Protein Alignment Myo10A and Myh6

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_006518740.1
• Gene: Myh6 / 17888
• MGIID: 97255
• Length: 1939
• Species: Mus musculus
• Alignment Length: 2007
• Identity: 491/2007 - (24%)
• Similarity: 816/2007 - (40%)
• Gaps: 406/2007 - (20%)

  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.:|..|||.::|:||:.||...:|||::|...:.|||||..| .|..||...|.|:.....
Mouse    87 IEDMAMLTFLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNAEVVAAYRGKKRSEA 150

  Fly   222 PPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGG--------GSASA 275
            |||:|:|...|:..:.:.   |.::|:||||:|||.:||.|:||.|::...|        .:...
Mouse   151 PPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRSKKENPNANKG 215

  Fly   276 VITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPG 339
            .:.:||::|.|.|||||||:|.||||||||||::.::| .:|.:..|.|..|||||||::.|...
Mouse   216 TLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKA 280

  Fly   340 ERNYHVFYELLGGLSETERSKYGLLE-------ADKYFYLNQGATDCASGRVDWESL---QGAMQ 394
            |||||:||::|      ...|..||:       ...|.:::||....|| ..|.|.|   ..|..
Mouse   281 ERNYHIFYQIL------SNKKPELLDMLLVTNNPYDYAFVSQGEVSVAS-IDDSEELLATDSAFD 338

  Fly   395 VLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRAL 459
            ||..:..|:.|:.::..|::|.||:.|.::|   .:|..|.....:...:|:|:.:::..|.:.|
Mouse   339 VLSFTAEEKAGVYKLTGAIMHYGNMKFKQKQ---REEQAEPDGTEDADKSAYLMGLNSADLLKGL 400

  Fly   460 TSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIF 524
            .....:...|.:.....:.|...:..|.||::|..:|||:|:|||:.::...... :.|.:|||.
Mouse   401 CHPRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQ-YFIGVLDIA 464

  Fly   525 GFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPV 589
            |||....|||||||||:.||.||.:||.|:|.|||.||.:|.:||..:.:..:|.....|.:||:
Mouse   465 GFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIDLIEKPM 529

  Fly   590 GICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARPR--IGAQE--FGVTHYAGQVWYCVDGF 649
            ||..:|::|..||:|:|::|..|.:.|| ..|..:.:||  .|.||  |.:.||||.|.|.:.|:
Mouse   530 GIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHFSLVHYAGTVDYNIMGW 594

  Fly   650 LDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFAD 714
            |:||:|.|...|:.|...|.|.|:..|.... |..|.|.: .||..|:  .......||:|...:
Mouse   595 LEKNKDPLNETVVGLYQKSSLKLMATLFSTY-ASADTGDS-GKGKGGK--KKGSSFQTVSALHRE 655

  Fly   715 SLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHF 779
            :|.:|:.::...||.|||||.||:.|....||.|.|:.|||..|:|:.|:|.::|:|.|:.:..|
Mouse   656 NLNKLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDF 720

  Fly   780 VERYRHLLPSPLARG--TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTER 842
            .:|||.|.|:.:..|  ...|:....||.::   .::...|:.|.|:||.:..|...||..|.||
Mouse   721 RQRYRILNPAAIPEGQFIDSRKGAEKLLGSL---DIDHNQYKFGHTKVFFKAGLLGLLEEMRDER 782

  Fly   843 LRRAAVSVQRHVRGMLVR---RQLARRQAAATRLQ---------ARWRGQRAQQRYERLRKGALT 895
            |.|....:|...||.|:|   :::..|:.|...:|         ..|...:...:.:.|.|.|.|
Mouse   783 LSRIITRIQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAET 847

  Fly   896 AQRLWRGRQARRRVQQL--RSDHRRRQ-------------------------------------- 920
            .:.:...::...||:..  :|:.||::
Mouse   848 EKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIK 912

  Fly   921 -------EAREAAQRAREARE------AKQAVLERSQLSYL--DIPAELAFIYSKLQGWSPPHGD 970
                   :.:|..:|..:..|      ||:..|| .:.|.|  ||. :|....:|::  ...|..
Mouse   913 NKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLE-DECSELKKDID-DLELTLAKVE--KEKHAT 973

  Fly   971 RHLVKVLGTVPGPPSSAV---------------QLPEDLGQFSFGKFSSVYCNGLRLQPRREPIT 1020
            .:.||.|..........:               |..:|| |....|.:::..:.::|:.:.:.:.
Mouse   974 ENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL-QAEEDKVNTLTKSKVKLEQQVDDLE 1037

  Fly  1021 APLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHK-----ALSSRGLRDE-- 1078
            ..|......| .|.:.|....:..|:.:.:..::...:||..:..:.|     :..:..:.||
Mouse  1038 GSLEQEKKVR-MDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDISQQNSKIEDEQA 1101

