DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and Myh3

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	NP_001093105.1	Gene:	Myh3 / 17883	MGIID:	1339709	Length:	1940	Species:	Mus musculus

Alignment Length:	2057	Identity:	514/2057 - (24%)
Similarity:	809/2057 - (39%)	Gaps:	476/2057 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 DVIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSIL 192
            ||.|.:|..|                 ..:|||.:|..|:|.::|:||:.||...:|||::|...
Mouse    76 DVYAMNPPKF-----------------DKIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFC 123

  Fly   193 IAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPSP---QVVVISGESGSGKTE 254
            :.|||||..| .|..||...|.|:.....|||:|:|...|:..:.:.   |.::|:||||:|||.
Mouse   124 VTVNPYKWLP-VYNPEVVDGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTV 187

  Fly   255 STKLVMQYLAAVVPGGGSA-------SAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVY 312
            :||.|:||.|.:...|..|       ...:.:||:.|.|||||||||:|.||||||||||::.::
Mouse   188 NTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIH 252

  Fly   313 F-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFY--LNQ 374
            | .:|.:..|.|..|||||||:..|...||:||:||::|.. .:.|..:..|:..:.|.|  ::|
Mouse   253 FGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSN-KKPELIELLLITTNPYDYPFISQ 316

  Fly   375 GATDCASGRVDWESL---QGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQE--GVE 434
            |....|| ..|.|.|   ..|:.:||.:..|:.|:.::..||:|.||:.|.::|.....|  |.|
Mouse   317 GEILVAS-IDDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTE 380

  Fly   435 VGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWL 499
            |...     .|:|:.:::..|.:||.....:...|.:.....:||...|.:|.:|::|..||.|:
Mouse   381 VADK-----TAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWM 440

  Fly   500 VSRINSIVQKGGTH--DAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEY 562
            |:|||   |:..|.  ..|.|.:|||.|||....||.||||||:.||.||.:||.|:|.|||.||
Mouse   441 VTRIN---QQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEY 502

  Fly   563 ARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARP 626
            .:|.:|||.:.:..:|.....|.:||:||..:|::|..||:|||.||..|.:..| ..|..:.:|
Mouse   503 KKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKP 567

  Fly   627 RI--GAQE--FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQL-RAQRDA 686
            ::  |..|  |.:.||||.|.|.|.|:|:||:|.|...|:.|...|...|:..|.... ....|.
Mouse   568 KVVKGKAEAHFSLVHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATTDADG 632

  Fly   687 GK---TLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMP 748
            ||   ...|||:.:         ||:|.|.::|.:|:.::...||.|||||.||:.|....|:..
Mouse   633 GKKKVAKKKGSSFQ---------TVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHS 688

  Fly   749 CVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARG--TPYRELCRALLEAMPRT 811
            .||.|||..|:|:.|:|.::|:|.|:.:..|.:|||.|..|.:..|  ...::.|..||.::
Mouse   689 LVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDSKKACEKLLASI--- 750

  Fly   812 GVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVR----RQLARRQA---- 868
            .::...|:.|.|:||.:..|...||..|.|||.:.....|...||.|:|    :.:.||::
Mouse   751 DIDHTQYKFGHTKVFFKAGLLGTLEEMRDERLAKLITRTQAVCRGFLMRVEFQKMMQRRESIFCI 815

  Fly   869 ----AATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQ-QLRSDHRRRQEARE---- 924
                .|......|...:...:.:.|.|.|.|.:.:...::..::.: :|.....:|:|..|
Mouse   816 QYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVT 880

  Fly   925 ---------------------AAQRAREAREAK-------QAVLERSQLSYLDIPAELAFIYSKL 961
                                 |.:|..:..:||       :.|.||:: ...:|.|||.....||
Mouse   881 LVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAE-DEEEINAELTAKKRKL 944

  Fly   962 QG-------------------WSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGK--FSSV 1005
            :.                   ....|...:.||.|      ......|.|.:.:.:..|  ....
Mouse   945 EDECSELKKDIDDLELTLAKVEKEKHATENKVKNL------TEELAGLDETIAKLTREKKALQEA 1003

  Fly  1006 YCNGL-RLQPRREPIT--APLLTRAASRDQDFQDALAVFK----------------------LIL 1045
            :...| .||...:.:.  :.|.::...:..|.:.:|...|                      .||
Mouse  1004 HQQTLDDLQAEEDKVNSLSKLKSKLEQQVDDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESIL 1068

  Fly  1046 RWSNDKALEGAKEKLLADYIVHKALSSRGLRDE--ILVQLCNQVHGLPPNSGE---------ATR 1099
            ...|||  :...|:|......:..|.|: :.||  :.:||..::..|.....|         |||
Mouse  1069 DLENDK--QQLDERLKKKDFEYSQLQSK-VEDEQTLSLQLQKKIKELQARIEELEEEIEAERATR 1130

  Fly  1100 LWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVP 1164
            .           :.....|.|....  :|..|.|          ::.||.:|..:.....|.
Mouse  1131 A-----------KTEKQRSDYAREL--EELSERL----------EEAGGVTSTQIELNKKRE--- 1169

