DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and Myh8

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	XP_036012291.1	Gene:	Myh8 / 17885	MGIID:	1339712	Length:	1966	Species:	Mus musculus

Alignment Length:	2078	Identity:	514/2078 - (24%)
Similarity:	829/2078 - (39%)	Gaps:	498/2078 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 RHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVN 196
            :..|.|.:.|.:          ...:|||.::..|||..:|:||:.||...:|||::|...:.||
Mouse    75 KEDQVFPMNPPK----------YDKIEDMAMMTHLHEPGVLYNLKERYAAWMIYTYSGLFCVTVN 129

  Fly   197 PYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKL 258
            |||..| .|..||...|.|:.....|||:|:|...|:..:.:.   |.::|:||||:|||.:||.
Mouse   130 PYKWLP-VYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKR 193

  Fly   259 VMQYLAAVVPGG-------GSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KS 315
            |:||.|.:...|       |.....:.:||:.|.|||||||||:|.||||||||||::.::| .:
Mouse   194 VIQYFATIAVTGDKKKEESGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTT 258

  Fly   316 GAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLE-------ADKYFYLN 373
            |.:..|.|..|||||||:..|...||:||:||::      |...|..|:|       ...|.:::
Mouse   259 GKLASADIETYLLEKSRVTFQLKAERSYHIFYQI------TSNKKPELIEMLLITTNPYDYAFVS 317

  Fly   374 QGATDCASGRVDWESL---QGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQE--GV 433
            ||.....| ..|.|.|   ..|:.:||.|..|:..|.::..||:|.||:.|.::|.....|  |.
Mouse   318 QGEITVPS-IDDQEELMATDSAIDILGFSPEEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGT 381

  Fly   434 EVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNW 498
            ||...     ||:|..:::..|.:||.....:...|.:.....:.|..:|..|.|||:|..:|.|
Mouse   382 EVADK-----AAYLQCLNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNAVGALAKAVYEKMFLW 441

  Fly   499 LVSRINSIVQKGGTHDAHR--ISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAE 561
            :|:|||   |:..|....:  |.:|||.|||....||.||||||:.||.||.:||.|:|.|||.|
Mouse   442 MVTRIN---QQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEE 503

  Fly   562 YARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYAR 625
            |.:|.:|||.:.:..:|.....|.:||:||..:|::|..||:|||.||..|.:..| ..|..:.:
Mouse   504 YKKEGIEWTFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQK 568

  Fly   626 PR--IGAQE--FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGEL-TKQLRAQRD 685
            |:  .|..|  |.:.||||.|.|.:.|:||||:|.|...|:.|...|.:..:..| :....|:.|
Mouse   569 PKPTKGKAEAHFSLVHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTLASLFSTYASAEAD 633

  Fly   686 AGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCV 750
            .|  ..||:..:..:.:    ||:|.|.::|.:|:.::...||.|||||.||:.|....|:...|
Mouse   634 GG--AKKGAKKKGSSFQ----TVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELV 692

  Fly   751 LQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEG 815
            |.|||..|:|:.|:|.::|:|.|:.:..|.:||:.|..|.:..| .:.:..:|..:.:....::.
Mouse   693 LHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEG-QFIDSKKASEKLLGSIDIDH 756

  Fly   816 PDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVR----RQLARRQ--------- 867
            ..|:.|.|:||.:..|...||..|.|:|.:.....|...||.|:|    :.|.||:
Mouse   757 TQYKFGHTKVFFKAGLLGLLEEMRDEKLAQIITRTQAVCRGYLMRVEYQKMLLRRESIFCIQYNV 821

  Fly   868 -----------------------AAATRLQARWRGQRAQQRYERLRKGALTAQRLWRG------- 902
                                   :|.|..:.....:..|:..:.|.|.....:.|...
Mouse   822 RAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKE 886

  Fly   903 ---------------RQARRRVQQL-RSDHRRRQEAREAAQRAREARE------AKQAVLERSQL 945
                           ..|..|.:|| ::..:...:.:|..:||.:..|      ||:..|| .:.
Mouse   887 KNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEDEEEINAELTAKKRKLE-DEC 950

  Fly   946 SYL--DIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGK--FSSVY 1006
            |.|  ||. :|....:|::  ...|...:.||.|      ......|.|::.:.:..|  ....:
Mouse   951 SELKKDID-DLELTLAKVE--KEKHATENKVKNL------TEEMAGLDENIAKLTKEKKALQEAH 1006

  Fly  1007 CNGL-RLQPRREPITAPLLTRAASR-DQDFQDALAVFKLILRWSNDKALEGAKEKL-----LADY 1064
            ...| .||...:.:..  ||:|.:: :|...|.....:...:...|  ||.||.||     ||..
Mouse  1007 QQTLDDLQAEEDKVNT--LTKAKTKLEQQVDDLEGSLEQEKKLRMD--LERAKRKLEGDLKLAQE 1067

  Fly  1065 IVHKALSSRGLRDEIL----VQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFV 1125
            ......:.:...||.|    .::.|.:..:........:|.:.:              |.|...:
Mouse  1068 STMDIENDKQQLDEKLKKKEFEISNLISKIEDEQAVEIQLQKKI--------------KELQARI 1118

