DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and Myh9

DIOPT Version :10

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_071855.2 Gene:Myh9 / 17886 MGIID:107717 Length:1960 Species:Mus musculus


Alignment Length:1962 Identity:509/1962 - (25%)
Similarity:813/1962 - (41%) Gaps:356/1962 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 SGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            |.||||..|..|:|||:|.||:.||..|||||::|...:.:||||..| .|..|:.:.|.|:...
Mouse    81 SKVEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLP-IYSEEIVEMYKGKKRH 144

  Fly   220 SLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSA--SAVITE 279
            .:|||::||...|:.::   ...|.::.:||||:||||:||.|:||||.|.....|.  ...:..
Mouse   145 EMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKSKKDQGELER 209

  Fly   280 QILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVTQAPGERNY 343
            |:|:|.|:|||||||:|.:|||||||||::.:.|. :|.||||.|..|||||||.:.||..||.:
Mouse   210 QLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTF 274

  Fly   344 HVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVDWESLQ---GAMQVLGVSEGEREG 405
            |:||.||.|..|..::...|...:||.:|:.|.. ...|:.|.:..|   .||:::|:.|.|:.|
Mouse   275 HIFYYLLSGAGEHLKTDLLLEPYNKYRFLSNGHV-TIPGQQDKDMFQETMEAMRIMGIPEDEQMG 338

  Fly   406 IVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRA-LTSRTTEAR-- 467
            ::||::.||.|||:.|.:.:   ..:...:..:...:..:|||.|:.....|. ||.|....|  
Mouse   339 LLRVISGVLQLGNIAFKKER---NTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDY 400

  Fly   468 AERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAEN 532
            .::..|.   :||..|.:|.|||.|..:|.|||.|||..:.|.....|..|.||||.|||....|
Mouse   401 VQKAQTK---EQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLN 462

  Fly   533 SFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWD-DNLPVIHLLAKK--PVGICHL 594
            |||||||||.||.||..||..:|.|||.||.||.:||..:.:. |..|.|.|:.|.  |.||..|
Mouse   463 SFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILAL 527

  Fly   595 LDDESNFPRATDLSFLEKCHYNHALSELYARPR--IGAQEFGVTHYAGQVWYCVDGFLDKNRDAL 657
            ||:|..||:|||.||:||..........:.:|:  ....:|.:.||||:|.|..|.:|.||.|.|
Mouse   528 LDEECWFPKATDKSFVEKVVQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPL 592

  Fly   658 RGDVLELLASSRLPLVGELTKQ----LRAQRDAGKT---LPKGSNGRFVTMKPRTPTVAARFADS 715
            ..::..||..|....|.||.|.    :...:.||.:   ||    |.|.|.|....||...:.:.
Mouse   593 NDNIATLLHQSSDKFVSELWKDVDRIIGLDQVAGMSETALP----GAFKTRKGMFRTVGQLYKEQ 653

  Fly   716 LQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFV 780
            |.:|:.::...:|.|||||.||.||.|.::|...||.|||..|:|:.|:|.::|:|.|:.||.|.
Mouse   654 LAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFR 718

  Fly   781 ERYRHLLPSPLARG-TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLR 844
            :||..|.|:.:.:| ...::.|..:::|:.   ::...|::|.::||.|..:...||..|..::.
Mouse   719 QRYEILTPNSIPKGFMDGKQACVLMIKALE---LDSNLYRIGQSKVFFRAGVLAHLEEERDLKIT 780

  Fly   845 RAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRV 909
            ...:..|...||.|.|:..|:||...|.::..   ||....|.|||.        |:..:...:|
Mouse   781 DVIIGFQACCRGYLARKAFAKRQQQLTAMKVL---QRNCAAYLRLRN--------WQWWRLFTKV 834

  Fly   910 QQLRSDHRRRQE--AREA-AQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDR 971
            :.|.:..|...|  |:|| ..:.||...|.:..|...:.....:.||...:..:||..:....:.
Mouse   835 KPLLNSIRHEDELLAKEAELTKVREKHLAAENRLTEMETMQSQLMAEKLQLQEQLQAETELCAEA 899

  Fly   972 HLVKV--------LGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCN------------GLRLQPRR 1016
            ..::.        |..:.....:.|:..|:..|:...:...:..|            ..|.:.:.
Mouse   900 EELRARLTAKKQELEEICHDLEARVEEEEERCQYLQAEKKKMQQNIQELEEQLEEEESARQKLQL 964

  Fly  1017 EPITAPLLTRAASRDQD---------------FQDALAVFKLILRWSNDKA-----LEGAKEKLL 1061
            |.:|.....:....||.               .:|.:|.|...|....:|:     |:...|.::
Mouse   965 EKVTTEAKLKKLEEDQIIMEDQNCKLAKEKKLLEDRVAEFTTNLMEEEEKSKSLAKLKNKHEAMI 1029

  Fly  1062 ADYIVHKALSSRGLRDEILVQLCNQVHGLPPN----SGEATRLWQLLGQCLCCFQPSAAFSKYLM 1122
            .|      |..|..|:|      .|...|...    .|::|.|...:.:.      .|..::..|
Mouse  1030 TD------LEERLRREE------KQRQELEKTRRKLEGDSTDLSDQIAEL------QAQIAELKM 1076

  Fly  1123 RF-------------VDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTR 1174
            :.             |::||.:....|...:.|..|............|.|:        :|..:
Mouse  1077 QLAKKEEELQAALARVEEEAAQKNMALKKIRELETQISELQEDLESERASRN--------KAEKQ 1133

