DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and myo-5

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_505094.1 Gene:myo-5 / 179190 WormBaseID:WBGene00019064 Length:1974 Species:Caenorhabditis elegans


Alignment Length:2222 Identity:499/2222 - (22%)
Similarity:835/2222 - (37%) Gaps:562/2222 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   158 EDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLP 222
            |||..|..|::||:|.|||.||...:|||::|...:.:||||..| .|...|.:.|.|:....:|
 Worm    84 EDMANLTFLNDASVLHNLRQRYYSMMIYTYSGLFCVVINPYKRLP-IYSESVCQMYLGKRRNEMP 147

  Fly   223 PHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGGGS------------ 272
            |||||:...|:..:.:.   |.::|:||||:||||:||.|:.|.|.|   |.|            
 Worm   148 PHLFAVSDEAYRNMTNDRENQSMLITGESGAGKTENTKKVISYFAMV---GASQQSNKKKSKKDK 209

  Fly   273 ASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKSGA-IVGAKITQYLLEKSRIVTQ 336
            |...:.:||::..|:|||||||:|.||:|||||||::.::|.:|. :.||.|..|||||||::.|
 Worm   210 AQVSLEDQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRIHFNTGGKVAGADIEHYLLEKSRVIKQ 274

  Fly   337 APGERNYHVFYELLGGLSETERSKYGLLEADK-YFYLNQGATDCASGRVDWESL---QGAMQVLG 397
            |||||:||:||::.....:..|.|..|....| |.:::| |.....|..|.|.:   ..|..::.
 Worm   275 APGERSYHIFYQIYSDAVKGLREKLFLTRPIKEYTFVSQ-AEVTIDGVDDKEEMLITDEAFDIMK 338

  Fly   398 VSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSR 462
            .:..|:..:..:.|.::|:|.:.|.:|. |..|..:|.|.:.|:  |..|..:.::....||...
 Worm   339 FTATEKSELFAITAGIMHMGELKFKQRP-REEQAELEEGKEGEL--ACKLYCVESEKFINALLKP 400

  Fly   463 TTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR---ISILDIF 524
            ..:...|.::....:||...|..|.||||:|.:|:||:.|.|..:.   ..|..|   |.:|||.
 Worm   401 RVKVGTEWVNKGQNLDQVNWAVGALAKALFARMFSWLIRRCNKTLD---AQDLSRDFFIGVLDIA 462

  Fly   525 GFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPV 589
            |||....||||||.||:.||.||.:||.|:|.|||.||.||.::|..:.:..:|.....|.:||:
 Worm   463 GFEIFDLNSFEQLWINFVNEKLQQFFNHHMFVLEQEEYKREGIQWEFIDFGLDLQACIELIEKPL 527

  Fly   590 GICHLLDDESNFPRATDLSFLEKCHYNHALSE---LYARPRIGAQ---EFGVTHYAGQVWYCVDG 648
            ||..:||:|...|:|:||:...|.:..|....   ...||..|.|   ...:.||||.|.|.|.|
 Worm   528 GIVSMLDEECIVPKASDLTLASKLNDQHLGKHPNFQKPRPPKGKQAEAHLAIVHYAGTVRYNVKG 592

  Fly   649 FLDKNRDALRGDVLELL-ASSRLPLVGELTKQLRAQRD-----------AGKTLPKGSNGRFVTM 701
            :|:||:|.|....:.:| |:....|:.:|......|.|           .||  .||.:..|:  
 Worm   593 WLEKNKDPLNDTAVTVLKANKGNQLMADLWADYATQEDVAAAAKDGKKAVGK--KKGKSASFM-- 653

  Fly   702 KPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIR 766
                 ||:..:.:||.:|:..:.:.||.|:|||.||:.|.|..:|...||.||...|:|:.|:|.
 Worm   654 -----TVSMMYRESLNKLMHMLHQTHPHFIRCIIPNELKKAGMIDANLVLNQLTCNGVLEGIRIC 713

