336 QAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASG---RVDWESLQGAMQVLG 397
            |||.|||||:||.:|.|:|..|:....|....:|.||..|:...:.|   ..|:..::.||::|.
Mouse   245 QAPEERNYHIFYCMLMGMSPEEKQMLSLGMPSEYHYLTMGSCTSSEGLSDAKDYAHVRSAMKILQ 309

  Fly   398 VSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSR 462
            .|:.|...|.::|||:||||||.| ...:....:..:|........|..||.:....|...|...
Mouse   310 FSDSENWDISKLLAAILHLGNVGF-MAAVFENLDSSDVMETPAFPLAMKLLEVQHQALRDCLIKH 373

  Fly   463 TTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR----ISILDI 523
            |.....|.:..|:.|.||.|.||||.|.:|..||.|:|.:||:.:......|...    |.:|||
Mouse   374 TIPVLGEFVSRPVNIAQATDRRDAFVKGIYGRLFQWIVKKINAAIFTPQAQDPQNVRRAIGLLDI 438

  Fly   524 FGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKP 588
            ||||:...|||||||||:|||:||.:|.||||.:||.||..|.:.|..:.:.||.|::.:||.||
Mouse   439 FGFENFQNNSFEQLCINFANEHLQQFFVKHVFTMEQEEYLSENITWNYIHYTDNQPILDMLALKP 503

  Fly   589 VGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPR-IGAQEFGVTHYAGQVWYCVDGFLDK 652
            :.|..|||:||.||:.||::.|:|.:..||.::.:..|| |....||:.|:||.|:|..:|||:|
Mouse   504 MSIISLLDEESRFPQGTDVTMLQKLNSIHANNKSFLSPRSIHDTRFGIAHFAGDVYYQAEGFLEK 568

  Fly   653 NRDALRGDVLELLASSRLPLVGEL----TKQLR------AQRDAGKTLPKGSNGRFVTMKPRTPT 707
            |||.|..|:|.|:.||:...:.|:    :.|.:      .|..||..|.|.|:    ::| |..|
Mouse   569 NRDVLSTDILILIHSSKNKFLKEIFNVDSSQTKLGHGTICQVKAGSQLFKSSD----SIK-RPVT 628

  Fly   708 VAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPV 772
            :|::|..||.||::.:..|.|:||||||||:.|..|..|....:|||||.||::|:.||:.|:|:
Mouse   629 LASQFKQSLDQLMRILTNCQPYFVRCIKPNEYKKPLLFDRELCIQQLRYSGMMETVHIRKSGFPI 693

  Fly   773 RLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPR----------TGVEGPDYQLGATRVFL 827
            |..|..|.:|:|.|||||.          |...:..||          .|.: .|:::|.|::||
Mouse   694 RYTFDEFSQRFRVLLPSPE----------RMQFQNKPRQMTLHIADLCLGTD-KDWKVGKTKIFL 747

  Fly   828 REALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRG------------- 879
            ::.....||..|::.|..||:.:||.:||...|::..|::.||..|||.|||
Mouse   748 KDHQDTVLEIRRSQALDGAAIRIQRVLRGHKYRKEFLRQRRAAVTLQAGWRGYSQRKNFKLILVG 812

  Fly   880 -QRAQ---------QRYERLRKGALTAQRLWRGR------QARRRVQQLRSDHRRRQEAREAAQR 928
             :|.|         ::::.:|:..:..|...||.      ||:||...:...|.|....|::..:
Mouse   813 FERLQAIARSHLLMRQFQAMRQRIVQLQARCRGYLVRQQVQAKRRAVVIIQAHARGMVVRKSYWQ 877

  Fly   929 ARE-------ARE--AKQAVLERSQLSYLDIPAELAFIYSKLQGWSP--------PHGDR----- 971
            .:.       |:|  |:.||.||.:.|..|...:.|.: .|:.|:.|        |...|
Mouse   878 QKSTGPQVILAKEPKAQVAVHERKRKSIYDTVTDTAMV-EKVFGFLPAMIGGQEGPAPTRFEDLE 941