  Fly  1126 DD-----EA-------PESLRPLLLRQLLR-----QQGGGTSSGAVGAGACRSFVPAWLEWRAWT 1173
            ::     ||       .|..|..|.|:|..     ::.||.:|..|.....|.     .|::...
Mouse  1119 EELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVEMNKKRE-----TEFQKLR 1178

  Fly  1174 RGCDMALPLTLPDEASQTVAVDSWTSCEEAAAL------AVSSLGVASRGWTLVLDDGQQLTDSC 1232
            |..:.|   ||..||:             ||||      :|:.||..       :|:.|::...
Mouse  1179 RDLEEA---TLQHEAT-------------AAALRKKHADSVAELGEQ-------IDNLQRVKQK- 1219

  Fly  1233 GLDYVMDLIAEKELCPAFPAPRSDL------LRSGA-----------KFARTTLPDAVKRPAVPP 1280
                     .|||        :|:|      |.|.|           |..| ||.|.|..
Mouse  1220 ---------LEKE--------KSELKMEIDDLSSNAEAIAKAKGNLEKMCR-TLEDQVSE----- 1261

  Fly  1281 PAPPTSSGKEDVPR---ERRSSRELLSRSSALNERYFEREPS----PGPGQGSSTGQAKSRSKSL 1338
                ..|.:|:..|   |..:.|..|...:....|..:.:.:    ....:.:||.|.:...:.|
Mouse  1262 ----LKSKEEEQQRLINELTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKRQL 1322

  Fly  1339 DD------LLAGDIVPVPTDCD--------SQEPLHTLGLSESRLN------------DRYHSAE 1377
            ::      .||..:.....|||        .||....|..:.|:.|            |.....|
Mouse  1323 EEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTE 1387

  Fly  1378 RLAPVGKDTGPRYQKS-QHAG---------------------------RRSHAA---------SH 1405
            .|....|....|.|.: :|..                           .|::||         :.
Mouse  1388 ELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNF 1452

  Fly  1406 GSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQAS------------DVDQFLDDLF 1458
            ....|::..|.| .|::...|...|:.:|::.:.:|:...:.|            ::.|.:.||.
Mouse  1453 DKVLSEWRQKYE-ETQAELESCQKESRTLSTELFKVKNAYEESLDHLETLRRENKNLQQEISDLT 1516

  Fly  1459 SPVLDGS--LDELSDAR--------SLAASIR--GGSYEQE-----------NEAESEID----D 1496
            ..:.:|.  :.||...:        .:.|::.  ..|.|.|           |:.:||||    :
Mouse  1517 EQIAEGGKHIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAE 1581

  Fly  1497 LDDYINDIFQ-PIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDE----ESEI----------E 1546
            .|:.|:.:.: .:.:|:     |.:..|.|.|:....|.:.:::.|    |.||          |
Mouse  1582 KDEEIDQLKRNHVRVVE-----TMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAE 1641

  Fly  1547 DLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQ 1611
            .|.:|.|        .:|:.|.| :.||..::|        |.:.|..||    ...|....|.|
Mouse  1642 SLRNYRN--------TQGILKDT-QLHLDDALR--------GQEDLKEQL----AIVERRANLLQ 1685

  Fly  1612 QQVQ--RAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPP 1674
            .:::  ||.|:.........:|:||..::.:|.|.:|.                   :||..:..
Mouse  1686 AEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQN-------------------TSLINTKK 1731

  Fly  1675 PPQSPMRMKATRSSLVVMESLQPPPPPPPP---------PMPPPLECKDPSETRHF--LDPYGRA 1728
            ..::.:....:....|:.||..........         .:|.|:.   |:.||.:  ||.:...
Mouse  1732 KLENDVSQLQSEVEEVIQESRNAEEKAKKAITDVSTTHITLPTPVL---PATTRAYFCLDLFASQ 1793

  Fly  1729 KTVRIGKWRWPPPQDEPQFQTEEDFFAF--KMRQHQRKTTPQAQH-----HQMTSNGGMMESGPG 1786
            ..:.           ..:.:.|:|..|.  :|:::..:|....||     .|:...||..:
Mouse  1794 AAMM-----------AEELKKEQDTSAHLERMKKNMEQTVKDLQHRLDEAEQLALKGGKKQ---- 1843

  Fly  1787 ARGASATAIEWE-EFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRET----QDVGQ 1846
            .:...|...|.| |.|.|..........|.:...|::..|..|       :.||:.    ||:..
Mouse  1844 IQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQT-------EEDRKNVLRLQDLVD 1901

  Fly  1847 PMQSVVTTKLAKKSFEIGADRPPPGSVGKL----KLSSEMRQRLEQVTAGHSVRSTVSTKSEQ 1905
            .:|:.|      ||::..|:.....|...|    ||..|:.:..|:.....|..:.:..||.:
Mouse  1902 KLQAKV------KSYKRQAEEAEEQSNANLAKFRKLQHELEEAEERADIAESQVNKLRVKSRE 1958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	258/710 (36%)
		MYSc_Myo15	169..828	CDD:276838	251/689 (36%)
		MyTH4	1014..1171	CDD:295320	34/183 (19%)
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myh8	XP_036012291.1	Myosin_N	37..75	CDD:397036	514/2078 (25%)
		Motor_domain	102..769	CDD:419868	251/689 (36%)
		Myosin_tail_1	849..1955	CDD:396244	236/1266 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000