  Fly  1175 GCDM-----ALPLTLPDEASQTVAVDSWTS-CEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCG 1233
            ..|:     ||...|.|....|.|.....| .|:..::...:|...::.....:.:.:|....  
Mouse  1134 KRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVSILKKTLEDEAKTHEAQIQEMRQKHSQ-- 1196

  Fly  1234 LDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRS 1298
                    |.:||        :|.|.. .|..:.||..|                |:.:..||  
Mouse  1197 --------AVEEL--------ADQLEQ-TKRVKATLEKA----------------KQTLENER-- 1226

  Fly  1299 SRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDL-------------LAGDIVPVP 1350
             .||.:...||.:           |:|.|..:.|.....|.:|             ||..:..:.
Mouse  1227 -GELANEVKALLQ-----------GKGDSEHKRKKVEAQLQELQVKFSEGERVRTELADKVTKLQ 1279

  Fly  1351 TDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADK 1415
            .:.||...|  |..|:|:.:........|....:||....|:...                  .|
Mouse  1280 VELDSVTGL--LSQSDSKSSKLTKDFSALESQLQDTQELLQEENR------------------QK 1324

  Fly  1416 AEYATRSSAMSDTSEAPSLASHVRR------------VRVPSQASDVDQFLDDLFSPVLDGSLDE 1468
            ...:|:...|.|  |..|....:..            ..:.:|.:|:.:.::|..     |.|:.
Mouse  1325 LSLSTKLKQMED--EKNSFREQLEEEEEAKRNLEKQIATLHAQVTDMKKKMEDGV-----GCLET 1382

  Fly  1469 LSDA-RSLAASIRG---------GSYEQENEAESEI-DDLDDYINDIFQPIPLVQNLEKLTSK-D 1521
            ..:| |.|...:.|         .:|::..:.::.: .:|||.:.|:......|.||||...| |
Mouse  1383 AEEAKRRLQKDLEGLSQRLEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSVSNLEKKQKKFD 1447

  Fly  1522 QLAAIIKGGGVASK-PEERD--------EESEIEDLDDYINELFEPIPVAEGLDK---------L 1568
            ||.|..|  .:::| .||||        :|::...|...:.|..|.....|.|:|         :
Mouse  1448 QLLAEEK--TISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLM 1510

  Fly  1569 TSKEHLAVSIRGGGSTD---SNGADPLLHQLMQLPGE---TESGPALYQ---QQVQRAF---LQS 1621
            :||:.:..|:.....:.   ....:.:..||.:|..|   ||......:   |.::..|   ||.
Mouse  1511 SSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQG 1575

  Fly  1622 AMAQNLQIQQQLLAQNQALQTLL----SQQAAAAAANNSTSPPPAPPILSSLS--ISPPPPQSPM 1680
            ...|:.:.::||:.|.:.::..|    .|::.|.||.......     |..|.  |.........
Mouse  1576 RDEQSEEKKKQLVRQVREMEAELEDERKQRSMAMAARKKLEMD-----LKDLEAHIDTANKNREE 1635

  Fly  1681 RMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEP 1745
            .:|..|.....|:...             .|..|...:|..:....:....::      ...:..
Mouse  1636 AIKQLRKLQAQMKDCM-------------RELDDTRASREEILAQAKENEKKL------KSMEAE 1681

  Fly  1746 QFQTEEDFFAFK--MRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPP 1808
            ..|.:|:..|.:  .||.|::....|.....:|..|.:......|..:..|...||.|.|.....
Mouse  1682 MIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTE 1746

  Fly  1809 PMSGQLMRSSIRLETTTT----TTTSAVNNRD-------RDRETQDVGQPMQSVVTTKLAKKSFE 1862
            .::.:|.:::::::...|    ..:.|..|.:       :::|.:...|.|:|.|.:|.......
Mouse  1747 LINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKAKLQEMESAVKSKYKASIAA 1811

  Fly  1863 IGADRPPPGSVGKL--KLSSEMRQRLEQVTAGHSVRST--------VSTKSEQRAPAKLED---- 1913
            :.|      .:.:|  :|.:|.::|   ..|...||.|        :..:.|:|...:.:|    
Mouse  1812 LEA------KIAQLEEQLDNETKER---QAASKQVRRTEKKLKDVLLQVEDERRNAEQFKDQADK 1867

  Fly  1914 --TRKLMLQQQL 1923
              ||...|::||
Mouse  1868 ASTRLKQLKRQL 1879

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc_Myo15 169..828 CDD:276838 267/683 (39%)
PTZ00121 <828..>943 CDD:173412 31/117 (26%)
MyTH4 1014..1171 CDD:470587 31/193 (16%)
Ubl1_cv_Nsp3_N-like 1178..>1245 CDD:475130 11/72 (15%)
MyTH4 2704..2810 CDD:459939
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
Myh9NP_071855.2 Mediates interaction with LIMCH1. /evidence=ECO:0000250|UniProtKB:P35579 2..838 296/782 (38%)
Myosin_N 27..72 CDD:460670
Motor_domain 95..764 CDD:473979 267/683 (39%)
Actin-binding 654..676 9/21 (43%)
Myosin_tail_1 842..1921 CDD:460256 212/1175 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1035..1057 6/27 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1117..1167 11/57 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1327..1352 5/26 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1768..1788 2/19 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1877..1908 2/3 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1939..1960
Blue background indicates that the domain is not in the aligned region.

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