  Fly   972 ------HLVKVLGTVPGPPSSAVQLPED----LGQFSFGKFSSVY----CNGLRLQPRREPITAP 1022
                  |.|. |.|||     .:.:||:    |.:::|.||:..|    .:...:|   :|:..|
Mouse   942 VKTQKLHEVD-LDTVP-----MMAMPEEEVDSLAEYTFPKFAVTYFQKSASHTHIQ---KPLRYP 997

  Fly  1023 LLTRAASRDQDFQDALAVFKLILRWSND---------KALEGAK------EKLLAD--------- 1063
            ||..  ..|.|...||.|:.:|||:..|         .:|.|:.      :||..|
Mouse   998 LLYH--ENDTDHSAALDVWIIILRFMGDLPEPVVYGRNSLTGSSVMRQIHDKLGKDSVTQHNRSS 1060

  Fly  1064 -------------------------------YIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEA 1097
                                           :||..|:...||||||..|:|.|:......|..|
Mouse  1061 QVASQLNFGEEAFKFDGPISDRPMSNLEKVHFIVGYAIMRPGLRDEIYCQICKQLSENYKTSSRA 1125

  Fly  1098 TRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSF 1162
             |.|.||..||.||.||..|.|||:.|: .:.|.|..|....:|.|....|.          |:.
Mouse  1126 -RGWILLSLCLGCFPPSERFMKYLLNFI-SQGPPSYGPFCAERLQRTFANGV----------RAE 1178

  Fly  1163 VPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASR-GWTL---VLD 1223
            .|.|||.:|......:.:.:.|....|.|::|||.::..|.........|:... |::|   |.|
Mouse  1179 PPTWLELQAVKSKKHIPIQVILATGRSLTISVDSASTSREICQHVAQKQGLRDNLGFSLQVAVYD 1243

  Fly  1224 DGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSG 1288
            ....|...|  |::||.:|:   |
Mouse  1244 KFWSLGSGC--DHLMDAVAQ---C----------------------------------------- 1262

  Fly  1289 KEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDC 1353
             |.:.|||                            |.|..||..|.
Mouse  1263 -EQLARER----------------------------GESQRQAPWRI------------------ 1280

  Fly  1354 DSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEY 1418
                                                                             
Mouse  1281 ----------------------------------------------------------------- 1280

  Fly  1419 ATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRG-- 1481
                                             .|..:.|:|..|...|.:|........:||
Mouse  1281 ---------------------------------YFRKEFFTPWHDSQEDPVSTELIYHQVLRGVW 1312

  Fly  1482 -GSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEI 1545
             |.|                            |.||                         |.|:
Mouse  1313 SGEY----------------------------NFEK-------------------------EEEL 1324

  Fly  1546 EDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALY 1610
            .:|
Mouse  1325 VEL-------------------------------------------------------------- 1327

  Fly  1611 QQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPP 1675
                        :|::..:|.....::.|:|.||                              |
Mouse  1328 ------------LARHCYVQLGATVKSNAVQELL------------------------------P 1350

  Fly  1676 PQSPMRMKATRS-----SLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGK 1735
            ...|.::..|:|     |||.....
Mouse  1351 SCVPSKLYRTKSPEKWASLVTAAHA---------------------------------------- 1375

  Fly  1736 WRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEF 1800
                                 |.:..|.|.||.|...|.               ..|..:.|
Mouse  1376 ---------------------KAQYTQSKATPLAVREQT---------------VEAARLLW--- 1401

  Fly  1801 EIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLAKKSFEIGA 1865
                                                          |:       |..:.||
Mouse  1402 ----------------------------------------------PL-------LFSRLFE--- 1410

  Fly  1866 DRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASV 1930
                                             |:|.|..|.|
Mouse  1411 ---------------------------------VTTLSGPRLP---------------------- 1420

  Fly  1931 SGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPP 1995
                             :||:..            :..|.|:.
Mouse  1421 -----------------KTQLVL------------AINWKGMY---------------------- 1434

  Fly  1996 APPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLEDHS 2060
                                               |:.::||...|.
Mouse  1435 -----------------------------------FLDQKERTLLGL------------------ 1446