  Fly   767 QRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTG-VEGPDYQLGATRVFLREA 830
            ::|:|.|:.|..|.:||..|.......|...::....:..|:.:.| ::..::|.|.|:||.:..
 Worm   714 RKGFPNRMPFLDFKQRYAVLAADAAKAGKDPKDAGEKISAALIKDGSLKQEEFQCGLTKVFFKAG 778

  Fly   831 LHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALT 895
            :...||..|.|.|.:.....|...|..|.:.:..|:......|....|..|           |..
 Worm   779 VLAHLEELRDEALGKIMAKFQCACRHYLAQCEYKRKLDQKVGLIVLQRNIR-----------AWC 832

  Fly   896 AQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLE----RSQLSYLDIPAELAF 956
            ..|.|...:...||:.|....::.:|.        ||.|.|..|||    :.:....|:.||.|.
 Worm   833 TLRSWSWFKLFGRVKPLIKGSKKNEEF--------EALEKKFKVLEEEKTQEERKRKDMEAENAR 889

  Fly   957 IYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITA 1021
            :.::.|                      :..:||.::....:.|                |..:|
 Worm   890 LEAEKQ----------------------ALLIQLEQERDSSAEG----------------EERSA 916

  Fly  1022 PLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQ 1086
            .||.:.|..::...:           .||                               |||::
 Worm   917 KLLAQKADLEKQMAN-----------MND-------------------------------QLCDE 939

  Fly  1087 VHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSS 1151
            .                        :.:||.:|...:...|.  |.|:..:              
 Worm   940 E------------------------EKNAALTKQKKKIEQDN--EGLKKTV-------------- 964

  Fly  1152 GAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSL----- 1211
                                      ..|..|:..:.|:..|.|.          .:.||     
 Worm   965 --------------------------SDLETTIKKQESEKQAKDH----------QIRSLQDEIQ 993

  Fly  1212 ---GVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFART--TLPD 1271
               .|.|:     |:..::..:......:.|:.||::..       :.|.::.||...|  .|.|
 Worm   994 SQDEVISK-----LNKEKKHQEEVNRKLLEDIQAEEDKV-------NHLNKTKAKLESTLDELED 1046

  Fly  1272 AVKRPAVPPPAPPTSSGKEDVPRERRS-------SRELLSRSSALNERYFEREPSPGPGQGSSTG 1329
            .::|         ...|::|..::||.       ::||:..   ||....|:|            
 Worm  1047 TLER---------EKRGRQDCEKQRRKVEGELKIAQELIEE---LNRHKHEQE------------ 1087

  Fly  1330 QAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQ 1394
             ...:.|.::                      |...:|||.|......:|....|:...|.|:.:
 Worm  1088 -QVIKKKDIE----------------------LSSIQSRLEDEQSLVAKLQRQIKELLARIQELE 1129

  Fly  1395 H---AGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDV-DQFLD 1455
            .   |.|.|.:.:..:.:....:..|...|.......::|....:..|...:.....|: |..::
 Worm  1130 EELDAERNSRSKAEKARNEMQMELEELGDRLDEAGGATQAQIELNKKREAELAKLRQDLEDAAIN 1194

  Fly  1456 DLFSPVL-----DGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLE 1515
            ...|...     :.::.||||.......:||....::|:.:.|:|:|.... |:  .....||.|
 Worm  1195 SETSMAALRKKHNDAVAELSDQLDTIQKMRGKLEREKNDKQREVDELQQSA-DV--EAKQRQNCE 1256

  Fly  1516 KLTSK------------DQLAAIIKG---GGVASKPEERDEESEIEDLDDYINELFEPIPVAEGL 1565
            ::..:            |:.|.:|:.   |......|.:|...::||.:..:.          .|
 Worm  1257 RMAKQLEAQLTDMTLKSDEQARLIQELTMGKNKVHNENQDLNRQLEDAEAQLC----------AL 1311

  Fly  1566 DKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQ-LPGETESGPALYQQ----QVQ----RAFLQS 1621
            :::..::|                 ..|.:|.: |..||....:|:.|    |::    |..|:.
 Worm  1312 NRIKQQQH-----------------SQLEELKRTLDQETRERQSLHSQVSNYQLECEQFRESLEE 1359

