DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and Myo15

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_034992.2 Gene:Myo15 / 17910 MGIID:1261811 Length:3511 Species:Mus musculus


Alignment Length:3213 Identity:927/3213 - (28%)
Similarity:1365/3213 - (42%) Gaps:894/3213 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 WQRGGGGSVTPSP-----AQSPSL-------------ALLSPHV-----LRRQRPASLEDFEDLP 94
            |.|....|.||:|     |..|.|             |::.|.|     .|.:.||.::..|...
Mouse  1059 WHRWKTVSRTPAPLAPTRAPGPLLKAGEQPRAEPGRFAVVMPQVRGVSSFRPKGPAPVQPPEHPD 1123

  Fly    95 NLSAKHPALPSSRLR--RL------KCRYPQVVKRLSTLCSDVIAR--------------HPQTF 137
            ....:.||..:..||  ||      .|.:    .|:.|..|....|              .||::
Mouse  1124 QDPEQGPAPQACSLRWPRLWPPTDAHCLW----SRIRTYSSQSHLRGHGGDCHKSLWKKTRPQSW 1184

  Fly   138 ALQ-------PGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAV 195
            ..:       |   |:|:|:.....||||||.|:||.|.::|.||:.|:::.||||:.||||::|
Mouse  1185 QNKMHSIRNLP---SMRSREQHREDGVEDMTQLEDLQETTVLANLKTRFERNLIYTYIGSILVSV 1246

  Fly   196 NPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTK 257
            |||:||. .||.|..:||:||.||..|||||||...|.|.:   ...|.|:|||||||||||:||
Mouse  1247 NPYRMFA-IYGPEQVQQYSGRALGENPPHLFAIANLAFAKMLDAKQNQCVIISGESGSGKTEATK 1310

  Fly   258 LVMQYLAAVVPGGGSASAVITE-QILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKSGAIVGA 321
            |:::.|||:    .....|:.: :||||.|||||||||:|.||||||||||::|::.:.|.|.||
Mouse  1311 LILRCLAAM----NQRRDVMQQIKILEATPLLEAFGNAKTVRNDNSSRFGKFVEIFLEGGVICGA 1371

  Fly   322 KITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRV-- 384
            ..:||||||||||.||..|||||:|||||.||....|..:.|.||:.|:|||||.....:|:.  
Mouse  1372 ITSQYLLEKSRIVFQAKNERNYHIFYELLAGLPAQLRQAFSLQEAETYYYLNQGGNCEIAGKSDA 1436

  Fly   385 -DWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLL 448
             |:..|..||:|||.:..:::.|.|:||::||||||||.:.: ...||...|.|..||:..|.||
Mouse  1437 DDFRRLLAAMEVLGFTSEDQDSIFRILASILHLGNVYFEKHE-TDAQEVASVVSAREIQAVAELL 1500

  Fly   449 HISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTH 513
            .:|.:||.:|:|.:.||...|::.|||.::.|:|||||.||.|||.||.||::|:|::|..  ..
Mouse  1501 QVSPEGLQKAITFKVTETIREKIFTPLTVESAVDARDAIAKVLYALLFGWLITRVNALVSP--KQ 1563

  Fly   514 DAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNL 578
            |...|:||||:|||||:.||||||||||||||||..|||.||:.||.||.||:::|..:|:.||.
Mouse  1564 DTLSIAILDIYGFEDLSFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQMDWREIAFADNQ 1628

  Fly   579 PVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQEFGVTHYAGQVW 643
            |.|:|::.||.||..:|||:..||:|||.:||:||||:|..:.||::|::...||.:.||||:|.
Mouse  1629 PCINLISLKPYGILRILDDQCCFPQATDHTFLQKCHYHHGANPLYSKPKMPLPEFTIKHYAGKVT 1693