  Fly  1165 AWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLT 1229
              .|:....|..:.|   ||..||  |||.......:.||.||..            :|:.|::.
Mouse  1170 --AEFLKLRRDLEEA---TLQHEA--TVATLRKKHADSAAELAEQ------------IDNLQRVK 1215

  Fly  1230 DSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFART---------TLPDAVKRPAVPPPAPPT 1285
            ..          .|||. ..|.....||..|....:::         ||.|.:..
Mouse  1216 QK----------LEKEK-SEFKLEIDDLSSSVESVSKSKANLEKICRTLEDQLSE---------- 1259

  Fly  1286 SSGKEDVPRERRSSRELLSRSSALN------ERYFEREPS----PGPGQGSSTGQAKSRSKSLDD 1340
            :.||.:  ..:||..||.::.|.|.      .|..|.:.|    ....:.:.|.|.:...:.|::
Mouse  1260 ARGKNE--EMQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQIEELKRQLEE 1322

  Fly  1341 ------LLAGDIVPVPTDCD--------SQEPLHTLGLSESRLN------------DRYHSAERL 1379
                  .||..:.....|||        .||....|..:.|:.|            |.....|.|
Mouse  1323 ENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEEL 1387

  Fly  1380 APVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVP 1444
            ....|....|.|.|:......:|.......:|...:.|.   ...|.|...|.|||:     .:.
Mouse  1388 EEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEV---EDLMVDVERANSLAA-----ALD 1444

  Fly  1445 SQASDVDQFLDDLFSPVLDGSLD---ELSDARSLAASI--RGGSYEQ----------ENE-AESE 1493
            .:..:.|:.|.:..:...:...:   .|.::|||:..:  ...:||:          ||: .|.|
Mouse  1445 KKQRNFDKVLAEWKTKCEESQAELEAALKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQE 1509

  Fly  1494 IDDLDDYINDIFQPIPLVQNLEKLTSKDQL--------------------AAIIK--------GG 1530
            |.||.:.|.:..:.|   ..|||...:.:|                    |.|::        ..
Mouse  1510 IADLTEQIAENGKSI---HELEKSRKQMELEKADIQMALEEAEAALEHEEAKILRIQLELTQVKS 1571

  Fly  1531 GVASKPEERDEESE---------IED----LDDYINELFEPIPVAEGLD--------KLT-SKEH 1573
            .:..|..|:|||.|         :|.    ||..:....|.|.:.:.::        :|: :...
Mouse  1572 EIDRKIAEKDEEIEQLKRNYQRTVETMQGALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQ 1636

  Fly  1574 LAVSIRGGGSTDSNGADPLLHQLMQLPGE---------TESGPALYQQQVQ--RAFLQSAMAQNL 1627
            .|.:|:...|......|..||....|.|:         .|....|.|.:|:  ||.|:.......
Mouse  1637 AAETIKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARK 1701

  Fly  1628 QIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVM 1692
            ..:|:||..|:.:|.|.:|..:.....                            |...:.|..:
Mouse  1702 LAEQELLDSNERVQLLHTQNTSLIHTK----------------------------KKLETDLTQL 1738

  Fly  1693 ESLQPPPPPPPPPMPPPLE--CKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFA 1755
            :|              .:|  |:|......      :||     |..........:.:.|:|..|
Mouse  1739 QS--------------EVEDACRDARNAEE------KAK-----KAITDAAMMAEELKKEQDTSA 1778

  Fly  1756 F--KMRQHQRKTTPQAQH-----HQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQ 1813
            .  :|:::..:|....||     .|:...||..:.     ....|.|...|||:|        |:
Mouse  1779 HLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQI-----QKLETRIRELEFELE--------GE 1830

  Fly  1814 LMRS--SIR-LETTTTTTTSAVNNRDRDRET----QDVGQPMQSVVTTKLAKKSFEIGADRPPPG 1871
            ..|:  |:: |..............:.||:.    ||:...:|  |..|..|:..| .||.....
Mouse  1831 QKRNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQ--VKVKSYKRQAE-EADEQANA 1892

  Fly  1872 SVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLED 1913
            .:.|.:.:....:..|:       |:.::.....:..||..|
Mouse  1893 HLTKFRKAQHELEEAEE-------RADIAESQVNKLRAKTRD 1927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	263/710 (37%)
		MYSc_Myo15	169..828	CDD:276838	256/689 (37%)
		MyTH4	1014..1171	CDD:295320	32/191 (17%)
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myh3	NP_001093105.1	Myosin_N	35..73	CDD:367160
		MYSc_Myh3	100..767	CDD:276878	256/689 (37%)
		Actin-binding. /evidence=ECO:0000250	656..678		10/21 (48%)
		Actin-binding. /evidence=ECO:0000250	758..772		5/13 (38%)
		Myosin_tail_1	847..1924	CDD:366712	224/1241 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1260..1289		8/30 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000