  Fly  2061 ASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLYE 2125
                                               ..|||.|
Mouse  1447 -----------------------------------SFAEVMG----------------------- 1453

  Fly  2126 IRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEHERKRKSSASSG 2190
                                 :.|:.|..||.:..     |||    :.::||
Mouse  1454 ---------------------LVANRDAPGGKKLL-----LAT----LQEEYE------------ 1476

  Fly  2191 MREELDSMHMTTPPPVIVPAPVPPPSSTSPGLGVVSGVLMGSGSGGSTACLTYNRVPWKLRVRKE 2255
                     ..:|..|.:...|              .:.:|.                 |:.|.
Mouse  1477 ---------FVSPSSVAIAEMV--------------ALFLGG-----------------LKERS- 1500

  Fly  2256 VFQPHEPIGPPVALDLLFAQVLGDVFGVTPCLRITPQEKSSALNMLHGHGVSVDTLSNRNGSGAG 2320
                            :||..|.| ...|..:.:.|.:|
Mouse  1501 ----------------VFAMALQD-RRATDDITLLPFKK-------------------------- 1522

  Fly  2321 GGGNGGQVRALVKRHLVDMARDWPLYFARLFAVQGAPLYPDVSIMGVSHSGLYLARRDADYLIVV 2385
                 |.:..|.|:..:..:.:|
Mouse  1523 -----GDLLILTKKQGLLASENW------------------------------------------ 1540

  Fly  2386 QAISFGEIQSAVTLPRPAALQLNLRNGKHLALHAARAAAIQSMVTTFVQEFRKSQSKASTLSSGA 2450
                              ||..|.|.||            ..:|.|         :...|:.|..
Mouse  1541 ------------------ALGQNDRTGK------------TGLVPT---------ACLYTIPSVT 1566

  Fly  2451 RAAAQTLNVPLERLESRQAHAQRNEHGVDGGSRQNEQLQQSELHHHLQQQQQQQQQQQHHQQQQQ 2515
            :.:.|.|::.....|.|:..|                                          |:
Mouse  1567 KPSTQLLSLLAMSPEKRKLAA------------------------------------------QE 1589

  Fly  2516 QQQLEDAMEEQHMATDHQQQQQQQLGQQQGQQQRFLKQQSYLHSARKSNAGQQPSSLTNGQVHHQ 2580
            .:.||..:|:|                                             ||.
Mouse  1590 VRALEPPLEDQ---------------------------------------------LTE------ 1603

  Fly  2581 EQMLQQQQQQSQSLPHHDLDANYLQDESNGGTPPSVTKYSLLQFAMQHFRNDQLRDADRHHERHQ 2645
                                                :.|:|.:|:.|.||..:           :
Mouse  1604 ------------------------------------SPYTLEEFSYQFFRAPE-----------K 1621

  Fly  2646 SAANRSYAELVKWQGH-------AIRLPLLRLPNDLAPL---ALECFDCILRYCGDIPLDPDLTE 2700
            ...:|:...:.:.:||       .:|.|||:..:|.|.|   |.:.|..||:|.||.|.......
Mouse  1622 ETISRAAMPMARSRGHLWAYSPEPLRQPLLKSVHDKAKLRDAACQIFLAILKYTGDYPSRQSWHS 1686

  Fly  2701 VKCVYTVLMHCHKYLALRDEVYCQLMKQTTANRSPCPDSSQRAWRLLSILAAYFGCSDALRPYLM 2765
            ::....:.....:..||:||:|||::||.|.|  ....|.:|||:||.:....|.....|.|:..
Mouse  1687 LELTDQMFSLALQDPALQDELYCQILKQLTHN--SIRFSEERAWQLLWLCTGLFPPGKTLLPHAQ 1749

  Fly  2766 EHLTSAASDRRRSCHGTAAVCLTNLRKTARCGGRKNVPSVEEVTAVSAGRSARRQIYRLPGGAER 2830
            :.:.|      |.....|..|...|.:..|.|.||..|...||.|.....|.......||....:
Mouse  1750 KFIDS------RKKKPLALDCSRRLHRVLRVGPRKQPPHDVEVKAAEQNVSKLHHEVYLPNDTSK 1808