  Fly   644 YCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTV 708
            |.|..|||||.|.:|.|||:|...||..:|..|.....|| .|...|.|.|:   :|...:..||
Mouse  1694 YQVHKFLDKNHDQVRQDVLDLFVHSRTRVVAHLFSSHAAQ-TAPPRLGKSSS---ITRLYKAHTV 1754

  Fly   709 AARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVR 773
            ||:|..||..|::.|.||:|.||||:|||.:|.....:...::.||||.|:|:|::||:.|:|||
Mouse  1755 AAKFQQSLLDLVEKMERCNPLFVRCLKPNHKKEPGLFEPDVMMAQLRYSGVLETVRIRKEGFPVR 1819

  Fly   774 LRFQHFVERYRHLLPSPL---ARGTPYRELCRALLEAMPRTGVEGPD-YQLGATRVFLREALHRA 834
            |.||.|::|||.|:...|   |.|    ::|.:||.   |.....|| |::|.:::||:|.||:.
Mouse  1820 LPFQVFIDRYRCLVALKLNVPADG----DMCVSLLS---RLCTVTPDMYRVGISKLFLKEHLHQL 1877

  Fly   835 LESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRL 899
            |||.|.....|||:::||::||..::|.....:.....||:|.||..|:|||:::|:..|..:.|
Mouse  1878 LESMRERVQNRAALTLQRYLRGFFIQRHFRSLRRKIILLQSRARGFLARQRYQQMRQSLLKFRSL 1942

  Fly   900 WRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGW 964
            ......|||..:||::.|||  |:||..|.:|....::.|..|    :|::|||:|.:.....|.
Mouse  1943 VHTYVNRRRYLKLRAEQRRR--AQEAWLREQEELSKREVVPVR----HLEVPAEVAGLLQAAAGL 2001

  Fly   965 SPPHGDRHLVKVLGTVPGPPSSA---VQLPEDLGQFSFGKFSSVYCNGLRLQPRREP----ITAP 1022
            ....|.|     :..|..|...|   |.||.|:..:...||  :.|:      .:||    :|.|
Mouse  2002 KLSSGPR-----VAVVRAPRLQAEPCVTLPLDINNYPMAKF--IRCH------FKEPSFGMLTVP 2053

  Fly  1023 L---LTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLC 1084
            |   |||...  :...:|::|||||||:..|..|.|.:|.:|.:||||:.|....||||||.||.
Mouse  2054 LKMPLTRLPV--EHHAEAISVFKLILRFMGDPHLHGTQEMILGNYIVHQGLVEPALRDEILAQLA 2116

  Fly  1085 NQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGT 1149
            ||| ...||:..:.|.|.||..||..|.||....|:|::||.|......:.:...:||:      
Mouse  2117 NQV-WRNPNAYNSKRGWLLLAACLSGFAPSPHLDKFLLKFVSDYGQNGFQAVCQHRLLQ------ 2174

  Fly  1150 SSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVA 1214
               |:|:||.|:|.|..|||.|......|||.::..:....:..|.:|::.|..|...:...|:|
Mouse  2175 ---AMGSGAARTFPPTQLEWTAIQEKASMALDVSCFNGDQFSCPVHTWSTGEAVAGDILKHRGLA 2236

  Fly  1215 S--RGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPA 1277
            .  ||||:.:.:|.|..:..|.|||:||:::.||...||..:|..: .||:              
Mouse  2237 DGWRGWTVAMKNGVQWAELAGHDYVLDLVSDLELLRDFPRQKSYFI-VGAE-------------- 2286

  Fly  1278 VPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLL 1342
                                                     .|..|:|.:.|             
Mouse  2287 -----------------------------------------GPLAGRGDTRG------------- 2297

  Fly  1343 AGDIVPVPTDC-DSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHG 1406
                  |..:| ||.|                           ||..|.|...|..:......:.
Mouse  2298 ------VFGNCWDSDE---------------------------DTPTRPQPQDHVAKMPDLDGYC 2329