  Fly  1622 AMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATR 1686
            .......:|:||...|..:|...::                   .....:|........|.|.|.
 Worm  1360 EQDAKTDVQRQLSKANSEIQQWRAK-------------------FEGEGVSRAEELEETRRKLTH 1405

  Fly  1687 SSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLD----PYGRAKTVR-------------IG 1734
            ....:.|.|:     ........|| |:.....|.|:    ...||.::.             :.
 Worm  1406 KVQEMQEQLE-----NANQKIGTLE-KNKQRLAHDLEDAQVDADRANSIASSLEKKQKGFDKVLD 1464

  Fly  1735 KWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQ-----HHQMTSNGGMMES----------- 1783
            :||           .:.:....::.|.||:|...|.     .:|:..:|...|:           
 Worm  1465 EWR-----------RKCEALVAEVEQSQRETRAAATETFRLRNQLEESGEQTEAVKRENKALAQE 1518

  Fly  1784 --------GPGARGA-------SATAIEWEEFE---------IESPTPPPMSGQL----MRSSI- 1819
                    |.|.:..       ....||.||.:         :|:.....|..|:    :||.| 
 Worm  1519 LKDIADQLGEGGKSVHDLQKMRRRLEIEKEELQQALDEAECALEAEEAKVMRAQIEVSQIRSEIE 1583

  Fly  1820 -RLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLAK---------KSFEIGADRPPPGSVG 1874
             ||:.......:...|..|..|:..|....:|....:|.|         ...||..|.....:|.
 Worm  1584 KRLQEKEEEFENTRKNHSRTIESMQVSLETESRGRAELLKTKKKLEGDVNELEIALDHSNKLNVD 1648

  Fly  1875 KLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVSGGNSGPGG 1939
            ..|...:::..:.::.  :.|.....:.||.|..|.|.:.|..:|||:...|            .
 Worm  1649 GQKSMKKLQDTIRELQ--YQVEEEQRSLSESRDHANLAERRSQVLQQEKEDL------------A 1699

  Fly  1940 VV--DSHATVR-TQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAP 2001
            ::  .|..|.| .::|..|.|.|......|.   .:||.....|......::  |....|...|.
 Worm  1700 IIYEQSERTRRQAELELAEVKDSVNELSNSN---SLLLATKRKVEGDLQLLQ--SEIEEAMSDAK 1759

  Fly  2002 QSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLEDHSASSSPA 2066
            .|...|:....:........:..:||  |....|.:.|.     :..:....:.|::..|     
 Worm  1760 TSDEKAKKAIMDASKLADELRSEQEH--ASNLNQSKKTL-----ESQVKDLQMRLDEAEA----- 1812

  Fly  2067 VAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGS------EKEREKRE-------- 2117
             |..:..:|:.::...|..:.|         .|:||.......      .|:|:.||        
 Worm  1813 -AGIKGGKRQLAKLDMRIHELE---------TELEGENRRHAETQKVLRNKDRKCRELQFQVDED 1867

  Fly  2118 -RERERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEHER 2181
             :.:||:|::  :|:.::..|.|:    |.|:.:....        :|.||.:| .:....|..:
 Worm  1868 KKSQERMYDL--IEKLQQKIKTYK----RQIEDAESLA--------SGNLAKYR-QLQHVVEDAQ 1917

  Fly  2182 KRKSSASSGMRE 2193
            :|..:|.:.:::
 Worm  1918 ERADAAENALQK 1929

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 251/719 (35%)
MYSc_Myo15 169..828 CDD:276838 246/700 (35%)
MyTH4 1014..1171 CDD:295320 16/156 (10%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
myo-5NP_505094.1 Myosin_N 31..68 CDD:280832
Myosin_head 83..776 CDD:278492 251/711 (35%)
MYSc_class_II 95..776 CDD:276951 246/700 (35%)
Myosin_tail_1 853..1933 CDD:279860 230/1422 (16%)
DUF4795 954..1129 CDD:292662 43/285 (15%)
Prefoldin 1111..1243 CDD:298833 24/131 (18%)
Tmemb_cc2 <1212..1322 CDD:287269 24/139 (17%)
DUF881 1746..>1838 CDD:303034 17/115 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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