  Fly  1079 ILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAP-------ESLRPL 1136
            :.:||..:   |..|......|.:.|                       ||.       |.||..
Mouse  1102 LALQLQKK---LKENQARIEELEEEL-----------------------EAERTARAKVEKLRSD 1140

  Fly  1137 LLRQLLR-----QQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDS 1196
            |.|:|..     ::.||.:|..:.....|.     .|::...|..:.|   ||..||:
Mouse  1141 LSRELEEISERLEEAGGATSVQIEMNKKRE-----AEFQKMRRDLEEA---TLQHEAT------- 1190

  Fly  1197 WTSCEEAAAL------AVSSLG--------------VASRGWTLVLDDGQQLTDSCGLDYVMDLI 1241
                  ||||      :|:.||              .....:.|.|||   :|.:  ::.::...
Mouse  1191 ------AAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDD---VTSN--MEQIIKAK 1244

  Fly  1242 AEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRS 1306
            |..|........:::..|...:.|:.:|.|...:.|    ...|.:|  ::.|:......|:|:.
Mouse  1245 ANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRA----KLQTENG--ELARQLEEKEALISQL 1303

  Fly  1307 SALNERYFEREPSPGPGQGSSTGQAKSRSKSLDD------LLAGDIVPVPTDCD----------- 1354
            :.              |:.|.|.|.:...:.|::      .||..:.....|||
Mouse  1304 TR--------------GKLSYTQQMEDLKRQLEEEGKAKNALAHALQSSRHDCDLLREQYEEEME 1354

  Fly  1355 -SQEPLHTLGLSESRL--------NDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSS 1410
             ..|....|..:.|.:        .|.....|.|....|....|.|.::.|....:|.......:
Mouse  1355 AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKT 1419

  Fly  1411 KYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSL 1475
            |:..:.|.   ...|.|...:.:.|:     .:..:..:.|:.|.: :....:.|..||..::..
Mouse  1420 KHRLQNEI---EDLMVDVERSNAAAA-----ALDKKQRNFDKILAE-WKQKYEESQSELESSQKE 1475

  Fly  1476 AASIRGGSYEQENEAESEIDDLDDY----------INDIFQPI----PLVQNLEKLTSK------ 1520
            |.|:....::.:|..|..::.|:.:          |:|:.:.:    ..|..|||:..:
Mouse  1476 ARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKL 1540

  Fly  1521 ---------------------------DQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEP 1558
                                       :|:.|.|:     .|..|:|||.|    ....|.|...
Mouse  1541 ELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE-----RKLAEKDEEME----QAKRNHLRMV 1596

  Fly  1559 IPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETE-----SGPALYQQQVQRAF 1618
            ..:...||..|...:.|:.::.....|.|..:..|.|..::..|.:     |...|...|:|
Mouse  1597 DSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKNSQAHLKDTQLQ--- 1658

  Fly  1619 LQSAMAQNLQIQQQLL---AQNQALQTLLSQQAAAA---------AANNSTSPPPAPPILSSLSI 1671
            |..|:..|..:::.:.   .:|..||..|.:..|..         |............:|.|.:.
Mouse  1659 LDDAVHANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNT 1723

  Fly  1672 SPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKW 1736
            |....:..|....|:....|.|::|              ||::..|         :||     |.
Mouse  1724 SLINQKKKMESDLTQLQTEVEEAVQ--------------ECRNAEE---------KAK-----KA 1760

  Fly  1737 RWPPPQDEPQFQTEEDFFAF--KMRQHQRKTTPQAQH-----HQMTSNGGMMESGPGARGASATA 1794
            .........:.:.|:|..|.  :|:::..:|....||     .|:...||..:    .:...|..
Mouse  1761 ITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQ----LQKLEARV 1821

  Fly  1795 IEWE-EFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLAK 1858
            .|.| |.|.|..........:.:|..|::..|..|.....|..|   .||:...:|  :..|..|
Mouse  1822 RELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLMR---LQDLVDKLQ--LKVKAYK 1881

  Fly  1859 KSFEIGADRPPPGSVGKL-KLSSEMRQRLEQVTAGHSVRSTVSTKSEQ-RAPAKLED 1913
            :..| .|:.....::.|. |:..|:.:..|:.....|..:.:..||.. .|..|:.|
Mouse  1882 RQAE-EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKQKMHD 1937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	248/687 (36%)
		PTZ00121	<828..>943	CDD:173412	33/179 (18%)
		MyTH4	1014..1171	CDD:470587	29/175 (17%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	18/86 (21%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myh6	XP_006518740.1	Myosin_N	32..76	CDD:460670
		MYSc_class_II	99..768	CDD:276951	248/687 (36%)
		Myosin_tail_1	848..1925	CDD:460256	210/1213 (17%)