  Fly  1407 SHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSD 1471
            ||..   |.....|.:...:...:|   ...:....||.:  ::|.:||.||.|||.....:|..
Mouse  2330 SHKE---DGTNGETEAQRWTSNRQA---VDSIGESTVPPR--ELDGYLDSLFDPVLACGDADLEK 2386

  Fly  1472 ARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKP 1536
            ..::|..::||.                      ||                     |||     
Mouse  2387 PTAIAYRMKGGG----------------------QP---------------------GGG----- 2403

  Fly  1537 EERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPG 1601
                                                       ||.:::.....|...:|..:||
Mouse  2404 -------------------------------------------GGSTSEDTSRRPPEPKLKPIPG 2425

  Fly  1602 ETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSP--PPAPP 1664
            ...|..||.|..:.|             |..|||:...||.|..||...:|.:....|  |.||.
Mouse  2426 LDASTLALQQAFIHR-------------QAVLLAREMTLQALALQQQPLSATSRPQLPERPLAPE 2477

  Fly  1665 ILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAK 1729
            ......:...||..|:.::.|..|. ...|:...|..|..|:..|:..:|               
Mouse  2478 ARPKTVVGTGPPAKPVLVRPTPQSW-APGSVAKAPKIPSKPVAVPILAQD--------------- 2526

  Fly  1730 TVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATA 1794
                    |..|:                                                |.:|
Mouse  2527 --------WTAPE------------------------------------------------SISA 2535

  Fly  1795 IEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLAKK 1859
                            |.:|:|            .|.:|:....:.||.:    :|::      |
Mouse  2536 ----------------SPELVR------------YSTLNSEHFPQPTQQI----RSII------K 2562

  Fly  1860 SFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGH-SVRSTVSTKSEQRAPAKLEDTRKLMLQQQL 1923
            .::    :||                    .||| ..|.|...|..:|.|...|:.  ||:.:..
Mouse  2563 QYK----QPP--------------------WAGHPEARRTDGGKVFRRPPDPHEEA--LMILKGQ 2601

  Fly  1924 GGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAP---PP 1985
            ....|.|.|                ||:.|.               ...::.|..|.|.|   |.
Mouse  2602 KTQLAVVPG----------------TQVSRE---------------AVAMVKPVTSAPRPCMGPT 2635

  Fly  1986 PIRPP-SMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMI 2049
            |::|. |:.||..|                                 :|.|              
Mouse  2636 PVQPSRSLEPPEDP---------------------------------VQTQ-------------- 2653

  Fly  2050 SSHHLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKERE 2114
                                                                             
Mouse  2654 ----------------------------------------------------------------- 2653

  Fly  2115 KRERERERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEH 2179
                                .|::..|                          .|          
Mouse  2654 --------------------LHRLVNP--------------------------NF---------- 2662

  Fly  2180 ERKRKSSASSGMREELDSMHMTTPPPVIVPAPVPPPSSTSPGLGVVSGVLMGSGSGGSTACLTYN 2244
                                                                         ..|.
Mouse  2663 -------------------------------------------------------------YGYQ 2666

  Fly  2245 RVPWKLRVRKEVFQPHEPIGPPVALDLLFAQVLGDVFGVTPCLRITPQEKSS-----ALNMLHGH 2304
            .:||::.:|||||.|.:....||.|||||.|:|.|.|. ..||||:..|:..     |.|.|   
Mouse  2667 DIPWRIFLRKEVFYPKDNYSHPVQLDLLFRQILHDTFS-EACLRISEDERLQMKALFAQNQL--- 2727

  Fly  2305 GVSVDTLSNRNGSGAGGGGNGGQVRALVKRHLVDMARD-WPLYFARLFAVQGAPLYPDVSIMGVS 2368
                ||             ....|...|||..:.|||| |.:||:|||...|: :...|.|:.||
Mouse  2728 ----DT-------------QRPLVTESVKRAAISMARDSWEIYFSRLFPAMGS-VGTGVQILAVS 2774

