| Sequence 1: | NP_001036269.2 | Gene: | Myo10A / 32028 | FlyBaseID: | FBgn0263705 | Length: | 3145 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_062345.2 | Gene: | Myo10 / 17909 | MGIID: | 107716 | Length: | 2062 | Species: | Mus musculus |
| Alignment Length: | 2015 | Identity: | 530/2015 - (26%) |
|---|---|---|---|
| Similarity: | 843/2015 - (41%) | Gaps: | 494/2015 - (24%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 115 YPQV-VKRLSTLCSD-VIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRL 177
Fly 178 RYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSP 239
Fly 240 QVVVISGESGSGKTESTKLVMQYLAAVVP-----GGGSASAVITEQILEAAPLLEAFGNARTARN 299
Fly 300 DNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGL 363
Fly 364 LEADKYFYLNQGATDCASGRV--DWESLQ---GAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHR 423
Fly 424 RQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFA 488
Fly 489 KALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKH 553
Fly 554 VFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHA 618
Fly 619 LSELYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQ 683
Fly 684 RDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMP 748
Fly 749 CVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGV 813
Fly 814 EGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWR 878
Fly 879 GQRAQQRYERLRKGALTAQRLWRGRQARRRVQQL------------RSDHRRRQE---AREAAQR 928
Fly 929 A-------REAREAKQAVLERSQLSY--LDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPP 984
Fly 985 SSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRRE-PITAPLLTRAAS-RDQDFQDALAVFKLILRW 1047
Fly 1048 SNDKALEGAKEKLLA------DYIVHKALSSRGLRDEI----LVQLCNQVHGLPPNSGEATRLWQ 1102
Fly 1103 LLGQCLCCFQPSAAFSKYLMRF-VDDEA-PESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPA 1165
Fly 1166 WLEWRAWTRGCDMALPLTLPDEASQT------VAVDSWTSCEEAAALAVSSLGVASRGWTLVLDD 1224
Fly 1225 GQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGK 1289
Fly 1290 EDVPRERRSSRELLSRSSALNERYFEREPSP----GPGQGSSTGQAKSRSKSLDDLLAGDIVPVP 1350
Fly 1351 TDCDSQEPLHTLGLSESRLNDR------------YHS------------AERLAPVGKDTGPRYQ 1391
Fly 1392 KSQHAGRRSHAASHGSHSSKYA----DKAEYATRSSAM----SDTSEAPSLASHVRRVRV----P 1444
Fly 1445 SQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIP 1509
Fly 1510 LVQNLEKLTSKDQ--LAAIIKGGGV----ASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKL 1568
Fly 1569 TSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQL 1633
Fly 1634 LAQNQALQ--TLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQ 1696
Fly 1697 PPPPPPPPPMPPPLECKDPSETRHF-LDPYGRAKTVRI------GKWRW----------PPPQDE 1744
Fly 1745 PQFQTEEDFFAFKMRQ------HQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIE 1803
Fly 1804 SPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQP---MQSVVTT----------- 1854
Fly 1855 --KLAKKSFEIGADRPPPGSVGK--------------------LKLSSEMRQRLEQVTAGHSV-- 1895
Fly 1896 ------RSTVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERM 1954
Fly 1955 1954 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Myo10A | NP_001036269.2 | MYSc | 156..836 | CDD:214580 | 302/693 (44%) |
| MYSc_Myo15 | 169..828 | CDD:276838 | 291/672 (43%) | ||
| MyTH4 | 1014..1171 | CDD:295320 | 34/170 (20%) | ||
| MyTH4 | 2704..2810 | CDD:279165 | |||
| B41 | 2823..3033 | CDD:214604 | |||
| FERM_B-lobe | 2920..3025 | CDD:271216 | |||
| FERM_C_MyoXV | 3029..3138 | CDD:270022 | |||
| Myo10 | NP_062345.2 | MYSc | 58..739 | CDD:214580 | 307/720 (43%) |
| MYSc_Myo10 | 77..727 | CDD:276840 | 291/672 (43%) | ||
| Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 | 619..641 | 10/21 (48%) | |||
| IQ | 741..763 | CDD:197470 | 8/21 (38%) | ||
| ARGLU | 796..939 | CDD:291991 | 40/186 (22%) | ||
| SAH. /evidence=ECO:0000250|UniProtKB:P79114, ECO:0000305|PubMed:16030012 | 815..907 | 22/124 (18%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 822..844 | 8/21 (38%) | |||
| SPEC | <843..957 | CDD:295325 | 28/157 (18%) | ||
| Mediates antiparallel dimerization. /evidence=ECO:0000250 | 882..932 | 11/83 (13%) | |||
| MYO10_CC | 882..932 | CDD:293340 | 11/83 (13%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 963..1047 | 21/131 (16%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1062..1089 | 9/62 (15%) | |||
| PH-like | 1185..>1227 | CDD:302622 | 4/41 (10%) | ||
| PH2_MyoX | 1219..1320 | CDD:270108 | 17/100 (17%) | ||
| PH | 1219..1314 | CDD:278594 | 17/94 (18%) | ||
| PH3_MyoX-like | 1385..1510 | CDD:270109 | 28/207 (14%) | ||
| PH | 1400..1499 | CDD:278594 | 24/174 (14%) | ||
| MyTH4 | 1553..1699 | CDD:214535 | 23/150 (15%) | ||
| UBQ | 1705..>1750 | CDD:294102 | 6/31 (19%) | ||
| B41 | 1708..1962 | CDD:214604 | 6/28 (21%) | ||
| FERM_M | 1803..1962 | CDD:278785 | |||
| FERM_C_MyoX | 1958..2046 | CDD:270023 | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E2759_KOG4229 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 1 | 0.900 | - | - | OOG6_100101 | |
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.710 | |||||