  Fly  2831 VVNTRCSTVVADVIAELCALLGVESE-AEQQEFSLYCIVQGDAFTMPLAADEYILDVTTEL---- 2890
            .:....|:.|.|    ||..:|...: |.....||:..:.....:  |...::..|...::
Mouse  1809 SMEVGSSSRVRD----LCEGIGTRLQLASWDGCSLFIKITDKVIS--LKEGDFFFDSLRQVSDWV 1867

  Fly  2891 -----LKSGQ----PFYLIFCRSVWHFALKREPAPMPLYVEVL-FNQVAPDYLEGL-------LL 2938
                 .|.|.    |:.:.|.|.:|   |...|........:| ::|..|.||.|.       .:
Mouse  1868 KKNRPQKEGASVTLPYQVFFMRKLW---LNVTPGKDVNADTILHYHQELPKYLRGFHKCSREDAI 1929

  Fly  2939 ELPGNGVPVPEMVRDMARIAALLHRAADLSHVPAMKEIKFLLPKPALGIREIRPAQWVGLVQS-A 3002
            .|.|              :...:...:|.|.:.::.::          ::|:.|.....|:.| .
Mouse  1930 HLGG--------------LICKIQFGSDSSQLASVSKV----------LKELVPQNLTRLMSSEE 1970

  Fly  3003 WPQVANL--------SPGQVKAQFLNVLATWPLFGSSFFAVKRIWAEEGPHVEDNHSPMWRD-LI 3058
            |.:...|        :..:.|.:||..:..||.|||:||.||:           ...|.:.| |:
Mouse  1971 WKKSLLLECDKNKRKTVAEAKVEFLKYMYRWPTFGSAFFEVKQ-----------TSEPSYPDILL 2024

  Fly  3059 LALNRRGVLFLDPNTHETLQHWSFMEVISTRKVRSEDGALFLDMKVGNLMQQRVIRVQTEQAHEI 3123
            :|:||.|:|.:.|.|.|.|..:.|.::.|.     ..|..:..|.:|:|.|...:..:|...:::
Mouse  2025 IAINRHGLLLIHPKTKELLNTYPFTKISSW-----SSGNTYFHMALGSLGQGSRLLCETSLGYKM 2084

  Fly  3124 SRLVRQYI 3131
            ..|:..|:
Mouse  2085 DDLLTSYV 2092

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	296/711 (42%)
		MYSc_Myo15	169..828	CDD:276838	287/690 (42%)
		MyTH4	1014..1171	CDD:295320	58/211 (27%)
		MyTH4	2704..2810	CDD:279165	32/105 (30%)
		B41	2823..3033	CDD:214604	45/240 (19%)
		FERM_B-lobe	2920..3025	CDD:271216	19/121 (16%)
		FERM_C_MyoXV	3029..3138	CDD:270022	28/104 (27%)
Myo7b	NP_115770.2	MYSc	60..759	CDD:214580	298/720 (41%)
		MYSc_Myo7	79..748	CDD:276832	287/690 (42%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	637..659		12/21 (57%)
		IQ	785..807	CDD:197470	9/21 (43%)
		Mediates interaction with ANKS4B. /evidence=ECO:0000269|PubMed:26812017	962..1578		191/1544 (12%)
		MyTH4	989..1189	CDD:214535	60/216 (28%)
		B41	1196..1409	CDD:214604	68/692 (10%)
		FERM_B-lobe	1299..1400	CDD:271216	32/333 (10%)
		FERM_C1_MyoVII	1403..1499	CDD:270019	34/404 (8%)
		Mediates interaction with CDHR2, CDHR5 and USH1C. /evidence=ECO:0000250|UniProtKB:Q6PIF6	1497..2113		163/923 (18%)
		SH3	1500..1560	CDD:302595	19/189 (10%)
		MyTH4	1641..1788	CDD:214535	47/154 (31%)
		B41	1797..2009	CDD:214604	45/244 (18%)
		FERM_M	1907..2009	CDD:278785	24/125 (19%)
		FERM_C2_MyoVII	2005..2100	CDD:270020	28/104 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710