  Fly  2369 HSGLYL------ARRDADYLIVVQAISFGEIQSAVTLPRPAALQLNLRNGKHLALHAARAAAIQS 2427
            |:|:.|      ::..:..|.|:.|.||.:| ..||:|....|:.||.|.| |.|.:|||..:::
Mouse  2775 HTGIKLLQMVKGSKEASRRLRVLCAYSFADI-LFVTMPSQNMLEFNLSNEK-LILFSARAQQVKT 2837

  Fly  2428 MVTTFVQEFRKSQSKASTLSSGARAAAQTLN------VPLERLESRQAHAQRNEHGVDGGSRQNE 2486
            :|.||:.|.:|.......:.:......:.|:      :.|:.||..:.       |...|....:
Mouse  2838 LVDTFILELKKDSDYVVAVRNFLSEDPELLSFHKGDIIHLQSLEPTRV-------GYSAGCVVRK 2895

  Fly  2487 QLQQSELHHHLQQQQQQQQQQQHHQQQQQQQQLEDAMEEQHMATDHQQQQQQQLGQQQGQQQRFL 2551
            :|...|                               |.:....|.    ..:.|...|:..|| 
Mouse  2896 KLVYLE-------------------------------ELRRRGPDF----GWRFGAVHGRVGRF- 2924

  Fly  2552 KQQSYLHSARKSNAGQQPSSLTNGQVH------HQEQMLQQQQQQSQSLPHHDLDANYLQDESNG 2610
             ....:..|...:..|.|:....|:..      ......|:..::.:..|.....|:  ..|.:.
Mouse  2925 -PSELVQPAAAPDFLQLPAEPGRGRAAAVAAAVASAAAAQEVGRRREGPPVRARSAD--SGEDSI 2986

  Fly  2611 GTPPSVTKYSLLQFAMQHFRNDQLRDAD----RHHERHQSAANRSYAELVKWQGHAIRLPLLRL- 2670
            ..|||    ::|:||.::||:.:.|..|    :..|..:|   ::..:::.:....|:..|:.| 
Mouse  2987 ALPPS----TMLEFAQKYFRDPRRRPRDGLKLKSKEDRES---KTLEDVLCFTKVPIQESLIELS 3044

  Fly  2671 PNDLAPLALECFDCILRYCGDIPLDPDLTEVKCVYTVLMHCHKYLALRDEVYCQLMKQTTANRSP 2735
            .::|..:|::.|..::|:.||.||... :|:..:.|:|..|..:..:|||.|||::||.|.|.||
Mouse  3045 DSNLNKMAVDMFVAVMRFMGDAPLKGQ-SELDVLCTLLKLCGDHEVMRDECYCQIVKQITDNSSP 3108

  Fly  2736 CPDSSQRAWRLLSILAAYFGCSDALRPYLMEHLTSAASDRRRSCHGTAAVCLTNLRKTARCGGRK 2800
            ..||.||.||||.|:|||:.||:...|||:..|...:........|.|..|..||:||.|.|||.
Mouse  3109 KQDSCQRGWRLLYIMAAYYSCSEVFYPYLIRFLQHVSWTPGLPFQGIAKACEQNLQKTLRFGGRL 3173

  Fly  2801 NVPSVEEVTAVSAGRSARRQIYRLPGGAERVVNTRCSTVVADVIAELCALLGVESEAEQQEFSLY 2865
            ..||..|:.|:.||||::||::.||||.||.:..:..||..|||..||..:.:.......|:.::
Mouse  3174 EFPSNMELRAMLAGRSSKRQLFLLPGGLERHLKIKTCTVALDVIEGLCTEMALTRPEAFDEYVIF 3238

  Fly  2866 CIVQGDAFTMPLAADEYILDVTTELLKSGQPFYLIFCRSVWHFALKREPAPMPLYVEVLFNQVAP 2930
            .:........||:...|||||.:|:.:....:.|.|.|.:|...||.|   ..|||.:.:|||.|
Mouse  3239 VVTNRGQHVCPLSCRAYILDVASEMEQVDGGYTLWFRRVLWDQPLKFE---NELYVTMHYNQVLP 3300

  Fly  2931 DYLEGLLLELPGNGVPVPEMVRDMARIAALLHRAADLSHVPAMKEIKFLLPKPALGIREIRPAQ- 2994
            |||:||...:|.. .|..:.::.::::|:|.|||.|..::|:::|           ::|..||| 
Mouse  3301 DYLKGLFSSVPAR-QPTEQQLQQVSKLASLQHRAKDHFYLPSVRE-----------VQEYIPAQL 3353

  Fly  2995 --------WVGLVQSAWPQVANLSPGQVKAQFLNVLATWPLFGSSFFAVKRIWAEEGPHVEDNHS 3051
                    |:.||.....|...|||.|.:||||.:|:.:||||||||.::.......|      :
Mouse  3354 YHTTAGDTWLNLVSQHRQQTQALSPHQARAQFLGLLSAFPLFGSSFFFIQSCSNVLVP------A 3412

  Fly  3052 PMWRDLILALNRRGVLFLDPNTHETLQHWSFMEVIS--TRKVRSEDGALFLDMKVGNLMQQRVIR 3114
            |    .|||:|..|:.||...|||.:......|:.|  |::..:.....::::.:|::..||.::
Mouse  3413 P----CILAVNHNGLNFLSTKTHELIVKIPLKEIQSTWTQQPTANSSYPYVEISLGDVAAQRTMQ 3473

  Fly  3115 VQTEQAHEISRLVRQYITMAQISQRDKR 3142
            :|.||..|:.|:|..::. :.:|.|::|
Mouse  3474 LQLEQGLELCRVVAVHVE-SMLSAREER 3500

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 342/690 (50%)
MYSc_Myo15 169..828 CDD:276838 328/669 (49%)
MyTH4 1014..1171 CDD:295320 65/163 (40%)
MyTH4 2704..2810 CDD:279165 47/105 (45%)
B41 2823..3033 CDD:214604 74/218 (34%)
FERM_B-lobe 2920..3025 CDD:271216 38/113 (34%)
FERM_C_MyoXV 3029..3138 CDD:270022 29/110 (26%)
Myo15NP_034992.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..44
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 574..690
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 712..1030
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1105..1135 6/29 (21%)
MYSc 1201..1883 CDD:214580 345/700 (49%)
MYSc_Myo15 1220..1871 CDD:276838 328/669 (49%)
Actin-binding. /evidence=ECO:0000255 1776..1783 5/6 (83%)
FliJ 1870..1960 CDD:280262 33/89 (37%)
Neck or regulatory domain 1872..2013 50/151 (33%)
Tail 2014..3511 504/2221 (23%)
MyTH4 2049..2195 CDD:214535 64/157 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2330..2359 5/34 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2392..2425 11/123 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2460..2509 11/49 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2565..2584 8/42 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2629..2648 7/18 (39%)
SH3 2852..2931 CDD:302595 14/122 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2964..2984 2/21 (10%)
MyTH4 3031..3185 CDD:214535 60/154 (39%)
B41 3195..3400 CDD:214604 74/219 (34%)
FERM_B-lobe 3290..3390 CDD:271216 37/111 (33%)
FERM_C_MyoXV 3396..3497 CDD:270022 30/111 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167837941
Domainoid 1 1.000 608 1.000 Domainoid score I194
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1244 1.000 Inparanoid score I182
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52622
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 1 1.000 - - otm42439
orthoMCL 1 0.900 - - OOG6_100101
Panther 1 1.100 - - LDO PTHR13140
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5032
SonicParanoid 1 1.000 - - X4354
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.790

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